A Study of AV-101 (Dry Powder Inhaled Imatinib) in Patients With Pulmonary Arterial Hypertension (PAH)
Public ClinicalTrials.gov record NCT05036135. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
IMPAHCT: A Phase 2b/3, Randomized, Double-Blind, Placebo-Controlled, 24-Week Dose Ranging and Confirmatory Study to Evaluate the Safety and Efficacy of AV-101 in Patients With Pulmonary Arterial Hypertension (PAH)
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
IMPAHCT: Inhaled iMatinib Pulmonary Arterial Hypertension Clinical Trial is a Phase 2b/Phase 3 study to evaluate the safety and efficacy of AV-101 (dry powder inhaled imatinib) in patients with Pulmonary Arterial Hypertension (PAH). The Phase 2b part of the study will assess three doses to establish an optimal dose for the Phase 3 part of the study. The Phase 2b primary endpoint will be the placebo corrected change in pulmonary vascular resistance (PVR). The Phase 3 primary endpoint will be the placebo corrected change in 6-minute walk distance (6MWD) after 24 weeks of treatment.
Study identification
- NCT ID
- NCT05036135
- Recruitment status
- Terminated
- Study type
- Interventional
- Phase
- Phase 2, Phase 3
- Enrollment
- 202 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 18 Years to 75 Years
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Dec 2, 2021 (Actual)
- Primary completion
- Aug 9, 2024 (Actual)
- Completion
- Aug 9, 2024 (Actual)
- Last update posted
- Aug 23, 2024
2021 – 2024
United States locations
- U.S. sites
- 39
- U.S. states
- 23
- U.S. cities
- 34
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Arizona Pulmonary Specialists, Ltd. | Phoenix | Arizona | 85012 | — |
| University of Arizona, Department of Medicine | Tucson | Arizona | 85724 | — |
| UCLA/David Geffen School of Medicine-Pulmonary and Criticial Care | Los Angeles | California | 90024 | — |
| Kaiser Permanente Los Angeles Medical Center | Los Angeles | California | 90027 | — |
| Cedars-Sinai Medical Center, Pulmonary & Critical Care | Los Angeles | California | 90048 | — |
| Dept of Veterans Affairs Greater Los Angeles Healthcare System | Los Angeles | California | 90073 | — |
| UC Davis Medical Center | Sacramento | California | 95817 | — |
| University of California | San Francisco | California | 94143 | — |
| LA Biomedical Research Institute Harbor | Torrance | California | 90509 | — |
| University of Colorado Denver | Aurora | Colorado | 80045 | — |
| National Jewish Health | Denver | Colorado | 80206 | — |
| George Washington University Medical Faculty Associates, Inc. | Washington D.C. | District of Columbia | 20073 | — |
| Mayo Clinic Florida | Jacksonville | Florida | 32224 | — |
| Orlando Heart Center | Orlando | Florida | 32804 | — |
| Emory University | Atlanta | Georgia | 30322 | — |
| Indiana University Health | Indianapolis | Indiana | 46202 | — |
| University of Iowa Hospitals & Clinics | Iowa City | Iowa | 52242 | — |
| University of Kansas Medical Center | Kansas City | Kansas | 66160 | — |
| Tufts Medical Center, Inc. | Boston | Massachusetts | 02111 | — |
| University of Michigan | Ann Arbor | Michigan | 48109 | — |
| University of Minnesota | Minneapolis | Minnesota | 55455 | — |
| Washington University School of Medicine | St Louis | Missouri | 63110 | — |
| University of Nebraska Medical Center- Hematology/Oncology Section | Omaha | Nebraska | 68198 | — |
| The Unviersity of New Mexico - UNM Hospitals | Albuquerque | New Mexico | 87131 | — |
| New York-Presbyterian Brooklyn Methodist Hospital | Brooklyn | New York | 11215 | — |
| NYU Langone Seaport | New York | New York | 10016 | — |
| Duke University Medical Center - Duke South Clinic | Durham | North Carolina | 27710 | — |
| The Lindner Center for Research and Education | Cincinnati | Ohio | 45219 | — |
| University of Cincinnati | Cincinnati | Ohio | 45267 | — |
| The Ohio State University Wexner Medical Center | Columbus | Ohio | 43210 | — |
| Bend Memorial Clinic | Oregon City | Oregon | 97701 | — |
| Hospital of the University of Pennsylvania | Philadelphia | Pennsylvania | 19104 | — |
| Thomas Jefferson University | Philadelphia | Pennsylvania | 19107 | — |
| UPMC Presbyterian Hospital | Pittsburgh | Pennsylvania | 15213 | — |
| Stat Care Pulmonary Consultants, PLLC | Knoxville | Tennessee | 37919 | — |
| Vanderbilt University Medical Center | Nashville | Tennessee | 37232 | — |
| Baylor University Medical Center | Dallas | Texas | 75246 | — |
| Houston Methodist Hospital | Houston | Texas | 77030 | — |
| Sentara Medical Group - Sentara Pulmonary & Critical Care Specialists | Norfolk | Virginia | 23507 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 89 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT05036135, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Aug 23, 2024 · Synced Oct 19, 2026
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Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT05036135 live on ClinicalTrials.gov.