A Study of Efruxifermin in Subjects With Compensated Cirrhosis Due to Nonalcoholic Steatohepatitis (NASH) (Symmetry)
Public ClinicalTrials.gov record NCT05039450. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Phase 2b, Randomized, Double-Blind, Placebo-Controlled Study Evaluating the Safety and Efficacy of Efruxifermin in Subjects With Compensated Cirrhosis Due to Nonalcoholic Steatohepatitis (NASH)
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
This is a multi-center evaluation of efruxifermin (EFX) in a randomized, double-blind, placebo-controlled study in cirrhotic subjects with biopsy-proven F4 compensated NASH.
Study identification
- NCT ID
- NCT05039450
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 2
- Enrollment
- 213 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 18 Years to 75 Years
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Jul 30, 2021 (Actual)
- Primary completion
- Dec 15, 2023 (Actual)
- Completion
- Aug 28, 2025 (Actual)
- Last update posted
- Jul 21, 2026
2021 – 2025
United States locations
- U.S. sites
- 46
- U.S. states
- 16
- U.S. cities
- 41
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Akero Clinical Study Site | Chandler | Arizona | 85224 | — |
| Akero Clinical Study Site | Glendale | Arizona | 85306 | — |
| Akero Clinical Study Site | Tucson | Arizona | 85711 | — |
| Akero Clinical Study Site | Tucson | Arizona | 85712 | — |
| Akero Clinical Study Site | North Little Rock | Arkansas | 72117 | — |
| Akero Clinical Study Site | Fresno | California | 93720 | — |
| Akero Clinical Study Site | Long Beach | California | 90808 | — |
| Akero Clinical Study Site | Los Angeles | California | 90036 | — |
| Akero Clinical Study Site | Pasadena | California | 91105 | — |
| Akero Clinical Study Site | Englewood | Colorado | 80113 | — |
| Akero Clinical Study Site | Clearwater | Florida | 33761 | — |
| Akero Clinical Study Site | Fort Myers | Florida | 33907 | — |
| Akero Clinical Study Site | Fort Myers | Florida | 33912 | — |
| Akero Clinical Study Site | Hialeah Gardens | Florida | 33016 | — |
| Akero Clinical Study Site | Lakewood Rch | Florida | 34211 | — |
| Akero Clinical Study Site | Miami Lakes | Florida | 33016 | — |
| Akero Clinical Study Site | Ocala | Florida | 34471 | — |
| Akero Clinical Study Site | Sarasota | Florida | 34240 | — |
| Akero Clinical Study Site | South Bend | Indiana | 46635 | — |
| Akero Clinical Study Site | Topeka | Kansas | 66606 | — |
| Akero Clinical Study Site | Bastrop | Louisiana | 71220 | — |
| Akero Clinical Study Site | Marrero | Louisiana | 70072 | — |
| Akero Clinical Study Site | Las Vegas | Nevada | 89109 | — |
| Akero Clinical Study Site | Concord | North Carolina | 28027 | — |
| Akero Clinical Study Site | Fayetteville | North Carolina | 28304 | — |
| Akero Clinical Study Site | Morehead City | North Carolina | 28557 | — |
| Akero Clinical Study Site | Springboro | Ohio | 45066 | — |
| Akero Clinical Study Site | Westlake | Ohio | 44145 | — |
| Akero Clinical Study Site | Greenville | South Carolina | 29605 | — |
| Akero Clinical Study Site | Greenwood | South Carolina | 29646 | — |
| Akero Clinical Study Site | Summerville | South Carolina | 29485 | — |
| Akero Clinical Study Site | Nashville | Tennessee | 37211 | — |
| Akero Clinical Study Site | Austin | Texas | 78746 | — |
| Akero Clinical Study Site | Dallas | Texas | 75246 | — |
| Akero Clinical Study Site | Edinburg | Texas | 78504 | — |
| Akero Clinical Study Site | Edinburg | Texas | 78539 | — |
| Akero Clinical Study Site | Fort Worth | Texas | 75044 | — |
| Akero Clinical Study Site | Fort Worth | Texas | 76104 | — |
| Akero Clinical Study Site | Houston | Texas | 77030 | — |
| Akero Clinical Study Site | Houston | Texas | 77079 | — |
| Akero Clinical Study Site | San Antonio | Texas | 78215 | — |
| Akero Clinical Study Site | Waco | Texas | 76710 | — |
| Akero Clinical Study Site | Webster | Texas | 77598 | — |
| Akero Clinical Study Site | Wichita Falls | Texas | 76301 | — |
| Akero Clinical Study Site | Ogden | Utah | 84405 | — |
| Akero Clinical Study Site | Richmond | Virginia | 23298 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 3 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT05039450, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Jul 21, 2026 · Synced Oct 21, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT05039450 live on ClinicalTrials.gov.