A Trial to Learn How Well Finerenone Works and How Safe it is in Adult Participants With Non-diabetic Chronic Kidney Disease
Public ClinicalTrials.gov record NCT05047263. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Randomized, Double-blind, Placebo-controlled, Parallel-group, Multicenter Phase 3 Study to Investigate the Efficacy and Safety of FInerenone, in Addition to Standard of Care, on the Progression of Kidney Disease in Patients With Non-Diabetic Chronic Kidney Disease
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
Researchers are looking for a better way to treat people who have non-diabetic chronic kidney disease (non-diabetic CKD). The trial treatment, finerenone, is being developed to help people who have long lasting kidney disease, also known as chronic kidney disease (CKD). It works by blocking a certain hormone called aldosterone that causes injury and inflammation in the heart and kidney which is known to play a role in CKD. In this trial, the researchers want to learn if finerenone helps to slow down the worsening of the participants' non-diabetic CKD compared to a placebo. A placebo looks like a trial treatment but does not have any medicine in it. The trial will include about 1,580 men and women who are at least 18 years old. The participants will take finerenone or a placebo once a day as tablets by mouth. All of the participants will also continue to take their current medicine for their CKD. The participants will be in the trial for up to about 50 months. During the trial, the doctors will collect blood and urine samples and check the participants' health. The participants will also answer questions about how they are feeling and what adverse events they are having. An adverse event is a medical problem that happens during the trial. Doctors keep track of all adverse events that happen in trials, even if they do not think the adverse events might be related to the trial treatments.
Study identification
- NCT ID
- NCT05047263
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 3
- Enrollment
- 1,584 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Sep 20, 2021
- Primary completion
- Dec 30, 2025
- Completion
- Feb 1, 2026
- Last update posted
- Feb 12, 2026
2021 – 2026
United States locations
- U.S. sites
- 57
- U.S. states
- 26
- U.S. cities
- 52
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Nephrology Consultants, LLC | Huntsville | Alabama | 35805 | — |
| Balboa Research SMO+ - Chula Vista - West | Chula Vista | California | 91910 | — |
| Balboa Research SMO+ - El Centro | El Centro | California | 92243 | — |
| UCLA Clinical and Translational Research Center - Nephrology | Los Angeles | California | 90095 | — |
| Balboa Nephrology Medical Group - Poway | Poway | California | 92064 | — |
| North America Research Institute - San Dimas | San Dimas | California | 91773 | — |
| United Clinical Research & Innovations | South Gate | California | 90280 | — |
| University of Colorado | Renal Research Office | Aurora | Colorado | 80045 | — |
| DaVita Clinical Research | Middlebury, CT | Middlebury | Connecticut | 55404 | — |
| Yale University | Nephrology Clinical Research | New Haven | Connecticut | 06520 | — |
| Chase Medical Research, LLC | Waterbury | Connecticut | 06708 | — |
| Research Physicians Network Alliance | Boca Raton | Florida | 33431 | — |
| Florida Kidney Physicians - Boca Raton | Boca Raton | Florida | 33487 | — |
| AdventHealth Translational Research Institute | Orlando | Florida | 32804 | — |
| Grady Memorial Hospital - Endocrinology | Atlanta | Georgia | 30303 | — |
| Southeastern Clinical Research Institute, LLC | Augusta | Georgia | 30904 | — |
| Central Georgia Kidney Specialists - Macon | Macon | Georgia | 31201 | — |
| Frenova Renal Research | Boise Kidney and Hypertension | Meridian | Idaho | 83642 | — |
| Northwestern Medicine - Feinberg School of Medicine - Nephrology and Hypertension | Chicago | Illinois | 60611 | — |
| Research by Design, LLC | Chicago, IL | Chicago | Illinois | 60643 | — |
| Nephrology Associates of Northern Illinois and Indiana - Hinsdale | Hinsdale | Illinois | 60521 | — |
| University of Iowa Health Care Medical Center - Cardiology | Iowa City | Iowa | 52242 | — |
| KUMC Clinical and Translational Science Unit - Nephrology | Kansas City | Kansas | 66160 | — |
| Kansas Nephrology Research Institute | Wichita | Kansas | 67214 | — |
| Wichita Nephrology Group, PA | Wichita | Kansas | 67214 | — |
| Northwest Louisiana Nephrology - Shreveport - 1800 Buckner St. | Shreveport | Louisiana | 71101 | — |
| Johns Hopkins Hospital - Nephrology | Baltimore | Maryland | 21287 | — |
| Tufts Medical Center | Nephrology Department | Boston | Massachusetts | 02111 | — |
| DaVita Clinical Research | Edina, MN | Edina | Minnesota | 55435 | — |
| University Hospital - UMMC - Nephrology | Jackson | Mississippi | 39216 | — |
| Clinical Research Consultants, a JCCT Company | Kansas City | Missouri | 64111 | — |
| St. Louis Heart and Vascular, PC - Christian Hospital Office | St Louis | Missouri | 63136 | — |
| UNM Clinical and Translational Science Center - Nephrology | Albuquerque | New Mexico | 87131 | — |
| Mountain Kidney & Hypertension Associates | Asheville | North Carolina | 28801 | — |
| UNC Hospitals Outpatient Center at Eastowne - Nephrology | Chapel Hill | North Carolina | 27514 | — |
| East Carolina University | Nephrology & Hypertension | Greenville | North Carolina | 27834 | — |
| Eastern Nephrology Associates | Wilmington | Wilmington | North Carolina | 28401 | — |
| UH Cleveland Medical Center - Nephrology | Cleveland | Ohio | 44106 | — |
| Cleveland Clinic | Urological and Kidney Department | Cleveland | Ohio | 44195 | — |
| Northeast Clinical Research Center | Bethlehem, PA | Bethlehem | Pennsylvania | 18017 | — |
| Geisinger Medical Center - Nephrology | Danville | Pennsylvania | 17822 | — |
| Temple Health - Nephrology | Philadelphia | Pennsylvania | 19140 | — |
| South Carolina Clinical Reserach | Orangeburg | South Carolina | 29118 | — |
| Knoxville Kidney Center, PLLC | Knoxville | Tennessee | 37923 | — |
| Vanderbilt University Medical Center - Nephrology Clinical Trials Center | Nashville | Tennessee | 37232 | — |
| Dallas Renal Group - Medical City | Dallas | Texas | 75230 | — |
| El Paso Medical Research Institute (MedResearch Inc) | El Paso, TX | El Paso | Texas | 79902 | — |
| DaVita Clinical Research | Houston, TX | Houston | Texas | 77054 | — |
| Gamma Medical Research, Inc. | McAllen | Texas | 78503 | — |
| Texas Diabetes Institute - Renal Clinic | San Antonio | Texas | 78207 | — |
| Clinical Advancement Center, PLLC | San Antonio | Texas | 78212 | — |
| DaVita Clinical Research | North Houston, TX | Shenandoah | Texas | 77384 | — |
| University of Utah School of Medicine | Kidney Research Clinic | Salt Lake City | Utah | 84132 | — |
| Utah Kidney Research Institute | Salt Lake City, UT | South Salt Lake | Utah | 84115 | — |
| Nephrology Associates of Northern Virginia - Fair Oaks | Fairfax | Virginia | 22033 | — |
| Mendez Center For Clinical Research | Woodbridge, VA | Woodbridge | Virginia | 22192 | — |
| Providence Medical Research Center | Spokane Valley | Washington | 99204 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 269 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT05047263, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Feb 12, 2026 · Synced Sep 2, 2026
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Open the official record
The complete protocol, eligibility criteria, and contact information for NCT05047263 live on ClinicalTrials.gov.