Testing the Addition of the Drug Relugolix to the Usual Radiation Therapy for Advanced-Stage Prostate Cancer, The NRG Promethean Study
Public ClinicalTrials.gov record NCT05053152. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Phase II Double-Blinded, Placebo-Controlled Trial of PROstate OligoMETastatic RadiotHErapy With or Without ANdrogen Deprivation Therapy in Oligometastatic Prostate Cancer (NRG Promethean)
Study identification
- NCT ID
- NCT05053152
- Recruitment status
- Active, not recruiting
- Study type
- Interventional
- Phase
- Phase 2
- Lead sponsor
- NRG Oncology
- Other
- Enrollment
- 194 participants
Conditions and interventions
Conditions
Interventions
- Biospecimen Collection Procedure
- Bone Scan Procedure
- Computed Tomography Procedure
- Fluciclovine F18 Other
- Magnetic Resonance Imaging Procedure
- PSMA PET Scan Procedure
- Placebo Administration Drug
- Positron Emission Tomography Procedure
- Relugolix Drug
- Stereotactic Body Radiation Therapy Radiation
Procedure · Other · Drug + 1 more
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- Male
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Apr 19, 2022
- Primary completion
- Jan 31, 2029
- Completion
- Jan 31, 2029
- Last update posted
- May 3, 2026
2022 – 2029
United States locations
- U.S. sites
- 242
- U.S. states
- 34
- U.S. cities
- 195
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Cancer Center at Saint Joseph's | Phoenix | Arizona | 85004 | — |
| Alta Bates Summit Medical Center-Herrick Campus | Berkeley | California | 94704 | — |
| Tower Cancer Research Foundation | Beverly Hills | California | 90211 | — |
| Marin General Hospital | Greenbrae | California | 94904 | — |
| UCI Health - Chao Family Comprehensive Cancer Center and Ambulatory Care | Irvine | California | 92612 | — |
| Los Angeles General Medical Center | Los Angeles | California | 90033 | — |
| USC / Norris Comprehensive Cancer Center | Los Angeles | California | 90033 | — |
| Cedars Sinai Medical Center | Los Angeles | California | 90048 | — |
| Memorial Medical Center | Modesto | California | 95355 | — |
| UC Irvine Health/Chao Family Comprehensive Cancer Center | Orange | California | 92868 | — |
| Sutter Medical Center Sacramento | Sacramento | California | 95816 | — |
| Sutter Pacific Medical Foundation | Santa Rosa | California | 95403 | — |
| Sutter Solano Medical Center/Cancer Center | Vallejo | California | 94589 | — |
| UCHealth University of Colorado Hospital | Aurora | Colorado | 80045 | — |
| Rocky Mountain Cancer Centers-Boulder | Boulder | Colorado | 80304 | — |
| UCHealth Memorial Hospital Central | Colorado Springs | Colorado | 80909 | — |
| Memorial Hospital North | Colorado Springs | Colorado | 80920 | — |
| AdventHealth Porter | Denver | Colorado | 80210 | — |
| Shaw Cancer Center | Edwards | Colorado | 81632 | — |
| Poudre Valley Hospital | Fort Collins | Colorado | 80524 | — |
| Cancer Care and Hematology-Fort Collins | Fort Collins | Colorado | 80528 | — |
| Banner North Colorado Medical Center | Greeley | Colorado | 80631 | — |
| UCHealth Greeley Hospital | Greeley | Colorado | 80631 | — |
| UCHealth Highlands Ranch Hospital | Highlands Ranch | Colorado | 80129 | — |
| AdventHealth Littleton | Littleton | Colorado | 80122 | — |
| Medical Center of the Rockies | Loveland | Colorado | 80538 | — |
| Banner North Colorado Medical Center - Loveland Campus | Loveland | Colorado | 80539 | — |
| AdventHealth Parker | Parker | Colorado | 80138 | — |
| Beebe South Coastal Health Campus | Millville | Delaware | 19967 | — |
| Helen F Graham Cancer Center | Newark | Delaware | 19713 | — |
| Medical Oncology Hematology Consultants PA | Newark | Delaware | 19713 | — |
| Beebe Health Campus | Rehoboth Beach | Delaware | 19971 | — |
| George Washington University Medical Center | Washington D.C. | District of Columbia | 20037 | — |
| AdventHealth Altamonte | Altamonte Springs | Florida | 32701 | — |
| AdventHealth Celebration | Celebration | Florida | 34747 | — |
| Jupiter Medical Center | Jupiter | Florida | 33458 | — |
| GenesisCare USA - Lakewood Ranch | Lakewood Rch | Florida | 34202 | — |
| AdventHealth Orlando | Orlando | Florida | 32803 | — |
| GenesisCare USA - Plantation | Plantation | Florida | 33324 | — |
| Moffitt Cancer Center at SouthShore | Ruskin | Florida | 33570 | — |
| Moffitt Cancer Center-International Plaza | Tampa | Florida | 33607 | — |
| Moffitt Cancer Center - McKinley Campus | Tampa | Florida | 33612 | — |
| Moffitt Cancer Center | Tampa | Florida | 33612 | — |
| Moffitt Cancer Center at Wesley Chapel | Wesley Chapel | Florida | 33544 | — |
| Cleveland Clinic-Weston | Weston | Florida | 33331 | — |
| Grady Health System | Atlanta | Georgia | 30303 | — |
| Emory University Hospital Midtown | Atlanta | Georgia | 30308 | — |
| Piedmont Hospital | Atlanta | Georgia | 30309 | — |
| Emory University Hospital/Winship Cancer Institute | Atlanta | Georgia | 30322 | — |
| Emory Saint Joseph's Hospital | Atlanta | Georgia | 30342 | — |
| WellStar Cobb Hospital | Austell | Georgia | 30106 | — |
| Emory Decatur Hospital | Decatur | Georgia | 30033 | — |
| Piedmont Fayette Hospital | Fayetteville | Georgia | 30214 | — |
| Emory Johns Creek Hospital | Johns Creek | Georgia | 30097 | — |
| Wellstar Kennestone Hospital | Marietta | Georgia | 30060 | — |
| Alton Memorial Hospital | Alton | Illinois | 62002 | — |
| Advocate Good Shepherd Hospital | Barrington | Illinois | 60010 | — |
| Advocate Illinois Masonic Medical Center | Chicago | Illinois | 60657 | — |
| AMG Crystal Lake - Oncology | Crystal Lake | Illinois | 60014 | — |
| Carle at The Riverfront | Danville | Illinois | 61832 | — |
| Decatur Memorial Hospital | Decatur | Illinois | 62526 | — |
| Advocate Good Samaritan Hospital | Downers Grove | Illinois | 60515 | — |
| Crossroads Cancer Center | Effingham | Illinois | 62401 | — |
| Advocate Sherman Hospital | Elgin | Illinois | 60123 | — |
| Advocate South Suburban Hospital | Hazel Crest | Illinois | 60429 | — |
| AMG Libertyville - Oncology | Libertyville | Illinois | 60048 | — |
| Carle Physician Group-Mattoon/Charleston | Mattoon | Illinois | 61938 | — |
| HSHS Saint Elizabeth's Hospital | O'Fallon | Illinois | 62269 | — |
| Advocate Christ Medical Center | Oak Lawn | Illinois | 60453-2699 | — |
| Advocate Lutheran General Hospital | Park Ridge | Illinois | 60068 | — |
| Methodist Medical Center of Illinois | Peoria | Illinois | 61636 | — |
| OSF Saint Francis Medical Center | Peoria | Illinois | 61637 | — |
| Memorial Hospital East | Shiloh | Illinois | 62269 | — |
| Springfield Memorial Hospital | Springfield | Illinois | 62781 | — |
| Carle Cancer Center | Urbana | Illinois | 61801 | — |
| Parkview Regional Medical Center | Fort Wayne | Indiana | 46845 | — |
| Goshen Center for Cancer Care | Goshen | Indiana | 46526 | — |
| Mary Greeley Medical Center | Ames | Iowa | 50010 | — |
| McFarland Clinic - Ames | Ames | Iowa | 50010 | — |
| Iowa Methodist Medical Center | Des Moines | Iowa | 50309 | — |
| UI Health Care Mission Cancer and Blood - Des Moines Clinic | Des Moines | Iowa | 50309 | — |
| The James Graham Brown Cancer Center at University of Louisville | Louisville | Kentucky | 40202 | — |
| UofL Health Medical Center Northeast | Louisville | Kentucky | 40245 | — |
| Mary Bird Perkins Cancer Center | Baton Rouge | Louisiana | 70809 | — |
| Mary Bird Perkins Cancer Center - Gonzales | Gonzales | Louisiana | 70737 | — |
| Mary Bird Perkins Cancer Center - Metairie | Metairie | Louisiana | 70002 | — |
| East Jefferson General Hospital | Metairie | Louisiana | 70006 | — |
| LSU Healthcare Network / Metairie Multi-Specialty Clinic | Metairie | Louisiana | 70006 | — |
| University Medical Center New Orleans | New Orleans | Louisiana | 70112 | — |
| Trinity Health Saint Joseph Mercy Hospital Ann Arbor | Ann Arbor | Michigan | 48106 | — |
| Trinity Health IHA Medical Group Hematology Oncology - Brighton | Brighton | Michigan | 48114 | — |
| Trinity Health Medical Center - Brighton | Brighton | Michigan | 48114 | — |
| Trinity Health IHA Medical Group Hematology Oncology - Canton | Canton | Michigan | 48188 | — |
| Trinity Health Medical Center - Canton | Canton | Michigan | 48188 | — |
| Chelsea Hospital | Chelsea | Michigan | 48118 | — |
| Trinity Health IHA Medical Group Hematology Oncology - Chelsea Hospital | Chelsea | Michigan | 48118 | — |
| Michigan Healthcare Professionals Clarkston | Clarkston | Michigan | 48346 | — |
| Michigan Healthcare Professionals Farmington | Farmington Hills | Michigan | 48334 | — |
| Corewell Health Grand Rapids Hospitals - Butterworth Hospital | Grand Rapids | Michigan | 49503 | — |
| Trinity Health Grand Rapids Hospital | Grand Rapids | Michigan | 49503 | — |
| Bronson Methodist Hospital | Kalamazoo | Michigan | 49007 | — |
| University of Michigan Health - Sparrow Lansing | Lansing | Michigan | 48912 | — |
| Trinity Health Saint Mary Mercy Livonia Hospital | Livonia | Michigan | 48154 | — |
| Michigan Healthcare Professionals Macomb | Macomb | Michigan | 48044 | — |
| Michigan Healthcare Professionals Madison Heights | Madison Heights | Michigan | 48071 | — |
| Trinity Health Saint Joseph Mercy Oakland Hospital | Pontiac | Michigan | 48341 | — |
| Corewell Health William Beaumont University Hospital | Royal Oak | Michigan | 48073 | — |
| Munson Medical Center | Traverse City | Michigan | 49684 | — |
| Corewell Health Beaumont Troy Hospital | Troy | Michigan | 48085 | — |
| Michigan Healthcare Professionals Troy | Troy | Michigan | 48098 | — |
| University of Michigan Health - West | Wyoming | Michigan | 49519 | — |
| Trinity Health IHA Medical Group Hematology Oncology Ann Arbor Campus | Ypsilanti | Michigan | 48197 | — |
| Regions Hospital | Saint Paul | Minnesota | 55101 | — |
| Saint Francis Medical Center | Cape Girardeau | Missouri | 63703 | — |
| Siteman Cancer Center at Saint Peters Hospital | City of Saint Peters | Missouri | 63376 | — |
| Siteman Cancer Center at West County Hospital | Creve Coeur | Missouri | 63141 | — |
| Phelps Health Delbert Day Cancer Institute | Rolla | Missouri | 65401 | — |
| Washington University School of Medicine | St Louis | Missouri | 63110 | — |
| Siteman Cancer Center-South County | St Louis | Missouri | 63129 | — |
| Siteman Cancer Center at Christian Hospital | St Louis | Missouri | 63136 | — |
| Benefis Sletten Cancer Institute | Great Falls | Montana | 59405 | — |
| Dartmouth Hitchcock Medical Center/Dartmouth Cancer Center | Lebanon | New Hampshire | 03756 | — |
| The Valley Hospital - Luckow Pavilion | Paramus | New Jersey | 07652 | — |
| University of New Mexico Cancer Center | Albuquerque | New Mexico | 87106 | — |
| Roswell Park Cancer Institute | Buffalo | New York | 14263 | — |
| Highland Hospital | Rochester | New York | 14620 | — |
| University of Rochester | Rochester | New York | 14642 | — |
| Wilmot Cancer Institute at Webster | Webster | New York | 14580 | — |
| East Carolina University | Greenville | North Carolina | 27834 | — |
| Sanford Broadway Medical Center | Fargo | North Dakota | 58122 | — |
| Sanford Roger Maris Cancer Center | Fargo | North Dakota | 58122 | — |
| Cleveland Clinic Akron General | Akron | Ohio | 44307 | — |
| UH Seidman Cancer Center at UH Avon Health Center | Avon | Ohio | 44011 | — |
| UHHS-Chagrin Highlands Medical Center | Beachwood | Ohio | 44122 | — |
| Miami Valley Hospital South | Centerville | Ohio | 45459 | — |
| Case Western Reserve University | Cleveland | Ohio | 44106 | — |
| MetroHealth Medical Center | Cleveland | Ohio | 44109 | — |
| Cleveland Clinic Cancer Center/Fairview Hospital | Cleveland | Ohio | 44111 | — |
| Cleveland Clinic Foundation | Cleveland | Ohio | 44195 | — |
| Ohio State University Comprehensive Cancer Center | Columbus | Ohio | 43210 | — |
| Miami Valley Hospital | Dayton | Ohio | 45409 | — |
| Premier Blood and Cancer Center | Dayton | Ohio | 45409 | — |
| Miami Valley Hospital North | Dayton | Ohio | 45415 | — |
| Atrium Medical Center-Middletown Regional Hospital | Franklin | Ohio | 45005-1066 | — |
| Hillcrest Hospital Cancer Center | Mayfield Heights | Ohio | 44124 | — |
| UH Seidman Cancer Center at Lake Health Mentor Campus | Mentor | Ohio | 44060 | — |
| University Hospitals Parma Medical Center | Parma | Ohio | 44129 | — |
| University Hospitals Portage Medical Center | Ravenna | Ohio | 44266 | — |
| Cleveland Clinic Cancer Center Strongsville | Strongsville | Ohio | 44136 | — |
| ProMedica Flower Hospital | Sylvania | Ohio | 43560 | — |
| Upper Valley Medical Center | Troy | Ohio | 45373 | — |
| University of Oklahoma Health Sciences Center | Oklahoma City | Oklahoma | 73104 | — |
| Oregon Health and Science University | Portland | Oregon | 97239 | — |
| Saint Luke's Cancer Center - Allentown | Allentown | Pennsylvania | 18104 | — |
| UPMC Altoona | Altoona | Pennsylvania | 16601 | — |
| UPMC-Heritage Valley Health System Beaver | Beaver | Pennsylvania | 15009 | — |
| Saint Luke's University Hospital-Bethlehem Campus | Bethlehem | Pennsylvania | 18015 | — |
| Bryn Mawr Hospital | Bryn Mawr | Pennsylvania | 19010 | — |
| Carlisle Regional Cancer Center | Carlisle | Pennsylvania | 17015 | — |
| Christiana Care Health System-Concord Health Center | Chadds Ford | Pennsylvania | 19317 | — |
| Chambersburg Hospital | Chambersburg | Pennsylvania | 17201 | — |
| Geisinger Medical Center | Danville | Pennsylvania | 17822 | — |
| Fox Chase Cancer Center - East Norriton Hospital Outpatient Center | East Norriton | Pennsylvania | 19401 | — |
| Saint Luke's Hospital-Anderson Campus | Easton | Pennsylvania | 18045 | — |
| Ephrata Cancer Center | Ephrata | Pennsylvania | 17522 | — |
| UPMC Hillman Cancer Center Erie | Erie | Pennsylvania | 16505 | — |
| UPMC Cancer Center at UPMC Horizon | Farrell | Pennsylvania | 16121 | — |
| Fox Chase Cancer Center Buckingham | Furlong | Pennsylvania | 18925 | — |
| Adams Cancer Center | Gettysburg | Pennsylvania | 17325 | — |
| UPMC Pinnacle Cancer Center/Community Osteopathic Campus | Harrisburg | Pennsylvania | 17109 | — |
| Penn State Milton S Hershey Medical Center | Hershey | Pennsylvania | 17033-0850 | — |
| IRMC Cancer Center | Indiana | Pennsylvania | 15701 | — |
| Sechler Family Cancer Center | Lebanon | Pennsylvania | 17042 | — |
| Geisinger Medical Oncology-Lewisburg | Lewisburg | Pennsylvania | 17837 | — |
| UPMC Hillman Cancer Center at Rocco And Nancy Ortenzio Cancer Pavilion | Mechanicsburg | Pennsylvania | 17050 | — |
| Riddle Memorial Hospital | Media | Pennsylvania | 19063 | — |
| UPMC Hillman Cancer Center in Coraopolis | Moon Township | Pennsylvania | 15108 | — |
| Paoli Memorial Hospital | Paoli | Pennsylvania | 19301 | — |
| Fox Chase Cancer Center | Philadelphia | Pennsylvania | 19111 | — |
| UPMC-Magee Womens Hospital | Pittsburgh | Pennsylvania | 15213 | — |
| UPMC-Saint Margaret | Pittsburgh | Pennsylvania | 15215 | — |
| University of Pittsburgh Cancer Institute (UPCI) | Pittsburgh | Pennsylvania | 15232 | — |
| UPMC-Shadyside Hospital | Pittsburgh | Pennsylvania | 15232 | — |
| UPMC-Passavant Hospital | Pittsburgh | Pennsylvania | 15237 | — |
| Geisinger Cancer Services-Pottsville | Pottsville | Pennsylvania | 17901 | — |
| Saint Luke's Hospital - Upper Bucks Campus | Quakertown | Pennsylvania | 18951 | — |
| UPMC Cancer Center at UPMC Northwest | Seneca | Pennsylvania | 16346 | — |
| Saint Luke's Hospital - Monroe Campus | Stroudsburg | Pennsylvania | 18360 | — |
| UPMC Washington Hospital Radiation Oncology | Washington | Pennsylvania | 15301 | — |
| Geisinger Wyoming Valley/Henry Cancer Center | Wilkes-Barre | Pennsylvania | 18711 | — |
| Divine Providence Hospital | Williamsport | Pennsylvania | 17754 | — |
| Lankenau Medical Center | Wynnewood | Pennsylvania | 19096 | — |
| WellSpan Health-York Cancer Center | York | Pennsylvania | 17403 | — |
| UPMC Memorial | York | Pennsylvania | 17408 | — |
| Ralph H Johnson VA Medical Center | Charleston | South Carolina | 29401 | — |
| Medical University of South Carolina | Charleston | South Carolina | 29425 | — |
| Carolina Regional Cancer Center | Myrtle Beach | South Carolina | 29577 | — |
| Sanford Cancer Center Oncology Clinic | Sioux Falls | South Dakota | 57104 | — |
| Sanford USD Medical Center - Sioux Falls | Sioux Falls | South Dakota | 57117-5134 | — |
| Covenant Medical Center-Lakeside | Lubbock | Texas | 79410 | — |
| Central Vermont Medical Center/National Life Cancer Treatment | Berlin Corners | Vermont | 05602 | — |
| University of Vermont Medical Center | Burlington | Vermont | 05401 | — |
| Dartmouth Cancer Center - North | Saint Johnsbury | Vermont | 05819 | — |
| Bon Secours Saint Francis Medical Center | Midlothian | Virginia | 23114 | — |
| Bon Secours Cancer Institute at Reynolds Crossing | Richmond | Virginia | 23230 | — |
| VCU Massey Cancer Center at Stony Point | Richmond | Virginia | 23235 | — |
| VCU Massey Comprehensive Cancer Center | Richmond | Virginia | 23298 | — |
| VCU Community Memorial Health Center | South Hill | Virginia | 23970 | — |
| FHCC at EvergreenHealth | Kirkland | Washington | 98034 | — |
| Fred Hutchinson Cancer Center | Seattle | Washington | 98109 | — |
| FHCC at Northwest Hospital | Seattle | Washington | 98133 | — |
| University of Washington Medical Center - Montlake | Seattle | Washington | 98195 | — |
| Edwards Comprehensive Cancer Center | Huntington | West Virginia | 25701 | — |
| Langlade Hospital and Cancer Center | Antigo | Wisconsin | 54409 | — |
| Marshfield Medical Center-EC Cancer Center | Eau Claire | Wisconsin | 54701 | — |
| Aurora Cancer Care-Grafton | Grafton | Wisconsin | 53024 | — |
| Aurora BayCare Medical Center | Green Bay | Wisconsin | 54311 | — |
| Aurora Bay Area Medical Group-Marinette | Marinette | Wisconsin | 54143 | — |
| Marshfield Medical Center-Marshfield | Marshfield | Wisconsin | 54449 | — |
| Froedtert Menomonee Falls Hospital | Menomonee Falls | Wisconsin | 53051 | — |
| Aurora Saint Luke's Medical Center | Milwaukee | Wisconsin | 53215 | — |
| Medical College of Wisconsin | Milwaukee | Wisconsin | 53226 | — |
| Aurora Sinai Medical Center | Milwaukee | Wisconsin | 53233 | — |
| Marshfield Medical Center - Minocqua | Minocqua | Wisconsin | 54548 | — |
| ProHealth D N Greenwald Center | Mukwonago | Wisconsin | 53149 | — |
| Cancer Center of Western Wisconsin | New Richmond | Wisconsin | 54017 | — |
| Drexel Town Square Health Center | Oak Creek | Wisconsin | 53154 | — |
| ProHealth Oconomowoc Memorial Hospital | Oconomowoc | Wisconsin | 53066 | — |
| Vince Lombardi Cancer Clinic - Oshkosh | Oshkosh | Wisconsin | 54904 | — |
| Aspirus Cancer Care - James Beck Cancer Center | Rhinelander | Wisconsin | 54501 | — |
| Marshfield Medical Center-Rice Lake | Rice Lake | Wisconsin | 54868 | — |
| Vince Lombardi Cancer Clinic-Sheboygan | Sheboygan | Wisconsin | 53081 | — |
| Aspirus Cancer Care - Stevens Point | Stevens Point | Wisconsin | 54481 | — |
| Marshfield Medical Center-River Region at Stevens Point | Stevens Point | Wisconsin | 54482 | — |
| Aurora Medical Center in Summit | Summit | Wisconsin | 53066 | — |
| UW Cancer Center at ProHealth Care | Waukesha | Wisconsin | 53188 | — |
| Aspirus Regional Cancer Center | Wausau | Wisconsin | 54401 | — |
| Aurora Cancer Care-Milwaukee West | Wauwatosa | Wisconsin | 53226 | — |
| Aurora West Allis Medical Center | West Allis | Wisconsin | 53227 | — |
| Froedtert West Bend Hospital/Kraemer Cancer Center | West Bend | Wisconsin | 53095 | — |
| Marshfield Medical Center - Weston | Weston | Wisconsin | 54476 | — |
| Aspirus Cancer Care - Wisconsin Rapids | Wisconsin Rapids | Wisconsin | 54494 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 3 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT05053152, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted May 3, 2026 · Synced May 6, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete protocol, eligibility criteria, and contact information for NCT05053152 live on ClinicalTrials.gov.