Combination Study of RMC-4630 and Sotorasib for NSCLC Subjects With KRASG12C Mutation After Failure of Prior Standard Therapies
Public ClinicalTrials.gov record NCT05054725. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Phase 2, Open-Label, Multicenter Study of the Combination of RMC-4630 and Sotorasib for Non-Small Cell Lung Cancer Subjects With KRASG12C Mutation After Failure of Prior Standard Therapies
Study identification
- NCT ID
- NCT05054725
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 2
- Lead sponsor
- Revolution Medicines, Inc.
- Industry
- Enrollment
- 47 participants
Conditions and interventions
Conditions
Interventions
- RMC-4630 Drug
- Sotorasib Drug
Drug
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Dec 29, 2021
- Primary completion
- Jul 2, 2024
- Completion
- Aug 28, 2024
- Last update posted
- Jan 5, 2026
2021 – 2024
United States locations
- U.S. sites
- 23
- U.S. states
- 17
- U.S. cities
- 23
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Florida Cancer Specialists | Fort Myers | Florida | 33901 | — |
| BRCR Medical Center Inc. | Plantation | Florida | 33322 | — |
| Cancer Specialists of North Florida | Saint Augustine | Florida | 32086 | — |
| GenHarp Clinical Solutions | Evergreen Park | Illinois | 60805 | — |
| Hematology Oncology Clinic | Baton Rouge | Louisiana | 70809 | — |
| New England Cancer Specialists | Scarborough | Maine | 04074 | — |
| American Oncology Partners of Maryland, PA | Bethesda | Maryland | 20817 | — |
| Maryland Oncology Hematology, P.A. | Columbia | Maryland | 21044 | — |
| Minnesota Oncology Hematology, P.A. | Minneapolis | Minnesota | 55404 | — |
| Nebraska Cancer Specialists | Omaha | Nebraska | 68130 | — |
| Comprehensive Cancer Centers of Nevada | Las Vegas | Nevada | 89169 | — |
| New Jersey Center for Cancer Research | Brick | New Jersey | 08724 | — |
| University of New Mexico Comprehensive Cancer Center | Albuquerque | New Mexico | 87131 | — |
| Roswell Park cancer Institute | Buffalo | New York | 14263 | — |
| Clinical Research Alliance, Inc. | New York | New York | 10021 | — |
| Zangmeister Cancer Center | Columbus | Ohio | 43219 | — |
| Charleston Oncology | Charleston | South Carolina | 29414 | — |
| Tennessee Oncology | Chattanooga | Tennessee | 37404 | — |
| Sarah Cannon Research Institute | Nashville | Tennessee | 37203 | — |
| CHRISTUS St. Michael-Colom and Carney Clinic P.A | Texarkana | Texas | 75503 | — |
| Virginia Cancer Specialists | Fairfax | Virginia | 22031 | — |
| Virginia Oncology Associates | Norfolk | Virginia | 23502 | — |
| Northwest Cancer specialists, P.C. | Vancouver | Washington | 98684 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 37 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT05054725, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Jan 5, 2026 · Synced Jul 21, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete protocol, eligibility criteria, and contact information for NCT05054725 live on ClinicalTrials.gov.