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Suspended Phase 2Phase 3 Interventional

Evaluating the Addition of the Immunotherapy Drug Atezolizumab to Standard Chemotherapy Treatment for Advanced or Metastatic Neuroendocrine Carcinomas That Originate Outside the Lung

ClinicalTrials.gov ID: NCT05058651

Public ClinicalTrials.gov record NCT05058651. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.

ClinicalTrials.gov public records Last synced Sep 5, 2026, 1:58 AM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

Official title

Randomized Phase II/III Trial of First Line Platinum/Etoposide With or Without Atezolizumab (NSC#783608) in Patients With Poorly Differentiated Extrapulmonary Small Cell Neuroendocrine Carcinomas (NEC)

Brief summary

Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.

This phase II/III trial compares the effect of immunotherapy with atezolizumab in combination with standard chemotherapy with a platinum drug (cisplatin or carboplatin) and etoposide versus standard therapy alone for the treatment of poorly differentiated extrapulmonary (originated outside the lung) neuroendocrine cancer that may have spread from where it first started to nearby tissue, lymph nodes, or distant parts of the body (advanced) or that has spread from where it first started (primary site) to other places in the body (metastatic). The other aim of this trial is to compare using atezolizumab just at the beginning of treatment versus continuing it beyond the initial treatment. Immunotherapy with monoclonal antibodies, such as atezolizumab, may help the body's immune system attack the cancer, and may interfere with the ability of tumor cells to grow and spread. Cisplatin and carboplatin are in a class of medications known as platinum-containing compounds that work by killing, stopping or slowing the growth of cancer cells. Etoposide is in a class of medications known as podophyllotoxin derivatives. It blocks a certain enzyme needed for cell division and DNA repair, and it may kill cancer cells. Giving atezolizumab in combination with a platinum drug (cisplatin or carboplatin) and etoposide may work better in treating patients with poorly differentiated extrapulmonary neuroendocrine cancer compared to standard therapy with a platinum drug (cisplatin or carboplatin) and etoposide alone.

Study identification

NCT ID
NCT05058651
Recruitment status
Suspended
Study type
Interventional
Phase
Phase 2, Phase 3
Enrollment
189 participants

Conditions and interventions

Eligibility (public fields only)

Age range
18 Years and older
Sex
All
Healthy volunteers
Healthy volunteers not accepted

This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.

Study timeline

Start date
Jun 27, 2022
Primary completion
Sep 30, 2028
Completion
Sep 30, 2028
Last update posted
Jul 30, 2026

2022 – 2028

United States locations

U.S. sites
255
U.S. states
34
U.S. cities
194
Facility City State ZIP Site status
Alaska Women's Cancer Care Anchorage Alaska 99508
Cancer Center at Saint Joseph's Phoenix Arizona 85004
Mayo Clinic Hospital in Arizona Phoenix Arizona 85054
Kaiser Permanente-Anaheim Anaheim California 92806
Sutter Auburn Faith Hospital Auburn California 95602
Sutter Cancer Centers Radiation Oncology Services-Auburn Auburn California 95603
Kaiser Permanente-Baldwin Park Baldwin Park California 91706
Kaiser Permanente-Bellflower Bellflower California 90706
Alta Bates Summit Medical Center-Herrick Campus Berkeley California 94704
Sutter Cancer Centers Radiation Oncology Services-Cameron Park Cameron Park California 95682
Mercy Cancer Center - Carmichael Carmichael California 95608
Mercy San Juan Medical Center Carmichael California 95608
Mercy Cancer Center - Elk Grove Elk Grove California 95758
Kaiser Permanente-Fontana Fontana California 92335
Palo Alto Medical Foundation-Fremont Fremont California 94538
Kaiser Permanente South Bay Harbor City California 90710
Kaiser Permanente-Irvine Irvine California 92618
Kaiser Permanente Los Angeles Medical Center Los Angeles California 90027
Kaiser Permanente West Los Angeles Los Angeles California 90034
Memorial Medical Center Modesto California 95355
Palo Alto Medical Foundation-Camino Division Mountain View California 94040
Kaiser Permanente-Ontario Ontario California 91761
Palo Alto Medical Foundation Health Care Palo Alto California 94301
Kaiser Permanente - Panorama City Panorama City California 91402
Kaiser Permanente-Riverside Riverside California 92505
Mercy Cancer Center - Rocklin Rocklin California 95765
Sutter Cancer Centers Radiation Oncology Services-Roseville Roseville California 95661
Sutter Roseville Medical Center Roseville California 95661
Mercy Cancer Center - Sacramento Sacramento California 95816
Sutter Medical Center Sacramento Sacramento California 95816
Kaiser Permanente-San Diego Zion San Diego California 92120
California Pacific Medical Center-Pacific Campus San Francisco California 94115
Kaiser Permanente-San Marcos San Marcos California 92078
Palo Alto Medical Foundation-Santa Cruz Santa Cruz California 95065
Sutter Pacific Medical Foundation Santa Rosa California 95403
Palo Alto Medical Foundation-Sunnyvale Sunnyvale California 94086
Sutter Solano Medical Center/Cancer Center Vallejo California 94589
Woodland Memorial Hospital Woodland California 95695
Kaiser Permanente-Woodland Hills Woodland Hills California 91367
AdventHealth Porter Denver Colorado 80210
AdventHealth Littleton Littleton Colorado 80122
AdventHealth Parker Parker Colorado 80138
Smilow Cancer Hospital-Derby Care Center Derby Connecticut 06418
Smilow Cancer Hospital Care Center-Fairfield Fairfield Connecticut 06824
Smilow Cancer Hospital Care Center at Glastonbury Glastonbury Connecticut 06033
Smilow Cancer Hospital Care Center at Greenwich Greenwich Connecticut 06830
Smilow Cancer Hospital Care Center - Guilford Guilford Connecticut 06437
Smilow Cancer Hospital Care Center at Saint Francis Hartford Connecticut 06105
Yale University New Haven Connecticut 06520
Yale-New Haven Hospital North Haven Medical Center North Haven Connecticut 06473
Smilow Cancer Hospital Care Center at Long Ridge Stamford Connecticut 06902
Smilow Cancer Hospital-Torrington Care Center Torrington Connecticut 06790
Smilow Cancer Hospital Care Center-Trumbull Trumbull Connecticut 06611
Smilow Cancer Hospital-Waterbury Care Center Waterbury Connecticut 06708
Smilow Cancer Hospital Care Center - Waterford Waterford Connecticut 06385
Holy Cross Hospital Fort Lauderdale Florida 33308
Mayo Clinic in Florida Jacksonville Florida 32224-9980
Moffitt Cancer Center Tampa Florida 33612
Hawaii Cancer Care Inc - Waterfront Plaza Honolulu Hawaii 96813
Queen's Cancer Cenrer - POB I Honolulu Hawaii 96813
Queen's Medical Center Honolulu Hawaii 96813
Straub Clinic and Hospital Honolulu Hawaii 96813
University of Hawaii Cancer Center Honolulu Hawaii 96813
Queen's Cancer Center - Kuakini Honolulu Hawaii 96817
Hawaii Cancer Care - Westridge ‘Aiea Hawaii 96701
Pali Momi Medical Center ‘Aiea Hawaii 96701
The Queen's Medical Center - West Oahu ‘Ewa Beach Hawaii 96706
Saint Alphonsus Cancer Care Center-Nampa Nampa Idaho 83687
Rush-Copley Medical Center Aurora Illinois 60504
Centralia Oncology Clinic Centralia Illinois 62801
Northwestern University Chicago Illinois 60611
University of Chicago Comprehensive Cancer Center Chicago Illinois 60637
Carle at The Riverfront Danville Illinois 61832
Cancer Care Specialists of Illinois - Decatur Decatur Illinois 62526
Decatur Memorial Hospital Decatur Illinois 62526
Northwestern Medicine Cancer Center Kishwaukee DeKalb Illinois 60115
Carle Physician Group-Effingham Effingham Illinois 62401
Crossroads Cancer Center Effingham Illinois 62401
Northwestern Medicine Cancer Center Delnor Geneva Illinois 60134
Northwestern Medicine Glenview Outpatient Center Glenview Illinois 60026
Northwestern Medicine Grayslake Outpatient Center Grayslake Illinois 60030
Ingalls Memorial Hospital Harvey Illinois 60426
Northwestern Medicine Lake Forest Hospital Lake Forest Illinois 60045
Carle Physician Group-Mattoon/Charleston Mattoon Illinois 61938
UC Comprehensive Cancer Center at Silver Cross New Lenox Illinois 60451
Carle BroMenn Medical Center Normal Illinois 61761
Carle Cancer Institute Normal Normal Illinois 61761
Cancer Care Center of O'Fallon O'Fallon Illinois 62269
Northwestern Medicine Orland Park Orland Park Illinois 60462
University of Chicago Medicine-Orland Park Orland Park Illinois 60462
UW Health Carbone Cancer Center Rockford Rockford Illinois 61114
Southern Illinois University School of Medicine Springfield Illinois 62702
Springfield Clinic Springfield Illinois 62702
Springfield Memorial Hospital Springfield Illinois 62781
Carle Cancer Center Urbana Illinois 61801
Northwestern Medicine Cancer Center Warrenville Warrenville Illinois 60555
Rush-Copley Healthcare Center Yorkville Illinois 60560
UChicago Medicine Northwest Indiana Crown Point Indiana 46307
Mary Greeley Medical Center Ames Iowa 50010
McFarland Clinic - Ames Ames Iowa 50010
UI Health Care Mission Cancer and Blood - Ankeny Clinic Ankeny Iowa 50023
McFarland Clinic - Boone Boone Iowa 50036
Saint Anthony Regional Hospital Carroll Iowa 51401
Mercy Cancer Center-West Lakes Clive Iowa 50325
UI Health Care Mission Cancer and Blood - West Des Moines Clinic Clive Iowa 50325
Greater Regional Medical Center Creston Iowa 50801
Iowa Methodist Medical Center Des Moines Iowa 50309
UI Health Care Mission Cancer and Blood - Des Moines Clinic Des Moines Iowa 50309
Broadlawns Medical Center Des Moines Iowa 50314
Mercy Medical Center - Des Moines Des Moines Iowa 50314
UI Health Care Mission Cancer and Blood - Laurel Clinic Des Moines Iowa 50314
McFarland Clinic - Trinity Cancer Center Fort Dodge Iowa 50501
McFarland Clinic - Jefferson Jefferson Iowa 50129
McFarland Clinic - Marshalltown Marshalltown Iowa 50158
UI Health Care Mission Cancer and Blood - Waukee Clinic Waukee Iowa 50263
Mercy Medical Center-West Lakes West Des Moines Iowa 50266
LSU Health Baton Rouge-North Clinic Baton Rouge Louisiana 70805
Our Lady of the Lake Physician Group Baton Rouge Louisiana 70808
East Jefferson General Hospital Metairie Louisiana 70006
LSU Healthcare Network / Metairie Multi-Specialty Clinic Metairie Louisiana 70006
University Medical Center New Orleans New Orleans Louisiana 70112
Lahey Clinic Burlington Massachusetts 01805
Lahey Clinic Peabody Peabody Massachusetts 01960
Trinity Health Saint Joseph Mercy Hospital Ann Arbor Ann Arbor Michigan 48106
University of Michigan Rogel Cancer Center Ann Arbor Michigan 48109
Bronson Battle Creek Battle Creek Michigan 49017
Trinity Health IHA Medical Group Hematology Oncology - Brighton Brighton Michigan 48114
Trinity Health Medical Center - Brighton Brighton Michigan 48114
Henry Ford Cancer Institute-Downriver Brownstown Michigan 48183
Trinity Health IHA Medical Group Hematology Oncology - Canton Canton Michigan 48188
Trinity Health Medical Center - Canton Canton Michigan 48188
Chelsea Hospital Chelsea Michigan 48118
Trinity Health IHA Medical Group Hematology Oncology - Chelsea Hospital Chelsea Michigan 48118
Henry Ford Macomb Hospital-Clinton Township Clinton Township Michigan 48038
Corewell Health Dearborn Hospital Dearborn Michigan 48124
Henry Ford Medical Center-Fairlane Dearborn Michigan 48126
Wayne State University/Karmanos Cancer Institute Detroit Michigan 48201
Henry Ford Hospital Detroit Michigan 48202
Henry Ford Health Saint John Hospital Detroit Michigan 48236
Henry Ford River District Hospital East China Township Michigan 48054
Weisberg Cancer Treatment Center Farmington Hills Michigan 48334
Corewell Health Farmington Hills Hospital Farmington Hills Michigan 48336
Cancer Hematology Centers - Flint Flint Michigan 48503
Genesee Hematology Oncology PC Flint Michigan 48503
Genesys Hurley Cancer Institute Flint Michigan 48503
Hurley Medical Center Flint Michigan 48503
Corewell Health Grand Rapids Hospitals - Butterworth Hospital Grand Rapids Michigan 49503
Trinity Health Grand Rapids Hospital Grand Rapids Michigan 49503
Henry Ford Saint John Hospital - Academic Grosse Pointe Woods Michigan 48236
Henry Ford Saint John Hospital - Breast Grosse Pointe Woods Michigan 48236
Henry Ford Saint John Hospital - Van Elslander Grosse Pointe Woods Michigan 48236
Allegiance Health Jackson Michigan 49201
Bronson Methodist Hospital Kalamazoo Michigan 49007
West Michigan Cancer Center Kalamazoo Michigan 49007
Karmanos Cancer Institute at McLaren Greater Lansing Lansing Michigan 48910
Trinity Health Saint Mary Mercy Livonia Hospital Livonia Michigan 48154
Henry Ford Saint John Hospital - Macomb Medical Macomb Michigan 48044
Henry Ford Warren Hospital - Breast Macomb Macomb Michigan 48044
Trinity Health Muskegon Hospital Muskegon Michigan 49444
Corewell Health Lakeland Hospitals - Niles Hospital Niles Michigan 49120
Cancer and Hematology Centers of Western Michigan - Norton Shores Norton Shores Michigan 49444
Henry Ford Medical Center-Columbus Novi Michigan 48377
Trinity Health Saint Joseph Mercy Oakland Hospital Pontiac Michigan 48341
Corewell Health Reed City Hospital Reed City Michigan 49677
Corewell Health William Beaumont University Hospital Royal Oak Michigan 48073
Corewell Health Lakeland Hospitals - Marie Yeager Cancer Center Saint Joseph Michigan 49085
Corewell Health Lakeland Hospitals - Saint Joseph Hospital Saint Joseph Michigan 49085
Munson Medical Center Traverse City Michigan 49684
Corewell Health Beaumont Troy Hospital Troy Michigan 48085
Henry Ford Health Warren Hospital Warren Michigan 48093
Henry Ford Madison Heights Hospital - Breast Warren Michigan 48093
Henry Ford Warren Hospital - GLCMS Warren Michigan 48093
Henry Ford West Bloomfield Hospital West Bloomfield Michigan 48322
Henry Ford Wyandotte Hospital Wyandotte Michigan 48192
University of Michigan Health - West Wyoming Michigan 49519
Huron Gastroenterology PC Ypsilanti Michigan 48106
Trinity Health IHA Medical Group Hematology Oncology Ann Arbor Campus Ypsilanti Michigan 48197
Minnesota Oncology - Burnsville Burnsville Minnesota 55337
Saint Luke's Hospital of Duluth Duluth Minnesota 55805
Fairview Southdale Hospital Edina Minnesota 55435
Abbott-Northwestern Hospital Minneapolis Minnesota 55407
Hennepin County Medical Center Minneapolis Minnesota 55415
Mayo Clinic in Rochester Rochester Minnesota 55905
Park Nicollet Clinic - Saint Louis Park Saint Louis Park Minnesota 55416
Regions Hospital Saint Paul Minnesota 55101
United Hospital Saint Paul Minnesota 55102
Saint Francis Regional Medical Center Shakopee Minnesota 55379
Saint Francis Medical Center Cape Girardeau Missouri 63703
Mercy Hospital Joplin Joplin Missouri 64804
Mercy Hospital Springfield Springfield Missouri 65804
CoxHealth South Hospital Springfield Missouri 65807
Mercy Hospital South St Louis Missouri 63128
Saint Vincent Frontier Cancer Center Billings Montana 59102
Dartmouth Hitchcock Medical Center/Dartmouth Cancer Center Lebanon New Hampshire 03756
Roswell Park Cancer Institute Buffalo New York 14263
Mount Sinai Hospital New York New York 10029
Stony Brook University Medical Center Stony Brook New York 11794
Duke Cancer Center Cary Cary North Carolina 27518
Carolinas Medical Center/Levine Cancer Institute Charlotte North Carolina 28203
Atrium Health Pineville/LCI-Pineville Charlotte North Carolina 28210
Levine Cancer Institute-SouthPark Charlotte North Carolina 28211
Atrium Health University City/LCI-University Charlotte North Carolina 28262
Levine Cancer Institute-Ballantyne Charlotte North Carolina 28277
Southeastern Medical Oncology Center-Clinton Clinton North Carolina 28328
Atrium Health Cabarrus/LCI-Concord Concord North Carolina 28025
Duke University Medical Center Durham North Carolina 27710
Levine Cancer Institute-Gaston Gastonia North Carolina 28054
Southeastern Medical Oncology Center-Goldsboro Goldsboro North Carolina 27534
Southeastern Medical Oncology Center-Jacksonville Jacksonville North Carolina 28546
FirstHealth of the Carolinas-Moore Regional Hospital Pinehurst North Carolina 28374
Duke Cancer Center Raleigh Raleigh North Carolina 27609
Atrium Health Cleveland/LCI-Cleveland Shelby North Carolina 28150
Ohio State University Comprehensive Cancer Center Columbus Ohio 43210
Toledo Clinic Cancer Centers-Toledo Toledo Ohio 43623
Cancer Centers of Southwest Oklahoma Research Lawton Oklahoma 73505
University of Oklahoma Health Sciences Center Oklahoma City Oklahoma 73104
Mercy Hospital Oklahoma City Oklahoma City Oklahoma 73120
Saint Charles Health System Bend Oregon 97701
Providence Cancer Institute Clackamas Clinic Clackamas Oregon 97015
Providence Newberg Medical Center Newberg Oregon 97132
Providence Willamette Falls Medical Center Oregon City Oregon 97045
Providence Portland Medical Center Portland Oregon 97213
Providence Saint Vincent Medical Center Portland Oregon 97225
WellSpan Medical Oncology and Hematology Chambersburg Pennsylvania 17201
Ephrata Cancer Center Ephrata Pennsylvania 17522
Adams Cancer Center Gettysburg Pennsylvania 17325
Sechler Family Cancer Center Lebanon Pennsylvania 17042
Cancer Care Associates of York York Pennsylvania 17403
WellSpan Health-York Cancer Center York Pennsylvania 17403
Smilow Cancer Hospital Care Center - Westerly Westerly Rhode Island 02891
Medical University of South Carolina Charleston South Carolina 29425
Levine Cancer Institute-Rock Hill Rock Hill South Carolina 29732
Rapid City Regional Hospital Rapid City South Dakota 57701
Vanderbilt University/Ingram Cancer Center Nashville Tennessee 37232
Parkland Memorial Hospital Dallas Texas 75235
UT Southwestern Simmons Cancer Center - RedBird Dallas Texas 75237
UT Southwestern/Simmons Cancer Center-Dallas Dallas Texas 75390
UT Southwestern/Simmons Cancer Center-Fort Worth Fort Worth Texas 76104
Baylor College of Medicine/Dan L Duncan Comprehensive Cancer Center Houston Texas 77030
Ben Taub General Hospital Houston Texas 77030
UT Southwestern Clinical Center at Richardson/Plano Richardson Texas 75080
Huntsman Cancer Institute/University of Utah Salt Lake City Utah 84112
Dartmouth Cancer Center - North Saint Johnsbury Vermont 05819
Fred Hutchinson Cancer Center Seattle Washington 98109
University of Washington Medical Center - Montlake Seattle Washington 98195
United Hospital Center Bridgeport West Virginia 26330
West Virginia University Healthcare Morgantown West Virginia 26506
Marshfield Medical Center-EC Cancer Center Eau Claire Wisconsin 54701
Gundersen Lutheran Medical Center La Crosse Wisconsin 54601
Marshfield Medical Center-Marshfield Marshfield Wisconsin 54449
Medical College of Wisconsin Milwaukee Wisconsin 53226
Marshfield Medical Center - Minocqua Minocqua Wisconsin 54548
Marshfield Medical Center-Rice Lake Rice Lake Wisconsin 54868
Marshfield Medical Center-River Region at Stevens Point Stevens Point Wisconsin 54482
Marshfield Medical Center - Weston Weston Wisconsin 54476

Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.

About this trial record page

What this page shows
Public field values for ClinicalTrials.gov record NCT05058651, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
What this page does not do
No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
Where the data comes from
Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
Last refresh
Last update posted Jul 30, 2026 · Synced Sep 5, 2026

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Open the official record

The complete protocol, eligibility criteria, and contact information for NCT05058651 live on ClinicalTrials.gov.

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