Evaluating the Addition of the Immunotherapy Drug Atezolizumab to Standard Chemotherapy Treatment for Advanced or Metastatic Neuroendocrine Carcinomas That Originate Outside the Lung

ClinicalTrials.gov ID: NCT05058651

Public ClinicalTrials.gov record NCT05058651. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.

View official ClinicalTrials.gov record → Back to search

ClinicalTrials.gov public records Last synced May 8, 2026, 8:08 AM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

Official title

Randomized Phase II/III Trial of First Line Platinum/Etoposide With or Without Atezolizumab (NSC#783608) in Patients With Poorly Differentiated Extrapulmonary Small Cell Neuroendocrine Carcinomas (NEC)

Study identification

NCT ID: NCT05058651
Recruitment status: Recruiting
Study type: Interventional
Phase: Phase 2, Phase 3
Lead sponsor: National Cancer Institute (NCI); NIH
Enrollment: 189 participants

Conditions and interventions

Conditions

Interventions

Atezolizumab Biological
Biospecimen Collection Procedure
Carboplatin Drug
Cisplatin Drug
Computed Tomography Procedure
Etoposide Drug
Magnetic Resonance Imaging Procedure
Patient Observation Other

Biological · Procedure · Drug + 1 more

Eligibility (public fields only)

Age range: 18 Years and older
Sex: All
Healthy volunteers: Healthy volunteers not accepted

This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.

Study timeline

Start date: Jun 27, 2022
Primary completion: Sep 30, 2028
Completion: Sep 30, 2028
Last update posted: May 5, 2026

2022 – 2028

United States locations

U.S. sites: 244
U.S. states: 34
U.S. cities: 191

Facility	City	State	ZIP	Site status
Alaska Women's Cancer Care	Anchorage	Alaska	99508	Suspended
Cancer Center at Saint Joseph's	Phoenix	Arizona	85004	Recruiting
Mayo Clinic Hospital in Arizona	Phoenix	Arizona	85054	Suspended
Kaiser Permanente-Anaheim	Anaheim	California	92806	Recruiting
Sutter Auburn Faith Hospital	Auburn	California	95602	Recruiting
Sutter Cancer Centers Radiation Oncology Services-Auburn	Auburn	California	95603	Recruiting
Kaiser Permanente-Baldwin Park	Baldwin Park	California	91706	Recruiting
Kaiser Permanente-Bellflower	Bellflower	California	90706	Recruiting
Alta Bates Summit Medical Center-Herrick Campus	Berkeley	California	94704	Recruiting
Sutter Cancer Centers Radiation Oncology Services-Cameron Park	Cameron Park	California	95682	Recruiting
Mercy Cancer Center - Carmichael	Carmichael	California	95608	Recruiting
Mercy San Juan Medical Center	Carmichael	California	95608	Recruiting
Mercy Cancer Center - Elk Grove	Elk Grove	California	95758	Recruiting
Kaiser Permanente-Fontana	Fontana	California	92335	Recruiting
Palo Alto Medical Foundation-Fremont	Fremont	California	94538	Recruiting
Kaiser Permanente South Bay	Harbor City	California	90710	Recruiting
Kaiser Permanente-Irvine	Irvine	California	92618	Recruiting
Kaiser Permanente Los Angeles Medical Center	Los Angeles	California	90027	Recruiting
Kaiser Permanente West Los Angeles	Los Angeles	California	90034	Recruiting
Memorial Medical Center	Modesto	California	95355	Recruiting
Palo Alto Medical Foundation-Camino Division	Mountain View	California	94040	Recruiting
Kaiser Permanente-Ontario	Ontario	California	91761	Recruiting
Palo Alto Medical Foundation Health Care	Palo Alto	California	94301	Suspended
Kaiser Permanente - Panorama City	Panorama City	California	91402	Recruiting
Kaiser Permanente-Riverside	Riverside	California	92505	Recruiting
Mercy Cancer Center - Rocklin	Rocklin	California	95765	Recruiting
Sutter Cancer Centers Radiation Oncology Services-Roseville	Roseville	California	95661	Recruiting
Sutter Roseville Medical Center	Roseville	California	95661	Recruiting
Mercy Cancer Center - Sacramento	Sacramento	California	95816	Recruiting
Sutter Medical Center Sacramento	Sacramento	California	95816	Recruiting
Kaiser Permanente-San Diego Zion	San Diego	California	92120	Recruiting
California Pacific Medical Center-Pacific Campus	San Francisco	California	94115	Recruiting
Kaiser Permanente-San Marcos	San Marcos	California	92078	Recruiting
Palo Alto Medical Foundation-Santa Cruz	Santa Cruz	California	95065	Recruiting
Sutter Pacific Medical Foundation	Santa Rosa	California	95403	Recruiting
Palo Alto Medical Foundation-Sunnyvale	Sunnyvale	California	94086	Recruiting
Sutter Solano Medical Center/Cancer Center	Vallejo	California	94589	Recruiting
Woodland Memorial Hospital	Woodland	California	95695	Recruiting
Kaiser Permanente-Woodland Hills	Woodland Hills	California	91367	Recruiting
AdventHealth Porter	Denver	Colorado	80210	Recruiting
AdventHealth Littleton	Littleton	Colorado	80122	Recruiting
AdventHealth Parker	Parker	Colorado	80138	Recruiting
Smilow Cancer Hospital-Derby Care Center	Derby	Connecticut	06418	Recruiting
Smilow Cancer Hospital Care Center-Fairfield	Fairfield	Connecticut	06824	Recruiting
Smilow Cancer Hospital Care Center at Glastonbury	Glastonbury	Connecticut	06033	Recruiting
Smilow Cancer Hospital Care Center at Greenwich	Greenwich	Connecticut	06830	Recruiting
Smilow Cancer Hospital Care Center - Guilford	Guilford	Connecticut	06437	Recruiting
Smilow Cancer Hospital Care Center at Saint Francis	Hartford	Connecticut	06105	Recruiting
Yale University	New Haven	Connecticut	06520	Recruiting
Yale-New Haven Hospital North Haven Medical Center	North Haven	Connecticut	06473	Recruiting
Smilow Cancer Hospital Care Center at Long Ridge	Stamford	Connecticut	06902	Recruiting
Smilow Cancer Hospital-Torrington Care Center	Torrington	Connecticut	06790	Recruiting
Smilow Cancer Hospital Care Center-Trumbull	Trumbull	Connecticut	06611	Recruiting
Smilow Cancer Hospital-Waterbury Care Center	Waterbury	Connecticut	06708	Recruiting
Smilow Cancer Hospital Care Center - Waterford	Waterford	Connecticut	06385	Recruiting
Holy Cross Hospital	Fort Lauderdale	Florida	33308	Recruiting
Mayo Clinic in Florida	Jacksonville	Florida	32224-9980	Recruiting
Moffitt Cancer Center	Tampa	Florida	33612	Recruiting
Hawaii Cancer Care Inc - Waterfront Plaza	Honolulu	Hawaii	96813	Recruiting
Queen's Cancer Cenrer - POB I	Honolulu	Hawaii	96813	Recruiting
Queen's Medical Center	Honolulu	Hawaii	96813	Recruiting
Straub Clinic and Hospital	Honolulu	Hawaii	96813	Recruiting
Queen's Cancer Center - Kuakini	Honolulu	Hawaii	96817	Recruiting
Hawaii Cancer Care - Westridge	‘Aiea	Hawaii	96701	Recruiting
Pali Momi Medical Center	‘Aiea	Hawaii	96701	Recruiting
The Queen's Medical Center - West Oahu	‘Ewa Beach	Hawaii	96706	Recruiting
Saint Alphonsus Cancer Care Center-Nampa	Nampa	Idaho	83687	Recruiting
Rush-Copley Medical Center	Aurora	Illinois	60504	Recruiting
Centralia Oncology Clinic	Centralia	Illinois	62801	Recruiting
Northwestern University	Chicago	Illinois	60611	Recruiting
University of Chicago Comprehensive Cancer Center	Chicago	Illinois	60637	Recruiting
Carle at The Riverfront	Danville	Illinois	61832	Recruiting
Northwestern Medicine Cancer Center Kishwaukee	DeKalb	Illinois	60115	Recruiting
Cancer Care Specialists of Illinois - Decatur	Decatur	Illinois	62526	Recruiting
Decatur Memorial Hospital	Decatur	Illinois	62526	Recruiting
Carle Physician Group-Effingham	Effingham	Illinois	62401	Recruiting
Crossroads Cancer Center	Effingham	Illinois	62401	Recruiting
Northwestern Medicine Cancer Center Delnor	Geneva	Illinois	60134	Recruiting
Northwestern Medicine Glenview Outpatient Center	Glenview	Illinois	60026	Recruiting
Northwestern Medicine Grayslake Outpatient Center	Grayslake	Illinois	60030	Recruiting
Ingalls Memorial Hospital	Harvey	Illinois	60426	Recruiting
Northwestern Medicine Lake Forest Hospital	Lake Forest	Illinois	60045	Recruiting
Carle Physician Group-Mattoon/Charleston	Mattoon	Illinois	61938	Recruiting
UC Comprehensive Cancer Center at Silver Cross	New Lenox	Illinois	60451	Recruiting
Carle BroMenn Medical Center	Normal	Illinois	61761	Recruiting
Carle Cancer Institute Normal	Normal	Illinois	61761	Recruiting
Cancer Care Center of O'Fallon	O'Fallon	Illinois	62269	Recruiting
Northwestern Medicine Orland Park	Orland Park	Illinois	60462	Recruiting
University of Chicago Medicine-Orland Park	Orland Park	Illinois	60462	Recruiting
UW Health Carbone Cancer Center Rockford	Rockford	Illinois	61114	Recruiting
Southern Illinois University School of Medicine	Springfield	Illinois	62702	Recruiting
Springfield Clinic	Springfield	Illinois	62702	Recruiting
Springfield Memorial Hospital	Springfield	Illinois	62781	Recruiting
Carle Cancer Center	Urbana	Illinois	61801	Recruiting
Northwestern Medicine Cancer Center Warrenville	Warrenville	Illinois	60555	Recruiting
Rush-Copley Healthcare Center	Yorkville	Illinois	60560	Recruiting
UChicago Medicine Northwest Indiana	Crown Point	Indiana	46307	Recruiting
Mary Greeley Medical Center	Ames	Iowa	50010	Recruiting
McFarland Clinic - Ames	Ames	Iowa	50010	Recruiting
UI Health Care Mission Cancer and Blood - Ankeny Clinic	Ankeny	Iowa	50023	Recruiting
McFarland Clinic - Boone	Boone	Iowa	50036	Suspended
Saint Anthony Regional Hospital	Carroll	Iowa	51401	Recruiting
Mercy Cancer Center-West Lakes	Clive	Iowa	50325	Recruiting
UI Health Care Mission Cancer and Blood - West Des Moines Clinic	Clive	Iowa	50325	Recruiting
Greater Regional Medical Center	Creston	Iowa	50801	Recruiting
Iowa Methodist Medical Center	Des Moines	Iowa	50309	Recruiting
UI Health Care Mission Cancer and Blood - Des Moines Clinic	Des Moines	Iowa	50309	Recruiting
Broadlawns Medical Center	Des Moines	Iowa	50314	Recruiting
Mercy Medical Center - Des Moines	Des Moines	Iowa	50314	Recruiting
UI Health Care Mission Cancer and Blood - Laurel Clinic	Des Moines	Iowa	50314	Recruiting
McFarland Clinic - Trinity Cancer Center	Fort Dodge	Iowa	50501	Recruiting
McFarland Clinic - Jefferson	Jefferson	Iowa	50129	Suspended
McFarland Clinic - Marshalltown	Marshalltown	Iowa	50158	Recruiting
UI Health Care Mission Cancer and Blood - Waukee Clinic	Waukee	Iowa	50263	Recruiting
Mercy Medical Center-West Lakes	West Des Moines	Iowa	50266	Recruiting
LSU Health Baton Rouge-North Clinic	Baton Rouge	Louisiana	70805	Recruiting
Our Lady of the Lake Physician Group	Baton Rouge	Louisiana	70808	Recruiting
East Jefferson General Hospital	Metairie	Louisiana	70006	Recruiting
LSU Healthcare Network / Metairie Multi-Specialty Clinic	Metairie	Louisiana	70006	Recruiting
University Medical Center New Orleans	New Orleans	Louisiana	70112	Recruiting
Lahey Hospital and Medical Center	Burlington	Massachusetts	01805	Recruiting
Lahey Medical Center-Peabody	Peabody	Massachusetts	01960	Recruiting
Trinity Health Saint Joseph Mercy Hospital Ann Arbor	Ann Arbor	Michigan	48106	Recruiting
University of Michigan Rogel Cancer Center	Ann Arbor	Michigan	48109	Recruiting
Bronson Battle Creek	Battle Creek	Michigan	49017	Recruiting
Trinity Health IHA Medical Group Hematology Oncology - Brighton	Brighton	Michigan	48114	Recruiting
Trinity Health Medical Center - Brighton	Brighton	Michigan	48114	Recruiting
Henry Ford Cancer Institute-Downriver	Brownstown	Michigan	48183	Recruiting
Trinity Health IHA Medical Group Hematology Oncology - Canton	Canton	Michigan	48188	Recruiting
Trinity Health Medical Center - Canton	Canton	Michigan	48188	Recruiting
Chelsea Hospital	Chelsea	Michigan	48118	Recruiting
Trinity Health IHA Medical Group Hematology Oncology - Chelsea Hospital	Chelsea	Michigan	48118	Recruiting
Henry Ford Macomb Hospital-Clinton Township	Clinton Township	Michigan	48038	Recruiting
Corewell Health Dearborn Hospital	Dearborn	Michigan	48124	Recruiting
Henry Ford Medical Center-Fairlane	Dearborn	Michigan	48126	Recruiting
Wayne State University/Karmanos Cancer Institute	Detroit	Michigan	48201	Active, not recruiting
Henry Ford Hospital	Detroit	Michigan	48202	Recruiting
Henry Ford Health Saint John Hospital	Detroit	Michigan	48236	Recruiting
Weisberg Cancer Treatment Center	Farmington Hills	Michigan	48334	Active, not recruiting
Corewell Health Farmington Hills Hospital	Farmington Hills	Michigan	48336	Recruiting
Cancer Hematology Centers - Flint	Flint	Michigan	48503	Recruiting
Genesee Hematology Oncology PC	Flint	Michigan	48503	Suspended
Genesys Hurley Cancer Institute	Flint	Michigan	48503	Recruiting
Hurley Medical Center	Flint	Michigan	48503	Recruiting
Corewell Health Grand Rapids Hospitals - Butterworth Hospital	Grand Rapids	Michigan	49503	Recruiting
Trinity Health Grand Rapids Hospital	Grand Rapids	Michigan	49503	Recruiting
Allegiance Health	Jackson	Michigan	49201	Recruiting
Bronson Methodist Hospital	Kalamazoo	Michigan	49007	Recruiting
West Michigan Cancer Center	Kalamazoo	Michigan	49007	Recruiting
Karmanos Cancer Institute at McLaren Greater Lansing	Lansing	Michigan	48910	Active, not recruiting
Trinity Health Saint Mary Mercy Livonia Hospital	Livonia	Michigan	48154	Recruiting
Trinity Health Muskegon Hospital	Muskegon	Michigan	49444	Recruiting
Corewell Health Lakeland Hospitals - Niles Hospital	Niles	Michigan	49120	Recruiting
Cancer and Hematology Centers of Western Michigan - Norton Shores	Norton Shores	Michigan	49444	Recruiting
Henry Ford Medical Center-Columbus	Novi	Michigan	48377	Recruiting
Trinity Health Saint Joseph Mercy Oakland Hospital	Pontiac	Michigan	48341	Recruiting
Corewell Health Reed City Hospital	Reed City	Michigan	49677	Recruiting
Corewell Health William Beaumont University Hospital	Royal Oak	Michigan	48073	Recruiting
Corewell Health Lakeland Hospitals - Marie Yeager Cancer Center	Saint Joseph	Michigan	49085	Recruiting
Corewell Health Lakeland Hospitals - Saint Joseph Hospital	Saint Joseph	Michigan	49085	Recruiting
Munson Medical Center	Traverse City	Michigan	49684	Recruiting
Corewell Health Beaumont Troy Hospital	Troy	Michigan	48085	Recruiting
Henry Ford Health Warren Hospital	Warren	Michigan	48093	Recruiting
Henry Ford West Bloomfield Hospital	West Bloomfield	Michigan	48322	Recruiting
Henry Ford Wyandotte Hospital	Wyandotte	Michigan	48192	Recruiting
University of Michigan Health - West	Wyoming	Michigan	49519	Recruiting
Huron Gastroenterology PC	Ypsilanti	Michigan	48106	Recruiting
Trinity Health IHA Medical Group Hematology Oncology Ann Arbor Campus	Ypsilanti	Michigan	48197	Recruiting
Minnesota Oncology - Burnsville	Burnsville	Minnesota	55337	Recruiting
Saint Luke's Hospital of Duluth	Duluth	Minnesota	55805	Active, not recruiting
Fairview Southdale Hospital	Edina	Minnesota	55435	Recruiting
Abbott-Northwestern Hospital	Minneapolis	Minnesota	55407	Recruiting
Hennepin County Medical Center	Minneapolis	Minnesota	55415	Recruiting
Mayo Clinic in Rochester	Rochester	Minnesota	55905	Recruiting
Park Nicollet Clinic - Saint Louis Park	Saint Louis Park	Minnesota	55416	Recruiting
Regions Hospital	Saint Paul	Minnesota	55101	Recruiting
Saint Francis Regional Medical Center	Shakopee	Minnesota	55379	Recruiting
Saint Francis Medical Center	Cape Girardeau	Missouri	63703	Recruiting
Mercy Hospital Joplin	Joplin	Missouri	64804	Recruiting
CoxHealth South Hospital	Springfield	Missouri	65807	Recruiting
Mercy Hospital South	St Louis	Missouri	63128	Recruiting
Saint Vincent Frontier Cancer Center	Billings	Montana	59102	Recruiting
Dartmouth Hitchcock Medical Center/Dartmouth Cancer Center	Lebanon	New Hampshire	03756	Recruiting
Roswell Park Cancer Institute	Buffalo	New York	14263	Active, not recruiting
Mount Sinai Hospital	New York	New York	10029	Active, not recruiting
Stony Brook University Medical Center	Stony Brook	New York	11794	Active, not recruiting
Duke Cancer Center Cary	Cary	North Carolina	27518	Suspended
Carolinas Medical Center/Levine Cancer Institute	Charlotte	North Carolina	28203	Recruiting
Atrium Health Pineville/LCI-Pineville	Charlotte	North Carolina	28210	Recruiting
Levine Cancer Institute-SouthPark	Charlotte	North Carolina	28211	Recruiting
Atrium Health University City/LCI-University	Charlotte	North Carolina	28262	Recruiting
Levine Cancer Institute-Ballantyne	Charlotte	North Carolina	28277	Recruiting
Southeastern Medical Oncology Center-Clinton	Clinton	North Carolina	28328	Recruiting
Atrium Health Cabarrus/LCI-Concord	Concord	North Carolina	28025	Recruiting
Duke University Medical Center	Durham	North Carolina	27710	Recruiting
Levine Cancer Institute-Gaston	Gastonia	North Carolina	28054	Recruiting
Southeastern Medical Oncology Center-Goldsboro	Goldsboro	North Carolina	27534	Recruiting
Southeastern Medical Oncology Center-Jacksonville	Jacksonville	North Carolina	28546	Recruiting
FirstHealth of the Carolinas-Moore Regional Hospital	Pinehurst	North Carolina	28374	Recruiting
Duke Cancer Center Raleigh	Raleigh	North Carolina	27609	Suspended
Atrium Health Cleveland/LCI-Cleveland	Shelby	North Carolina	28150	Recruiting
Ohio State University Comprehensive Cancer Center	Columbus	Ohio	43210	Recruiting
Toledo Clinic Cancer Centers-Toledo	Toledo	Ohio	43623	Suspended
Cancer Centers of Southwest Oklahoma Research	Lawton	Oklahoma	73505	Recruiting
University of Oklahoma Health Sciences Center	Oklahoma City	Oklahoma	73104	Recruiting
Mercy Hospital Oklahoma City	Oklahoma City	Oklahoma	73120	Recruiting
Saint Charles Health System	Bend	Oregon	97701	Recruiting
Providence Cancer Institute Clackamas Clinic	Clackamas	Oregon	97015	Suspended
Providence Newberg Medical Center	Newberg	Oregon	97132	Recruiting
Providence Willamette Falls Medical Center	Oregon City	Oregon	97045	Recruiting
Providence Portland Medical Center	Portland	Oregon	97213	Recruiting
Providence Saint Vincent Medical Center	Portland	Oregon	97225	Recruiting
WellSpan Medical Oncology and Hematology	Chambersburg	Pennsylvania	17201	Recruiting
Ephrata Cancer Center	Ephrata	Pennsylvania	17522	Recruiting
Adams Cancer Center	Gettysburg	Pennsylvania	17325	Recruiting
Sechler Family Cancer Center	Lebanon	Pennsylvania	17042	Recruiting
Cancer Care Associates of York	York	Pennsylvania	17403	Recruiting
WellSpan Health-York Cancer Center	York	Pennsylvania	17403	Recruiting
Smilow Cancer Hospital Care Center - Westerly	Westerly	Rhode Island	02891	Recruiting
Medical University of South Carolina	Charleston	South Carolina	29425	Suspended
Levine Cancer Institute-Rock Hill	Rock Hill	South Carolina	29732	Recruiting
Rapid City Regional Hospital	Rapid City	South Dakota	57701	Recruiting
Vanderbilt University/Ingram Cancer Center	Nashville	Tennessee	37232	Recruiting
Parkland Memorial Hospital	Dallas	Texas	75235	Recruiting
UT Southwestern Simmons Cancer Center - RedBird	Dallas	Texas	75237	Recruiting
UT Southwestern/Simmons Cancer Center-Dallas	Dallas	Texas	75390	Recruiting
UT Southwestern/Simmons Cancer Center-Fort Worth	Fort Worth	Texas	76104	Recruiting
Baylor College of Medicine/Dan L Duncan Comprehensive Cancer Center	Houston	Texas	77030	Recruiting
Ben Taub General Hospital	Houston	Texas	77030	Recruiting
UT Southwestern Clinical Center at Richardson/Plano	Richardson	Texas	75080	Recruiting
Huntsman Cancer Institute/University of Utah	Salt Lake City	Utah	84112	Recruiting
Dartmouth Cancer Center - North	Saint Johnsbury	Vermont	05819	Recruiting
Fred Hutchinson Cancer Center	Seattle	Washington	98109	Recruiting
University of Washington Medical Center - Montlake	Seattle	Washington	98195	Recruiting
United Hospital Center	Bridgeport	West Virginia	26330	Recruiting
West Virginia University Healthcare	Morgantown	West Virginia	26506	Recruiting
Marshfield Medical Center-EC Cancer Center	Eau Claire	Wisconsin	54701	Recruiting
Gundersen Lutheran Medical Center	La Crosse	Wisconsin	54601	Recruiting
Marshfield Medical Center-Marshfield	Marshfield	Wisconsin	54449	Recruiting
Medical College of Wisconsin	Milwaukee	Wisconsin	53226	Recruiting
Marshfield Medical Center - Minocqua	Minocqua	Wisconsin	54548	Recruiting
Marshfield Medical Center-Rice Lake	Rice Lake	Wisconsin	54868	Recruiting
Marshfield Medical Center-River Region at Stevens Point	Stevens Point	Wisconsin	54482	Recruiting
Marshfield Medical Center - Weston	Weston	Wisconsin	54476	Recruiting

Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.

About this trial record page

What this page shows: Public field values for ClinicalTrials.gov record NCT05058651, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
What this page does not do: No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
Where the data comes from: Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
Last refresh: Last update posted May 5, 2026 · Synced May 8, 2026

Open the official record

The complete protocol, eligibility criteria, and contact information for NCT05058651 live on ClinicalTrials.gov.

View official ClinicalTrials.gov record →