ClinicalTrials.gov record
Testing the Use of Investigational Drugs Atezolizumab and/or Bevacizumab With or Without Standard Chemotherapy in the Second-Line Treatment of Advanced-Stage Head and Neck Cancers
ClinicalTrials.gov ID: NCT05063552
Public ClinicalTrials.gov record NCT05063552. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Phase II/III Trial of Chemotherapy + Cetuximab vs Chemotherapy + Bevacizumab vs Atezolizumab + Bevacizumab Following Progression on Immune Checkpoint Inhibition in Recurrent/Metastatic Head and Neck Cancers
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
This phase II/III compares the standard therapy (chemotherapy plus cetuximab) versus adding bevacizumab to standard chemotherapy, versus combination of just bevacizumab and atezolizumab in treating patients with head and neck cancer that has spread to other places in the body (metastatic or advanced stage) or has come back after prior treatment (recurrent). Immunotherapy with monoclonal antibodies, such as atezolizumab, may help the body's immune system attack the cancer, and may interfere with the ability of tumor cells to grow and spread. Bevacizumab is in a class of medications called antiangiogenic agents. It works by stopping the formation of blood vessels that bring oxygen and nutrients to tumor. This may slow the growth and spread of tumor. Cetuximab is in a class of medications called monoclonal antibodies. It binds to a protein called EGFR, which is found on some types of cancer cells. This may help keep cancer cells from growing. Cisplatin and carboplatin are in a class of chemotherapy medications known as platinum-containing compounds. They work by killing, stopping, or slowing the growth of cancer cells. Docetaxel is in a class of chemotherapy medications called taxanes. It stops cancer cells from growing and dividing and may kill them. The addition of bevacizumab to standard chemotherapy or combination therapy with bevacizumab and atezolizumab may be better than standard chemotherapy plus cetuximab in treating patients with recurrent/metastatic head and neck cancers.
Study identification
- NCT ID
- NCT05063552
- Recruitment status
- Active, not recruiting
- Study type
- Interventional
- Phase
- Phase 2, Phase 3
- Enrollment
- 430 participants
Conditions and interventions
Conditions
- Clinical Stage IV HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8
- Metastatic Head and Neck Squamous Cell Carcinoma
- Metastatic Hypopharyngeal Squamous Cell Carcinoma
- Metastatic Laryngeal Squamous Cell Carcinoma
- Metastatic Lip and Oral Cavity Carcinoma
- Metastatic Nasal Cavity Squamous Cell Carcinoma
- Metastatic Nasopharyngeal Squamous Cell Carcinoma
- Metastatic Pharyngeal Squamous Cell Carcinoma
- Metastatic Sinonasal Squamous Cell Carcinoma
- Recurrent Head and Neck Squamous Cell Carcinoma
- Recurrent Hypopharyngeal Squamous Cell Carcinoma
- Recurrent Laryngeal Squamous Cell Carcinoma
- Recurrent Lip and Oral Cavity Squamous Cell Carcinoma
- Recurrent Nasopharyngeal Squamous Cell Carcinoma
- Recurrent Pharyngeal Squamous Cell Carcinoma
- Recurrent Sinonasal Squamous Cell Carcinoma
- Stage IV Head and Neck Cutaneous Squamous Cell Carcinoma AJCC v8
- Stage IV Hypopharyngeal Carcinoma AJCC v8
- Stage IV Laryngeal Cancer AJCC v8
- Stage IV Lip and Oral Cavity Cancer AJCC v8
- Stage IV Nasopharyngeal Carcinoma AJCC v8
- Stage IV Oropharyngeal (p16-Negative) Carcinoma AJCC v8
- Stage IV Sinonasal Cancer AJCC v8
Interventions
- Atezolizumab Biological
- Bevacizumab Biological
- Biospecimen Collection Procedure
- Carboplatin Drug
- Cetuximab Biological
- Cisplatin Drug
- Computed Tomography Procedure
- Docetaxel Drug
- Echocardiography Test Procedure
- Magnetic Resonance Imaging Procedure
- Positron Emission Tomography Procedure
Biological · Procedure · Drug
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Mar 13, 2023 (Actual)
- Primary completion
- Dec 15, 2027 (Estimated)
- Completion
- Dec 15, 2027 (Estimated)
- Last update posted
- Oct 1, 2026
2023 – 2027
United States locations
- U.S. sites
- 172
- U.S. states
- 30
- U.S. cities
- 138
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| University of Arkansas for Medical Sciences | Little Rock | Arkansas | 72205 | — |
| Epic Care-Dublin | Dublin | California | 94568 | — |
| Epic Care Partners in Cancer Care | Emeryville | California | 94608 | — |
| UCI Health - Chao Family Comprehensive Cancer Center and Ambulatory Care | Irvine | California | 92612 | — |
| Contra Costa Regional Medical Center | Martinez | California | 94553-3156 | — |
| UC Irvine Health/Chao Family Comprehensive Cancer Center | Orange | California | 92868 | — |
| Stanford Cancer Institute Palo Alto | Palo Alto | California | 94304 | — |
| VA Palo Alto Health Care System | Palo Alto | California | 94304 | — |
| Smilow Cancer Hospital-Derby Care Center | Derby | Connecticut | 06418 | — |
| Smilow Cancer Hospital Care Center-Fairfield | Fairfield | Connecticut | 06824 | — |
| Smilow Cancer Hospital Care Center at Glastonbury | Glastonbury | Connecticut | 06033 | — |
| Smilow Cancer Hospital Care Center at Greenwich | Greenwich | Connecticut | 06830 | — |
| Smilow Cancer Hospital Care Center - Guilford | Guilford | Connecticut | 06437 | — |
| Smilow Cancer Hospital Care Center at Saint Francis | Hartford | Connecticut | 06105 | — |
| Yale University | New Haven | Connecticut | 06520 | — |
| Yale-New Haven Hospital North Haven Medical Center | North Haven | Connecticut | 06473 | — |
| Smilow Cancer Hospital-Orange Care Center | Orange | Connecticut | 06477 | — |
| Smilow Cancer Hospital Care Center at Long Ridge | Stamford | Connecticut | 06902 | — |
| Smilow Cancer Hospital-Torrington Care Center | Torrington | Connecticut | 06790 | — |
| Smilow Cancer Hospital Care Center-Trumbull | Trumbull | Connecticut | 06611 | — |
| Smilow Cancer Hospital-Waterbury Care Center | Waterbury | Connecticut | 06708 | — |
| Smilow Cancer Hospital Care Center - Waterford | Waterford | Connecticut | 06385 | — |
| Helen F Graham Cancer Center | Newark | Delaware | 19713 | — |
| Medical Oncology Hematology Consultants PA | Newark | Delaware | 19713 | — |
| MedStar Washington Hospital Center | Washington D.C. | District of Columbia | 20010 | — |
| UM Sylvester Comprehensive Cancer Center at Coral Gables | Coral Gables | Florida | 33146 | — |
| UM Sylvester Comprehensive Cancer Center at Deerfield Beach | Deerfield Beach | Florida | 33442 | — |
| Broward Health Medical Center | Fort Lauderdale | Florida | 33316 | — |
| University of Miami Miller School of Medicine-Sylvester Cancer Center | Miami | Florida | 33136 | — |
| UM Sylvester Comprehensive Cancer Center at Kendall | Miami | Florida | 33176 | — |
| UM Sylvester Comprehensive Cancer Center at Plantation | Plantation | Florida | 33324 | — |
| Emory University Hospital Midtown | Atlanta | Georgia | 30308 | — |
| Emory University Hospital/Winship Cancer Institute | Atlanta | Georgia | 30322 | — |
| Hawaii Cancer Care Inc - Waterfront Plaza | Honolulu | Hawaii | 96813 | — |
| Queen's Cancer Cenrer - POB I | Honolulu | Hawaii | 96813 | — |
| Queen's Medical Center | Honolulu | Hawaii | 96813 | — |
| Queen's Cancer Center - Kuakini | Honolulu | Hawaii | 96817 | — |
| Hawaii Cancer Care - Westridge | ‘Aiea | Hawaii | 96701 | — |
| Saint Luke's Cancer Institute - Boise | Boise | Idaho | 83712 | — |
| Kootenai Health - Coeur d'Alene | Coeur d'Alene | Idaho | 83814 | — |
| Saint Luke's Cancer Institute - Fruitland | Fruitland | Idaho | 83619 | — |
| Saint Luke's Cancer Institute - Meridian | Meridian | Idaho | 83642 | — |
| Saint Luke's Cancer Institute - Nampa | Nampa | Idaho | 83687 | — |
| Kootenai Clinic Cancer Services - Post Falls | Post Falls | Idaho | 83854 | — |
| Kootenai Clinic Cancer Services - Sandpoint | Sandpoint | Idaho | 83864 | — |
| Saint Luke's Cancer Institute - Twin Falls | Twin Falls | Idaho | 83301 | — |
| Rush-Copley Medical Center | Aurora | Illinois | 60504 | — |
| Centralia Oncology Clinic | Centralia | Illinois | 62801 | — |
| John H Stroger Jr Hospital of Cook County | Chicago | Illinois | 60612 | — |
| University of Illinois | Chicago | Illinois | 60612 | — |
| University of Chicago Comprehensive Cancer Center | Chicago | Illinois | 60637 | — |
| Carle at The Riverfront | Danville | Illinois | 61832 | — |
| Cancer Care Specialists of Illinois - Decatur | Decatur | Illinois | 62526 | — |
| Decatur Memorial Hospital | Decatur | Illinois | 62526 | — |
| Carle Physician Group-Effingham | Effingham | Illinois | 62401 | — |
| Crossroads Cancer Center | Effingham | Illinois | 62401 | — |
| Ingalls Memorial Hospital | Harvey | Illinois | 60426 | — |
| Carle Physician Group-Mattoon/Charleston | Mattoon | Illinois | 61938 | — |
| UC Comprehensive Cancer Center at Silver Cross | New Lenox | Illinois | 60451 | — |
| Cancer Care Center of O'Fallon | O'Fallon | Illinois | 62269 | — |
| HSHS Saint Elizabeth's Hospital | O'Fallon | Illinois | 62269 | — |
| University of Chicago Medicine-Orland Park | Orland Park | Illinois | 60462 | — |
| Southern Illinois University School of Medicine | Springfield | Illinois | 62702 | — |
| Springfield Clinic | Springfield | Illinois | 62702 | — |
| Springfield Memorial Hospital | Springfield | Illinois | 62781 | — |
| Carle Cancer Center | Urbana | Illinois | 61801 | — |
| Rush-Copley Healthcare Center | Yorkville | Illinois | 60560 | — |
| Mary Greeley Medical Center | Ames | Iowa | 50010 | — |
| McFarland Clinic - Ames | Ames | Iowa | 50010 | — |
| UI Health Care Mission Cancer and Blood - Ankeny Clinic | Ankeny | Iowa | 50023 | — |
| McFarland Clinic - Boone | Boone | Iowa | 50036 | — |
| Mercy Cancer Center-West Lakes | Clive | Iowa | 50325 | — |
| UI Health Care Mission Cancer and Blood - West Des Moines Clinic | Clive | Iowa | 50325 | — |
| Greater Regional Medical Center | Creston | Iowa | 50801 | — |
| Iowa Methodist Medical Center | Des Moines | Iowa | 50309 | — |
| UI Health Care Mission Cancer and Blood - Des Moines Clinic | Des Moines | Iowa | 50309 | — |
| Mercy Medical Center - Des Moines | Des Moines | Iowa | 50314 | — |
| UI Health Care Mission Cancer and Blood - Laurel Clinic | Des Moines | Iowa | 50314 | — |
| McFarland Clinic - Trinity Cancer Center | Fort Dodge | Iowa | 50501 | — |
| McFarland Clinic - Jefferson | Jefferson | Iowa | 50129 | — |
| McFarland Clinic - Marshalltown | Marshalltown | Iowa | 50158 | — |
| UI Health Care Mission Cancer and Blood - Waukee Clinic | Waukee | Iowa | 50263 | — |
| Mercy Medical Center-West Lakes | West Des Moines | Iowa | 50266 | — |
| University Medical Center New Orleans | New Orleans | Louisiana | 70112 | — |
| University of Maryland/Greenebaum Cancer Center | Baltimore | Maryland | 21201 | — |
| Greater Baltimore Medical Center | Baltimore | Maryland | 21204 | — |
| Johns Hopkins University/Sidney Kimmel Cancer Center | Baltimore | Maryland | 21287 | — |
| UPMC Western Maryland | Cumberland | Maryland | 21502 | — |
| UMass Memorial Medical Center - University Campus | Worcester | Massachusetts | 01655 | — |
| Mercy Hospital | Coon Rapids | Minnesota | 55433 | — |
| Abbott-Northwestern Hospital | Minneapolis | Minnesota | 55407 | — |
| Hennepin County Medical Center | Minneapolis | Minnesota | 55415 | — |
| Park Nicollet Clinic - Saint Louis Park | Saint Louis Park | Minnesota | 55416 | — |
| Regions Hospital | Saint Paul | Minnesota | 55101 | — |
| Saint Francis Medical Center | Cape Girardeau | Missouri | 63703 | — |
| Mercy Hospital South | St Louis | Missouri | 63128 | — |
| Community Hospital of Anaconda | Anaconda | Montana | 59711 | — |
| Billings Clinic Cancer Center | Billings | Montana | 59101 | — |
| Bozeman Health Deaconess Hospital | Bozeman | Montana | 59715 | — |
| Benefis Sletten Cancer Institute | Great Falls | Montana | 59405 | — |
| Community Medical Center | Missoula | Montana | 59804 | — |
| Dartmouth Hitchcock Medical Center/Dartmouth Cancer Center | Lebanon | New Hampshire | 03756 | — |
| University of New Mexico Cancer Center | Albuquerque | New Mexico | 87106 | — |
| Memorial Medical Center-Las Cruces | Las Cruces | New Mexico | 88011 | — |
| Southeastern Medical Oncology Center-Clinton | Clinton | North Carolina | 28328 | — |
| Southeastern Medical Oncology Center-Goldsboro | Goldsboro | North Carolina | 27534 | — |
| Southeastern Medical Oncology Center-Jacksonville | Jacksonville | North Carolina | 28546 | — |
| Miami Valley Hospital South | Centerville | Ohio | 45459 | — |
| Miami Valley Hospital | Dayton | Ohio | 45409 | — |
| Premier Blood and Cancer Center | Dayton | Ohio | 45409 | — |
| Dayton Physician LLC - Englewood | Dayton | Ohio | 45415 | — |
| Miami Valley Hospital North | Dayton | Ohio | 45415 | — |
| Atrium Medical Center-Middletown Regional Hospital | Franklin | Ohio | 45005-1066 | — |
| Miami Valley Cancer Care and Infusion | Greenville | Ohio | 45331 | — |
| Kettering Medical Center | Kettering | Ohio | 45429 | — |
| Trinity's Tony Teramana Cancer Center | Steubenville | Ohio | 43952 | — |
| Toledo Clinic Cancer Centers-Toledo | Toledo | Ohio | 43623 | — |
| Upper Valley Medical Center | Troy | Ohio | 45373 | — |
| University of Oklahoma Health Sciences Center | Oklahoma City | Oklahoma | 73104 | — |
| Providence Cancer Institute Clackamas Clinic | Clackamas | Oregon | 97015 | — |
| Providence Newberg Medical Center | Newberg | Oregon | 97132 | — |
| Providence Portland Medical Center | Portland | Oregon | 97213 | — |
| Providence Saint Vincent Medical Center | Portland | Oregon | 97225 | — |
| UPMC Altoona | Altoona | Pennsylvania | 16601 | — |
| UPMC-Heritage Valley Health System Beaver | Beaver | Pennsylvania | 15009 | — |
| UPMC Hillman Cancer Center at Butler Health System | Butler | Pennsylvania | 16001 | — |
| UPMC Camp Hill | Camp Hill | Pennsylvania | 17011 | — |
| Carlisle Regional Cancer Center | Carlisle | Pennsylvania | 17015 | — |
| UPMC Hillman Cancer Center - Passavant - Cranberry | Cranberry Township | Pennsylvania | 16066 | — |
| UPMC Hillman Cancer Center Erie | Erie | Pennsylvania | 16505 | — |
| UPMC Cancer Center at UPMC Horizon | Farrell | Pennsylvania | 16121 | — |
| UPMC Cancer Centers - Arnold Palmer Pavilion | Greensburg | Pennsylvania | 15601 | — |
| UPMC Hillman Cancer Center in Greenville/UPMC Horizon | Greenville | Pennsylvania | 16125 | — |
| UPMC Pinnacle Cancer Center/Community Osteopathic Campus | Harrisburg | Pennsylvania | 17109 | — |
| IRMC Cancer Center | Indiana | Pennsylvania | 15701 | — |
| UPMC-Johnstown/John P. Murtha Regional Cancer Center | Johnstown | Pennsylvania | 15901 | — |
| UPMC Cancer Center at UPMC McKeesport | McKeesport | Pennsylvania | 15132 | — |
| UPMC Hillman Cancer Center at Rocco And Nancy Ortenzio Cancer Pavilion | Mechanicsburg | Pennsylvania | 17050 | — |
| Forbes Hospital | Monroeville | Pennsylvania | 15146 | — |
| UPMC Hillman Cancer Center - Monroeville | Monroeville | Pennsylvania | 15146 | — |
| UPMC Hillman Cancer Center in Coraopolis | Moon Township | Pennsylvania | 15108 | — |
| UPMC Hillman Cancer Center - Part of Frick Hospital | Mount Pleasant | Pennsylvania | 15666 | — |
| Arnold Palmer Cancer Center Medical Oncology Norwin | N. Huntingdon | Pennsylvania | 15642 | — |
| UPMC Cancer Center-Natrona Heights | Natrona Heights | Pennsylvania | 15065 | — |
| UPMC Hillman Cancer Center - New Castle | New Castle | Pennsylvania | 16105 | — |
| Thomas Jefferson University Hospital | Philadelphia | Pennsylvania | 19107 | — |
| Jefferson Torresdale Hospital | Philadelphia | Pennsylvania | 19114 | — |
| Allegheny General Hospital | Pittsburgh | Pennsylvania | 15212 | — |
| UPMC-Saint Margaret | Pittsburgh | Pennsylvania | 15215 | — |
| UPMC-Mercy Hospital | Pittsburgh | Pennsylvania | 15219 | — |
| UPMC Hillman Cancer Center | Pittsburgh | Pennsylvania | 15232 | — |
| UPMC-Passavant Hospital | Pittsburgh | Pennsylvania | 15237 | — |
| UPMC-Saint Clair Hospital Cancer Center | Pittsburgh | Pennsylvania | 15243 | — |
| UPMC Cancer Center at UPMC Northwest | Seneca | Pennsylvania | 16346 | — |
| UPMC Cancer Center-Uniontown | Uniontown | Pennsylvania | 15401 | — |
| UPMC Cancer Center-Washington | Washington | Pennsylvania | 15301 | — |
| UPMC West Mifflin-Cancer Center Jefferson | West Mifflin | Pennsylvania | 15122 | — |
| Divine Providence Hospital | Williamsport | Pennsylvania | 17754 | — |
| Asplundh Cancer Pavilion | Willow Grove | Pennsylvania | 19090 | — |
| UPMC Memorial | York | Pennsylvania | 17408 | — |
| Smilow Cancer Hospital Care Center - Westerly | Westerly | Rhode Island | 02891 | — |
| Rapid City Regional Hospital | Rapid City | South Dakota | 57701 | — |
| Covenant Health Cancer Centers | Knoxville | Tennessee | 37916 | — |
| Covenant Health Cancer Centers - West | Knoxville | Tennessee | 37932 | — |
| Covenant Health Oncology Group - Lenoir City | Lenoir City | Tennessee | 37772 | — |
| Vanderbilt University/Ingram Cancer Center | Nashville | Tennessee | 37232 | — |
| Covenant Health Oncology Group - Oak Ridge | Oak Ridge | Tennessee | 37830 | — |
| Dartmouth Cancer Center - North | Saint Johnsbury | Vermont | 05819 | — |
| Vandalia Health/CAMC Institute for Academic Medicine | Charleston | West Virginia | 25304 | — |
| ProHealth D N Greenwald Center | Mukwonago | Wisconsin | 53149 | — |
| ProHealth Oconomowoc Memorial Hospital | Oconomowoc | Wisconsin | 53066 | — |
| UW Cancer Center at ProHealth Care | Waukesha | Wisconsin | 53188 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT05063552, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Oct 1, 2026 · Synced Oct 17, 2026
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Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT05063552 live on ClinicalTrials.gov.