Research Study Looking at How Well Semaglutide Works in People Suffering From Obesity and Knee Osteoarthritis
Public ClinicalTrials.gov record NCT05064735. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
Effect of Subcutaneous Semaglutide 2.4 mg Once-weekly Compared to Placebo in Subjects With Obesity and Knee Osteoarthritis
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
This study will look at participants body weight from the start to the end of the study. It will also look at how much pain participants have in participants knee from the start to the end of the study and how this affects participants daily life. This is to compare the effect on body weight and pain in the knee in people taking semaglutide with people taking "dummy" medicine. Participants will either get semaglutide or "dummy" medicine. Which treatment participants get is decided by chance. Participants will need to take 1 injection once a week. The study medicine is injected with a thin needle in a skin fold in the stomach, thigh or upper arm. During the study, participants will have talks with study staff about how to eat healthy food and how to be more physically active. The study will last for about 1 ½ years. Participants will have 14 clinic visits with the study staff. At the first clinic visit participants will have a blood sample taken. Participants will have an X-ray of participants knee taken at the first visit. If participants have had an X-ray recently, this may not be needed. At 6 of the clinic visits participants cannot take pain medications for 3 days before the visit. Participants cannot take part if participants have had a joint replacement surgery in participants knee. Participants cannot take part if participants have or have had diabetes. Women: Women cannot take part if pregnant, breast-feeding or plan to become pregnant during the study period.
Study identification
- NCT ID
- NCT05064735
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 3
- Enrollment
- 407 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- Not listed
- Sex
- All
- Healthy volunteers
- Accepts healthy volunteers
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Sep 30, 2021
- Primary completion
- Jul 23, 2023
- Completion
- Sep 7, 2023
- Last update posted
- Nov 16, 2025
2021 – 2023
United States locations
- U.S. sites
- 61
- U.S. states
- 23
- U.S. cities
- 55
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Baptist Health System | Montgomery | Alabama | 36106 | — |
| Ortho Arizona | Phoenix | Arizona | 85018 | — |
| Anaheim Clinical Trials, LLC | Anaheim | California | 92801 | — |
| Stuart L. Silverman MD - A Medical Corporation | Beverly Hills | California | 90211 | — |
| Valley Research | Fresno | California | 93720 | — |
| Providence Medical Foundation | Fullerton | California | 92835 | — |
| Desert Oasis Hlthcr Med Group | Palm Springs | California | 92262 | — |
| Encompass Clinical Research_Spring Valley | Spring Valley | California | 91978 | — |
| Diablo Clinical Research, Inc. | Walnut Creek | California | 94598 | — |
| Clinical Research of Hollywood_Hollywood | Hollywood | Florida | 33024 | — |
| Westside Center For Clinical Research | Jacksonville | Florida | 32205 | — |
| Jacksonville Ctr For Clin Res | Jacksonville | Florida | 32216 | — |
| Well Pharma Medical Research Corp | Miami | Florida | 33143 | — |
| Renstar Medical Research | Ocala | Florida | 34470 | — |
| Clinical Trial Res Assoc,Inc | Plantation | Florida | 33324 | — |
| East West Medical Research Institute_Honolulu | Honolulu | Hawaii | 96814 | — |
| Clinical Invest Special_Gurnee | Gurnee | Illinois | 60031 | — |
| Evanston Premier Hlthcr Res | Skokie | Illinois | 60077 | — |
| Clinical Invest Special_Gurnee | Wauconda | Illinois | 60084 | — |
| MediSphere Medical RC | Evansville | Indiana | 47714 | — |
| Velocity Clin. Res Valparaiso | Valparaiso | Indiana | 46383 | — |
| KU MedWest | Shawnee Mission | Kansas | 66217 | — |
| L-MARC Research Center | Louisville | Kentucky | 40213 | — |
| Maryland Veterans Administration Health Care System | Baltimore | Maryland | 21201 | — |
| Centennial Medical Group | Elkridge | Maryland | 21075-6437 | — |
| Brigham & Women's Hospital | Boston | Massachusetts | 02115-5804 | — |
| Arcturus Healthcare, PLC. | Troy | Michigan | 48098 | — |
| StudyMetrix Research LLC | City of Saint Peters | Missouri | 63303 | — |
| The Center For Pharmaceutical Research PC | Kansas City | Missouri | 64114 | — |
| Sundance Clinical Research LLC | St Louis | Missouri | 63141 | — |
| NYU Langone Medical Cent-Joan H Tisch Cnt for Women's Health | New York | New York | 10010 | — |
| Hospital For Special Surgery | New York | New York | 10021 | — |
| Rochester Clinical Research, Inc. | Rochester | New York | 14609 | — |
| DaVita Clinical Research - New York | The Bronx | New York | 10461 | — |
| Southgate Medical Group, LLP | West Seneca | New York | 14224 | — |
| Great Lakes Medical Research | Westfield | New York | 14787 | — |
| University of North Carolina- Chapel Hill Adults | Chapel Hill | North Carolina | 27517 | — |
| Medication Mgmnt, LLC_Grnsboro | Greensboro | North Carolina | 27405 | — |
| PharmQuest Life Sciences LLC | Greensboro | North Carolina | 27408 | — |
| Raleigh Medical Group | Raleigh | North Carolina | 27609-7216 | — |
| Accellacare | Wilmington | North Carolina | 28401 | — |
| Piedmont Medical Research Associates | Winston-Salem | North Carolina | 27103 | — |
| Velocity Clin Res_Cincinnati | Cincinnati | Ohio | 45242 | — |
| Louis Stokes Clvlnd VA Med Ctr | Cleveland | Ohio | 44106-1702 | — |
| Cleveland Clinic_Cleveland | Cleveland | Ohio | 44195 | — |
| Prestige Clinical Research | Franklin | Ohio | 45005 | — |
| New Venture Medical Research | Wadsworth | Ohio | 44281 | — |
| Altoona Osteoporosis Center | Duncansville | Pennsylvania | 16635-8406 | — |
| The University of Penn Center | Philadelphia | Pennsylvania | 19104-3317 | — |
| Parkside Family Medicine | Philadelphia | Pennsylvania | 19144 | — |
| Rhode Island Hospital | Providence | Rhode Island | 02903 | — |
| Accellacare US Inc._SC | Mt. Pleasant | South Carolina | 29464 | — |
| Coastal Carolina Res Ctr. | North Charleston | South Carolina | 29405 | — |
| Palmetto Clinical Research | Summerville | South Carolina | 29485 | — |
| Tennova HC Turkey Creek MC | Knoxville | Tennessee | 37934 | — |
| PrimeCare Medical Group | Houston | Texas | 77024 | — |
| Southwest Houston Research Ltd | Houston | Texas | 77099 | — |
| DM Clin Rsrch/Fam Diag Clinic | Tomball | Texas | 77375 | — |
| Health Res of Hampton Roads | Newport News | Virginia | 23606 | — |
| National Clin Res Inc. | Richmond | Virginia | 23294 | — |
| Capital Clin Res Ctr,LLC | Olympia | Washington | 98502 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 61 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT05064735, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Nov 16, 2025 · Synced Sep 13, 2026
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Open the official record
The complete protocol, eligibility criteria, and contact information for NCT05064735 live on ClinicalTrials.gov.