Treatment of Acute Ischemic Stroke (ReMEDy2 Trial)
Public ClinicalTrials.gov record NCT05065216. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
Phase 2/3 Adaptive Design, Randomized Double-blind Placebo-controlled Study to Evaluate the Safety and Efficacy of DM199 for the Treatment of Acute Ischemic Stroke (ReMEDy2 Trial)
Study identification
- NCT ID
- NCT05065216
- Recruitment status
- Recruiting
- Study type
- Interventional
- Phase
- Phase 2, Phase 3
- Lead sponsor
- DiaMedica Therapeutics Inc
- Industry
- Enrollment
- 728 participants
Conditions and interventions
Conditions
Interventions
- Placebo for DM199 Solution for Injection Other
- Recombinant human tissue kallikrein Drug
Other · Drug
Eligibility (public fields only)
- Age range
- 18 Years to 90 Years
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Nov 6, 2021
- Primary completion
- Nov 30, 2026
- Completion
- Nov 30, 2026
- Last update posted
- Apr 27, 2026
2021 – 2026
United States locations
- U.S. sites
- 35
- U.S. states
- 19
- U.S. cities
- 31
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Gulf Health Hospitals d/b/a Thomas Hospital | Fairhope | Alabama | 36532 | Recruiting |
| USC Arcadia Hospital | Arcadia | California | 91007 | Recruiting |
| Glendale Adventist Medical Center d/b/a Adventist Health Glendale | Glendale | California | 91206-4152 | Recruiting |
| Kaiser Permanente Los Angeles Medical Center | Los Angeles | California | 90027-5209 | Recruiting |
| Ronald Reagan UCLA Medical Center | Los Angeles | California | 90095 | Recruiting |
| Stanford Health Care | Stanford | California | 94305 | Recruiting |
| The Lundquist Institute at Harbor UCLA Medical Center | Torrance | California | 90502 | Recruiting |
| Memorialcare Long Beach Medical Center | Torrance | California | 90806 | Recruiting |
| HCA Florida - JFK Medical Center | Atlantis | Florida | 33462-1149 | Recruiting |
| Boca Raton Regional Hospital Marcus Neuroscience Institute | Boca Raton | Florida | 33486 | Recruiting |
| Holy Cross Health | Fort Lauderdale | Florida | 33308 | Recruiting |
| University of Florida Jacksonville | Jacksonville | Florida | 32209 | Recruiting |
| Sarasota Memorial Hospital | Sarasota | Florida | 34239-2617 | Recruiting |
| Tampa General Hospital (TGH) - The Stroke Center | Tampa | Florida | 33606-3603 | Recruiting |
| OSF HealthCare Saint Francis Medical Center | Peoria | Illinois | 61637 | Recruiting |
| Ascension Via Christi Hospitals Wichita Inc. | Wichita | Kansas | 67214 | Recruiting |
| Ochsner Clinic Foundation | New Orleans | Louisiana | 70121 | Recruiting |
| UMASS Chan Medical School | Worcester | Massachusetts | 01655 | Recruiting |
| Trinity Health Grand Rapids Hospital | Grand Rapids | Michigan | 49503 | Recruiting |
| Abbott Northwestern Hospital | Minneapolis | Minnesota | 55407 | Recruiting |
| University Medical Center of Southern Nevada | Las Vegas | Nevada | 89102 | Recruiting |
| The University of New Mexico - School of Medicine | Albuquerque | New Mexico | 87131 | Recruiting |
| Northwell Health Physician Partners - Neurology at Lenox Hill | New York | New York | 10075 | Recruiting |
| Summa Health Clinical Research Center | Akron | Ohio | 44304 | Recruiting |
| The Clinical Neuroscience Institute | Dayton | Ohio | 45431 | Active, not recruiting |
| Mercy Health - St. Vincent Medical Center | Toledo | Ohio | 43608 | Recruiting |
| The University of Oklahoma Health Sciences Center | Oklahoma City | Oklahoma | 73104 | Recruiting |
| Ascension St. John | Tulsa | Oklahoma | 74104 | Active, not recruiting |
| Oregon Health & Science University | Portland | Oregon | 97239 | Recruiting |
| The Hospital of the University of Pennsylvania | Philadelphia | Pennsylvania | 19104 | Recruiting |
| Prisma Health-Greenville Memorial Hospital | Greenville | South Carolina | 29605 | Recruiting |
| Erlanger Hospital | Chattanooga | Tennessee | 37403 | Recruiting |
| Chattanooga Center for Neurologic Research | Chattanooga | Tennessee | 37404-1163 | Recruiting |
| Houston Methodist Neurological Institute | Houston | Texas | 77030 | Recruiting |
| Memorial Hermann Hospital, Texas Medical Center | Houston | Texas | 77030 | Recruiting |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 31 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT05065216, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Apr 27, 2026 · Synced Apr 29, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete protocol, eligibility criteria, and contact information for NCT05065216 live on ClinicalTrials.gov.