ClinicalTrials.gov record
A Study of Olezarsen (ISIS 678354) Administered to Participants With Severe Hypertriglyceridemia
ClinicalTrials.gov ID: NCT05079919
Public ClinicalTrials.gov record NCT05079919. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Randomized, Double-Blind, Placebo-Controlled, Phase 3 Study of ISIS 678354 Administered Subcutaneously to Patients With Severe Hypertriglyceridemia
Study identification
- NCT ID
- NCT05079919
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 3
- Lead sponsor
- Ionis Pharmaceuticals, Inc.
- Industry
- Enrollment
- 617 participants
Conditions and interventions
Conditions
Interventions
- Olezarsen Drug
- Placebo Drug
Drug
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Oct 24, 2021
- Primary completion
- Oct 21, 2024
- Completion
- Jul 7, 2025
- Last update posted
- Feb 9, 2026
2021 – 2025
United States locations
- U.S. sites
- 56
- U.S. states
- 27
- U.S. cities
- 54
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Accel Research Sites Network | Birmingham | Alabama | 35216 | — |
| Mayo Clinic | Scottsdale | Arizona | 85259 | — |
| Velocity Clinical Research | Chula Vista | California | 91911 | — |
| Diabetes/Lipid Management & Research Center | Huntington Beach | California | 92648 | — |
| University of California, San Diego (UCSD) | La Jolla | California | 92037 | — |
| LA Universal Research Center, Inc. | Los Angeles | California | 90057 | — |
| America Clinical Trials | Tarzana | California | 91356 | — |
| Excel Medical Clinical Trials, LLC | Boca Raton | Florida | 33434 | — |
| Southeast Clinical Research LLC | Chiefland | Florida | 32626 | — |
| Westside Center for Clinical Research | Jacksonville | Florida | 32205 | — |
| Finlay Medical Research | Miami | Florida | 33126 | — |
| Innovia Research Center, INC | Miramar | Florida | 33027 | — |
| Ocala Cardiovascular Research | Ocala | Florida | 34471 | — |
| IMA Clinical Research | St. Petersburg | Florida | 33709 | — |
| VICIS Clinical Research | Tampa | Florida | 33614 | — |
| Bayside Clinical Research | Trinity | Florida | 34655 | — |
| IACT Health | Columbus | Georgia | 31904 | — |
| IMA Clinical Research Chicago | Chicago | Illinois | 60602 | — |
| Affinity Health | Oak Brook | Illinois | 60523 | — |
| West Broadway Clinic | Council Bluffs | Iowa | 51501 | — |
| Kansas University Medical Center | Kansas City | Kansas | 66160 | — |
| Clinical Trials of America, LLC | Monroe | Louisiana | 71201 | — |
| Continental Clinical Solutions | Towson | Maryland | 21204 | — |
| University of Michigan Hospital and Health Systems/ Dept. of Pharmacy-Research Pharmacy | Ann Arbor | Michigan | 48109 | — |
| Aa Mrc, Llc | Flint | Michigan | 48504 | — |
| Washington University School of Medicine | St Louis | Missouri | 63110 | — |
| IMA Clinical Research | St Louis | Missouri | 63117 | — |
| Bryan Medical Center Clinical Research | Lincoln | Nebraska | 68506 | — |
| Palm Research Center, INC. | Las Vegas | Nevada | 89148 | — |
| Hudson County Clinical Trials Research Center | Union City | New Jersey | 07087 | — |
| Modern Medicine | Brooklyn | New York | 11235 | — |
| Northwell Health | Great Neck | New York | 11021 | — |
| Circuit Clinical (Crystal Run Healthcare) | Middletown | New York | 10941 | — |
| NYU Langone | New York | New York | 10016 | — |
| Columbia University | New York | New York | 10032 | — |
| Circuit Clinical | Niagara Falls | New York | 14304 | — |
| Modern Medical | Syosset | New York | 11791 | — |
| Novant Health Cancer Institute Elizabeth Investigational Drug Services | Charlotte | North Carolina | 28204 | — |
| Cone Medical Center | Greensboro | North Carolina | 27401 | — |
| Clinical Trials of America, LLC | Mount Airy | North Carolina | 27030 | — |
| Wake Forest University Health Sciences | Salem | North Carolina | 27157 | — |
| Aventiv Research | Columbus | Ohio | 43213 | — |
| Summit Research Group, LLC | Munroe Falls | Ohio | 44262 | — |
| Hightower Clinical Trial Services | Oklahoma City | Oklahoma | 73102 | — |
| Velocity Clinical Research | Medford | Oregon | 97504 | — |
| The Miriam Hospital | Providence | Rhode Island | 02906 | — |
| Health Concepts | Rapid City | South Dakota | 57702 | — |
| Chattanooga Research & Medicine, PLLC | Chattanooga | Tennessee | 37404 | — |
| Velocity Clinical Research | Cedar Park | Texas | 78613 | — |
| University of Texas Southwestern | Dallas | Texas | 75390 | — |
| Baylor College of Medicine | Houston | Texas | 77030 | — |
| Medicus Alliance Clinical Research | Sugar Land | Texas | 77478 | — |
| Velocity Clinical | West Jordan | Utah | 84088 | — |
| Manassas Clinical Research Center | Manassas | Virginia | 20110 | — |
| York Clinical Research LLC | Norfolk | Virginia | 23510 | — |
| West Virginia University Heart and Vascular Institute | Morgantown | West Virginia | 26506 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 153 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT05079919, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Feb 9, 2026 · Synced May 20, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete protocol, eligibility criteria, and contact information for NCT05079919 live on ClinicalTrials.gov.