ClinicalTrials.gov record
Active, not recruiting Phase 3 Interventional

Testing the Addition of the Anti-cancer Drug, Cabozantinib, to the Usual Immunotherapy Treatment, Avelumab, in Patients With Metastatic Urothelial Cancer, MAIN-CAV Study

ClinicalTrials.gov ID: NCT05092958

Public ClinicalTrials.gov record NCT05092958. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.

ClinicalTrials.gov public records Last synced May 10, 2026, 2:57 AM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

Official title

MAIN-CAV: Phase III Randomized Trial of Maintenance Cabozantinib and Avelumab vs Maintenance Avelumab After First-Line Platinum-Based Chemotherapy in Patients With Metastatic Urothelial Cancer

Study identification

NCT ID
NCT05092958
Recruitment status
Active, not recruiting
Study type
Interventional
Phase
Phase 3
Lead sponsor
National Cancer Institute (NCI)
NIH
Enrollment
654 participants

Conditions and interventions

Eligibility (public fields only)

Age range
18 Years and older
Sex
All
Healthy volunteers
Healthy volunteers not accepted

This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.

Study timeline

Start date
Jun 2, 2022
Primary completion
Jun 14, 2026
Completion
Jun 14, 2026
Last update posted
Apr 30, 2026

2022 – 2026

United States locations

U.S. sites
271
U.S. states
34
U.S. cities
217
Facility City State ZIP Site status
Mayo Clinic Hospital in Arizona Phoenix Arizona 85054
Sutter Auburn Faith Hospital Auburn California 95602
Alta Bates Summit Medical Center-Herrick Campus Berkeley California 94704
Palo Alto Medical Foundation-Fremont Fremont California 94538
Memorial Medical Center Modesto California 95355
Palo Alto Medical Foundation-Camino Division Mountain View California 94040
Palo Alto Medical Foundation Health Care Palo Alto California 94301
Sutter Roseville Medical Center Roseville California 95661
Sutter Medical Center Sacramento Sacramento California 95816
University of California Davis Comprehensive Cancer Center Sacramento California 95817
California Pacific Medical Center-Pacific Campus San Francisco California 94115
Palo Alto Medical Foundation-Santa Cruz Santa Cruz California 95065
Palo Alto Medical Foundation-Sunnyvale Sunnyvale California 94086
Sutter Solano Medical Center/Cancer Center Vallejo California 94589
Beebe South Coastal Health Campus Millville Delaware 19967
Helen F Graham Cancer Center Newark Delaware 19713
Medical Oncology Hematology Consultants PA Newark Delaware 19713
Beebe Health Campus Rehoboth Beach Delaware 19971
MedStar Washington Hospital Center Washington D.C. District of Columbia 20010
UF Health Cancer Institute - Gainesville Gainesville Florida 32610
Mayo Clinic in Florida Jacksonville Florida 32224-9980
Cleveland Clinic-Weston Weston Florida 33331
Rush-Copley Medical Center Aurora Illinois 60504
Advocate Good Shepherd Hospital Barrington Illinois 60010
Illinois CancerCare-Bloomington Bloomington Illinois 61704
Illinois CancerCare-Canton Canton Illinois 61520
Illinois CancerCare-Carthage Carthage Illinois 62321
Centralia Oncology Clinic Centralia Illinois 62801
Northwestern University Chicago Illinois 60611
Rush MD Anderson Cancer Center Chicago Illinois 60612
University of Illinois Chicago Illinois 60612
Advocate Illinois Masonic Medical Center Chicago Illinois 60657
AMG Crystal Lake - Oncology Crystal Lake Illinois 60014
Carle at The Riverfront Danville Illinois 61832
Northwestern Medicine Cancer Center Kishwaukee DeKalb Illinois 60115
Cancer Care Specialists of Illinois - Decatur Decatur Illinois 62526
Illinois CancerCare-Dixon Dixon Illinois 61021
Advocate Good Samaritan Hospital Downers Grove Illinois 60515
Carle Physician Group-Effingham Effingham Illinois 62401
Crossroads Cancer Center Effingham Illinois 62401
Advocate Sherman Hospital Elgin Illinois 60123
Illinois CancerCare-Eureka Eureka Illinois 61530
Illinois CancerCare-Galesburg Galesburg Illinois 61401
Northwestern Medicine Cancer Center Delnor Geneva Illinois 60134
Advocate South Suburban Hospital Hazel Crest Illinois 60429
Illinois CancerCare-Kewanee Clinic Kewanee Illinois 61443
Northwestern Medicine Lake Forest Hospital Lake Forest Illinois 60045
AMG Libertyville - Oncology Libertyville Illinois 60048
Condell Memorial Hospital Libertyville Illinois 60048
Illinois CancerCare-Macomb Macomb Illinois 61455
Carle Physician Group-Mattoon/Charleston Mattoon Illinois 61938
Cancer Care Center of O'Fallon O'Fallon Illinois 62269
Advocate Christ Medical Center Oak Lawn Illinois 60453-2699
Illinois CancerCare-Ottawa Clinic Ottawa Illinois 61350
Advocate Lutheran General Hospital Park Ridge Illinois 60068
Illinois CancerCare-Pekin Pekin Illinois 61554
Illinois CancerCare-Peoria Peoria Illinois 61615
Illinois CancerCare-Peru Peru Illinois 61354
Illinois CancerCare-Princeton Princeton Illinois 61356
UW Health Carbone Cancer Center Rockford Rockford Illinois 61114
Memorial Hospital East Shiloh Illinois 62269
Southern Illinois University School of Medicine Springfield Illinois 62702
Springfield Clinic Springfield Illinois 62702
Springfield Memorial Hospital Springfield Illinois 62781
Carle Cancer Center Urbana Illinois 61801
Northwestern Medicine Cancer Center Warrenville Warrenville Illinois 60555
Illinois CancerCare - Washington Washington Illinois 61571
Rush-Copley Healthcare Center Yorkville Illinois 60560
Northwest Cancer Center - Crown Point Crown Point Indiana 46307
Northwest Oncology LLC Dyer Indiana 46311
Northwest Cancer Center - Hobart Hobart Indiana 46342
Saint Mary Medical Center Hobart Indiana 46342
Saint Catherine Hospital Indianapolis Indiana 46312
The Community Hospital Munster Indiana 46321
Women's Diagnostic Center - Munster Munster Indiana 46321
Northwest Cancer Center - Valparaiso Valparaiso Indiana 46383
Mary Greeley Medical Center Ames Iowa 50010
McFarland Clinic - Ames Ames Iowa 50010
McFarland Clinic - Boone Boone Iowa 50036
McFarland Clinic - Trinity Cancer Center Fort Dodge Iowa 50501
University of Iowa/Holden Comprehensive Cancer Center Iowa City Iowa 52242
McFarland Clinic - Jefferson Jefferson Iowa 50129
McFarland Clinic - Marshalltown Marshalltown Iowa 50158
Baptist Health Louisville Louisville Kentucky 40207
Harold Alfond Center for Cancer Care Augusta Maine 04330
National Institutes of Health Clinical Center Bethesda Maryland 20892
UMass Memorial Medical Center - University Campus Worcester Massachusetts 01655
Trinity Health Saint Joseph Mercy Hospital Ann Arbor Ann Arbor Michigan 48106
Bronson Battle Creek Battle Creek Michigan 49017
Trinity Health IHA Medical Group Hematology Oncology - Brighton Brighton Michigan 48114
Trinity Health Medical Center - Brighton Brighton Michigan 48114
Trinity Health IHA Medical Group Hematology Oncology - Canton Canton Michigan 48188
Trinity Health Medical Center - Canton Canton Michigan 48188
Chelsea Hospital Chelsea Michigan 48118
Trinity Health IHA Medical Group Hematology Oncology - Chelsea Hospital Chelsea Michigan 48118
Hematology Oncology Consultants-Clarkston Clarkston Michigan 48346
Newland Medical Associates-Clarkston Clarkston Michigan 48346
Cancer Hematology Centers - Flint Flint Michigan 48503
Genesee Hematology Oncology PC Flint Michigan 48503
Genesys Hurley Cancer Institute Flint Michigan 48503
Hurley Medical Center Flint Michigan 48503
Corewell Health Grand Rapids Hospitals - Butterworth Hospital Grand Rapids Michigan 49503
Trinity Health Grand Rapids Hospital Grand Rapids Michigan 49503
Bronson Methodist Hospital Kalamazoo Michigan 49007
West Michigan Cancer Center Kalamazoo Michigan 49007
Beacon Kalamazoo Cancer Center Kalamazoo Michigan 49009
University of Michigan Health - Sparrow Lansing Lansing Michigan 48912
Trinity Health Saint Mary Mercy Livonia Hospital Livonia Michigan 48154
Henry Ford Saint John Hospital - Macomb Medical Macomb Michigan 48044
Trinity Health Muskegon Hospital Muskegon Michigan 49444
Cancer and Hematology Centers of Western Michigan - Norton Shores Norton Shores Michigan 49444
Hope Cancer Center Pontiac Michigan 48341
Michigan Healthcare Professionals Pontiac Pontiac Michigan 48341
Newland Medical Associates-Pontiac Pontiac Michigan 48341
Trinity Health Saint Joseph Mercy Oakland Hospital Pontiac Michigan 48341
Corewell Health Reed City Hospital Reed City Michigan 49677
Corewell Health Lakeland Hospitals - Marie Yeager Cancer Center Saint Joseph Michigan 49085
Munson Medical Center Traverse City Michigan 49684
University of Michigan Health - West Wyoming Michigan 49519
Huron Gastroenterology PC Ypsilanti Michigan 48106
Trinity Health IHA Medical Group Hematology Oncology Ann Arbor Campus Ypsilanti Michigan 48197
Sanford Joe Lueken Cancer Center Bemidji Minnesota 56601
Abbott-Northwestern Hospital Minneapolis Minnesota 55407
Hennepin County Medical Center Minneapolis Minnesota 55415
Mayo Clinic in Rochester Rochester Minnesota 55905
Coborn Cancer Center at Saint Cloud Hospital Saint Cloud Minnesota 56303
Park Nicollet Clinic - Saint Louis Park Saint Louis Park Minnesota 55416
Regions Hospital Saint Paul Minnesota 55101
Rice Memorial Hospital Willmar Minnesota 56201
Saint Francis Medical Center Cape Girardeau Missouri 63703
Siteman Cancer Center at Saint Peters Hospital City of Saint Peters Missouri 63376
MU Health - University Hospital/Ellis Fischel Cancer Center Columbia Missouri 65212
Siteman Cancer Center at West County Hospital Creve Coeur Missouri 63141
Saint Luke's Hospital of Kansas City Kansas City Missouri 64111
Saint Luke's East - Lee's Summit Lee's Summit Missouri 64086
Washington University School of Medicine St Louis Missouri 63110
Siteman Cancer Center-South County St Louis Missouri 63129
Siteman Cancer Center at Christian Hospital St Louis Missouri 63136
Mercy Hospital Saint Louis St Louis Missouri 63141
OptumCare Cancer Care at Charleston Las Vegas Nevada 89102
OptumCare Cancer Care at Fort Apache Las Vegas Nevada 89183
New Hampshire Oncology Hematology PA-Concord Concord New Hampshire 03301
Solinsky Center for Cancer Care Manchester New Hampshire 03103
Memorial Sloan Kettering Basking Ridge Basking Ridge New Jersey 07920
Hackensack University Medical Center Hackensack New Jersey 07601
Memorial Sloan Kettering Monmouth Middletown New Jersey 07748
Memorial Sloan Kettering Bergen Montvale New Jersey 07645
Morristown Medical Center Morristown New Jersey 07960
Saint Joseph's Regional Medical Center Paterson New Jersey 07503
Overlook Hospital Summit New Jersey 07902
University of New Mexico Cancer Center Albuquerque New Mexico 87106
Memorial Medical Center-Las Cruces Las Cruces New Mexico 88011
Memorial Sloan Kettering Commack Commack New York 11725
Arnot Ogden Medical Center/Falck Cancer Center Elmira New York 14905
Glens Falls Hospital Glens Falls New York 12801
Memorial Sloan Kettering Westchester Harrison New York 10604
Memorial Sloan Kettering Cancer Center New York New York 10065
Upstate Cancer Center at Oswego Oswego New York 13126
Stony Brook University Medical Center Stony Brook New York 11794
State University of New York Upstate Medical University Syracuse New York 13210
SUNY Upstate Medical Center-Community Campus Syracuse New York 13215
Memorial Sloan Kettering Nassau Uniondale New York 11553
Upstate Cancer Center at Verona Verona New York 13478
Carolinas Medical Center/Levine Cancer Institute Charlotte North Carolina 28203
Levine Cancer Institute-SouthPark Charlotte North Carolina 28211
Atrium Health University City/LCI-University Charlotte North Carolina 28262
Levine Cancer Institute-Ballantyne Charlotte North Carolina 28277
Southeastern Medical Oncology Center-Clinton Clinton North Carolina 28328
Atrium Health Cabarrus/LCI-Concord Concord North Carolina 28025
Southeastern Medical Oncology Center-Goldsboro Goldsboro North Carolina 27534
Southeastern Medical Oncology Center-Jacksonville Jacksonville North Carolina 28546
Atrium Health Lincoln/LCI-Lincolnton Lincolnton North Carolina 28092
Atrium Health Cleveland/LCI-Cleveland Shelby North Carolina 28150
Wake Forest University Health Sciences Winston-Salem North Carolina 27157
Sanford Bismarck Medical Center Bismarck North Dakota 58501
Sanford Broadway Medical Center Fargo North Dakota 58122
Sanford Roger Maris Cancer Center Fargo North Dakota 58122
Cleveland Clinic Akron General Akron Ohio 44307
Miami Valley Hospital South Centerville Ohio 45459
Cleveland Clinic Cancer Center/Fairview Hospital Cleveland Ohio 44111
Cleveland Clinic Foundation Cleveland Ohio 44195
Premier Blood and Cancer Center Dayton Ohio 45409
Dayton Physician LLC - Englewood Dayton Ohio 45415
Miami Valley Hospital North Dayton Ohio 45415
Atrium Medical Center-Middletown Regional Hospital Franklin Ohio 45005-1066
Miami Valley Cancer Care and Infusion Greenville Ohio 45331
Kettering Medical Center Kettering Ohio 45429
Cleveland Clinic Cancer Center Mansfield Mansfield Ohio 44906
Hillcrest Hospital Cancer Center Mayfield Heights Ohio 44124
North Coast Cancer Care Sandusky Ohio 44870
Cleveland Clinic Cancer Center Strongsville Strongsville Ohio 44136
Toledo Clinic Cancer Centers-Toledo Toledo Ohio 43623
Upper Valley Medical Center Troy Ohio 45373
South Pointe Hospital Warrensville Heights Ohio 44122
Cleveland Clinic Wooster Family Health and Surgery Center Wooster Ohio 44691
University of Oklahoma Health Sciences Center Oklahoma City Oklahoma 73104
Oklahoma Cancer Specialists and Research Institute-Tulsa Tulsa Oklahoma 74146
Legacy Mount Hood Medical Center Gresham Oregon 97030
Legacy Good Samaritan Hospital and Medical Center Portland Oregon 97210
Legacy Meridian Park Hospital Tualatin Oregon 97062
Lehigh Valley Hospital-Cedar Crest Allentown Pennsylvania 18103
Lehigh Valley Hospital - Muhlenberg Bethlehem Pennsylvania 18017
Penn State Health Medical Group - Andrews Patel Hematology/Oncology East Harrisburg Pennsylvania 17111
Penn State Milton S Hershey Medical Center Hershey Pennsylvania 17033-0850
Thomas Jefferson University Hospital Philadelphia Pennsylvania 19107
Jefferson Methodist Hospital Philadelphia Pennsylvania 19148
Prisma Health Cancer Institute - Spartanburg Boiling Springs South Carolina 29316
Medical University of South Carolina Charleston South Carolina 29425
Prisma Health Cancer Institute - Easley Easley South Carolina 29640
Prisma Health Cancer Institute - Butternut Greenville South Carolina 29605
Prisma Health Cancer Institute - Faris Greenville South Carolina 29605
Prisma Health Greenville Memorial Hospital Greenville South Carolina 29605
Prisma Health Cancer Institute - Eastside Greenville South Carolina 29615
Prisma Health Cancer Institute - Greer Greer South Carolina 29650
Levine Cancer Institute-Rock Hill Rock Hill South Carolina 29732
Prisma Health Cancer Institute - Seneca Seneca South Carolina 29672
Avera Cancer Institute-Aberdeen Aberdeen South Dakota 57401
Rapid City Regional Hospital Rapid City South Dakota 57701
Sanford Cancer Center Oncology Clinic Sioux Falls South Dakota 57104
Avera Cancer Institute Sioux Falls South Dakota 57105
Sanford USD Medical Center - Sioux Falls Sioux Falls South Dakota 57117-5134
Avera Cancer Institute at Yankton Yankton South Dakota 57078
University Cancer Specialists - Alcoa Alcoa Tennessee 37701
University of Tennessee - Knoxville Knoxville Tennessee 37920
UT Southwestern Simmons Cancer Center - RedBird Dallas Texas 75237
UT Southwestern/Simmons Cancer Center-Dallas Dallas Texas 75390
UT Southwestern/Simmons Cancer Center-Fort Worth Fort Worth Texas 76104
UT Southwestern Clinical Center at Richardson/Plano Richardson Texas 75080
Bon Secours Memorial Regional Medical Center Mechanicsville Virginia 23116
Bon Secours Saint Francis Medical Center Midlothian Virginia 23114
Bon Secours Saint Mary's Hospital Richmond Virginia 23226
Virginia Cancer Institute Richmond Virginia 23229
VCU Massey Cancer Center at Stony Point Richmond Virginia 23235
VCU Massey Comprehensive Cancer Center Richmond Virginia 23298
VCU Community Memorial Health Center South Hill Virginia 23970
Shenandoah Oncology PC Winchester Virginia 22601
Valley Medical Center Renton Washington 98055
Legacy Cancer Institute Medical Oncology and Day Treatment Vancouver Washington 98684
Legacy Salmon Creek Hospital Vancouver Washington 98686
West Virginia University Charleston Division Charleston West Virginia 25304
Aurora Cancer Care-Southern Lakes VLCC Burlington Wisconsin 53105
Marshfield Medical Center-EC Cancer Center Eau Claire Wisconsin 54701
Aurora Health Care Germantown Health Center Germantown Wisconsin 53022
Aurora Cancer Care-Grafton Grafton Wisconsin 53024
Aurora BayCare Medical Center Green Bay Wisconsin 54311
Aurora Cancer Care-Kenosha South Kenosha Wisconsin 53142
Aurora Bay Area Medical Group-Marinette Marinette Wisconsin 54143
Marshfield Medical Center-Marshfield Marshfield Wisconsin 54449
Froedtert Menomonee Falls Hospital Menomonee Falls Wisconsin 53051
Aurora Cancer Care-Milwaukee Milwaukee Wisconsin 53209
Aurora Saint Luke's Medical Center Milwaukee Wisconsin 53215
Medical College of Wisconsin Milwaukee Wisconsin 53226
Aurora Sinai Medical Center Milwaukee Wisconsin 53233
Marshfield Medical Center - Minocqua Minocqua Wisconsin 54548
ProHealth D N Greenwald Center Mukwonago Wisconsin 53149
Cancer Center of Western Wisconsin New Richmond Wisconsin 54017
Drexel Town Square Health Center Oak Creek Wisconsin 53154
ProHealth Oconomowoc Memorial Hospital Oconomowoc Wisconsin 53066
Vince Lombardi Cancer Clinic - Oshkosh Oshkosh Wisconsin 54904
Aurora Cancer Care-Racine Racine Wisconsin 53406
Marshfield Medical Center-Rice Lake Rice Lake Wisconsin 54868
Vince Lombardi Cancer Clinic-Sheboygan Sheboygan Wisconsin 53081
Marshfield Medical Center-River Region at Stevens Point Stevens Point Wisconsin 54482
Aurora Medical Center in Summit Summit Wisconsin 53066
Vince Lombardi Cancer Clinic-Two Rivers Two Rivers Wisconsin 54241
ProHealth Waukesha Memorial Hospital Waukesha Wisconsin 53188
UW Cancer Center at ProHealth Care Waukesha Wisconsin 53188
Aurora Cancer Care-Milwaukee West Wauwatosa Wisconsin 53226
Aurora West Allis Medical Center West Allis Wisconsin 53227
Froedtert West Bend Hospital/Kraemer Cancer Center West Bend Wisconsin 53095
Marshfield Medical Center - Weston Weston Wisconsin 54476

Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.

Non-U.S. locations

This page focuses on the U.S. directory. The official record also lists 4 non-U.S. sites.

About this trial record page

What this page shows
Public field values for ClinicalTrials.gov record NCT05092958, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
What this page does not do
No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
Where the data comes from
Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
Last refresh
Last update posted Apr 30, 2026 · Synced May 10, 2026

Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.

Open the official record

The complete protocol, eligibility criteria, and contact information for NCT05092958 live on ClinicalTrials.gov.

View official ClinicalTrials.gov record →