Independent directory Public ClinicalTrials.gov records United States
ClinicalTrials.gov record
Active, not recruiting Phase 3 Interventional

Testing the Addition of the Anti-cancer Drug, Cabozantinib, to the Usual Immunotherapy Treatment, Avelumab, in Patients With Metastatic Urothelial Cancer, MAIN-CAV Study

ClinicalTrials.gov ID: NCT05092958

Public ClinicalTrials.gov record NCT05092958. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.

ClinicalTrials.gov public records Last synced Oct 16, 2026, 8:37 PM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

Official title

MAIN-CAV: Phase III Randomized Trial of Maintenance Cabozantinib and Avelumab vs Maintenance Avelumab After First-Line Platinum-Based Chemotherapy in Patients With Metastatic Urothelial Cancer

Brief summary

Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.

This phase III trial compares the effect of adding cabozantinib to avelumab versus avelumab alone in treating patients with urothelial cancer that has spread from where it first started (primary site) to other places in the body (metastatic). Cabozantinib may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. Immunotherapy with monoclonal antibodies, such as avelumab, may help the body's immune system attack the cancer, and may interfere with the ability of tumor cells to grow and spread. Giving cabozantinib and avelumab together may further shrink the cancer or prevent it from returning/progressing.

Study identification

NCT ID
NCT05092958
Recruitment status
Active, not recruiting
Study type
Interventional
Phase
Phase 3
Enrollment
654 participants

Conditions and interventions

Eligibility (public fields only)

Age range
18 Years and older
Sex
All
Healthy volunteers
Healthy volunteers not accepted

This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.

Study timeline

Start date
Jun 3, 2022 (Actual)
Primary completion
Jul 15, 2029 (Estimated)
Completion
Jul 15, 2029 (Estimated)
Last update posted
Oct 1, 2026

2022 – 2029

United States locations

U.S. sites
271
U.S. states
34
U.S. cities
217
Facility City State ZIP Site status
Mayo Clinic Hospital in Arizona Phoenix Arizona 85054 —
Sutter Auburn Faith Hospital Auburn California 95602 —
Alta Bates Summit Medical Center-Herrick Campus Berkeley California 94704 —
Palo Alto Medical Foundation-Fremont Fremont California 94538 —
Memorial Medical Center Modesto California 95355 —
Palo Alto Medical Foundation-Camino Division Mountain View California 94040 —
Palo Alto Medical Foundation Health Care Palo Alto California 94301 —
Sutter Roseville Medical Center Roseville California 95661 —
Sutter Medical Center Sacramento Sacramento California 95816 —
University of California Davis Comprehensive Cancer Center Sacramento California 95817 —
California Pacific Medical Center-Pacific Campus San Francisco California 94115 —
Palo Alto Medical Foundation-Santa Cruz Santa Cruz California 95065 —
Palo Alto Medical Foundation-Sunnyvale Sunnyvale California 94086 —
Sutter Solano Medical Center/Cancer Center Vallejo California 94589 —
Beebe South Coastal Health Campus Millville Delaware 19967 —
Helen F Graham Cancer Center Newark Delaware 19713 —
Medical Oncology Hematology Consultants PA Newark Delaware 19713 —
Beebe Health Campus Rehoboth Beach Delaware 19971 —
MedStar Washington Hospital Center Washington D.C. District of Columbia 20010 —
UF Health Cancer Institute - Gainesville Gainesville Florida 32610 —
Mayo Clinic in Florida Jacksonville Florida 32224-9980 —
Cleveland Clinic-Weston Weston Florida 33331 —
Rush-Copley Medical Center Aurora Illinois 60504 —
Advocate Good Shepherd Hospital Barrington Illinois 60010 —
Illinois CancerCare-Bloomington Bloomington Illinois 61704 —
Illinois CancerCare-Canton Canton Illinois 61520 —
Illinois CancerCare-Carthage Carthage Illinois 62321 —
Centralia Oncology Clinic Centralia Illinois 62801 —
Northwestern University Chicago Illinois 60611 —
Rush MD Anderson Cancer Center Chicago Illinois 60612 —
University of Illinois Chicago Illinois 60612 —
Advocate Illinois Masonic Medical Center Chicago Illinois 60657 —
AMG Crystal Lake - Oncology Crystal Lake Illinois 60014 —
Carle at The Riverfront Danville Illinois 61832 —
Cancer Care Specialists of Illinois - Decatur Decatur Illinois 62526 —
Northwestern Medicine Cancer Center Kishwaukee DeKalb Illinois 60115 —
Illinois CancerCare-Dixon Dixon Illinois 61021 —
Advocate Good Samaritan Hospital Downers Grove Illinois 60515 —
Carle Physician Group-Effingham Effingham Illinois 62401 —
Crossroads Cancer Center Effingham Illinois 62401 —
Advocate Sherman Hospital Elgin Illinois 60123 —
Illinois CancerCare-Eureka Eureka Illinois 61530 —
Illinois CancerCare-Galesburg Galesburg Illinois 61401 —
Northwestern Medicine Cancer Center Delnor Geneva Illinois 60134 —
Advocate South Suburban Hospital Hazel Crest Illinois 60429 —
Illinois CancerCare-Kewanee Clinic Kewanee Illinois 61443 —
Northwestern Medicine Lake Forest Hospital Lake Forest Illinois 60045 —
AMG Libertyville - Oncology Libertyville Illinois 60048 —
Condell Memorial Hospital Libertyville Illinois 60048 —
Illinois CancerCare-Macomb Macomb Illinois 61455 —
Carle Physician Group-Mattoon/Charleston Mattoon Illinois 61938 —
Cancer Care Center of O'Fallon O'Fallon Illinois 62269 —
Advocate Christ Medical Center Oak Lawn Illinois 60453-2699 —
Illinois CancerCare-Ottawa Clinic Ottawa Illinois 61350 —
Advocate Lutheran General Hospital Park Ridge Illinois 60068 —
Illinois CancerCare-Pekin Pekin Illinois 61554 —
Illinois CancerCare-Peoria Peoria Illinois 61615 —
Illinois CancerCare-Peru Peru Illinois 61354 —
Illinois CancerCare-Princeton Princeton Illinois 61356 —
UW Health Carbone Cancer Center Rockford Rockford Illinois 61114 —
Memorial Hospital East Shiloh Illinois 62269 —
Southern Illinois University School of Medicine Springfield Illinois 62702 —
Springfield Clinic Springfield Illinois 62702 —
Springfield Memorial Hospital Springfield Illinois 62781 —
Carle Cancer Center Urbana Illinois 61801 —
Northwestern Medicine Cancer Center Warrenville Warrenville Illinois 60555 —
Illinois CancerCare - Washington Washington Illinois 61571 —
Rush-Copley Healthcare Center Yorkville Illinois 60560 —
Northwest Cancer Center - Crown Point Crown Point Indiana 46307 —
Northwest Oncology LLC Dyer Indiana 46311 —
Northwest Cancer Center - Hobart Hobart Indiana 46342 —
Saint Mary Medical Center Hobart Indiana 46342 —
Saint Catherine Hospital Indianapolis Indiana 46312 —
The Community Hospital Munster Indiana 46321 —
Women's Diagnostic Center - Munster Munster Indiana 46321 —
Northwest Cancer Center - Valparaiso Valparaiso Indiana 46383 —
Mary Greeley Medical Center Ames Iowa 50010 —
McFarland Clinic - Ames Ames Iowa 50010 —
McFarland Clinic - Boone Boone Iowa 50036 —
McFarland Clinic - Trinity Cancer Center Fort Dodge Iowa 50501 —
University of Iowa/Holden Comprehensive Cancer Center Iowa City Iowa 52242 —
McFarland Clinic - Jefferson Jefferson Iowa 50129 —
McFarland Clinic - Marshalltown Marshalltown Iowa 50158 —
Baptist Health Louisville Louisville Kentucky 40207 —
Harold Alfond Center for Cancer Care Augusta Maine 04330 —
National Institutes of Health Clinical Center Bethesda Maryland 20892 —
UMass Memorial Medical Center - University Campus Worcester Massachusetts 01655 —
Trinity Health Saint Joseph Mercy Hospital Ann Arbor Ann Arbor Michigan 48106 —
Bronson Battle Creek Battle Creek Michigan 49017 —
Trinity Health IHA Medical Group Hematology Oncology - Brighton Brighton Michigan 48114 —
Trinity Health Medical Center - Brighton Brighton Michigan 48114 —
Trinity Health IHA Medical Group Hematology Oncology - Canton Canton Michigan 48188 —
Trinity Health Medical Center - Canton Canton Michigan 48188 —
Chelsea Hospital Chelsea Michigan 48118 —
Trinity Health IHA Medical Group Hematology Oncology - Chelsea Hospital Chelsea Michigan 48118 —
Hematology Oncology Consultants-Clarkston Clarkston Michigan 48346 —
Newland Medical Associates-Clarkston Clarkston Michigan 48346 —
Cancer Hematology Centers - Flint Flint Michigan 48503 —
Genesee Hematology Oncology PC Flint Michigan 48503 —
Genesys Hurley Cancer Institute Flint Michigan 48503 —
Hurley Medical Center Flint Michigan 48503 —
Corewell Health Grand Rapids Hospitals - Butterworth Hospital Grand Rapids Michigan 49503 —
Trinity Health Grand Rapids Hospital Grand Rapids Michigan 49503 —
Bronson Methodist Hospital Kalamazoo Michigan 49007 —
West Michigan Cancer Center Kalamazoo Michigan 49007 —
Beacon Kalamazoo Cancer Center Kalamazoo Michigan 49009 —
University of Michigan Health - Sparrow Lansing Lansing Michigan 48912 —
Trinity Health Saint Mary Mercy Livonia Hospital Livonia Michigan 48154 —
Henry Ford Saint John Hospital - Macomb Medical Macomb Michigan 48044 —
Trinity Health Muskegon Hospital Muskegon Michigan 49444 —
Cancer and Hematology Centers of Western Michigan - Norton Shores Norton Shores Michigan 49444 —
Hope Cancer Center Pontiac Michigan 48341 —
Michigan Healthcare Professionals Pontiac Pontiac Michigan 48341 —
Newland Medical Associates-Pontiac Pontiac Michigan 48341 —
Trinity Health Saint Joseph Mercy Oakland Hospital Pontiac Michigan 48341 —
Corewell Health Reed City Hospital Reed City Michigan 49677 —
Corewell Health Lakeland Hospitals - Marie Yeager Cancer Center Saint Joseph Michigan 49085 —
Munson Medical Center Traverse City Michigan 49684 —
University of Michigan Health - West Wyoming Michigan 49519 —
Huron Gastroenterology PC Ypsilanti Michigan 48106 —
Trinity Health IHA Medical Group Hematology Oncology Ann Arbor Campus Ypsilanti Michigan 48197 —
Sanford Joe Lueken Cancer Center Bemidji Minnesota 56601 —
Abbott-Northwestern Hospital Minneapolis Minnesota 55407 —
Hennepin County Medical Center Minneapolis Minnesota 55415 —
Mayo Clinic in Rochester Rochester Minnesota 55905 —
Coborn Cancer Center at Saint Cloud Hospital Saint Cloud Minnesota 56303 —
Park Nicollet Clinic - Saint Louis Park Saint Louis Park Minnesota 55416 —
Regions Hospital Saint Paul Minnesota 55101 —
Rice Memorial Hospital Willmar Minnesota 56201 —
Saint Francis Medical Center Cape Girardeau Missouri 63703 —
Siteman Cancer Center at Saint Peters Hospital City of Saint Peters Missouri 63376 —
MU Health - University Hospital/Ellis Fischel Cancer Center Columbia Missouri 65212 —
Siteman Cancer Center at West County Hospital Creve Coeur Missouri 63141 —
Saint Luke's Hospital of Kansas City Kansas City Missouri 64111 —
Saint Luke's East - Lee's Summit Lee's Summit Missouri 64086 —
Washington University School of Medicine St Louis Missouri 63110 —
Siteman Cancer Center-South County St Louis Missouri 63129 —
Siteman Cancer Center at Christian Hospital St Louis Missouri 63136 —
Mercy Hospital Saint Louis St Louis Missouri 63141 —
OptumCare Cancer Care at Charleston Las Vegas Nevada 89102 —
OptumCare Cancer Care at Fort Apache Las Vegas Nevada 89183 —
New Hampshire Oncology Hematology PA-Concord Concord New Hampshire 03301 —
Solinsky Center for Cancer Care Manchester New Hampshire 03103 —
Memorial Sloan Kettering Basking Ridge Basking Ridge New Jersey 07920 —
Hackensack University Medical Center Hackensack New Jersey 07601 —
Memorial Sloan Kettering Monmouth Middletown New Jersey 07748 —
Memorial Sloan Kettering Bergen Montvale New Jersey 07645 —
Morristown Medical Center Morristown New Jersey 07960 —
Saint Joseph's Regional Medical Center Paterson New Jersey 07503 —
Overlook Hospital Summit New Jersey 07902 —
University of New Mexico Cancer Center Albuquerque New Mexico 87106 —
Memorial Medical Center-Las Cruces Las Cruces New Mexico 88011 —
Memorial Sloan Kettering Commack Commack New York 11725 —
Arnot Ogden Medical Center/Falck Cancer Center Elmira New York 14905 —
Glens Falls Hospital Glens Falls New York 12801 —
Memorial Sloan Kettering Westchester Harrison New York 10604 —
Memorial Sloan Kettering Cancer Center New York New York 10065 —
Upstate Cancer Center at Oswego Oswego New York 13126 —
Stony Brook University Medical Center Stony Brook New York 11794 —
State University of New York Upstate Medical University Syracuse New York 13210 —
SUNY Upstate Medical Center-Community Campus Syracuse New York 13215 —
Memorial Sloan Kettering Nassau Uniondale New York 11553 —
Upstate Cancer Center at Verona Verona New York 13478 —
Carolinas Medical Center/Levine Cancer Institute Charlotte North Carolina 28203 —
Levine Cancer Institute-SouthPark Charlotte North Carolina 28211 —
Atrium Health University City/LCI-University Charlotte North Carolina 28262 —
Levine Cancer Institute-Ballantyne Charlotte North Carolina 28277 —
Southeastern Medical Oncology Center-Clinton Clinton North Carolina 28328 —
Atrium Health Cabarrus/LCI-Concord Concord North Carolina 28025 —
Southeastern Medical Oncology Center-Goldsboro Goldsboro North Carolina 27534 —
Southeastern Medical Oncology Center-Jacksonville Jacksonville North Carolina 28546 —
Atrium Health Lincoln/LCI-Lincolnton Lincolnton North Carolina 28092 —
Atrium Health Cleveland/LCI-Cleveland Shelby North Carolina 28150 —
Wake Forest University Health Sciences Winston-Salem North Carolina 27157 —
Sanford Bismarck Medical Center Bismarck North Dakota 58501 —
Sanford Broadway Medical Center Fargo North Dakota 58122 —
Sanford Roger Maris Cancer Center Fargo North Dakota 58122 —
Cleveland Clinic Akron General Akron Ohio 44307 —
Miami Valley Hospital South Centerville Ohio 45459 —
Cleveland Clinic Cancer Center/Fairview Hospital Cleveland Ohio 44111 —
Cleveland Clinic Foundation Cleveland Ohio 44195 —
Premier Blood and Cancer Center Dayton Ohio 45409 —
Dayton Physician LLC - Englewood Dayton Ohio 45415 —
Miami Valley Hospital North Dayton Ohio 45415 —
Atrium Medical Center-Middletown Regional Hospital Franklin Ohio 45005-1066 —
Miami Valley Cancer Care and Infusion Greenville Ohio 45331 —
Kettering Medical Center Kettering Ohio 45429 —
Cleveland Clinic Cancer Center Mansfield Mansfield Ohio 44906 —
Hillcrest Hospital Cancer Center Mayfield Heights Ohio 44124 —
North Coast Cancer Care Sandusky Ohio 44870 —
Cleveland Clinic Cancer Center Strongsville Strongsville Ohio 44136 —
Toledo Clinic Cancer Centers-Toledo Toledo Ohio 43623 —
Upper Valley Medical Center Troy Ohio 45373 —
South Pointe Hospital Warrensville Heights Ohio 44122 —
Cleveland Clinic Wooster Family Health and Surgery Center Wooster Ohio 44691 —
University of Oklahoma Health Sciences Center Oklahoma City Oklahoma 73104 —
Oklahoma Cancer Specialists and Research Institute-Tulsa Tulsa Oklahoma 74146 —
Legacy Mount Hood Medical Center Gresham Oregon 97030 —
Legacy Good Samaritan Hospital and Medical Center Portland Oregon 97210 —
Legacy Meridian Park Hospital Tualatin Oregon 97062 —
Lehigh Valley Hospital-Cedar Crest Allentown Pennsylvania 18103 —
Lehigh Valley Hospital - Muhlenberg Bethlehem Pennsylvania 18017 —
Penn State Health Medical Group - Andrews Patel Hematology/Oncology East Harrisburg Pennsylvania 17111 —
Penn State Milton S Hershey Medical Center Hershey Pennsylvania 17033-0850 —
Thomas Jefferson University Hospital Philadelphia Pennsylvania 19107 —
Jefferson Methodist Hospital Philadelphia Pennsylvania 19148 —
Prisma Health Cancer Institute - Spartanburg Boiling Springs South Carolina 29316 —
Medical University of South Carolina Charleston South Carolina 29425 —
Prisma Health Cancer Institute - Easley Easley South Carolina 29640 —
Prisma Health Cancer Institute - Butternut Greenville South Carolina 29605 —
Prisma Health Cancer Institute - Faris Greenville South Carolina 29605 —
Prisma Health Greenville Memorial Hospital Greenville South Carolina 29605 —
Prisma Health Cancer Institute - Eastside Greenville South Carolina 29615 —
Prisma Health Cancer Institute - Greer Greer South Carolina 29650 —
Levine Cancer Institute-Rock Hill Rock Hill South Carolina 29732 —
Prisma Health Cancer Institute - Seneca Seneca South Carolina 29672 —
Avera Cancer Institute-Aberdeen Aberdeen South Dakota 57401 —
Rapid City Regional Hospital Rapid City South Dakota 57701 —
Sanford Cancer Center Oncology Clinic Sioux Falls South Dakota 57104 —
Avera Cancer Institute Sioux Falls South Dakota 57105 —
Sanford USD Medical Center - Sioux Falls Sioux Falls South Dakota 57117-5134 —
Avera Cancer Institute at Yankton Yankton South Dakota 57078 —
University Cancer Specialists - Alcoa Alcoa Tennessee 37701 —
University of Tennessee - Knoxville Knoxville Tennessee 37920 —
UT Southwestern Simmons Cancer Center - RedBird Dallas Texas 75237 —
UT Southwestern/Simmons Cancer Center-Dallas Dallas Texas 75390 —
UT Southwestern/Simmons Cancer Center-Fort Worth Fort Worth Texas 76104 —
UT Southwestern Clinical Center at Richardson/Plano Richardson Texas 75080 —
Bon Secours Memorial Regional Medical Center Mechanicsville Virginia 23116 —
Bon Secours Saint Francis Medical Center Midlothian Virginia 23114 —
Bon Secours Saint Mary's Hospital Richmond Virginia 23226 —
Virginia Cancer Institute Richmond Virginia 23229 —
VCU Massey Cancer Center at Stony Point Richmond Virginia 23235 —
VCU Massey Comprehensive Cancer Center Richmond Virginia 23298 —
VCU Community Memorial Health Center South Hill Virginia 23970 —
Shenandoah Oncology PC Winchester Virginia 22601 —
Valley Medical Center Renton Washington 98055 —
Legacy Cancer Institute Medical Oncology and Day Treatment Vancouver Washington 98684 —
Legacy Salmon Creek Hospital Vancouver Washington 98686 —
Vandalia Health/CAMC Institute for Academic Medicine Charleston West Virginia 25304 —
Aurora Cancer Care-Southern Lakes VLCC Burlington Wisconsin 53105 —
Marshfield Medical Center-EC Cancer Center Eau Claire Wisconsin 54701 —
Aurora Health Care Germantown Health Center Germantown Wisconsin 53022 —
Aurora Cancer Care-Grafton Grafton Wisconsin 53024 —
Aurora BayCare Medical Center Green Bay Wisconsin 54311 —
Aurora Cancer Care-Kenosha South Kenosha Wisconsin 53142 —
Aurora Bay Area Medical Group-Marinette Marinette Wisconsin 54143 —
Marshfield Medical Center-Marshfield Marshfield Wisconsin 54449 —
Froedtert Menomonee Falls Hospital Menomonee Falls Wisconsin 53051 —
Aurora Cancer Care-Milwaukee Milwaukee Wisconsin 53209 —
Aurora Saint Luke's Medical Center Milwaukee Wisconsin 53215 —
Medical College of Wisconsin Milwaukee Wisconsin 53226 —
Aurora Sinai Medical Center Milwaukee Wisconsin 53233 —
Marshfield Medical Center - Minocqua Minocqua Wisconsin 54548 —
ProHealth D N Greenwald Center Mukwonago Wisconsin 53149 —
Cancer Center of Western Wisconsin New Richmond Wisconsin 54017 —
Drexel Town Square Health Center Oak Creek Wisconsin 53154 —
ProHealth Oconomowoc Memorial Hospital Oconomowoc Wisconsin 53066 —
Vince Lombardi Cancer Clinic - Oshkosh Oshkosh Wisconsin 54904 —
Aurora Cancer Care-Racine Racine Wisconsin 53406 —
Marshfield Medical Center-Rice Lake Rice Lake Wisconsin 54868 —
Vince Lombardi Cancer Clinic-Sheboygan Sheboygan Wisconsin 53081 —
Marshfield Medical Center-River Region at Stevens Point Stevens Point Wisconsin 54482 —
Aurora Medical Center in Summit Summit Wisconsin 53066 —
Vince Lombardi Cancer Clinic-Two Rivers Two Rivers Wisconsin 54241 —
ProHealth Waukesha Memorial Hospital Waukesha Wisconsin 53188 —
UW Cancer Center at ProHealth Care Waukesha Wisconsin 53188 —
Aurora Cancer Care-Milwaukee West Wauwatosa Wisconsin 53226 —
Aurora West Allis Medical Center West Allis Wisconsin 53227 —
Froedtert West Bend Hospital/Kraemer Cancer Center West Bend Wisconsin 53095 —
Marshfield Medical Center - Weston Weston Wisconsin 54476 —

Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.

Non-U.S. locations

This page focuses on the U.S. directory. The official record also lists 4 non-U.S. sites.

About this trial record page

What this page shows
Public field values for ClinicalTrials.gov record NCT05092958, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
What this page does not do
No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
Where the data comes from
Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
Last refresh
Last update posted Oct 1, 2026 · Synced Oct 16, 2026

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Open the official record

The complete public registry record, listed eligibility criteria, and available contact information for NCT05092958 live on ClinicalTrials.gov.

View official ClinicalTrials.gov record →