EMANATE: A Study of Setmelanotide in Patients With Specific Gene Variants in the MC4R Pathway
Public ClinicalTrials.gov record NCT05093634. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Phase 3, Randomized, Double-Blind, Placebo-Controlled Trial: Multiple Independent Sub-studies of Setmelanotide in Patients With POMC/PCSK1, LEPR, NCOA1(SRC1), or SH2B1 Gene Variants in the Melanocortin-4 Receptor Pathway
Study identification
- NCT ID
- NCT05093634
- Recruitment status
- Active, not recruiting
- Study type
- Interventional
- Phase
- Phase 3
- Lead sponsor
- Rhythm Pharmaceuticals, Inc.
- Industry
- Enrollment
- 296 participants
Conditions and interventions
Conditions
Interventions
- Placebo Drug
- Setmelanotide Drug
Drug
Eligibility (public fields only)
- Age range
- 6 Years to 65 Years
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Dec 9, 2021
- Primary completion
- Dec 21, 2025
- Completion
- Dec 30, 2026
- Last update posted
- Feb 9, 2026
2021 – 2026
United States locations
- U.S. sites
- 32
- U.S. states
- 19
- U.S. cities
- 29
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Phoenix Children's Hospital | Phoenix | Arizona | 85016 | — |
| HonorHealth Bariatric Center | Scottsdale | Arizona | 85258 | — |
| Children's Hospital Los Angeles | Los Angeles | California | 90027 | — |
| Children's Hospital Colorado | Aurora | Colorado | 80045 | — |
| Yale Center for Clinical Investigation | New Haven | Connecticut | 06519 | — |
| Advent Health | Altamonte Springs | Florida | 32701 | — |
| InQuest Medical Research | Suwanee | Georgia | 30024 | — |
| UMASS Memorial Medical Center | Worcester | Massachusetts | 01655 | — |
| University of Michigan | Ann Arbor | Michigan | 48105 | — |
| Metro Detroit Endocrinology Center | Dearborn | Michigan | 48126-2619 | — |
| Mayo Clinic | Rochester | Minnesota | 55902 | — |
| St. Luke's Hospital | Chesterfield | Missouri | 63017 | — |
| Washington University in St. Louis | St Louis | Missouri | 63130 | — |
| University of Buffalo | Buffalo | New York | 14260 | — |
| Metropolitan Hospital Center | New York | New York | 10029 | — |
| Mount Sinai Hospital | New York | New York | 10029 | — |
| Columbia University | New York | New York | 10032 | — |
| Ten's Medical Center - Pediatric Endocrinology Clinic | Staten Island | New York | 10306 | — |
| Cincinnati Children's Hospital Medical Center | Cincinnati | Ohio | 45229 | — |
| Oregon Health & Science University | Portland | Oregon | 97239 | — |
| Geisinger Clinic | Danville | Pennsylvania | 17822 | — |
| Children's Hospital of Philadelphia | Philadelphia | Pennsylvania | 19104 | — |
| UPMC Montefiore | Pittsburgh | Pennsylvania | 15213 | — |
| Vanderbilt University School of Medicine | Nashville | Tennessee | 37232 | — |
| Texas Tech | Amarillo | Texas | 79106 | — |
| Texas Children's Hospital | Houston | Texas | 77030 | — |
| Biopharma Informatic | Houston | Texas | 77084 | — |
| Rio Grande Valley Endocrine Center | McAllen | Texas | 78503 | — |
| Endocrine Associates of Dallas and Plano | Plano | Texas | 75093 | — |
| MultiCare Health System Institute for Research and Innovation | Tacoma | Washington | 98405 | — |
| West Virginia University | Morgantown | West Virginia | 26506 | — |
| Marshfield Clinic Research Foundation, a Division of Marshfield Clinic, Inc | Marshfield | Wisconsin | 54449 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 24 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT05093634, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Feb 9, 2026 · Synced May 18, 2026
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Open the official record
The complete protocol, eligibility criteria, and contact information for NCT05093634 live on ClinicalTrials.gov.