ClinicalTrials.gov record
Zilebesiran as Add-on Therapy in Patients With Hypertension Not Adequately Controlled by a Standard of Care Antihypertensive Medication (KARDIA-2)
ClinicalTrials.gov ID: NCT05103332
Public ClinicalTrials.gov record NCT05103332. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Randomized, Double-blind, Placebo-controlled, Multicenter Study to Evaluate the Efficacy and Safety of Zilebesiran Used as Add-on Therapy in Patients With Hypertension Not Adequately Controlled by a Standard of Care Antihypertensive Medication
Study identification
- NCT ID
- NCT05103332
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 2
- Lead sponsor
- Alnylam Pharmaceuticals
- Industry
- Enrollment
- 663 participants
Conditions and interventions
Conditions
Interventions
- Amlodipine Drug
- Indapamide Drug
- Olmesartan Drug
- Placebo Drug
- Zilebesiran Drug
Drug
Eligibility (public fields only)
- Age range
- 18 Years to 75 Years
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Nov 4, 2021
- Primary completion
- Dec 10, 2023
- Completion
- Sep 12, 2024
- Last update posted
- Nov 2, 2025
2021 – 2024
United States locations
- U.S. sites
- 74
- U.S. states
- 18
- U.S. cities
- 65
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Clinical Trial Site | Mesa | Arizona | 85213 | — |
| Clinical Trial Site | Tempe | Arizona | 85281 | — |
| Clinical Trial Site | Tempe | Arizona | 85282 | — |
| Clinical Trial Site | Bell Gardens | California | 90201 | — |
| Clinical Trials Site | Beverly Hills | California | 90211 | — |
| Clinical Trial Site | Canoga Park | California | 91304 | — |
| Clinical Trial Site | Carlsbad | California | 92008 | — |
| Clinical Trial Site | Encinitas | California | 92024 | — |
| Clinical Trial Site | Garden Grove | California | 92844 | — |
| Clinical Trial Site | Hollywood | California | 91606 | — |
| Clinical Trial Site | Huntington Beach | California | 92647 | — |
| Clinical Trial Site | Irvine | California | 92614 | — |
| Clinical Trial Site | Long Beach | California | 90805 | — |
| Clinical Trial Site | Los Angeles | California | 90057 | — |
| Clinical Trial Site | Mission Hills | California | 91345 | — |
| Clinical Trial Site | Oceanside | California | 92056 | — |
| Clinical Trial Site | Panorama City | California | 91402 | — |
| Clinical Trial Site | San Diego | California | 92103 | — |
| Clinical Trial Site | Santa Clarita | California | 91355 | — |
| Clinical Trial Site | South Gate | California | 90280 | — |
| Clinical Trial Site | Tustin | California | 92780 | — |
| Clinical Trial Site | Upland | California | 91786 | — |
| Clinical Trial Site | Washington D.C. | District of Columbia | 20011 | — |
| Clinical Trial Site | Clearwater | Florida | 33756 | — |
| Clinical Trial Site | Coconut Creek | Florida | 33073 | — |
| Clinical Trial Site | Coral Gables | Florida | 33134 | — |
| Clinical Trial Site | Hollywood | Florida | 33021 | — |
| Clinical Trial Site | Hollywood | Florida | 33024 | — |
| Clinical Trial Site | Inverness | Florida | 34452 | — |
| Clinical Trial Site | Jacksonville | Florida | 32256 | — |
| Clinical Trial Site | Miami | Florida | 33032 | — |
| Clinical Trial Site | Miami | Florida | 33125 | — |
| Clinical Trial Site | Miami | Florida | 33135 | — |
| Clinical Trial Site | Miami | Florida | 33144 | — |
| Clinical Trial Site | Miami | Florida | 33176 | — |
| Clinical Trial Site | Naples | Florida | 34105 | — |
| Clinical Trial Site | Orlando | Florida | 32162 | — |
| Clinical Trial Site | Orlando | Florida | 32801 | — |
| Clinical Trial Site | Pembroke Pines | Florida | 33027 | — |
| Clinical Trial Site | Tampa | Florida | 33603 | — |
| Clinical Trial Site | Winter Haven | Florida | 33880 | — |
| Clinical Trial Site | Winter Park | Florida | 32789 | — |
| Clinical Trial Site | Acworth | Georgia | 30101 | — |
| Clinical Trial Site | Canton | Georgia | 30114 | — |
| Clinical Trial Site | Columbus | Georgia | 31904 | — |
| Clinical Trial Site | Savannah | Georgia | 31406 | — |
| Clinical Trial Site | Louisville | Kentucky | 40202 | — |
| Clinical Trial Site | New Orleans | Louisiana | 70769 | — |
| Clinical Trial Site | Southgate | Michigan | 48195 | — |
| Clinical Trial Site | Jackson | Mississippi | 39209 | — |
| Clinical Trial Site | Hazelwood | Missouri | 63042 | — |
| Clinical Trial Site | Jefferson City | Missouri | 65109 | — |
| Clinical Trial Site | New York | New York | 10036 | — |
| Clinical Trial Site | Greensboro | North Carolina | 27403 | — |
| Clinical Trial Site | Greensboro | North Carolina | 27410 | — |
| Clinical Trial Site | Monroe | North Carolina | 28112 | — |
| Clinical Trial site | Winston-Salem | North Carolina | 27157 | — |
| Clinical Trial Site | Norman | Oklahoma | 73072 | — |
| Clinical Trial Site | Little River | South Carolina | 29566 | — |
| Clinical Trial Site | Memphis | Tennessee | 38119 | — |
| Clinical Trial Site | Amarillo | Texas | 79109 | — |
| Clinical Trial Site | Coppell | Texas | 75019 | — |
| Clinical Trial Site | Dallas | Texas | 75251 | — |
| Clinical Trial Site | Houston | Texas | 77074 | — |
| Clinical Trial Site | Houston | Texas | 77081 | — |
| Clinical Trial Site | Lake Jackson | Texas | 77566 | — |
| Clinical Trial Site | Plano | Texas | 75024 | — |
| Clinical Trial Site | Sherman | Texas | 75092 | — |
| Clinical Trial Site | Splendora | Texas | 77372 | — |
| Clinical Trial Site | Stephenville | Texas | 76401 | — |
| Clinical Trial Site | Tomball | Texas | 77375 | — |
| Clinical Trial Site | Waco | Texas | 76708 | — |
| Clinical Trial Site | Burke | Virginia | 22015 | — |
| Clinical Trial Site | Kenosha | Wisconsin | 53142 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 36 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT05103332, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Nov 2, 2025 · Synced May 19, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete protocol, eligibility criteria, and contact information for NCT05103332 live on ClinicalTrials.gov.