ClinicalTrials.gov record
Phase 2 Basket Trial of Nab-sirolimus in Patients With Malignant Solid Tumors With Pathogenic Alterations in TSC1/TSC2 Genes (PRECISION 1)
ClinicalTrials.gov ID: NCT05103358
Public ClinicalTrials.gov record NCT05103358. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
ClinicalTrials.gov public records Last synced May 6, 2026, 8:21 AM EDT
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Phase 2 Multi-center Open-label Basket Trial of Nab-sirolimus for Adult and Adolescent Patients With Malignant Solid Tumors Harboring Pathogenic Inactivating Alterations in TSC1 or TSC2 Genes.
Study identification
- NCT ID
- NCT05103358
- Recruitment status
- Active, not recruiting
- Study type
- Interventional
- Phase
- Phase 2
- Lead sponsor
- Aadi Bioscience, Inc.
- Industry
- Enrollment
- 120 participants
Conditions and interventions
Conditions
Interventions
- nab-sirolimus Drug
Drug
Eligibility (public fields only)
- Age range
- 12 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Feb 14, 2022
- Primary completion
- Dec 30, 2024
- Completion
- Dec 30, 2025
- Last update posted
- Jun 2, 2024
2022 – 2025
United States locations
- U.S. sites
- 159
- U.S. states
- 33
- U.S. cities
- 140
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Alabama Oncology | Birmingham | Alabama | 35243 | — |
| Southern Cancer Center | Mobile | Alabama | 36607 | — |
| Arizona Oncology Associates | Goodyear | Arizona | 85395 | — |
| Honor Health | Phoenix | Arizona | 85016 | — |
| Arizona Oncology Associates | Prescott Valley | Arizona | 86301 | — |
| Yuma Regional Medical Center | Yuma | Arizona | 85364 | — |
| PCR Oncology | Arroyo Grande | California | 93420 | — |
| Nextgen Oncology | Beverly Hills | California | 90212 | — |
| City of Hope | Duarte | California | 91010 | — |
| Providence Medical Foundation (Fullerton) | Fullerton | California | 92835 | — |
| MemorialCare | Long Beach | California | 90806 | — |
| USC Norris Comprehensive Cancer Center | Los Angeles | California | 90033 | — |
| UCLA - Jonsson Comprehensive Cancer Center | Los Angeles | California | 90095 | — |
| Providence Medical Foundation (Napa) | Napa | California | 94558 | — |
| Hoag Memorial Hospital Presbyterian | Newport Beach | California | 92663 | — |
| Sharp HealthCare | San Diego | California | 92123 | — |
| UCSF Helen Diller Family Comprehensive Cancer Center | San Francisco | California | 94115 | — |
| Ridley-Tree Cancer Center | Santa Barbara | California | 93105 | — |
| Sarcoma Oncology Research Center | Santa Monica | California | 90403 | — |
| Providence Medical Foundation | Santa Rosa | California | 95403 | — |
| Stanford Cancer Center | Stanford | California | 94305 | — |
| The Oncology Institute of Hope & Innovation | Whittier | California | 90602 | — |
| Rocky Mountain Cancer Centers | Aurora | Colorado | 80012 | — |
| Rocky Mountain Cancer Centers | Boulder | Colorado | 80303 | — |
| Rocky Mountain Cancer Centers | Colorado Springs | Colorado | 80907 | — |
| Rocky Mountain Cancer Centers (Williams St) | Denver | Colorado | 80218 | — |
| Rocky Mountain Cancer Centers | Denver | Colorado | 80220 | — |
| Rocky Mountain Cancer Centers | Lakewood | Colorado | 80228 | — |
| Rocky Mountain Cancer Centers | Littleton | Colorado | 80120 | — |
| Rocky Mountain Cancer Centers | Lone Tree | Colorado | 80124 | — |
| Rocky Mountain Cancer Centers | Longmont | Colorado | 80501 | — |
| Rocky Mountain Cancer Centers | Pueblo | Colorado | 81008 | — |
| Rocky Mountain Cancer Centers | Thornton | Colorado | 80260 | — |
| Hartford Healthcare | Hartford | Connecticut | 06102 | — |
| Eastern Connecticut Hematology and Oncology | Norwich | Connecticut | 06360 | — |
| Florida Cancer Specialists - North Division | Altamonte Springs | Florida | 32701 | — |
| Florida Cancer Specialists - South Division | Bonita Springs | Florida | 34135 | — |
| Florida Cancer Specialists - South Division | Bradenton | Florida | 34205 | — |
| Florida Cancer Specialists - South Division | Bradenton | Florida | 34211 | — |
| Florida Cancer Specialists - North Division | Brandon | Florida | 33511 | — |
| Florida Cancer Specialists - South Division | Cape Coral | Florida | 33909 | — |
| Florida Cancer Specialists - North Division | Clearwater | Florida | 33761 | — |
| Cancer Specialist - East | Daytona Beach | Florida | 32117 | — |
| Holy Cross Hospital | Fort Lauderdale | Florida | 33308 | — |
| Florida Cancer Specialists South Division | Fort Myers | Florida | 33901 | — |
| Florida Cancer Specialists - South | Fort Myers | Florida | 33905 | — |
| Florida Cancer Specialists - South | Fort Myers | Florida | 33908 | — |
| Florida Cancer Specialists - North Division | Gainesville | Florida | 32605 | — |
| Cancer Specialists of North Florida | Jacksonville | Florida | 32256 | — |
| The Oncology Institute of Hope and Innovation | Lakeland | Florida | 33812 | — |
| TOI Florida | Lakeland | Florida | 33812 | — |
| Florida Cancer Specialists - North Division | Largo | Florida | 33770 | — |
| Florida Cancer Specialists - North Division | Lecanto | Florida | 34461 | — |
| Florida Cancer Specialists - South Division | Naples | Florida | 34102 | — |
| Florida Cancer Specialists - North Division | Ocala | Florida | 34474 | — |
| Ocala Oncology | Ocala | Florida | 34474 | — |
| Florida Cancer Specialists - North Division | Orange City | Florida | 32763 | — |
| Florida Cancer Specialists - North Division | Orlando | Florida | 32806 | — |
| Florida Cancer Specialists - South Division | Port Charlotte | Florida | 33980 | — |
| Florida Cancer Specialists - South Division | Sarasota | Florida | 34232 | — |
| Florida Cancer Specialists - South Division | Sarasota | Florida | 34236 | — |
| Florida Cancer Specialists and Research Institute - North Division | St. Petersburg | Florida | 33705 | — |
| Florida Cancer Specialists - North | St. Petersburg | Florida | 33707 | — |
| Florida Cancer Specialist - East | Stuart | Florida | 34994 | — |
| Florida Cancer Specialists - North Division | Tampa | Florida | 33607 | — |
| Florida Cancer Specialists - North Division | Tavares | Florida | 32778 | — |
| Florida Cancer Specialists - North Division | Trinity | Florida | 34655 | — |
| Florida Cancer Specialists - South Division | Venice | Florida | 34285 | — |
| Florida Cancer Specialists - South Division | Venice | Florida | 34292 | — |
| Florida Cancer Specialists - East | Vero Beach | Florida | 32960 | — |
| Florida Cancer Specialists - East | Wellington | Florida | 33414 | — |
| Florida Cancer Specialists - East | West Palm Beach | Florida | 33401 | — |
| Morehouse School of Medicine | Atlanta | Georgia | 30303 | — |
| Hawaii Cancer Center | Honolulu | Hawaii | 96813 | — |
| Hope and Healing Cancer Services | Hinsdale | Illinois | 60521 | — |
| Northwest Oncology and Hematology | Rolling Meadows | Illinois | 60008 | — |
| Urology of Indiana | Carmel | Indiana | 46032 | — |
| Fort Wayne Medical Oncology and Hematology | Fort Wayne | Indiana | 46804 | — |
| Goshen Health | Goshen | Indiana | 46526 | — |
| Our Lady of the Lake | Baton Rouge | Louisiana | 70817 | — |
| Pontchartrain | Hammond | Louisiana | 70403 | — |
| American Oncology Partners of Maryland PA (Center for Cancer & Blood Disorders) | Bethesda | Maryland | 20817 | — |
| Frederick Health | Frederick | Maryland | 21702 | — |
| Maryland Oncology Hematology | Rockville | Maryland | 20850 | — |
| Dana Farber Cancer Institute | Boston | Massachusetts | 02215 | — |
| Southcoast Centers for Cancer Care | Fairhaven | Massachusetts | 02719 | — |
| Barbara Ann Karmanos Cancer Institute | Detroit | Michigan | 48201 | — |
| Sparrow Hospital | Lansing | Michigan | 48912 | — |
| Minnesota Oncology Hematology | Minneapolis | Minnesota | 55404 | — |
| Central Care Cancer Center | Bolivar | Missouri | 65613 | — |
| Lake Regional | Osage Beach | Missouri | 65065 | — |
| Mosaic Life Care | Saint Joseph | Missouri | 64507 | — |
| Oncology Hematology Associates | Springfield | Missouri | 65807 | — |
| Washington University School of Medicine | St Louis | Missouri | 63110 | — |
| Nebraska Cancer Specialists | Grand Island | Nebraska | 68803 | — |
| Nebraska Methodist Hospital | Omaha | Nebraska | 68114 | — |
| OptumCare Cancer Care-Parent | Las Vegas | Nevada | 89102 | — |
| Comprehensive Cancer Centers of Nevada | Las Vegas | Nevada | 89169 | — |
| New Jersey Cancer Care and Blood Disorders | Belleville | New Jersey | 07109 | — |
| Englewood Hospital and Medical Center | Englewood | New Jersey | 07631 | — |
| Summit Medical Group - NJ | Florham Park | New Jersey | 07932 | — |
| Atlantic Health System - Morristown Medical Center | Morristown | New Jersey | 07960 | — |
| Roswell Park Comprehensive Cancer Center | Buffalo | New York | 14263 | — |
| HOACNY | East Syracuse | New York | 13057 | — |
| Cayuga Medical Center | Ithaca | New York | 14850 | — |
| David H. Koch Center for Cancer Care at Memorial Sloan Kettering Cancer Center | New York | New York | 10065 | — |
| Southeastern Medical Oncology | Goldsboro | North Carolina | 27534 | — |
| Sanford Health-Fargo | Fargo | North Dakota | 58102 | — |
| Aultman Medical Group | Canton | Ohio | 44708 | — |
| TriHealth | Cincinnati | Ohio | 45220 | — |
| University of Cincinnati (UC) - Cancer Institute | Cincinnati | Ohio | 45627 | — |
| Cleveland Clinic | Cleveland | Ohio | 44195 | — |
| The Toledo Clinic | Toledo | Ohio | 43623 | — |
| Oklahoma State University (OSU) - Stephenson Cancer Center | Oklahoma City | Oklahoma | 73104 | — |
| Oklahoma Cancer Specialist | Tulsa | Oklahoma | 74146 | — |
| Gettysburg-PCSRI | Gettysburg | Pennsylvania | 17325 | — |
| Alliance Cancer Specialists | Langhorne | Pennsylvania | 19047 | — |
| Thomas Jefferson University | Philadelphia | Pennsylvania | 19107 | — |
| Cancer Care Associates of York - Parent | York | Pennsylvania | 17403 | — |
| Prisma Health Cancer Institute | Greenville | South Carolina | 29605 | — |
| Avera Cancer Institute | Sioux Falls | South Dakota | 57105 | — |
| Sanford Health | Sioux Falls | South Dakota | 57117 | — |
| Sarah Cannon and HCA Research Institute | Dickson | Tennessee | 37055 | — |
| Sarah Cannon and HCA Research Institute | Franklin | Tennessee | 37067 | — |
| Sarah Cannon and HCA Research Institute | Gallatin | Tennessee | 37066 | — |
| West Cancer Center | Germantown | Tennessee | 38138 | — |
| Sarah Cannon and HCA Research Institute | Henderson | Tennessee | 37075 | — |
| Sarah Cannon and HCA Research Institute | Hermitage | Tennessee | 37076 | — |
| Sarah Cannon and HCA Research Institute | Lebanon | Tennessee | 37090 | — |
| Baptist Cancer Center | Memphis | Tennessee | 38120 | — |
| Sarah Cannon and HCA Research Institute | Murfreesboro | Tennessee | 37129 | — |
| Sarah Cannon and HCA Research Institute | Nashville | Tennessee | 37203 | — |
| Sarah Cannon and HCA Research Institute | Nashville | Tennessee | 37205 | — |
| Sarah Cannon and HCA Research Institute | Nashville | Tennessee | 37207 | — |
| Sarah Cannon and HCA Research Institute | Nashville | Tennessee | 37211 | — |
| Sarah Cannon and HCA Research Institute | Shelbyville | Tennessee | 37160 | — |
| Sarah Cannon and HCA Research Institute | Smyrna | Tennessee | 37167 | — |
| Mary Crowley Cancer Research | Dallas | Texas | 75230 | — |
| Texas Oncology - DFW | Dallas | Texas | 75246 | — |
| Texas Oncology | El Paso | Texas | 79915 | — |
| MD Anderson Cancer Center | Houston | Texas | 77030 | — |
| Oncology Consultants | Houston | Texas | 77030 | — |
| Arizona Oncology Associates | Irving | Texas | 75063 | — |
| Lumi Research | Kingwood | Texas | 77339 | — |
| Texas Oncology Central-South | McAllen | Texas | 78503 | — |
| South Texas Accelerated Research Therapeutics (START) | San Antonio | Texas | 78229 | — |
| Texas Oncology | Tyler | Texas | 75702 | — |
| Community Cancer Trials of Utah | Ogden | Utah | 84405 | — |
| Utah Cancer Specialists | Salt Lake City | Utah | 84106 | — |
| Virginia Cancer Specialists | Fairfax | Virginia | 22031 | — |
| Hematology Oncology Associates of Fredericksburg | Fredericksburg | Virginia | 22408 | — |
| Virginia Urology | Richmond | Virginia | 23235 | — |
| University of Washington Cancer Consortium | Seattle | Washington | 98109 | — |
| Spokane Urology | Spokane | Washington | 99202 | — |
| Cancer Care Northwest | Spokane | Washington | 99216 | — |
| Northwest Medical Specialties | Tacoma | Washington | 98405 | — |
| ThedaCare | Appleton | Wisconsin | 54911 | — |
| Gunderson Health System | La Crosse | Wisconsin | 54601 | — |
| University of Wisconsin - Carbone Cancer Center | Madison | Wisconsin | 53705 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 7 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT05103358, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Jun 2, 2024 · Synced May 6, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete protocol, eligibility criteria, and contact information for NCT05103358 live on ClinicalTrials.gov.