A Study of Donanemab (LY3002813) Compared With Aducanumab in Participants With Early Symptomatic Alzheimer's Disease (TRAILBLAZER-ALZ 4)
Public ClinicalTrials.gov record NCT05108922. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Phase 3, Open-Label, Parallel-Group, 2-Arm Study to Investigate Amyloid Plaque Clearance With Donanemab Compared With Aducanumab-avwa in Participants With Early Symptomatic Alzheimer's Disease
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
The main purpose of this study is to compare donanemab to aducanumab on brain amyloid plaque clearance in participants with early symptomatic Alzheimer's Disease (AD).
Study identification
- NCT ID
- NCT05108922
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 3
- Enrollment
- 148 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 50 Years to 85 Years
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Nov 16, 2021 (Actual)
- Primary completion
- Sep 9, 2022 (Actual)
- Completion
- Sep 19, 2023 (Actual)
- Last update posted
- Nov 29, 2024
2021 – 2023
United States locations
- U.S. sites
- 31
- U.S. states
- 13
- U.S. cities
- 30
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Neurology Center of North Orange County | Fullerton | California | 92835 | — |
| Irvine Clinical Research | Irvine | California | 92614 | — |
| California Neuroscience Research Medical Group, Inc. | Sherman Oaks | California | 91403 | — |
| Institute for Neurodegenerative Disorders | New Haven | Connecticut | 06510 | — |
| JEM Research Institute | Atlantis | Florida | 33462 | — |
| Brain Matters Research | Delray Beach | Florida | 33445 | — |
| Neuropsychiatric Research Center of Southwest Florida | Fort Myers | Florida | 33912 | — |
| Infinity Clinical Research, LLC | Hollywood | Florida | 33024 | — |
| Jacksonville Center for Clinical Research | Jacksonville | Florida | 32216 | — |
| Charter Research - Lady Lake | Lady Lake | Florida | 32159 | — |
| ClinCloud - Maitland | Maitland | Florida | 32751 | — |
| ClinCloud - Viera | Melbourne | Florida | 32940 | — |
| Merritt Island Medical Research, LLC | Merritt Island | Florida | 32952 | — |
| Optimus U Corporation | Miami | Florida | 33125 | — |
| Brainstorm Research | Miami | Florida | 33176 | — |
| Brain Matters Research | Stuart | Florida | 34997 | — |
| Axiom Clinical Research of Florida | Tampa | Florida | 33609 | — |
| Conquest Research | Winter Park | Florida | 32789 | — |
| Columbus Memory Center, PC | Columbus | Georgia | 31909 | — |
| Josephson Wallack Munshower Neurology, PC | Indianapolis | Indiana | 46256 | — |
| Donald S. Marks M.D., P.C. | Plymouth | Massachusetts | 02360 | — |
| Adams Clinical | Watertown | Massachusetts | 02472 | — |
| Clinical Research Professionals | Chesterfield | Missouri | 63005 | — |
| Las Vegas Medical Research | Las Vegas | Nevada | 89113 | — |
| The Cognitive and Research Center of New Jersey | Springfield | New Jersey | 07081 | — |
| Advanced Memory Research Institute of New Jersey | Toms River | New Jersey | 08755 | — |
| Neurology Diagnostics, Inc. | Dayton | Ohio | 45459 | — |
| Abington Neurological Associates, Ltd. | Abington | Pennsylvania | 19001 | — |
| The Clinical Trial Center, LLC | Jenkintown | Pennsylvania | 19046 | — |
| Kerwin Medical Center | Dallas | Texas | 75231 | — |
| National Clinical Research, Inc | Richmond | Virginia | 23294 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT05108922, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Nov 29, 2024 · Synced Oct 21, 2026
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Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT05108922 live on ClinicalTrials.gov.