Using Nivolumab Alone or With Cabozantinib to Prevent Mucosal Melanoma Return After Surgery

ClinicalTrials.gov ID: NCT05111574

Public ClinicalTrials.gov record NCT05111574. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.

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ClinicalTrials.gov public records Last synced May 8, 2026, 12:28 AM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

Official title

A Randomized Phase II Trial of Adjuvant Nivolumab With or Without Cabozantinib in Patients With Resected Mucosal Melanoma

Study identification

NCT ID: NCT05111574
Recruitment status: Recruiting
Study type: Interventional
Phase: Phase 2
Lead sponsor: National Cancer Institute (NCI); NIH
Enrollment: 101 participants

Conditions and interventions

Conditions

Interventions

Biospecimen Collection Procedure
Bone Scan Procedure
Cabozantinib S-malate Drug
Computed Tomography Procedure
Echocardiography Test Procedure
Magnetic Resonance Imaging Procedure
Nivolumab Biological
Placebo Administration Drug
Positron Emission Tomography Procedure

Procedure · Drug · Biological

Eligibility (public fields only)

Age range: 18 Years and older
Sex: All
Healthy volunteers: Healthy volunteers not accepted

This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.

Study timeline

Start date: Aug 10, 2022
Primary completion: Aug 31, 2026
Completion: Aug 31, 2026
Last update posted: May 5, 2026

2022 – 2026

United States locations

U.S. sites: 143
U.S. states: 21
U.S. cities: 120

Facility	City	State	ZIP	Site status
Sutter Auburn Faith Hospital	Auburn	California	95602	Recruiting
Alta Bates Summit Medical Center-Herrick Campus	Berkeley	California	94704	Recruiting
Palo Alto Medical Foundation-Fremont	Fremont	California	94538	Recruiting
Keck Medicine of USC Koreatown	Los Angeles	California	90020	Recruiting
Los Angeles General Medical Center	Los Angeles	California	90033	Recruiting
USC / Norris Comprehensive Cancer Center	Los Angeles	California	90033	Recruiting
Memorial Medical Center	Modesto	California	95355	Recruiting
USC Norris Oncology/Hematology-Newport Beach	Newport Beach	California	92663	Recruiting
Palo Alto Medical Foundation Health Care	Palo Alto	California	94301	Suspended
Stanford Cancer Institute Palo Alto	Palo Alto	California	94304	Recruiting
Sutter Roseville Medical Center	Roseville	California	95661	Recruiting
Sutter Medical Center Sacramento	Sacramento	California	95816	Recruiting
California Pacific Medical Center-Pacific Campus	San Francisco	California	94115	Recruiting
UCSF Medical Center-Mission Bay	San Francisco	California	94158	Recruiting
Mills Health Center	San Mateo	California	94401	Recruiting
Palo Alto Medical Foundation-Santa Cruz	Santa Cruz	California	95065	Recruiting
Sutter Pacific Medical Foundation	Santa Rosa	California	95403	Recruiting
Palo Alto Medical Foundation-Sunnyvale	Sunnyvale	California	94086	Recruiting
Sutter Solano Medical Center/Cancer Center	Vallejo	California	94589	Recruiting
The Melanoma and Skin Cancer Institute	Englewood	Colorado	80113	Active, not recruiting
UM Sylvester Comprehensive Cancer Center at Aventura	Aventura	Florida	33180	Active, not recruiting
UM Sylvester Comprehensive Cancer Center at Coral Gables	Coral Gables	Florida	33146	Active, not recruiting
UM Sylvester Comprehensive Cancer Center at Deerfield Beach	Deerfield Beach	Florida	33442	Active, not recruiting
University of Miami Miller School of Medicine-Sylvester Cancer Center	Miami	Florida	33136	Active, not recruiting
UM Sylvester Comprehensive Cancer Center at Plantation	Plantation	Florida	33324	Active, not recruiting
Saint Alphonsus Cancer Care Center-Boise	Boise	Idaho	83706	Suspended
Saint Alphonsus Cancer Care Center-Caldwell	Caldwell	Idaho	83605	Suspended
Kootenai Health - Coeur d'Alene	Coeur d'Alene	Idaho	83814	Recruiting
Saint Alphonsus Cancer Care Center-Nampa	Nampa	Idaho	83687	Suspended
Kootenai Clinic Cancer Services - Post Falls	Post Falls	Idaho	83854	Recruiting
Kootenai Clinic Cancer Services - Sandpoint	Sandpoint	Idaho	83864	Recruiting
Rush-Copley Medical Center	Aurora	Illinois	60504	Recruiting
Centralia Oncology Clinic	Centralia	Illinois	62801	Recruiting
Northwestern University	Chicago	Illinois	60611	Recruiting
Carle at The Riverfront	Danville	Illinois	61832	Recruiting
Northwestern Medicine Cancer Center Kishwaukee	DeKalb	Illinois	60115	Recruiting
Cancer Care Specialists of Illinois - Decatur	Decatur	Illinois	62526	Recruiting
Decatur Memorial Hospital	Decatur	Illinois	62526	Recruiting
Carle Physician Group-Effingham	Effingham	Illinois	62401	Recruiting
Crossroads Cancer Center	Effingham	Illinois	62401	Recruiting
Northwestern Medicine Cancer Center Delnor	Geneva	Illinois	60134	Recruiting
Northwestern Medicine Glenview Outpatient Center	Glenview	Illinois	60026	Recruiting
Northwestern Medicine Grayslake Outpatient Center	Grayslake	Illinois	60030	Recruiting
Northwestern Medicine Lake Forest Hospital	Lake Forest	Illinois	60045	Recruiting
Carle Physician Group-Mattoon/Charleston	Mattoon	Illinois	61938	Recruiting
Cancer Care Center of O'Fallon	O'Fallon	Illinois	62269	Recruiting
Northwestern Medicine Orland Park	Orland Park	Illinois	60462	Recruiting
Southern Illinois University School of Medicine	Springfield	Illinois	62702	Recruiting
Springfield Clinic	Springfield	Illinois	62702	Recruiting
Springfield Memorial Hospital	Springfield	Illinois	62781	Recruiting
Carle Cancer Center	Urbana	Illinois	61801	Recruiting
Northwestern Medicine Cancer Center Warrenville	Warrenville	Illinois	60555	Recruiting
Rush-Copley Healthcare Center	Yorkville	Illinois	60560	Recruiting
Mary Greeley Medical Center	Ames	Iowa	50010	Recruiting
McFarland Clinic - Ames	Ames	Iowa	50010	Recruiting
UI Health Care Mission Cancer and Blood - Ankeny Clinic	Ankeny	Iowa	50023	Recruiting
McFarland Clinic - Boone	Boone	Iowa	50036	Suspended
UI Health Care Mission Cancer and Blood - West Des Moines Clinic	Clive	Iowa	50325	Recruiting
Mercy Medical Center - Des Moines	Des Moines	Iowa	50314	Recruiting
UI Health Care Mission Cancer and Blood - Laurel Clinic	Des Moines	Iowa	50314	Recruiting
McFarland Clinic - Trinity Cancer Center	Fort Dodge	Iowa	50501	Recruiting
McFarland Clinic - Jefferson	Jefferson	Iowa	50129	Suspended
McFarland Clinic - Marshalltown	Marshalltown	Iowa	50158	Recruiting
UI Health Care Mission Cancer and Blood - Waukee Clinic	Waukee	Iowa	50263	Recruiting
Dana-Farber Cancer Institute	Boston	Massachusetts	02215	Recruiting
Bronson Battle Creek	Battle Creek	Michigan	49017	Recruiting
Corewell Health Grand Rapids Hospitals - Butterworth Hospital	Grand Rapids	Michigan	49503	Recruiting
Trinity Health Grand Rapids Hospital	Grand Rapids	Michigan	49503	Recruiting
Bronson Methodist Hospital	Kalamazoo	Michigan	49007	Recruiting
West Michigan Cancer Center	Kalamazoo	Michigan	49007	Recruiting
Beacon Kalamazoo Cancer Center	Kalamazoo	Michigan	49009	Recruiting
Trinity Health Muskegon Hospital	Muskegon	Michigan	49444	Recruiting
Corewell Health Lakeland Hospitals - Niles Hospital	Niles	Michigan	49120	Recruiting
Cancer and Hematology Centers of Western Michigan - Norton Shores	Norton Shores	Michigan	49444	Recruiting
Corewell Health Reed City Hospital	Reed City	Michigan	49677	Recruiting
Corewell Health Lakeland Hospitals - Marie Yeager Cancer Center	Saint Joseph	Michigan	49085	Recruiting
Munson Medical Center	Traverse City	Michigan	49684	Recruiting
University of Michigan Health - West	Wyoming	Michigan	49519	Recruiting
Minnesota Oncology - Burnsville	Burnsville	Minnesota	55337	Recruiting
Mercy Hospital	Coon Rapids	Minnesota	55433	Recruiting
Fairview Southdale Hospital	Edina	Minnesota	55435	Recruiting
Abbott-Northwestern Hospital	Minneapolis	Minnesota	55407	Recruiting
North Memorial Medical Health Center	Robbinsdale	Minnesota	55422	Recruiting
Mayo Clinic in Rochester	Rochester	Minnesota	55905	Recruiting
Park Nicollet Clinic - Saint Louis Park	Saint Louis Park	Minnesota	55416	Recruiting
Regions Hospital	Saint Paul	Minnesota	55101	Recruiting
United Hospital	Saint Paul	Minnesota	55102	Recruiting
Parkland Health Center - Farmington	Farmington	Missouri	63640	Recruiting
Sainte Genevieve County Memorial Hospital	Sainte Genevieve	Missouri	63670	Recruiting
Missouri Baptist Medical Center	St Louis	Missouri	63131	Recruiting
Missouri Baptist Sullivan Hospital	Sullivan	Missouri	63080	Recruiting
BJC Outpatient Center at Sunset Hills	Sunset Hills	Missouri	63127	Recruiting
Community Hospital of Anaconda	Anaconda	Montana	59711	Recruiting
Billings Clinic Cancer Center	Billings	Montana	59101	Recruiting
Bozeman Health Deaconess Hospital	Bozeman	Montana	59715	Recruiting
Benefis Sletten Cancer Institute	Great Falls	Montana	59405	Recruiting
Logan Health Medical Center	Kalispell	Montana	59901	Recruiting
Community Medical Center	Missoula	Montana	59804	Recruiting
Memorial Sloan Kettering Basking Ridge	Basking Ridge	New Jersey	07920	Recruiting
Hematology Oncology Associates of CNY at Camillus	Camillus	New York	13031	Recruiting
Hematology Oncology Associates of Central New York-East Syracuse	East Syracuse	New York	13057	Recruiting
Memorial Sloan Kettering Westchester	Harrison	New York	10604	Recruiting
Northwell Health/Center for Advanced Medicine	Lake Success	New York	11042	Recruiting
NYU Langone Hospital - Long Island	Mineola	New York	11501	Recruiting
Laura and Isaac Perlmutter Cancer Center at NYU Langone	New York	New York	10016	Recruiting
Memorial Sloan Kettering Cancer Center	New York	New York	10065	Recruiting
Miami Valley Hospital South	Centerville	Ohio	45459	Recruiting
Good Samaritan Hospital - Cincinnati	Cincinnati	Ohio	45220	Recruiting
Case Western Reserve University	Cleveland	Ohio	44106	Recruiting
MetroHealth Medical Center	Cleveland	Ohio	44109	Recruiting
Miami Valley Hospital	Dayton	Ohio	45409	Recruiting
Premier Blood and Cancer Center	Dayton	Ohio	45409	Recruiting
Dayton Physician LLC - Englewood	Dayton	Ohio	45415	Active, not recruiting
Miami Valley Hospital North	Dayton	Ohio	45415	Recruiting
Atrium Medical Center-Middletown Regional Hospital	Franklin	Ohio	45005-1066	Recruiting
Miami Valley Cancer Care and Infusion	Greenville	Ohio	45331	Recruiting
Kettering Medical Center	Kettering	Ohio	45429	Active, not recruiting
Upper Valley Medical Center	Troy	Ohio	45373	Recruiting
Cancer Centers of Southwest Oklahoma Research	Lawton	Oklahoma	73505	Recruiting
University of Oklahoma Health Sciences Center	Oklahoma City	Oklahoma	73104	Recruiting
Saint Alphonsus Cancer Care Center-Ontario	Ontario	Oregon	97914	Suspended
Thomas Jefferson University Hospital	Philadelphia	Pennsylvania	19107	Active, not recruiting
University of Pittsburgh Cancer Institute (UPCI)	Pittsburgh	Pennsylvania	15232	Recruiting
Asplundh Cancer Pavilion	Willow Grove	Pennsylvania	19090	Active, not recruiting
Rapid City Regional Hospital	Rapid City	South Dakota	57701	Active, not recruiting
Avera Cancer Institute	Sioux Falls	South Dakota	57105	Recruiting
M D Anderson Cancer Center	Houston	Texas	77030	Recruiting
VCU Massey Cancer Center at Stony Point	Richmond	Virginia	23235	Recruiting
VCU Massey Comprehensive Cancer Center	Richmond	Virginia	23298	Recruiting
HSHS Sacred Heart Hospital	Eau Claire	Wisconsin	54701	Suspended
Marshfield Medical Center-EC Cancer Center	Eau Claire	Wisconsin	54701	Recruiting
Saint Vincent Hospital Cancer Center Green Bay	Green Bay	Wisconsin	54301	Recruiting
Saint Vincent Hospital Cancer Center at Saint Mary's	Green Bay	Wisconsin	54303	Recruiting
University of Wisconsin Carbone Cancer Center - Eastpark Medical Center	Madison	Wisconsin	53718	Recruiting
University of Wisconsin Carbone Cancer Center - University Hospital	Madison	Wisconsin	53792	Recruiting
Marshfield Medical Center-Marshfield	Marshfield	Wisconsin	54449	Recruiting
Marshfield Medical Center - Minocqua	Minocqua	Wisconsin	54548	Recruiting
Saint Vincent Hospital Cancer Center at Oconto Falls	Oconto Falls	Wisconsin	54154	Recruiting
Marshfield Medical Center-Rice Lake	Rice Lake	Wisconsin	54868	Recruiting
Saint Vincent Hospital Cancer Center at Sheboygan	Sheboygan	Wisconsin	53081	Recruiting
Marshfield Medical Center-River Region at Stevens Point	Stevens Point	Wisconsin	54482	Recruiting
Saint Vincent Hospital Cancer Center at Sturgeon Bay	Sturgeon Bay	Wisconsin	54235-1495	Recruiting
Marshfield Medical Center - Weston	Weston	Wisconsin	54476	Recruiting

Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.

Non-U.S. locations

This page focuses on the U.S. directory. The official record also lists 4 non-U.S. sites.

About this trial record page

What this page shows: Public field values for ClinicalTrials.gov record NCT05111574, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
What this page does not do: No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
Where the data comes from: Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
Last refresh: Last update posted May 5, 2026 · Synced May 8, 2026

Open the official record

The complete protocol, eligibility criteria, and contact information for NCT05111574 live on ClinicalTrials.gov.

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