ClinicalTrials.gov record
Testing Nivolumab With or Without Ipilimumab in Deficient Mismatch Repair System (dMMR) Recurrent Endometrial Carcinoma
ClinicalTrials.gov ID: NCT05112601
Public ClinicalTrials.gov record NCT05112601. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
ClinicalTrials.gov public records Last synced May 5, 2026, 3:16 AM EDT
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Randomized Phase II Trial of Nivolumab and Ipilimumab Compared to Nivolumab Monotherapy in Patients With Deficient Mismatch Repair System Recurrent Endometrial Carcinoma
Study identification
- NCT ID
- NCT05112601
- Recruitment status
- Recruiting
- Study type
- Interventional
- Phase
- Phase 2
- Lead sponsor
- National Cancer Institute (NCI)
- NIH
- Enrollment
- 81 participants
Conditions and interventions
Conditions
- Endometrial Adenocarcinoma
- Endometrial Clear Cell Adenocarcinoma
- Endometrial Dedifferentiated Carcinoma
- Endometrial Endometrioid Adenocarcinoma
- Endometrial Mixed Cell Adenocarcinoma
- Endometrial Mucinous Adenocarcinoma
- Endometrial Undifferentiated Carcinoma
- Endometrioid Adenocarcinoma
- Recurrent Endometrial Carcinoma
Interventions
- Biospecimen Collection Procedure
- Computed Tomography Procedure
- Ipilimumab Biological
- Magnetic Resonance Imaging Procedure
- Nivolumab Biological
Procedure · Biological
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- Female
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Jun 1, 2022
- Primary completion
- Apr 29, 2026
- Completion
- Apr 29, 2026
- Last update posted
- Apr 20, 2026
2022 – 2026
United States locations
- U.S. sites
- 137
- U.S. states
- 27
- U.S. cities
- 110
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| University of Alabama at Birmingham Cancer Center | Birmingham | Alabama | 35233 | Recruiting |
| University Cancer and Blood Center LLC | Athens | Georgia | 30607 | Recruiting |
| Augusta University Medical Center | Augusta | Georgia | 30912 | Recruiting |
| Saint Alphonsus Cancer Care Center-Boise | Boise | Idaho | 83706 | Suspended |
| Saint Luke's Cancer Institute - Boise | Boise | Idaho | 83712 | Recruiting |
| Saint Alphonsus Cancer Care Center-Caldwell | Caldwell | Idaho | 83605 | Suspended |
| Kootenai Health - Coeur d'Alene | Coeur d'Alene | Idaho | 83814 | Recruiting |
| Saint Luke's Cancer Institute - Fruitland | Fruitland | Idaho | 83619 | Recruiting |
| Saint Luke's Cancer Institute - Meridian | Meridian | Idaho | 83642 | Recruiting |
| Saint Alphonsus Cancer Care Center-Nampa | Nampa | Idaho | 83687 | Suspended |
| Saint Luke's Cancer Institute - Nampa | Nampa | Idaho | 83687 | Recruiting |
| Kootenai Clinic Cancer Services - Post Falls | Post Falls | Idaho | 83854 | Recruiting |
| Kootenai Clinic Cancer Services - Sandpoint | Sandpoint | Idaho | 83864 | Recruiting |
| University of Illinois | Chicago | Illinois | 60612 | Suspended |
| Carle at The Riverfront | Danville | Illinois | 61832 | Recruiting |
| Carle Physician Group-Effingham | Effingham | Illinois | 62401 | Recruiting |
| Carle Physician Group-Mattoon/Charleston | Mattoon | Illinois | 61938 | Recruiting |
| Carle BroMenn Medical Center | Normal | Illinois | 61761 | Recruiting |
| Carle Cancer Institute Normal | Normal | Illinois | 61761 | Recruiting |
| Carle Cancer Center | Urbana | Illinois | 61801 | Recruiting |
| IU Health North Hospital | Carmel | Indiana | 46032 | Recruiting |
| Northwest Cancer Center - Crown Point | Crown Point | Indiana | 46307 | Recruiting |
| Northwest Oncology LLC | Dyer | Indiana | 46311 | Recruiting |
| Northwest Cancer Center - Hobart | Hobart | Indiana | 46342 | Recruiting |
| Saint Mary Medical Center | Hobart | Indiana | 46342 | Recruiting |
| Indiana University/Melvin and Bren Simon Cancer Center | Indianapolis | Indiana | 46202 | Recruiting |
| Saint Catherine Hospital | Indianapolis | Indiana | 46312 | Recruiting |
| The Community Hospital | Munster | Indiana | 46321 | Recruiting |
| Women's Diagnostic Center - Munster | Munster | Indiana | 46321 | Recruiting |
| Northwest Cancer Center - Valparaiso | Valparaiso | Indiana | 46383 | Recruiting |
| University of Iowa/Holden Comprehensive Cancer Center | Iowa City | Iowa | 52242 | Recruiting |
| The James Graham Brown Cancer Center at University of Louisville | Louisville | Kentucky | 40202 | Recruiting |
| UofL Health Medical Center Northeast | Louisville | Kentucky | 40245 | Recruiting |
| MaineHealth Maine Medical Center- Scarborough | Scarborough | Maine | 04074 | Recruiting |
| Bronson Battle Creek | Battle Creek | Michigan | 49017 | Recruiting |
| Corewell Health Grand Rapids Hospitals - Butterworth Hospital | Grand Rapids | Michigan | 49503 | Recruiting |
| Trinity Health Grand Rapids Hospital | Grand Rapids | Michigan | 49503 | Recruiting |
| Bronson Methodist Hospital | Kalamazoo | Michigan | 49007 | Recruiting |
| West Michigan Cancer Center | Kalamazoo | Michigan | 49007 | Recruiting |
| Beacon Kalamazoo Cancer Center | Kalamazoo | Michigan | 49009 | Recruiting |
| Trinity Health Muskegon Hospital | Muskegon | Michigan | 49444 | Recruiting |
| Corewell Health Lakeland Hospitals - Niles Hospital | Niles | Michigan | 49120 | Recruiting |
| Cancer and Hematology Centers of Western Michigan - Norton Shores | Norton Shores | Michigan | 49444 | Recruiting |
| Corewell Health Reed City Hospital | Reed City | Michigan | 49677 | Recruiting |
| Corewell Health Lakeland Hospitals - Marie Yeager Cancer Center | Saint Joseph | Michigan | 49085 | Recruiting |
| Corewell Health Lakeland Hospitals - Saint Joseph Hospital | Saint Joseph | Michigan | 49085 | Recruiting |
| Munson Medical Center | Traverse City | Michigan | 49684 | Recruiting |
| University of Michigan Health - West | Wyoming | Michigan | 49519 | Recruiting |
| Mercy Hospital | Coon Rapids | Minnesota | 55433 | Recruiting |
| Essentia Health - Deer River Clinic | Deer River | Minnesota | 56636 | Recruiting |
| Essentia Health Cancer Center | Duluth | Minnesota | 55805 | Recruiting |
| Miller-Dwan Hospital | Duluth | Minnesota | 55805 | Recruiting |
| Fairview Southdale Hospital | Edina | Minnesota | 55435 | Recruiting |
| Essentia Health Hibbing Clinic | Hibbing | Minnesota | 55746 | Recruiting |
| Abbott-Northwestern Hospital | Minneapolis | Minnesota | 55407 | Recruiting |
| Park Nicollet Clinic - Saint Louis Park | Saint Louis Park | Minnesota | 55416 | Recruiting |
| Regions Hospital | Saint Paul | Minnesota | 55101 | Recruiting |
| United Hospital | Saint Paul | Minnesota | 55102 | Recruiting |
| Essentia Health Sandstone | Sandstone | Minnesota | 55072 | Recruiting |
| Saint Francis Regional Medical Center | Shakopee | Minnesota | 55379 | Recruiting |
| Essentia Health Virginia Clinic | Virginia | Minnesota | 55792 | Recruiting |
| MU Health - University Hospital/Ellis Fischel Cancer Center | Columbia | Missouri | 65212 | Recruiting |
| Washington University School of Medicine | St Louis | Missouri | 63110 | Recruiting |
| Community Hospital of Anaconda | Anaconda | Montana | 59711 | Recruiting |
| Billings Clinic Cancer Center | Billings | Montana | 59101 | Recruiting |
| Saint Vincent Frontier Cancer Center | Billings | Montana | 59102 | Recruiting |
| Intermountain Health West End Clinic | Billings | Montana | 59106 | Recruiting |
| Bozeman Health Deaconess Hospital | Bozeman | Montana | 59715 | Recruiting |
| Benefis Sletten Cancer Institute | Great Falls | Montana | 59405 | Recruiting |
| Logan Health Medical Center | Kalispell | Montana | 59901 | Recruiting |
| Community Medical Center | Missoula | Montana | 59804 | Recruiting |
| Nebraska Methodist Hospital | Omaha | Nebraska | 68114 | Recruiting |
| Women's Cancer Center of Nevada | Las Vegas | Nevada | 89106 | Recruiting |
| University of New Mexico Cancer Center | Albuquerque | New Mexico | 87106 | Recruiting |
| Roswell Park Cancer Institute | Buffalo | New York | 14263 | Active, not recruiting |
| University of Rochester | Rochester | New York | 14642 | Recruiting |
| State University of New York Upstate Medical University | Syracuse | New York | 13210 | Recruiting |
| Wilmot Cancer Institute at Webster | Webster | New York | 14580 | Recruiting |
| Duke University Medical Center | Durham | North Carolina | 27710 | Recruiting |
| Duke Women's Cancer Care Raleigh | Raleigh | North Carolina | 27607 | Recruiting |
| Essentia Health Cancer Center-South University Clinic | Fargo | North Dakota | 58103 | Recruiting |
| UHHS-Chagrin Highlands Medical Center | Beachwood | Ohio | 44122 | Recruiting |
| Miami Valley Hospital South | Centerville | Ohio | 45459 | Recruiting |
| Geauga Hospital | Chardon | Ohio | 44024 | Recruiting |
| Good Samaritan Hospital - Cincinnati | Cincinnati | Ohio | 45220 | Recruiting |
| Case Western Reserve University | Cleveland | Ohio | 44106 | Recruiting |
| Cleveland Clinic Cancer Center/Fairview Hospital | Cleveland | Ohio | 44111 | Recruiting |
| Cleveland Clinic Foundation | Cleveland | Ohio | 44195 | Recruiting |
| Ohio State University Comprehensive Cancer Center | Columbus | Ohio | 43210 | Recruiting |
| Hillcrest Hospital Cancer Center | Mayfield Heights | Ohio | 44124 | Recruiting |
| UH Seidman Cancer Center at Lake Health Mentor Campus | Mentor | Ohio | 44060 | Recruiting |
| University Hospitals Parma Medical Center | Parma | Ohio | 44129 | Recruiting |
| UH Seidman Cancer Center at Saint John Medical Center | Westlake | Ohio | 44145 | Recruiting |
| University of Oklahoma Health Sciences Center | Oklahoma City | Oklahoma | 73104 | Recruiting |
| Oklahoma Cancer Specialists and Research Institute-Tulsa | Tulsa | Oklahoma | 74146 | Recruiting |
| Saint Alphonsus Cancer Care Center-Ontario | Ontario | Oregon | 97914 | Suspended |
| Providence Portland Medical Center | Portland | Oregon | 97213 | Recruiting |
| Providence Saint Vincent Medical Center | Portland | Oregon | 97225 | Recruiting |
| UPMC-Heritage Valley Health System Beaver | Beaver | Pennsylvania | 15009 | Recruiting |
| UPMC Hillman Cancer Center at Butler Health System | Butler | Pennsylvania | 16001 | Recruiting |
| UPMC Hillman Cancer Center - Passavant - Cranberry | Cranberry Township | Pennsylvania | 16066 | Recruiting |
| UPMC Hillman Cancer Center Erie | Erie | Pennsylvania | 16505 | Recruiting |
| UPMC Cancer Center at UPMC Horizon | Farrell | Pennsylvania | 16121 | Recruiting |
| UPMC Cancer Centers - Arnold Palmer Pavilion | Greensburg | Pennsylvania | 15601 | Recruiting |
| IRMC Cancer Center | Indiana | Pennsylvania | 15701 | Recruiting |
| UPMC-Johnstown/John P. Murtha Regional Cancer Center | Johnstown | Pennsylvania | 15901 | Recruiting |
| UPMC Cancer Center at UPMC McKeesport | McKeesport | Pennsylvania | 15132 | Recruiting |
| UPMC Hillman Cancer Center at Rocco And Nancy Ortenzio Cancer Pavilion | Mechanicsburg | Pennsylvania | 17050 | Recruiting |
| UPMC Hillman Cancer Center - Monroeville | Monroeville | Pennsylvania | 15146 | Recruiting |
| UPMC Hillman Cancer Center in Coraopolis | Moon Township | Pennsylvania | 15108 | Recruiting |
| UPMC Hillman Cancer Center - Part of Frick Hospital | Mount Pleasant | Pennsylvania | 15666 | Recruiting |
| Arnold Palmer Cancer Center Medical Oncology Norwin | N. Huntingdon | Pennsylvania | 15642 | Recruiting |
| UPMC Cancer Center-Natrona Heights | Natrona Heights | Pennsylvania | 15065 | Recruiting |
| UPMC Hillman Cancer Center - New Castle | New Castle | Pennsylvania | 16105 | Recruiting |
| UPMC-Magee Womens Hospital | Pittsburgh | Pennsylvania | 15213 | Recruiting |
| UPMC-Saint Margaret | Pittsburgh | Pennsylvania | 15215 | Recruiting |
| UPMC-Mercy Hospital | Pittsburgh | Pennsylvania | 15219 | Recruiting |
| University of Pittsburgh Cancer Institute (UPCI) | Pittsburgh | Pennsylvania | 15232 | Recruiting |
| UPMC-Passavant Hospital | Pittsburgh | Pennsylvania | 15237 | Recruiting |
| UPMC-Saint Clair Hospital Cancer Center | Pittsburgh | Pennsylvania | 15243 | Recruiting |
| UPMC Cancer Center at UPMC Northwest | Seneca | Pennsylvania | 16346 | Recruiting |
| UPMC Cancer Center-Washington | Washington | Pennsylvania | 15301 | Recruiting |
| UPMC West Mifflin-Cancer Center Jefferson | West Mifflin | Pennsylvania | 15122 | Recruiting |
| Women and Infants Hospital | Providence | Rhode Island | 02905 | Recruiting |
| Parkland Memorial Hospital | Dallas | Texas | 75235 | Recruiting |
| UT Southwestern/Simmons Cancer Center-Dallas | Dallas | Texas | 75390 | Recruiting |
| UT Southwestern/Simmons Cancer Center-Fort Worth | Fort Worth | Texas | 76104 | Recruiting |
| UT Southwestern Clinical Center at Richardson/Plano | Richardson | Texas | 75080 | Recruiting |
| University of Virginia Cancer Center | Charlottesville | Virginia | 22908 | Recruiting |
| Henrico Doctor's Hospital | Richmond | Virginia | 23229 | Recruiting |
| VCU Massey Comprehensive Cancer Center | Richmond | Virginia | 23298 | Recruiting |
| Swedish Cancer Institute-Edmonds | Edmonds | Washington | 98026 | Recruiting |
| Swedish Cancer Institute-Issaquah | Issaquah | Washington | 98029 | Recruiting |
| Fred Hutchinson Cancer Center | Seattle | Washington | 98109 | Active, not recruiting |
| Swedish Medical Center-First Hill | Seattle | Washington | 98122 | Recruiting |
| Duluth Clinic Ashland | Ashland | Wisconsin | 54806 | Recruiting |
| Northwest Wisconsin Cancer Center | Ashland | Wisconsin | 54806 | Recruiting |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT05112601, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Apr 20, 2026 · Synced May 5, 2026
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Open the official record
The complete protocol, eligibility criteria, and contact information for NCT05112601 live on ClinicalTrials.gov.