A Biomarker-Guided, Randomized, Placebo-Controlled Efficacy and Safety Study of Liafensine in Patients With TRD
Public ClinicalTrials.gov record NCT05113771. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Biomarker-Guided, Randomized, Double-Blind, Placebo-Controlled Efficacy and Safety Study of Liafensine in Patients With Treatment-Resistant Depression
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
This study was conducted as a randomized, double-blind, placebo-controlled, multi-center Phase 2b study. Approximately 180 subjects with treatment resistant depression who meet all eligibility criteria will be enrolled. The primary endpoint is to demonstrate liafensine is superior to placebo in DGM4 positive patients with TRD.
Study identification
- NCT ID
- NCT05113771
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 2
- Enrollment
- 197 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 18 Years to 70 Years
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Jun 29, 2022 (Actual)
- Primary completion
- Feb 6, 2024 (Actual)
- Completion
- Mar 5, 2024 (Actual)
- Last update posted
- May 15, 2025
2022 – 2024
United States locations
- U.S. sites
- 41
- U.S. states
- 19
- U.S. cities
- 39
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| University of Alabama at Birmingham | Huntsville | Alabama | 35801 | — |
| Alea Research | Phoenix | Arizona | 85012 | — |
| Collaborative Neuroschience Research, LLC | Garden Grove | California | 92845 | — |
| Behavioral Research Specialists, LLC | Glendale | California | 91206 | — |
| Sunwise Clinical Research, LLC. | Lafayette | California | 94549 | — |
| Excell Research | Oceanside | California | 92056 | — |
| Anderson Clinical Reseach | Redlands | California | 92374 | — |
| Schuster Medical Research Institute | Sherman Oaks | California | 91403 | — |
| Collaborative Neuroscience Research, LLC | Torrance | California | 90502 | — |
| Pacific Clinical Research Management Group | Upland | California | 91786 | — |
| Clinical Research of Brandon, LLC | Brandon | Florida | 33511 | — |
| Access Research Institute | Brooksville | Florida | 34613 | — |
| The Medicine Medical Research | Hollywood | Florida | 33121 | — |
| Nuovida Research Center | Miami | Florida | 33145 | — |
| SG Research, LLC | Miami | Florida | 33145 | — |
| Aqualane Clinical Research | Naples | Florida | 34105 | — |
| Clinical Neuroscience Solutions, Inc. | Orlando | Florida | 32801 | — |
| CenExel Atlanta Center for Medical Research | Atlanta | Georgia | 30331 | — |
| Psych Atlanta, PC | Marietta | Georgia | 30060 | — |
| Revive Research Institute, Inc | Elgin | Illinois | 60123 | — |
| Ascension Via Christi Research, a division of Ascension Via Christi Hospitals Wichita, Inc. | Wichita | Kansas | 67214 | — |
| Pharmasite Research, Inc. | Baltimore | Maryland | 21208 | — |
| CBH Health LLC | Gaithersburg | Maryland | 20877 | — |
| Boston Clinical Trials & Medical Research | Boston | Massachusetts | 02131 | — |
| Neurobehavioral Medicine Group | Bloomfield | Michigan | 48302 | — |
| Alivation Research, LLC | Lincoln | Nebraska | 68526 | — |
| Altea Research Institute, Las Vegas | Las Vegas | Nevada | 89102 | — |
| Hassman Research Institute | Marlton | New Jersey | 08053 | — |
| Global Medical Institutes, LLC | Princeton | New Jersey | 08510 | — |
| Global Medical Institutes, LLC | Princeton | New Jersey | 08540 | — |
| Bio Behavior Health | Toms River | New Jersey | 08755 | — |
| IMA Clinical Research | Albuquerque | New Mexico | 87109 | — |
| Zucker Hillside Hospital | Glen Oaks | New York | 11004 | — |
| The Ohio State University Department of Psychiatry | Columbus | Ohio | 43210 | — |
| Lehigh Center for Clinical Research, LLC | Allentown | Pennsylvania | 18104 | — |
| Global Medical Institutes, LLC | Moosic | Pennsylvania | 18507 | — |
| FutureSearch Trials of Dallas | Dallas | Texas | 75231 | — |
| InSite Clinical Research | DeSoto | Texas | 75115 | — |
| North Texas Clinical Trials | Fort Worth | Texas | 76014 | — |
| University of Texas Medical School at Houston | Houston | Texas | 77054 | — |
| Core Clinical Research | Everett | Washington | 98201 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 4 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT05113771, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted May 15, 2025 · Synced Oct 4, 2026
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Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT05113771 live on ClinicalTrials.gov.