Safety, Efficacy and Tolerability of Ianalumab Versus Placebo, Combination With SoC Therapy, in Participants With Active Lupus Nephritis
Public ClinicalTrials.gov record NCT05126277. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Randomized, Double-blind, Parallel Group, Placebo-controlled, Multicenter Phase 3 Trial to Evaluate Efficacy, Safety and Tolerability of Ianalumab on Top of Standard-of-care Therapy in Participants With Active Lupus Nephritis (SIRIUS-LN).
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
This trial will evaluate efficacy, safety, and tolerability of subcutaneous (s.c.) ianalumab given every 4 weeks (q4w) or every 12 weeks (q12w) compared to placebo, in combination with SoC, in adult participants with active LN
Study identification
- NCT ID
- NCT05126277
- Recruitment status
- Active, not recruiting
- Study type
- Interventional
- Phase
- Phase 3
- Enrollment
- 452 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 18 Years to 100 Years
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Jul 14, 2022 (Actual)
- Primary completion
- Sep 21, 2027 (Estimated)
- Completion
- Feb 4, 2031 (Estimated)
- Last update posted
- Oct 15, 2026
2022 – 2031
United States locations
- U.S. sites
- 25
- U.S. states
- 12
- U.S. cities
- 23
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| University Of Alabama | Birmingham | Alabama | 35294 | — |
| Advanced Medical Research | La Palma | California | 90623 | — |
| University of California Irvine | Orange | California | 92868 | — |
| School Of Medicine | Sacromento | California | 95817 | — |
| University of California San Diego | San Deigo | California | 92037 | — |
| Kaiser Permanente | San Diego | California | 92111 | — |
| Mayo Clinic Jacksonville | Jacksonville | Florida | 32224 | — |
| University Of Miami | Miami | Florida | 33136 | — |
| Emory University School of Medicine | Atlanta | Georgia | 30303 | — |
| Fides Clinical Research | Atlanta | Georgia | 30342 | — |
| Parris and Associates Rheumatology | Lawrenceville | Georgia | 30044 | — |
| Accurate Clinical Research | Lake Charles | Louisiana | 70601 | — |
| UMC New Orleans | New Orleans | Louisiana | 70112 | — |
| Wayne State University | Detroit | Michigan | 48201 | — |
| Univ of Nevada School of Med | Las Vegas | Nevada | 89102 | — |
| NY Nephrology | Clifton Park | New York | 12065 | — |
| Hospital for Special Surgery | New York | New York | 10021 | — |
| Northwell Health | New York | New York | 10028 | — |
| Circuit Clinical | Orchard Park | New York | 14127 | — |
| University Of Cincinnati | Cincinnati | Ohio | 45267 | — |
| Univ of Pennsylvania Medical Center | Philadelphia | Pennsylvania | 19104 | — |
| Precision Comprehensive Research | Colleyville | Texas | 76034 | — |
| Univof Texas Southwestern Med Cntr | Dallas | Texas | 75235 | — |
| Uni of Texas Health Science Center | San Antonio | Texas | 78229 | — |
| Uni Wisconsin School Med Pub Health | Madison | Wisconsin | 53792 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 120 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT05126277, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Oct 15, 2026 · Synced Oct 23, 2026
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Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT05126277 live on ClinicalTrials.gov.