Study Testing Response Effect of KY1005 Against Moderate-to-Severe Atopic Dermatitis, The STREAM-AD Study
Public ClinicalTrials.gov record NCT05131477. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Phase IIb, Randomized, Double-blind, Placebo-controlled, Parallel Group, Multicenter Dose Ranging Study of a Subcutaneous Anti-OX40L Monoclonal Antibody (KY1005) in Moderate-to-Severe Atopic Dermatitis
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
This is an interventional, randomized, parallel group, treatment, Phase IIb, double blind, 5-arm study to assess the effect of Anti-OX40L Monoclonal Antibody (KY1005) in adult participants with moderate to severe atopic dermatitis. The estimated duration is 28 days for screening and then up to approximately day 477 (last dose no later than day 337+140 days safety follow-up) for all patients unless enrolled into the Long-Term Extension (LTE) protocol (NCT05492578) at either Day 169 depending on responder status or no later than Day 365 due to loss of clinical response.
Study identification
- NCT ID
- NCT05131477
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 2
- Enrollment
- 390 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 18 Years to 75 Years
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Dec 13, 2021 (Actual)
- Primary completion
- Apr 26, 2023 (Actual)
- Completion
- Feb 21, 2024 (Actual)
- Last update posted
- Jul 3, 2025
2021 – 2024
United States locations
- U.S. sites
- 20
- U.S. states
- 13
- U.S. cities
- 19
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Investigative Site Number: 1018 | Fremont | California | 94538-1601 | — |
| Investigative site #1022 | Sacramento | California | 95816-3370 | — |
| Investigative Site Number: 1006 | Boca Raton | Florida | 33428 | — |
| Investigative Site Number: 1001 | Clearwater | Florida | 33756-3424 | — |
| Investigative Site Number: 1019 | Coral Gables | Florida | 33134-2950 | — |
| Investigative Site Number: 1007 | Miami | Florida | 33176-2264 | — |
| Investigative Site Number: 1013 | Tampa | Florida | 33615-3816 | — |
| Investigative Site Number: 1004 | Savannah | Georgia | 31406-2668 | — |
| Investigative Site Number: 1010 | Clarksville | Indiana | 47129-2201 | — |
| Investigative Site Number: 1015 | Indianapolis | Indiana | 46250-2041 | — |
| Investigative Site Number: 1021 | Louisville | Kentucky | 40241 | — |
| Investigative Site Number: 1011 | Towson | Maryland | 21204-7448 | — |
| Investigative Site Number: 1014 | Beverly | Massachusetts | 01915-1666 | — |
| Investigative Site Number: 1012 | Troy | Michigan | 48084-3536 | — |
| Investigative Site Number: 1005 | Tulsa | Oklahoma | 74136-7049 | — |
| Investigative Site Number: 1017 | Portland | Oregon | 97223-6683 | — |
| Investigative Site Number: 1009 | Portland | Oregon | 97239 | — |
| Investigative Site Number: 1003 | Anderson | South Carolina | 29621-2062 | — |
| Investigative Site Number: 1008 | Murfreesboro | Tennessee | 37130-2450 | — |
| Investigative site #1023 | Mansfield | Texas | 76063 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 83 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT05131477, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Jul 3, 2025 · Synced Oct 19, 2026
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Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT05131477 live on ClinicalTrials.gov.