ClinicalTrials.gov record
Recruiting Phase 2 Interventional

BiCaZO: A Study Combining Two Immunotherapies (Cabozantinib and Nivolumab) to Treat Patients With Advanced Melanoma or Squamous Cell Head and Neck Cancer, an immunoMATCH Pilot Study

ClinicalTrials.gov ID: NCT05136196

Public ClinicalTrials.gov record NCT05136196. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.

ClinicalTrials.gov public records Last synced May 10, 2026, 1:32 PM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

Official title

Biomarker Stratified CaboZantinib (NSC#761968) and NivOlumab (NSC#748726) (BiCaZO) - A Phase II Study of Combining Cabozantinib and Nivolumab in Participants With Advanced Solid Tumors (IO Refractory Melanoma or HNSCC) Stratified by Tumor Biomarkers - an immunoMATCH Pilot Study

Study identification

NCT ID
NCT05136196
Recruitment status
Recruiting
Study type
Interventional
Phase
Phase 2
Lead sponsor
National Cancer Institute (NCI)
NIH
Enrollment
150 participants

Conditions and interventions

Eligibility (public fields only)

Age range
18 Years and older
Sex
All
Healthy volunteers
Healthy volunteers not accepted

This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.

Study timeline

Start date
Dec 5, 2022
Primary completion
Dec 31, 2026
Completion
Dec 31, 2026
Last update posted
May 7, 2026

2022 – 2027

United States locations

U.S. sites
221
U.S. states
30
U.S. cities
175
Facility City State ZIP Site status
Mayo Clinic Hospital in Arizona Phoenix Arizona 85054 Recruiting
University of Arkansas for Medical Sciences Little Rock Arkansas 72205 Recruiting
Tower Cancer Research Foundation Beverly Hills California 90211 Recruiting
UCI Health - Chao Family Comprehensive Cancer Center and Ambulatory Care Irvine California 92612 Recruiting
The Angeles Clinic and Research Institute - West Los Angeles Office Los Angeles California 90025 Recruiting
Cedars-Sinai Medical Center Los Angeles California 90048 Recruiting
UC Irvine Health/Chao Family Comprehensive Cancer Center Orange California 92868 Recruiting
Rocky Mountain Regional VA Medical Center Aurora Colorado 80045 Active, not recruiting
UCHealth Memorial Hospital Central Colorado Springs Colorado 80909 Recruiting
Memorial Hospital North Colorado Springs Colorado 80920 Recruiting
Poudre Valley Hospital Fort Collins Colorado 80524 Recruiting
Cancer Care and Hematology-Fort Collins Fort Collins Colorado 80528 Recruiting
UCHealth Greeley Hospital Greeley Colorado 80631 Recruiting
Medical Center of the Rockies Loveland Colorado 80538 Recruiting
Helen F Graham Cancer Center Newark Delaware 19713 Recruiting
Medical Oncology Hematology Consultants PA Newark Delaware 19713 Recruiting
Mayo Clinic in Florida Jacksonville Florida 32224-9980 Recruiting
Hawaii Cancer Care Inc - Waterfront Plaza Honolulu Hawaii 96813 Active, not recruiting
Queen's Cancer Cenrer - POB I Honolulu Hawaii 96813 Active, not recruiting
Queen's Medical Center Honolulu Hawaii 96813 Active, not recruiting
Queen's Cancer Center - Kuakini Honolulu Hawaii 96817 Active, not recruiting
Hawaii Cancer Care - Westridge ‘Aiea Hawaii 96701 Active, not recruiting
Saint Alphonsus Cancer Care Center-Boise Boise Idaho 83706 Recruiting
Saint Luke's Cancer Institute - Boise Boise Idaho 83712 Recruiting
Saint Alphonsus Cancer Care Center-Caldwell Caldwell Idaho 83605 Recruiting
Kootenai Health - Coeur d'Alene Coeur d'Alene Idaho 83814 Recruiting
Saint Luke's Cancer Institute - Fruitland Fruitland Idaho 83619 Recruiting
Saint Luke's Cancer Institute - Meridian Meridian Idaho 83642 Recruiting
Saint Alphonsus Cancer Care Center-Nampa Nampa Idaho 83687 Recruiting
Saint Luke's Cancer Institute - Nampa Nampa Idaho 83687 Recruiting
Kootenai Clinic Cancer Services - Post Falls Post Falls Idaho 83854 Recruiting
Kootenai Clinic Cancer Services - Sandpoint Sandpoint Idaho 83864 Recruiting
Saint Luke's Cancer Institute - Twin Falls Twin Falls Idaho 83301 Recruiting
Rush-Copley Medical Center Aurora Illinois 60504 Recruiting
Illinois CancerCare-Bloomington Bloomington Illinois 61704 Recruiting
Illinois CancerCare-Canton Canton Illinois 61520 Recruiting
Illinois CancerCare-Carthage Carthage Illinois 62321 Recruiting
Centralia Oncology Clinic Centralia Illinois 62801 Recruiting
Northwestern University Chicago Illinois 60611 Recruiting
University of Illinois Chicago Illinois 60612 Recruiting
Carle at The Riverfront Danville Illinois 61832 Recruiting
Northwestern Medicine Cancer Center Kishwaukee DeKalb Illinois 60115 Recruiting
Cancer Care Specialists of Illinois - Decatur Decatur Illinois 62526 Recruiting
Decatur Memorial Hospital Decatur Illinois 62526 Recruiting
Illinois CancerCare-Dixon Dixon Illinois 61021 Recruiting
Carle Physician Group-Effingham Effingham Illinois 62401 Recruiting
Crossroads Cancer Center Effingham Illinois 62401 Recruiting
Illinois CancerCare-Eureka Eureka Illinois 61530 Recruiting
Illinois CancerCare-Galesburg Galesburg Illinois 61401 Recruiting
Northwestern Medicine Cancer Center Delnor Geneva Illinois 60134 Recruiting
Illinois CancerCare-Kewanee Clinic Kewanee Illinois 61443 Recruiting
Northwestern Medicine Lake Forest Hospital Lake Forest Illinois 60045 Recruiting
Illinois CancerCare-Macomb Macomb Illinois 61455 Recruiting
Carle Physician Group-Mattoon/Charleston Mattoon Illinois 61938 Recruiting
Cancer Care Center of O'Fallon O'Fallon Illinois 62269 Recruiting
Northwestern Medicine Orland Park Orland Park Illinois 60462 Recruiting
Illinois CancerCare-Ottawa Clinic Ottawa Illinois 61350 Recruiting
Illinois CancerCare-Pekin Pekin Illinois 61554 Recruiting
Illinois CancerCare-Peoria Peoria Illinois 61615 Recruiting
Illinois CancerCare-Peru Peru Illinois 61354 Recruiting
Illinois CancerCare-Princeton Princeton Illinois 61356 Recruiting
Memorial Hospital East Shiloh Illinois 62269 Recruiting
Southern Illinois University School of Medicine Springfield Illinois 62702 Recruiting
Springfield Clinic Springfield Illinois 62702 Recruiting
Springfield Memorial Hospital Springfield Illinois 62781 Recruiting
Carle Cancer Center Urbana Illinois 61801 Recruiting
Northwestern Medicine Cancer Center Warrenville Warrenville Illinois 60555 Recruiting
Illinois CancerCare - Washington Washington Illinois 61571 Recruiting
Rush-Copley Healthcare Center Yorkville Illinois 60560 Recruiting
Mary Greeley Medical Center Ames Iowa 50010 Recruiting
McFarland Clinic - Ames Ames Iowa 50010 Recruiting
UI Health Care Mission Cancer and Blood - Ankeny Clinic Ankeny Iowa 50023 Recruiting
McFarland Clinic - Boone Boone Iowa 50036 Suspended
Mercy Hospital Cedar Rapids Iowa 52403 Recruiting
Oncology Associates at Mercy Medical Center Cedar Rapids Iowa 52403 Recruiting
Mercy Cancer Center-West Lakes Clive Iowa 50325 Recruiting
UI Health Care Mission Cancer and Blood - West Des Moines Clinic Clive Iowa 50325 Recruiting
UI Health Care Mission Cancer and Blood - Des Moines Clinic Des Moines Iowa 50309 Recruiting
Mercy Medical Center - Des Moines Des Moines Iowa 50314 Recruiting
UI Health Care Mission Cancer and Blood - Laurel Clinic Des Moines Iowa 50314 Recruiting
McFarland Clinic - Trinity Cancer Center Fort Dodge Iowa 50501 Recruiting
McFarland Clinic - Jefferson Jefferson Iowa 50129 Suspended
McFarland Clinic - Marshalltown Marshalltown Iowa 50158 Recruiting
UI Health Care Mission Cancer and Blood - Waukee Clinic Waukee Iowa 50263 Recruiting
Tufts Medical Center Boston Massachusetts 02111 Recruiting
Baystate Medical Center Springfield Massachusetts 01199 Recruiting
Tufts Medical Center Cancer Center Stoneham Stoneham Massachusetts 02180 Recruiting
Trinity Health Saint Joseph Mercy Hospital Ann Arbor Ann Arbor Michigan 48106 Recruiting
University of Michigan Rogel Cancer Center Ann Arbor Michigan 48109 Recruiting
Bronson Battle Creek Battle Creek Michigan 49017 Recruiting
Trinity Health IHA Medical Group Hematology Oncology - Brighton Brighton Michigan 48114 Recruiting
Trinity Health Medical Center - Brighton Brighton Michigan 48114 Recruiting
Trinity Health IHA Medical Group Hematology Oncology - Canton Canton Michigan 48188 Recruiting
Trinity Health Medical Center - Canton Canton Michigan 48188 Recruiting
Chelsea Hospital Chelsea Michigan 48118 Recruiting
Trinity Health IHA Medical Group Hematology Oncology - Chelsea Hospital Chelsea Michigan 48118 Recruiting
Wayne State University/Karmanos Cancer Institute Detroit Michigan 48201 Active, not recruiting
OSF Saint Francis Hospital and Medical Group Escanaba Michigan 49829 Recruiting
Weisberg Cancer Treatment Center Farmington Hills Michigan 48334 Active, not recruiting
Cancer Hematology Centers - Flint Flint Michigan 48503 Recruiting
Genesee Hematology Oncology PC Flint Michigan 48503 Suspended
Genesys Hurley Cancer Institute Flint Michigan 48503 Recruiting
Hurley Medical Center Flint Michigan 48503 Recruiting
Corewell Health Grand Rapids Hospitals - Butterworth Hospital Grand Rapids Michigan 49503 Recruiting
Trinity Health Grand Rapids Hospital Grand Rapids Michigan 49503 Recruiting
Bronson Methodist Hospital Kalamazoo Michigan 49007 Recruiting
West Michigan Cancer Center Kalamazoo Michigan 49007 Recruiting
Beacon Kalamazoo Cancer Center Kalamazoo Michigan 49009 Recruiting
University of Michigan Health - Sparrow Lansing Lansing Michigan 48912 Recruiting
Trinity Health Saint Mary Mercy Livonia Hospital Livonia Michigan 48154 Recruiting
Trinity Health Muskegon Hospital Muskegon Michigan 49444 Recruiting
Corewell Health Lakeland Hospitals - Niles Hospital Niles Michigan 49120 Recruiting
Cancer and Hematology Centers of Western Michigan - Norton Shores Norton Shores Michigan 49444 Recruiting
Trinity Health Saint Joseph Mercy Oakland Hospital Pontiac Michigan 48341 Recruiting
Corewell Health Reed City Hospital Reed City Michigan 49677 Recruiting
Corewell Health Lakeland Hospitals - Marie Yeager Cancer Center Saint Joseph Michigan 49085 Recruiting
Munson Medical Center Traverse City Michigan 49684 Recruiting
University of Michigan Health - West Wyoming Michigan 49519 Recruiting
Huron Gastroenterology PC Ypsilanti Michigan 48106 Recruiting
Trinity Health IHA Medical Group Hematology Oncology Ann Arbor Campus Ypsilanti Michigan 48197 Recruiting
Sanford Joe Lueken Cancer Center Bemidji Minnesota 56601 Recruiting
Essentia Health Saint Joseph's Medical Center Brainerd Minnesota 56401 Recruiting
Mercy Hospital Coon Rapids Minnesota 55433 Recruiting
Essentia Health - Deer River Clinic Deer River Minnesota 56636 Recruiting
Essentia Health Saint Mary's - Detroit Lakes Clinic Detroit Lakes Minnesota 56501 Recruiting
Essentia Health Cancer Center Duluth Minnesota 55805 Recruiting
Fairview Southdale Hospital Edina Minnesota 55435 Recruiting
Essentia Health - Fosston Fosston Minnesota 56542 Recruiting
Unity Hospital Fridley Minnesota 55432 Active, not recruiting
Essentia Health Hibbing Clinic Hibbing Minnesota 55746 Recruiting
Saint John's Hospital - Healtheast Maplewood Minnesota 55109 Recruiting
Abbott-Northwestern Hospital Minneapolis Minnesota 55407 Recruiting
Essentia Health - Park Rapids Park Rapids Minnesota 56470 Recruiting
Mayo Clinic in Rochester Rochester Minnesota 55905 Recruiting
Park Nicollet Clinic - Saint Louis Park Saint Louis Park Minnesota 55416 Recruiting
Regions Hospital Saint Paul Minnesota 55101 Recruiting
United Hospital Saint Paul Minnesota 55102 Recruiting
Essentia Health Sandstone Sandstone Minnesota 55072 Recruiting
Essentia Health Virginia Clinic Virginia Minnesota 55792 Recruiting
Ridgeview Medical Center Waconia Minnesota 55387 Recruiting
Minnesota Oncology Hematology PA-Woodbury Woodbury Minnesota 55125 Recruiting
Saint Francis Medical Center Cape Girardeau Missouri 63703 Recruiting
Siteman Cancer Center at Saint Peters Hospital City of Saint Peters Missouri 63376 Recruiting
Siteman Cancer Center at West County Hospital Creve Coeur Missouri 63141 Recruiting
Washington University School of Medicine St Louis Missouri 63110 Recruiting
Mercy Hospital South St Louis Missouri 63128 Recruiting
Siteman Cancer Center-South County St Louis Missouri 63129 Recruiting
Siteman Cancer Center at Christian Hospital St Louis Missouri 63136 Recruiting
Community Hospital of Anaconda Anaconda Montana 59711 Recruiting
Billings Clinic Cancer Center Billings Montana 59101 Recruiting
Bozeman Health Deaconess Hospital Bozeman Montana 59715 Recruiting
Benefis Sletten Cancer Institute Great Falls Montana 59405 Recruiting
Logan Health Medical Center Kalispell Montana 59901 Recruiting
Community Medical Center Missoula Montana 59804 Recruiting
Nebraska Medicine-Bellevue Bellevue Nebraska 68123 Recruiting
Nebraska Medicine-Village Pointe Omaha Nebraska 68118 Recruiting
University of Nebraska Medical Center Omaha Nebraska 68198 Recruiting
Dartmouth Hitchcock Medical Center/Dartmouth Cancer Center Lebanon New Hampshire 03756 Recruiting
University of New Mexico Cancer Center Albuquerque New Mexico 87106 Recruiting
Northwell Health/Center for Advanced Medicine Lake Success New York 11042 Active, not recruiting
NYU Langone Hospital - Long Island Mineola New York 11501 Recruiting
Laura and Isaac Perlmutter Cancer Center at NYU Langone New York New York 10016 Recruiting
Southeastern Medical Oncology Center-Clinton Clinton North Carolina 28328 Recruiting
Southeastern Medical Oncology Center-Goldsboro Goldsboro North Carolina 27534 Recruiting
Southeastern Medical Oncology Center-Jacksonville Jacksonville North Carolina 28546 Recruiting
Sanford Bismarck Medical Center Bismarck North Dakota 58501 Recruiting
Essentia Health Cancer Center-South University Clinic Fargo North Dakota 58103 Recruiting
Sanford Broadway Medical Center Fargo North Dakota 58122 Recruiting
Sanford Roger Maris Cancer Center Fargo North Dakota 58122 Recruiting
Essentia Health - Jamestown Clinic Jamestown North Dakota 58401 Recruiting
Miami Valley Hospital South Centerville Ohio 45459 Recruiting
Premier Blood and Cancer Center Dayton Ohio 45409 Recruiting
Miami Valley Hospital North Dayton Ohio 45415 Recruiting
Atrium Medical Center-Middletown Regional Hospital Franklin Ohio 45005-1066 Recruiting
Miami Valley Cancer Care and Infusion Greenville Ohio 45331 Recruiting
Upper Valley Medical Center Troy Ohio 45373 Recruiting
University of Oklahoma Health Sciences Center Oklahoma City Oklahoma 73104 Recruiting
Saint Charles Health System Bend Oregon 97701 Recruiting
Clackamas Radiation Oncology Center Clackamas Oregon 97015 Recruiting
Providence Newberg Medical Center Newberg Oregon 97132 Recruiting
Saint Alphonsus Cancer Care Center-Ontario Ontario Oregon 97914 Recruiting
Providence Willamette Falls Medical Center Oregon City Oregon 97045 Recruiting
Providence Portland Medical Center Portland Oregon 97213 Recruiting
Providence Saint Vincent Medical Center Portland Oregon 97225 Recruiting
Thomas Jefferson University Hospital Philadelphia Pennsylvania 19107 Recruiting
Jefferson Torresdale Hospital Philadelphia Pennsylvania 19114 Active, not recruiting
Asplundh Cancer Pavilion Willow Grove Pennsylvania 19090 Active, not recruiting
Rapid City Regional Hospital Rapid City South Dakota 57701 Recruiting
Sanford Cancer Center Oncology Clinic Sioux Falls South Dakota 57104 Recruiting
Sanford USD Medical Center - Sioux Falls Sioux Falls South Dakota 57117-5134 Recruiting
Huntsman Cancer Institute/University of Utah Salt Lake City Utah 84112 Recruiting
Dartmouth Cancer Center - North Saint Johnsbury Vermont 05819 Recruiting
Inova Alexandria Hospital Alexandria Virginia 22304 Recruiting
Inova Schar Cancer Institute Fairfax Virginia 22031 Recruiting
Inova Fair Oaks Hospital Fairfax Virginia 22033 Recruiting
Inova Fairfax Hospital Falls Church Virginia 22042 Recruiting
Centra Alan B Pearson Regional Cancer Center Lynchburg Virginia 24501 Recruiting
Virginia Cancer Institute Richmond Virginia 23229 Recruiting
VCU Massey Cancer Center at Stony Point Richmond Virginia 23235 Recruiting
VCU Massey Comprehensive Cancer Center Richmond Virginia 23298 Recruiting
VCU Health Tappahannock Hospital Tappahannock Virginia 22560 Recruiting
Duluth Clinic Ashland Ashland Wisconsin 54806 Recruiting
Marshfield Medical Center-EC Cancer Center Eau Claire Wisconsin 54701 Recruiting
Saint Vincent Hospital Cancer Center Green Bay Green Bay Wisconsin 54301 Recruiting
Saint Vincent Hospital Cancer Center at Saint Mary's Green Bay Wisconsin 54303 Recruiting
Gundersen Lutheran Medical Center La Crosse Wisconsin 54601 Recruiting
Marshfield Medical Center-Marshfield Marshfield Wisconsin 54449 Recruiting
Medical College of Wisconsin Milwaukee Wisconsin 53226 Recruiting
Marshfield Medical Center - Minocqua Minocqua Wisconsin 54548 Recruiting
ProHealth D N Greenwald Center Mukwonago Wisconsin 53149 Recruiting
Cancer Center of Western Wisconsin New Richmond Wisconsin 54017 Recruiting
ProHealth Oconomowoc Memorial Hospital Oconomowoc Wisconsin 53066 Recruiting
Saint Vincent Hospital Cancer Center at Oconto Falls Oconto Falls Wisconsin 54154 Recruiting
Marshfield Medical Center-Rice Lake Rice Lake Wisconsin 54868 Recruiting
Saint Vincent Hospital Cancer Center at Sheboygan Sheboygan Wisconsin 53081 Recruiting
Marshfield Medical Center-River Region at Stevens Point Stevens Point Wisconsin 54482 Recruiting
Saint Vincent Hospital Cancer Center at Sturgeon Bay Sturgeon Bay Wisconsin 54235-1495 Recruiting
Essentia Health Saint Mary's Hospital - Superior Superior Wisconsin 54880 Recruiting
ProHealth Waukesha Memorial Hospital Waukesha Wisconsin 53188 Recruiting
UW Cancer Center at ProHealth Care Waukesha Wisconsin 53188 Recruiting
Marshfield Medical Center - Weston Weston Wisconsin 54476 Recruiting

Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.

About this trial record page

What this page shows
Public field values for ClinicalTrials.gov record NCT05136196, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
What this page does not do
No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
Where the data comes from
Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
Last refresh
Last update posted May 7, 2026 · Synced May 10, 2026

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The complete protocol, eligibility criteria, and contact information for NCT05136196 live on ClinicalTrials.gov.

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