OASIS-HAE: A Study to Evaluate the Safety and Efficacy of Donidalorsen (ISIS 721744 or IONIS-PKK-LRx) in Participants With Hereditary Angioedema (HAE)
Public ClinicalTrials.gov record NCT05139810. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Phase 3 Double-Blind, Placebo-Controlled Study to Evaluate the Efficacy and Safety of ISIS 721744 in Patients With Hereditary Angioedema (HAE)
Study identification
- NCT ID
- NCT05139810
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 3
- Lead sponsor
- Ionis Pharmaceuticals, Inc.
- Industry
- Enrollment
- 91 participants
Conditions and interventions
Conditions
Interventions
- Donidalorsen Drug
- Placebo Drug
Drug
Eligibility (public fields only)
- Age range
- 12 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Dec 2, 2021
- Primary completion
- Nov 8, 2023
- Completion
- Nov 8, 2023
- Last update posted
- Mar 5, 2025
2021 – 2023
United States locations
- U.S. sites
- 15
- U.S. states
- 12
- U.S. cities
- 15
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Ionis Investigative Site | Scottsdale | Arizona | 85251 | — |
| Ionis Investigative Site | San Diego | California | 92122 | — |
| Ionis Investigative Site | Santa Monica | California | 90404 | — |
| Ionis Investigative Site | Walnut Creek | California | 94598 | — |
| Ionis Investigative Site | Colorado Springs | Colorado | 80907 | — |
| Ionis Investigative Site | Tampa | Florida | 33613 | — |
| Ionis Investigative Site | Kansas City | Kansas | 66205 | — |
| Ionis Investigative Site | Boston | Massachusetts | 02114 | — |
| Ionis Investigative Site | Ann Arbor | Michigan | 48109 | — |
| Ionis Investigative Site | St Louis | Missouri | 63110 | — |
| Ionis Investigative Site | Columbus | Ohio | 43235 | — |
| Ionis Investigative Site | Toledo | Ohio | 43617 | — |
| Ionis Investigative Site | Hershey | Pennsylvania | 17033 | — |
| Ionis Investigative Site | Dallas | Texas | 75231 | — |
| Ionis Investigative Site | Murray | Utah | 84107 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 36 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT05139810, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Mar 5, 2025 · Synced Jul 22, 2026
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Open the official record
The complete protocol, eligibility criteria, and contact information for NCT05139810 live on ClinicalTrials.gov.