Testing a Novel Data-to-Suppression (D2S) Intervention Strategy in the Ryan White HIV/AIDS Program

ClinicalTrials.gov ID: NCT05140421

Public ClinicalTrials.gov record NCT05140421. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.

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Official title

Strengthening the Safety Net: Testing a Novel Data-to-Suppression (D2S) Intervention Strategy in the Ryan White HIV/AIDS Program

Brief summary

Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.

The Ryan White HIV/AIDS Program (RWHAP) for low-income people with HIV (PWH) is a key resource for reducing HIV health disparities and scaling up evidence-based interventions. As RWHAP serves \>50% of US PWH, RWHAP outcomes are vital to achieving "getting-to-zero"/ Ending the HIV Epidemic (EHE) Plan targets. As a grantee for RWHAP Part A (RWPA) funding distributed to the counties/cities severely affected by HIV, New York City (NYC) conducts regular HIV care continuum monitoring citywide and in its RWPA programs, which offer support services to reduce social and behavioral barriers to care/treatment. Local data consistently show lower viral suppression (VS) among RWPA clients in HIV care than among non-RWPA PWH in HIV care. Relative to NYC HIV cases overall, NYC RWPA clients (\~14,000 per year) over-represent Black and Latinx PWH and high-poverty neighborhoods. To address local outcome disparities and to fill gaps left by data-to-care strategies and research focused on medical care (re-)linkage, the investigators propose to implement and rigorously evaluate the effectiveness of a novel 'data-to-suppression' (D2S) intervention among RWPA behavioral health and housing program clients who are in HIV care but unsuppressed. Surveillance-based reports on unsuppressed clients plus D2S capacity-building assistance will guide RWPA providers in targeting and delivering evidence-informed strategies to improve VS.

Study identification

NCT ID: NCT05140421
Recruitment status: Active, not recruiting
Study type: Interventional
Phase: Not applicable
Lead sponsor: City University of New York; Other
Enrollment: 1,494 participants

Conditions and interventions

Conditions

Interventions

Data to Suppression (D2S) Other
Usual practice Other

Other

Eligibility (public fields only)

Age range: Not listed
Sex: All
Healthy volunteers: Healthy volunteers not accepted

This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.

Study timeline

Start date: Dec 14, 2021
Primary completion: May 31, 2024
Completion: Apr 29, 2026
Last update posted: Mar 18, 2026

2021 – 2026

United States locations

U.S. sites: 27
U.S. states: 1
U.S. cities: 1

Facility	City	State	ZIP	Site status
Alliance for Positive Change	New York	New York	10001	—
Mount Sinai Beth Israel	New York	New York	10003	—
Exponents, Inc.	New York	New York	10004	—
GMHC	New York	New York	10018	—
African Services Committee, Inc.	New York	New York	10027	—
Harlem United	New York	New York	10027	—
New York Presbyterian Hospital	New York	New York	10032	—
Bailey House, Inc.	New York	New York	10035	—
New York Harm Reduction Educators, Inc.	New York	New York	10035	—
The Institute for Family Health	New York	New York	10035	—
NYC Health and Hospitals Harlem	New York	New York	10037	—
Project Hospitality, Inc.	New York	New York	10302	—
Boom!Health	New York	New York	10451	—
BronxWorks, Inc.	New York	New York	10453	—
St. Ann's Corner of Harm Reduction	New York	New York	10459	—
Tolentine Zeiser Community Life Center	New York	New York	10463	—
Housing Works	New York	New York	11201	—
Research Foundation of State University of New York	New York	New York	11203	—
La Nueva Esperanza, Inc.	New York	New York	11206	—
NYC Health and Hospitals Woodhull	New York	New York	11206	—
Interfaith Medical Center	New York	New York	11213	—
Bridging Access to Care, Inc.	New York	New York	11216	—
After Hours Project	New York	New York	11221	—
Planned Parenthood of Greater New York	New York	New York	11225	—
CAMBA, Inc.	New York	New York	11226	—
AIDS Center of Queens County, Inc.	New York	New York	11432	—
NYC Health and Hospitals Queens	New York	New York	11432	—

Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.

About this trial record page

What this page shows: Public field values for ClinicalTrials.gov record NCT05140421, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
What this page does not do: No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
Where the data comes from: Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
Last refresh: Last update posted Mar 18, 2026 · Synced Sep 2, 2026

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