Randomized Study to Evaluate the Effect of Obicetrapib on Top of Maximum Tolerated Lipid-Modifying Therapies
Public ClinicalTrials.gov record NCT05142722. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Placebo-Controlled, Double-Blind, Randomized Phase 3 Study to Evaluate the Effect of 10mg Obicetrapib in Participants With HeFH and/or ASCVD Who Are Not Adequately Controlled by Their Lipid Modifying Therapies
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
This study will be a placebo-controlled, double-blind, randomized, phase 3 study in participants with underlying heterozygous familial hypercholesterolemia (HeFH) and/or ASCVD to evaluate the efficacy, safety, and tolerability of obicetrapib as an adjunct to diet and maximally tolerated lipid-lowering therapy
Study identification
- NCT ID
- NCT05142722
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 3
- Enrollment
- 2,530 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Dec 15, 2021 (Actual)
- Primary completion
- Sep 26, 2024 (Actual)
- Completion
- Sep 26, 2024 (Actual)
- Last update posted
- Sep 19, 2025
2021 – 2024
United States locations
- U.S. sites
- 69
- U.S. states
- 25
- U.S. cities
- 63
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Pinnacle Research Group | Anniston | Alabama | 36207 | — |
| Central Alabama Research | Birmingham | Alabama | 35209 | — |
| Synexus Clinical Research US, Inc. / Simon Williamson Clinic, PC | Birmingham | Alabama | 35211 | — |
| The Center for Clinical Trials, Inc | Saraland | Alabama | 36571 | — |
| Syed Research Consultants, LLC | Sheffield | Alabama | 35660 | — |
| Clinical Research Institute of Arizona, LLC | Sun City West | Arizona | 85375 | — |
| Synexus Clinical Research US, Inc. / Orange Grove Family Practice | Tucson | Arizona | 85741 | — |
| Eclipse Clinical Research | Tucson | Arizona | 85745 | — |
| American Institute of Research | Beverly Hills | California | 90211 | — |
| Orange County Research Center | Tustin | California | 92780 | — |
| Synexus Clinical Research US, Inc. | Vista | California | 92083 | — |
| Excel Medical Clinical Trials | Boca Raton | Florida | 33434 | — |
| Pioneer Clinical Studies | Ft. Pierce | Florida | 34950 | — |
| New Generation of Medical Research | Hialeah | Florida | 33016 | — |
| East Coast Institute for Research, LLC | Jacksonville | Florida | 32204 | — |
| East Coast Institute for Research, LLC - Jacksonville University Blvd | Jacksonville | Florida | 32216 | — |
| East Coast Institute for Research- Lake City | Lake City | Florida | 32055 | — |
| ClinCloud LLC | Maitland | Florida | 32751 | — |
| Columbus Clinical Services, LLC | Miami | Florida | 33125 | — |
| Kendall South Medical Center, Inc. | Miami | Florida | 33185 | — |
| Advanced Research Institute Inc | New Port Richey | Florida | 34653 | — |
| Progressive Medical Research | Port Orange | Florida | 32127 | — |
| East Coast Institute for Research | Saint Augustine | Florida | 32086 | — |
| Synexus Clinical Research US, Inc. | The Villages | Florida | 32162 | — |
| Synexus Clinical Research US, Inc. | Atlanta | Georgia | 30328 | — |
| East Coast Institute for Research - Canton | Canton | Georgia | 30114 | — |
| Centricity Research | Columbus | Georgia | 31904 | — |
| East Coast Institute for Research, LLC | Macon | Georgia | 31210 | — |
| Alta Pharmaceutical Research Center | Peachtree Corners | Georgia | 30092 | — |
| SouthCoast Health | Savannah | Georgia | 31406 | — |
| Biofortis, Inc | Addison | Illinois | 60101 | — |
| Evanston Premier Healthcare Research LLC | Skokie | Illinois | 60077 | — |
| Synexus Clinical Research US, Inc. | Evansville | Indiana | 47714 | — |
| Midwest Institute for Clinical Research | Indianapolis | Indiana | 46260 | — |
| Cotton-O'Neil Clinical Research Center | Topeka | Kansas | 66606 | — |
| Louisville Metabolic and Atherosclerosis Research Center (L-MARC) | Louisville | Kentucky | 40213 | — |
| Research Integrity, LLC | Owensboro | Kentucky | 42303 | — |
| Cambridge Medical Trials | Alexandria | Louisiana | 71301 | — |
| Grace Research, LLC | Bossier City | Louisiana | 71111 | — |
| Tandem Clinical Research | Marrero | Louisiana | 70072 | — |
| Tandem Clinical Research GI - Metairie | Metairie | Louisiana | 70006 | — |
| Grace Research, LLC | Shreveport | Louisiana | 71105 | — |
| Southern Clinical Research, LLC | Zachary | Louisiana | 70791 | — |
| Northern Light Cardiology | Bangor | Maine | 04401 | — |
| Privia Medical Group, LLC | Silver Spring | Maryland | 20901 | — |
| Oakland Medical Research | Troy | Michigan | 48085 | — |
| Arcturus Healthcare, Troy Internal Medicine Research Division | Troy | Michigan | 48098 | — |
| AB Clinical Trials | Las Vegas | Nevada | 89119 | — |
| Inspira Medical Centers dba Internal Medicine Associates, P.A. | Bridgeton | New Jersey | 08302 | — |
| Mid Hudson Medical Research | New Windsor | New York | 12553 | — |
| Synexus Clinical Research US, Inc. | New York | New York | 10017 | — |
| Tandem Clinical Research GI, LLC | New York | New York | 10033 | — |
| Chear Center LLC | The Bronx | New York | 10455 | — |
| Diabetes and Endocrinology Consultants, P.C. | Morehead City | North Carolina | 28557 | — |
| Lillestol Research, LLC | Fargo | North Dakota | 58104 | — |
| Summit Research Group, LLC | Stow | Ohio | 44224 | — |
| Monument Health Clinical Research | Rapid City | South Dakota | 57701 | — |
| Cardiovascular Research of Knoxville, LLC | Powell | Tennessee | 37849 | — |
| Amarillo Heart Clinical Research Institute, Inc | Amarillo | Texas | 79106 | — |
| Inquest Clinical Research | Baytown | Texas | 77521 | — |
| Apex Mobile Clinical Research | Bellaire | Texas | 77401 | — |
| Javara Inc. | Conroe | Texas | 77384 | — |
| Prime Revival Research Institute, LLC | Coppell | Texas | 75019 | — |
| Thyroid, Endocrinology & Diabetes, PA | Dallas | Texas | 75208 | — |
| Northwest Houston Clinical Research | Tomball | Texas | 77375 | — |
| Synexus Clinical Research US, Inc. | Salt Lake City | Utah | 84106 | — |
| Manassas Clinical Research Center | Manassas | Virginia | 20110 | — |
| Hampton Roads Center for Clinical Research | Suffolk | Virginia | 23434 | — |
| Universal Research Group, LLC | Tacoma | Washington | 98405 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 112 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT05142722, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Sep 19, 2025 · Synced Oct 23, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT05142722 live on ClinicalTrials.gov.