A Study of Loncastuximab Tesirine and Rituximab (Lonca-R) in Previously Untreated Unfit/Frail Participants With Diffuse Large B-cell Lymphoma (DLBCL)
Public ClinicalTrials.gov record NCT05144009. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Phase 2 Open-label Study of Loncastuximab Tesirine in Combination With Rituximab (Lonca-R) in Previously Untreated Unfit/Frail Patients With Diffuse Large B-cell Lymphoma (DLBCL) (LOTIS-9)
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
The main objective of the trial is to assess the efficacy and tolerability of Lonca-R in unfit and frail participants with previously untreated DLBCL.
Study identification
- NCT ID
- NCT05144009
- Recruitment status
- Terminated
- Study type
- Interventional
- Phase
- Phase 2
- Enrollment
- 41 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 65 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Jun 21, 2022 (Actual)
- Primary completion
- Jan 22, 2024 (Actual)
- Completion
- Jan 22, 2024 (Actual)
- Last update posted
- Jan 30, 2025
2022 – 2024
United States locations
- U.S. sites
- 29
- U.S. states
- 16
- U.S. cities
- 27
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| University of Arizona Cancer Center | Tucson | Arizona | 85724 | — |
| Winthrop P. Rockefeller Cancer Institute | Little Rock | Arkansas | 72205 | — |
| Rocky Mountain Cancer Centers - Aurora | Aurora | Colorado | 80012 | — |
| USOR - Illinois Cancer Specialists - Niles | Niles | Illinois | 60714 | — |
| Leonard Lawson Cancer Center | Pikeville | Kentucky | 41501 | — |
| Cancer Care Specialists - Nevada | Reno | Nevada | 89511 | — |
| New York Cancer & Blood Specialists - New Hyde Park | Babylon | New York | 11702 | — |
| New York Cancer & Blood Specialists - Babylon Medical Oncology | Port Jefferson | New York | 11776 | — |
| Novant Health Cancer Specialists - Charlotte | Charlotte | North Carolina | 28204 | — |
| USOR - Oncology Hematology Care - Kenwood | Cincinnati | Ohio | 45236 | — |
| University Hospitals Cleveland Medical Center | Cleveland | Ohio | 44106 | — |
| Ohio Health - Research and Innovation Institute | Columbus | Ohio | 43210 | — |
| Willamette Valley Cancer Institute and Research Center - Eugene | Eugene | Oregon | 97401 | — |
| Reading Hospital - Tower Health | Reading | Pennsylvania | 19611 | — |
| Prisma Health Cancer Institute | Greenville | South Carolina | 29605 | — |
| Avera Cancer Institute | Sioux Falls | South Dakota | 57105 | — |
| Texas Oncology - Austin Midtown | Austin | Texas | 78705 | — |
| Texas Oncology - Medical City Dallas | Dallas | Texas | 75230 | — |
| USOR - Texas Oncology - Presbyterian Cancer Center Dallas | Dallas | Texas | 75231 | — |
| USOR - Texas Oncology - Baylor Charles A. Sammons Cancer Center | Dallas | Texas | 75246 | — |
| University of Texas MD Anderson Cancer Center | Houston | Texas | 77030 | — |
| USOR - Texas Oncology - San Antonio | San Antonio | Texas | 78240 | — |
| Texas Oncology Northeast Texas - Tyler | Tyler | Texas | 75702 | — |
| Blue Ridge Cancer Care - Blacksburg | Blacksburg | Virginia | 24060 | — |
| USOR - Virginia Cancer Specialists - Gainesville Office | Gainesville | Virginia | 20155 | — |
| Virginia Cancer Institute - West End | Richmond | Virginia | 23229 | — |
| USOR - Virginia Oncology Associates | Virginia Beach | Virginia | 23456 | — |
| Kadlec Clinic - Hematology and Oncology | Richland | Washington | 99352 | — |
| USOR - Northwest Cancer Specialists, P.C. dba Compass Oncology - Vancouver Cancer Center | Vancouver | Washington | 98684 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 12 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT05144009, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Jan 30, 2025 · Synced Oct 19, 2026
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Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT05144009 live on ClinicalTrials.gov.