A Research Study Looking at How Well a Combination of the Medicines Semaglutide and NNC0480-0389 Works in People With Type 2 Diabetes
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This page only displays public information reproduced from the official ClinicalTrials.gov record NCT05144984. It adds no medical advice, opinions, or eligibility judgments. The official record remains the source of truth for eligibility criteria, enrollment, and contact information.
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Official title
Investigation of the Safety and Efficacy of Semaglutide s.c. in Combination With NNC0480-0389 in Participants With Type 2 Diabetes - a Dose Finding Study
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
This study is looking at semaglutide in combination with a potential new medicine (NNC0480-0389) in people with type 2 diabetes. The study is being conducted to see how well semaglutide, in combination with different doses of NNC0480-0389, work to lower blood sugar levels. Results from this study will be used to select the doses of the two medicines for other studies. Participants will either get: Semaglutide (a medicine doctors can already prescribe for treatment of type 2 diabetes) in combination with NNC0480-0389 (a potential new medicine) or placebo (a 'dummy' medicine that looks like the medicines but without any medicine). NNC0480-0389 alone, or semaglutide alone which treatment participant get is decided by chance. Participant will need to take 2-3 injections once every week during the study. One injection will be with semaglutide or placebo and 1-2 injections will be with NNC0480-0389 or placebo. Participant must inject the study medicines themself into the stomach, thigh, or upper arm. The study will last for about 41weeks. Participant will have 20 clinic visits. Participant will have blood samples taken at all clinic visits. At 3 clinic visits, participant will also have an electrocardiogram (ECG). This is a test to check participants heart. Participant will have their eyes checked before or at the start of the study and at the end of the study. Women can only take part in the study if they are not able to become pregnant
Study identification
- NCT ID
- NCT05144984
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 2
- Enrollment
- 500 participants
Conditions and interventions
Conditions
Interventions
- NNC0480-0389 Drug
- Semaglutide Drug
- Placebo (NNC080-0389) Drug
- Placebo (semaglutide) Drug
Drug
Eligibility (public fields only)
- Age range
- 18 Years to 75 Years
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Nov 29, 2021 (Actual)
- Primary completion
- Feb 13, 2023 (Actual)
- Completion
- Mar 23, 2023 (Actual)
- Last update posted
- Apr 9, 2026
2021 – 2023
United States locations
- U.S. sites
- 71
- U.S. states
- 29
- U.S. cities
- 66
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Pinnacle Research Group LLC | Anniston | Alabama | 36207 | — |
| Synexus Clinical Research | Glendale | Arizona | 85308 | — |
| University of Arizona/Banner Health | Phoenix | Arizona | 85006 | — |
| American Clinical Trials | Buena Park | California | 90620 | — |
| San Fernando Valley Hlth Inst, LLC | Canoga Park | California | 91304 | — |
| Velocity Clin Res-Chula Vista | Chula Vista | California | 91911 | — |
| Headlands Research California, LLC | Escondido | California | 92025 | — |
| Valley Research | Fresno | California | 93720 | — |
| Providence Medical Foundation | Fullerton | California | 92835 | — |
| Velocity Clinical Research San Diego | La Mesa | California | 91942 | — |
| First Valley Med Grp Lancaster | Lancaster | California | 93534 | — |
| Torrance Clin Res Inst, Inc. | Lomita | California | 90717 | — |
| Velocity Clin Res Los Angeles | Los Angeles | California | 90017 | — |
| Valley Clinical Trials, Inc. | Northridge | California | 91325 | — |
| Artemis Insitute for Clin Res | Riverside | California | 92503 | — |
| Artemis Institute for Clin Res | San Diego | California | 92103 | — |
| Shahram Jacobs MD Inc. | Sherman Oaks | California | 91403 | — |
| Diablo Clinical Research, Inc. | Walnut Creek | California | 94598 | — |
| Northeast Research Institute | Jacksonville | Florida | 32204 | — |
| Reyes Clinical Research, Inc | Miami | Florida | 33175 | — |
| South Broward Research LLC | Miramar | Florida | 33027 | — |
| Clinical Trial Res Assoc,Inc | Plantation | Florida | 33324 | — |
| Progressive Medical Research | Port Orange | Florida | 32127 | — |
| Headlands Research - Sarasota | Sarasota | Florida | 34243 | — |
| Appalachian Clinical Res LLC | Adairsville | Georgia | 30103 | — |
| Solaris Clinical Research | Meridian | Idaho | 83646 | — |
| Cedar-Crosse Research Center | Chicago | Illinois | 60607 | — |
| Macoupin Research Group | Gillespie | Illinois | 62033 | — |
| UnityPoint Health-Diabetes Care Center | Peoria | Illinois | 61603 | — |
| Clin Invest Spec, Inc | Wauconda | Illinois | 60084 | — |
| Iowa Diabetes & Endo Res Ctr | West Des Moines | Iowa | 50265 | — |
| Cotton O'Neil Diab & Endo Ctr | Topeka | Kansas | 66606 | — |
| The Research Group of Lexington LLC | Lexington | Kentucky | 40503 | — |
| L-MARC Research Center | Louisville | Kentucky | 40213 | — |
| Centex Studies, Inc._Lake Charles | Lake Charles | Louisiana | 70601 | — |
| Endo And Metab Cons | Rockville | Maryland | 20852 | — |
| Brigham & Women's Hospital | Boston | Massachusetts | 02115-5804 | — |
| Arcturus HC PLC Troy Med Res | Troy | Michigan | 48098 | — |
| StudyMetrix Research LLC | City of Saint Peters | Missouri | 63303 | — |
| Mercury Str Med Grp, PLLC | Butte | Montana | 59701 | — |
| Princeton Endo Assoc | Princeton | New Jersey | 08540 | — |
| Premier Research Inc. | Trenton | New Jersey | 08611 | — |
| AMC Community Endocrinology | Albany | New York | 12203 | — |
| Mid Hudson Med Res-New Windsor | New Windsor | New York | 12553 | — |
| University of North Carolina | Chapel Hill | North Carolina | 27514 | — |
| PharmQuest Life Sciences LLC | Greensboro | North Carolina | 27408 | — |
| Physicians East Endocrinology | Greenville | North Carolina | 27834 | — |
| Piedmont Healthcare/Research | Statesville | North Carolina | 28625 | — |
| Lillestol Research LLC | Fargo | North Dakota | 58104 | — |
| Albert J Weisbrot | Mason | Ohio | 45040-6815 | — |
| Advanced Med Res Maumee | Maumee | Ohio | 43537 | — |
| Intend Research | Norman | Oklahoma | 73069 | — |
| Essential Medical Research LLC | Tulsa | Oklahoma | 74137 | — |
| CCT Research | Hatboro | Pennsylvania | 19040 | — |
| Preferred Primary Care Physicians_Pittsburgh | Pittsburgh | Pennsylvania | 15236 | — |
| Spartanburg Medical Research | Spartanburg | South Carolina | 29303 | — |
| Chattanooga Medical Research, LLC | Chattanooga | Tennessee | 37404 | — |
| Clinical Neuroscience Solutions | Memphis | Tennessee | 38119 | — |
| Velocity Clinical Res-Dallas | Dallas | Texas | 75230 | — |
| UT Southwestern Med Cntr | Dallas | Texas | 75390-9302 | — |
| Centex Studies, Inc. | Houston | Texas | 77058 | — |
| Juno Research, LLC | Houston | Texas | 77074 | — |
| Southwest Clinical Trials | Houston | Texas | 77074 | — |
| Centex Studies | Houston | Texas | 77090 | — |
| Quality Research Inc | San Antonio | Texas | 78209 | — |
| VIP Trials_San Antonio | San Antonio | Texas | 78230 | — |
| Consano Clinical Research, LLC | Shavano Park | Texas | 78231 | — |
| Simcare Medical Research, LLC | Sugar Land | Texas | 77478 | — |
| Advanced Research Institute | Ogden | Utah | 84405 | — |
| York Clinical Research LLC | Norfolk | Virginia | 23504 | — |
| Capital Clin Res Ctr,LLC | Olympia | Washington | 98502 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 58 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT05144984, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Apr 9, 2026 · Synced Nov 14, 2026
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