Efficacy and Safety of Remibrutinib Compared to Teriflunomide in Participants With Relapsing Multiple Sclerosis (RMS) (REMODEL-1)
Public ClinicalTrials.gov record NCT05147220. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Randomized, Double-blind, Double-dummy, Parallel-group Study, Comparing the Efficacy and Safety of Remibrutinib Versus Teriflunomide in Participants With Relapsing Multiple Sclerosis, Followed by Extended Treatment With Open-label Remibrutinib
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
To compare the efficacy and safety of remibrutinib versus teriflunomide in patients with relapsing multiple sclerosis (RMS)
Study identification
- NCT ID
- NCT05147220
- Recruitment status
- Active, not recruiting
- Study type
- Interventional
- Phase
- Phase 3
- Enrollment
- 1,000 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 18 Years to 55 Years
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Dec 16, 2021 (Actual)
- Primary completion
- Jul 21, 2026 (Actual)
- Completion
- Oct 30, 2030 (Estimated)
- Last update posted
- Aug 18, 2026
2021 – 2030
United States locations
- U.S. sites
- 52
- U.S. states
- 27
- U.S. cities
- 50
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| AZ Integrated Neuro and Spine | Phoenix | Arizona | 85037 | — |
| Center for Neurosciences | Tucson | Arizona | 85718 | — |
| The Belinga Clinic | Fort Smith | Arkansas | 72916 | — |
| The Research and Education Inst of Alta Bates Summit Med Grp | Berkeley | California | 94705 | — |
| The Neuron Clinic | Chula Vista | California | 91910 | — |
| Glendale Adventist Medical Center | Glendale | California | 91206 | — |
| Hoag Health System | Newport Beach | California | 92663 | — |
| SC3 Research Pasadena | Pasadena | California | 91105 | — |
| Neuro Center | Pomona | California | 91767 | — |
| Alpine Clinical Research Center | Boulder | Colorado | 80301 | — |
| Christiana Care Health Services | Newark | Delaware | 19713 | — |
| Washington Hospital Center | Washington D.C. | District of Columbia | 20010 | — |
| Neurology of Central FL Res Ctr | Altamonte Springs | Florida | 32714 | — |
| Arrow Clinical Trials | Daytona Beach | Florida | 32117 | — |
| Homestead Assoc In Research Inc | Homestead | Florida | 33033 | — |
| Reliant Medical Research | Miami | Florida | 33165 | — |
| Neurological Services of Orlando PA | Orlando | Florida | 32806 | — |
| Orlando Health Clinical Trials | Orlando | Florida | 32806 | — |
| Comprehensive Neurology Clinic | Orlando | Florida | 32825 | — |
| Neurology Associates of Ormond Beach | Ormond Beach | Florida | 32174 | — |
| Neurostudies Inc | Port Charlotte | Florida | 33952 | — |
| Accel Research Sites St Pete-Largo | Seminole | Florida | 33777 | — |
| University Of South Florida | Tampa | Florida | 33612 | — |
| Conquest Research | Winter Park | Florida | 32789 | — |
| Rush University Medical Center | Chicago | Illinois | 60612 | — |
| IU Health Inc | Fort Wayne | Indiana | 46815 | — |
| College Park Family Care Center | Overland Park | Kansas | 66210 | — |
| Norton Neurology MS Services | Louisville | Kentucky | 40207 | — |
| American Oncology Partners PA Center for Cancer and Blood Disorders | Bethesda | Maryland | 20817 | — |
| Neurology Center of New England PC | Foxborough | Massachusetts | 02035 | — |
| Wayne State University Multiple Sclerosis Clinic | Detroit | Michigan | 48201 | — |
| The MS Center for Innovation in Care | St Louis | Missouri | 63131 | — |
| SCL Health | Billings | Montana | 59101 | — |
| Jersey Shore University Medical Ctr | Neptune City | New Jersey | 07753 | — |
| Neurological Associates of Long Island PC | Lake Success | New York | 11042 | — |
| NYU Langone Med Center CV Research | New York | New York | 10016 | — |
| The Neurological Institute PA | Charlotte | North Carolina | 28204 | — |
| Velocity Clinical Research | Raleigh | North Carolina | 27607 | — |
| Columbus Neuroscience | Westerville | Ohio | 43082 | — |
| Multiple Sclerosis Center of Excellence of OMRF | Oklahoma City | Oklahoma | 73104 | — |
| Providence St Vincent Med Center | Portland | Oregon | 97225 | — |
| University Of Pittsburgh Medical Ctr Magee-Womens Hospital | Pittsburgh | Pennsylvania | 15213 | — |
| Reading Hospital | Reading | Pennsylvania | 19611 | — |
| Palmetto Clinical Research | Summerville | South Carolina | 29485 | — |
| Texas Neurology | Dallas | Texas | 75206 | — |
| John Peter Smith Hospital | Fort Worth | Texas | 76104 | — |
| Neuro Eye Clinical Trials Inc | Houston | Texas | 77074 | — |
| DHR Health Institute | McAllen | Texas | 78504 | — |
| Saturn Research Solutions LLC | Plano | Texas | 75024 | — |
| MS Center of Greater Washington, P.C. | Vienna | Virginia | 22182 | — |
| University of Wisconsin Madison | Madison | Wisconsin | 53792 | — |
| Neuroscience Group | Neenah | Wisconsin | 54956 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 148 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT05147220, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Aug 18, 2026 · Synced Oct 21, 2026
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Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT05147220 live on ClinicalTrials.gov.