Clinical Trial of Lurbinectedin as Single-agent or in Combination With Irinotecan Versus Topotecan or Irinotecan in Patients With Relapsed Small-cell Lung Cancer (LAGOON)
Public ClinicalTrials.gov record NCT05153239. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Randomized, Multicenter, Open-label, Phase III Study of Lurbinectedin Single-Agent or Lurbinectedin in Combination With Irinotecan Versus Investigator's Choice (Topotecan or Irinotecan) in Relapsed Small Cell Lung Cancer Patients (LAGOON Trial)
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
Multicenter, open-label, randomized, controlled phase III clinical trial to evaluate and compare the activity and safety of two experimental arms consisting of lurbinectedin as single agent (Group A) or the combination of lurbinectedin with irinotecan (Group B) versus Investigator's Choice (topotecan or irinotecan) as control arm (Group C), in Small-cell Lung Cancer (SCLC) patients who failed one prior platinum-containing line.
Study identification
- NCT ID
- NCT05153239
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 3
- Enrollment
- 705 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Jul 22, 2022 (Actual)
- Primary completion
- Apr 10, 2026 (Actual)
- Completion
- Apr 10, 2026 (Actual)
- Last update posted
- Oct 21, 2026
2022 – 2026
United States locations
- U.S. sites
- 15
- U.S. states
- 11
- U.S. cities
- 15
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Ironwood Cancer & Research Centers | Chandler | Arizona | 85224 | — |
| Genesis Cancer and Blood | Hot Springs | Arkansas | 71913 | — |
| Florida Cancer Specialists - South | Fort Myers | Florida | 33901 | — |
| Florida Cancer Specialists - North | St. Petersburg | Florida | 33705 | — |
| Florida Cancer Specialists - Panhandle | Tallahassee | Florida | 32308 | — |
| Florida Cancer Specialists - East | West Palm Beach | Florida | 33401 | — |
| Duly Health and Care | Joliet | Illinois | 60435 | — |
| Norton Cancer Institue, Downtown | Louisville | Kentucky | 40202 | — |
| Dana-Farber Cancer Institute | Boston | Massachusetts | 02215 | — |
| Oncology Hematology West, PC (Grand Island) | Grand Island | Nebraska | 68803 | — |
| Oncology Hematology West, PC dba Nebraska Cancer Specialists | Omaha | Nebraska | 68130 | — |
| FirstHealth Outpatient Cancer Center | Pinehurst | North Carolina | 28374 | — |
| Utah Cancer Specialists | Salt Lake City | Utah | 84106 | — |
| MultiCare Regional Cancer Center - Tacoma | Tacoma | Washington | 98405 | — |
| Froedtert Hospital/Medical College of Wisconsin | Milwaukee | Wisconsin | 53226 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 195 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT05153239, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Oct 21, 2026 · Synced Oct 23, 2026
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Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT05153239 live on ClinicalTrials.gov.