A Study of TAK-330 to Reverse the Effects of Factor Xa Inhibitors For Adults Needing Urgent Surgery

ClinicalTrials.gov ID: NCT05156983

Public ClinicalTrials.gov record NCT05156983. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.

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ClinicalTrials.gov public records Last synced Jul 22, 2026, 9:47 PM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

Official title

A Phase 3, Prospective, Randomized, Open-label, Adaptive Group Sequential, Multicenter Trial With Blinded Endpoint Assessment to Evaluate the Efficacy and Safety of TAK-330 for the Reversal of Direct Oral Factor Xa Inhibitor-induced Anticoagulation in Patients Requiring Urgent Surgery/Invasive Procedure

Study identification

NCT ID: NCT05156983
Recruitment status: Recruiting
Study type: Interventional
Phase: Phase 3
Lead sponsor: Takeda; Industry
Enrollment: 440 participants

Conditions and interventions

Conditions

Coagulation Disorder

Interventions

TAK-330 Drug
SOC 4F-PCC Drug

Drug

Eligibility (public fields only)

Age range: 18 Years and older
Sex: All
Healthy volunteers: Healthy volunteers not accepted

This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.

Study timeline

Start date: Aug 23, 2022
Primary completion: Aug 29, 2028
Completion: Aug 29, 2028
Last update posted: Jun 17, 2026

2022 – 2028

United States locations

U.S. sites: 13
U.S. states: 11
U.S. cities: 13

Facility	City	State	ZIP	Site status
University of Arkansas Medical Sciences	Arkansas City	Arkansas	72205	Recruiting
University of California Davis Health System	Sacramento	California	95817	Recruiting
Denver Metro Orthopedics, P.C.	Englewood	Colorado	80012	Recruiting
University of Florida	Gainesville	Florida	32608	Recruiting
Rutgers, The State University of New Jersey	New Brunswick	New Jersey	07103	Recruiting
ECU Health Medical Center	Greenville	North Carolina	27858	Recruiting
Metro Health Medical Center	Cleveland	Ohio	44109	Recruiting
Ohio State University	Columbus	Ohio	43210	Recruiting
Ascension St. John Medical Center	Tulsa	Oklahoma	74104	Recruiting
University of Pennsylvania - Perelman School of Medicine	Philadelphia	Pennsylvania	19104	Recruiting
UPMC	Pittsburgh	Pennsylvania	15213	Recruiting
University of Texas Southwestern Medical Center	Dallas	Texas	75390	Recruiting
Carilion Medical Center	Virginia Beach	Virginia	24014	Recruiting

Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.

Non-U.S. locations

This page focuses on the U.S. directory. The official record also lists 51 non-U.S. sites.

About this trial record page

What this page shows: Public field values for ClinicalTrials.gov record NCT05156983, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
What this page does not do: No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
Where the data comes from: Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
Last refresh: Last update posted Jun 17, 2026 · Synced Jul 22, 2026

Open the official record

The complete protocol, eligibility criteria, and contact information for NCT05156983 live on ClinicalTrials.gov.

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