Safety, Tolerability, and Immunogenicity of V110 or V114 Co-administered With a Booster Dose of mRNA-1273 in Healthy Adults (V110-911)
Public ClinicalTrials.gov record NCT05158140. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Phase 3, Randomized, Double-blind, Placebo-controlled Study to Evaluate the Safety, Tolerability, and Immunogenicity of the Concomitant Administration of Either 23-Valent Pneumococcal Polysaccharide Vaccine or 15-Valent Pneumococcal Conjugate Vaccine With a Booster Dose of SARS-CoV-2 mRNA Vaccine in Healthy Adults 50 Years of Age or Older.
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
The purpose of this study is to evaluate the concomitant and non-concomitant use of messenger ribonucleic acid (mRNA) mRNA-1273, the nucleoside-modified mRNA vaccine for active immunization to prevent coronavirus disease (COVID-19) caused by severe acute respiratory syndrome coronavirus (SARS-CoV-2), with a 23-valent pneumococcal polysaccharide vaccine (V110) for the prevention of pneumococcal disease, or a 15-valent pneumococcal conjugate vaccine (V114) indicated for the prevention of invasive pneumococcal disease.
Study identification
- NCT ID
- NCT05158140
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 3
- Enrollment
- 850 participants
Conditions and interventions
Conditions
Interventions
- V110 Biological
- V114 Biological
- mRNA-1273 Biological
- Placebo for V110 Biological
- Placebo for V114 Biological
Biological
Eligibility (public fields only)
- Age range
- 50 Years and older
- Sex
- All
- Healthy volunteers
- Accepts healthy volunteers
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Jan 12, 2022 (Actual)
- Primary completion
- Feb 21, 2023 (Actual)
- Completion
- Feb 21, 2023 (Actual)
- Last update posted
- Jul 18, 2025
2022 – 2023
United States locations
- U.S. sites
- 42
- U.S. states
- 19
- U.S. cities
- 41
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Carbon Health ( Site 0045) | North Hollywood | California | 91606 | — |
| Valley Clinical Trials Inc. ( Site 0002) | Northridge | California | 91325 | — |
| Center for Clinical Trials, LLC ( Site 0022) | Paramount | California | 90723 | — |
| Artemis Institute for Clinical Research ( Site 0024) | San Diego | California | 92103 | — |
| California Research Foundation ( Site 0004) | San Diego | California | 92123 | — |
| Millennium Clinical Trials ( Site 0027) | Simi Valley | California | 93065 | — |
| Diablo Clinical Research, Inc ( Site 0043) | Walnut Creek | California | 94598 | — |
| Alliance for Multispecialty Research, LLC ( Site 0036) | Coral Gables | Florida | 33134 | — |
| Indago Research and Health Center Inc ( Site 0006) | Hialeah | Florida | 33012 | — |
| Optimal Research LLC ( Site 0019) | Melbourne | Florida | 32934 | — |
| Advanced Medical Research, LLC ( Site 0030) | Miami | Florida | 33174 | — |
| Lakes Research LLC ( Site 0012) | Miami Lakes | Florida | 33014 | — |
| Atlanta Center For Medical Research ( Site 0053) | Atlanta | Georgia | 30331 | — |
| Optimal Research ( Site 0054) | Peoria | Illinois | 61614 | — |
| Alliance for Multispecialty Research, LLC ( Site 0018) | Newton | Kansas | 67114 | — |
| AMR Lexington ( Site 0055) | Lexington | Kentucky | 40509 | — |
| Centennial Medical Group ( Site 0016) | Elkridge | Maryland | 21075 | — |
| Community Clinical Research Center ( Site 0032) | Marlborough | Massachusetts | 01752 | — |
| Alliance for Multispecialty Research, LLC ( Site 0011) | Kansas City | Missouri | 64114 | — |
| Wake Research Clinical Research Center of Nevada, LLC ( Site 0021) | Las Vegas | Nevada | 89106 | — |
| AXCES Research Group ( Site 0017) | Santa Fe | New Mexico | 87505 | — |
| Certified Research Associates ( Site 0042) | Cortland | New York | 13045 | — |
| Corning Center for Clinical Research ( Site 0052) | Horseheads | New York | 14845 | — |
| Rochester Clinical Research, Inc. ( Site 0010) | Rochester | New York | 14609 | — |
| Accellacare - Winston-Salem ( Site 0049) | Winston-Salem | North Carolina | 27103 | — |
| Velocity Clinical Research- Cleveland ( Site 0023) | Cleveland | Ohio | 44122 | — |
| Velocity Clinical Research-Providence ( Site 0015) | East Greenwich | Rhode Island | 02818 | — |
| Coastal Carolina Research Center ( Site 0044) | North Charleston | South Carolina | 29405 | — |
| Benchmark Research ( Site 0007) | Austin | Texas | 78705 | — |
| South Texas Clinical Research ( Site 0033) | Corpus Christi | Texas | 78413 | — |
| Benchmark Research ( Site 0039) | Fort Worth | Texas | 76135 | — |
| University of Texas Medical Branch at Galveston ( Site 0037) | Galveston | Texas | 77555-1115 | — |
| Texas Center For Drug Development ( Site 0013) | Houston | Texas | 77081 | — |
| Wellness Clinical Research Associates ( Site 0051) | McKinney | Texas | 75071 | — |
| Diagnostics Research Group ( Site 0001) | San Antonio | Texas | 78229 | — |
| DM Clinical Research ( Site 0025) | Tomball | Texas | 77375 | — |
| Crossroads Clinical Research LLC ( Site 0020) | Victoria | Texas | 77901 | — |
| Velocity Clinical Research, Salt Lake City ( Site 0035) | West Jordan | Utah | 84088 | — |
| Charlottesville Medical Research Center, LLC ( Site 0008) | Charlottesville | Virginia | 22911 | — |
| Health Research of Hampton Roads, Inc. ( Site 0014) | Newport News | Virginia | 23606 | — |
| Alliance for Multispecialty Research LLC (AMR - Norfolk) ( Site 0057) | Norfolk | Virginia | 23502 | — |
| Clinical Research Partners, LLC. ( Site 0005) | Richmond | Virginia | 23226 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 4 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT05158140, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Jul 18, 2025 · Synced Oct 25, 2026
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Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT05158140 live on ClinicalTrials.gov.