Phase 3 Trial to Evaluate the Efficacy and Safety of Aficamten Compared to Placebo in Adults With Symptomatic oHCM
Public ClinicalTrials.gov record NCT05186818. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Phase 3, Multi-Center, Randomized, Double-blind, Placebo-controlled Trial to Evaluate the Efficacy and Safety of CK-3773274 in Adults With Symptomatic Hypertrophic Cardiomyopathy and Left Ventricular Outflow Tract Obstruction
Study identification
- NCT ID
- NCT05186818
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 3
- Lead sponsor
- Cytokinetics
- Industry
- Enrollment
- 282 participants
Conditions and interventions
Interventions
- Aficamten (5 mg, 10 mg, 15 mg, and 20 mg) Drug
- Placebo to match aficamten Drug
Drug
Eligibility (public fields only)
- Age range
- 18 Years to 85 Years
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Jan 31, 2022
- Primary completion
- Nov 9, 2023
- Completion
- Dec 17, 2023
- Last update posted
- Mar 2, 2026
2022 – 2023
United States locations
- U.S. sites
- 48
- U.S. states
- 26
- U.S. cities
- 42
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Alaska Heart and Vascular Institute | Anchorage | Alaska | 99508 | — |
| UC San Diego Health - Sulpizio Cardiovascular Center | La Jolla | California | 92037 | — |
| Cedars-Sinai Medical Center - Smidt Heart Institute Clinic | Los Angeles | California | 90048 | — |
| University of California San Francisco | San Francisco | California | 94143 | — |
| Stanford University Hospital | Stanford | California | 94305 | — |
| Yale School of Medicine | New Haven | Connecticut | 06511 | — |
| Yale University School of Medicine | New Haven | Connecticut | 06519 | — |
| MedStar Washington Hospital Center | Washington D.C. | District of Columbia | 20010 | — |
| Holy Cross Hospital / Cardiology Associates | Fort Lauderdale | Florida | 33308 | — |
| Mayo Clinic Florida | Jacksonville | Florida | 32224 | — |
| Emory Clinic | Atlanta | Georgia | 30322 | — |
| Piedmont Fayette Hospital | Fayetteville | Georgia | 30214 | — |
| Northwestern University | Chicago | Illinois | 60614 | — |
| University of Iowa | Iowa City | Iowa | 52242 | — |
| MedStar Medical Group Cardiology at Union Memorial | Baltimore | Maryland | 21218 | — |
| Medstar Franklin Square Medical Center | Baltimore | Maryland | 21237 | — |
| Massachusetts General Hospital | Boston | Massachusetts | 02114 | — |
| Brigham and Women's Hospital | Boston | Massachusetts | 02115 | — |
| Lahey Hospital & Medical Center | Burlington | Massachusetts | 01805 | — |
| Michigan Medicine | Ann Arbor | Michigan | 48109 | — |
| Henry Ford Medical Center | Detroit | Michigan | 48202 | — |
| Spectrum Health Medical Group Cardiovascular Medicine | Grand Rapids | Michigan | 49525 | — |
| M Health Fairview University of Minnesota Medical Center - East Bank | Minneapolis | Minnesota | 55455 | — |
| Mayo Clinic | Rochester | Minnesota | 55905 | — |
| Saint Luke's Hospital of Kansas City | Kansas City | Missouri | 64111 | — |
| Washington University School of Medicine | St Louis | Missouri | 63110 | — |
| Morristown Medical Center | Morristown | New Jersey | 07960 | — |
| NYU Langone Health | New York | New York | 10016 | — |
| Mount Sinai Hospital | New York | New York | 10029 | — |
| Columbia University Medical Center/NY Presbyterian Hospital | New York | New York | 10032 | — |
| Westchester Medical Center | Valhalla | New York | 10595 | — |
| Sanger Heart and Vascular Institute | Charlotte | North Carolina | 10595 | — |
| Sanger Heart and Vascular Institute - HCM Clinic | Charlotte | North Carolina | 28204 | — |
| Duke Health Center Arringdon | Morrisville | North Carolina | 27560 | — |
| Cleveland Clinic | Cleveland | Ohio | 44195 | — |
| The Ohio State University Wexner Medical Center | Columbus | Ohio | 43210 | — |
| Ascension St. John Clinical Research Institute | Tulsa | Oklahoma | 74104 | — |
| Oregon Health & Science University | Portland | Oregon | 97239 | — |
| Hospital of the University of Pennsylvania (University of Pennsylvania School of Medicine) | Philadelphia | Pennsylvania | 19104 | — |
| UPMC Presbyterian | Pittsburgh | Pennsylvania | 15213 | — |
| Stern Cardiovascular Foundation, Inc | Germantown | Tennessee | 38138 | — |
| Vanderbilt University Medical Center | Nashville | Tennessee | 37232 | — |
| The University of Texas Southwestern Medical Center | Dallas | Texas | 75390 | — |
| Houston Methodist Hospital | Houston | Texas | 77030 | — |
| University of Utah Hospital | Salt Lake City | Utah | 84132 | — |
| University of Virginia Health System University Hospital | Charlottesville | Virginia | 22908 | — |
| University of Washington Medical | Seattle | Washington | 98195 | — |
| Froedtert Hospital | Milwaukee | Wisconsin | 53226 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 66 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT05186818, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Mar 2, 2026 · Synced Jul 22, 2026
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Open the official record
The complete protocol, eligibility criteria, and contact information for NCT05186818 live on ClinicalTrials.gov.