4D-150 in Patients With Neovascular (Wet) Age-Related Macular Degeneration
Public ClinicalTrials.gov record NCT05197270. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Phase 1/2 Dose-Escalation and Randomized, Controlled, Masked Expansion Trial of Intravitreal 4D-150 Gene Therapy in Adults With Neovascular (Wet) Age-Related Macular Degeneration
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
Phase 1/2 dose-escalation and randomized, controlled, masked expansion trial in adults with wet AMD undergoing active anti-VEGF treatment. Substudies will evaluate the safety and tolerability of 4D-150 contralateral eye dosing and characterize vector shedding.
Study identification
- NCT ID
- NCT05197270
- Recruitment status
- Recruiting
- Study type
- Interventional
- Phase
- Phase 1, Phase 2
- Enrollment
- 215 participants
Conditions and interventions
Eligibility (public fields only)
- Age range
- 50 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Dec 8, 2021
- Primary completion
- Feb 28, 2027
- Completion
- Dec 31, 2030
- Last update posted
- Aug 20, 2026
2021 – 2031
United States locations
- U.S. sites
- 25
- U.S. states
- 16
- U.S. cities
- 24
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Barnet Delaney Perkins Eye Center | Phoenix | Arizona | 85016 | Recruiting |
| California Retina Consultants | Oxnard | California | 93036 | Recruiting |
| Retinal Consultants Medical Group | Sacramento | California | 95841 | Recruiting |
| Colorado Retina Associates | Lakewood | Colorado | 80288 | Recruiting |
| Rand Eye Institute | Deerfield Beach | Florida | 33064 | Suspended |
| Retina Group of Florida | Fort Lauderdale | Florida | 33308 | Recruiting |
| Retina Vitreous Consultants, LLP DBA Retina Group of Florida | Fort Lauderdale | Florida | 33308 | Active, not recruiting |
| Vitreo Retinal Associates | Gainesville | Florida | 32607 | Recruiting |
| Florida Eye Associates | Melbourne | Florida | 32901 | Recruiting |
| Retinal Specialty Institute | Pensacola | Florida | 32503 | Recruiting |
| Retina Vitreous Associates of Florida | Tampa | Florida | 33607 | Recruiting |
| University Retina and Macula Associates | Oak Forest | Illinois | 60452 | Recruiting |
| Retina Partners Midwest | Carmel | Indiana | 46290 | Recruiting |
| Cumberland Valley Retina Consultants | Hagerstown | Maryland | 21740 | Recruiting |
| Ophthalmic Consultants of Boston & Boston Eye Surgery and Laser Center | Boston | Massachusetts | 02114 | Recruiting |
| Sierra Eye Associates | Reno | Nevada | 89502 | Recruiting |
| Western Carolina Retinal Associates | Asheville | North Carolina | 28803 | Withdrawn |
| Verum Research, LLC | Eugene | Oregon | 97401 | Recruiting |
| Mid Atlantic Retina | Bethlehem | Pennsylvania | 18017 | Recruiting |
| Palmetto Retina Center, LLC | West Columbia | South Carolina | 29169 | Recruiting |
| Tennessee Retina | Nashville | Tennessee | 37203 | Recruiting |
| Austin Clinical Research | Austin | Texas | 78750 | Recruiting |
| Valley Retina Institute, PA | McAllen | Texas | 78503 | Recruiting |
| Retina Consultants of Texas | The Woodlands | Texas | 77384 | Withdrawn |
| Pacific Northwest Retina LLC | Bellevue | Washington | 98004 | Withdrawn |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 1 non-U.S. site.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT05197270, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Aug 20, 2026 · Synced Sep 2, 2026
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Open the official record
The complete protocol, eligibility criteria, and contact information for NCT05197270 live on ClinicalTrials.gov.