Study to Assess the Safety, Pharmacokinetics, and Efficacy of KPL-404 in Participants With Rheumatoid Arthritis With Inadequate Response or Intolerance to at Least One Biologic Disease-modifying Anti-rheumatic Drug or a Janus Kinase Inhibitor
Public ClinicalTrials.gov record NCT05198310. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Phase 2, Multicenter, Randomized, Double-blind, Placebo Controlled Study to Assess the Safety, Pharmacokinetics, and Efficacy of KPL-404 in Subjects With Moderate to Severe Active Rheumatoid Arthritis With Inadequate Response or Intolerance to at Least One Biologic Disease-modifying Anti-rheumatic Drug or a Janus Kinase Inhibitor
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
Phase 2 study of the safety, tolerability, pharmacokinetics (PK), pharmacodynamics (PD) and efficacy of KPL-404 in subjects with moderate to severe Rheumatoid Arthritis.
Study identification
- NCT ID
- NCT05198310
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 2
- Enrollment
- 145 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 18 Years to 80 Years
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Dec 14, 2021 (Actual)
- Primary completion
- Feb 8, 2024 (Actual)
- Completion
- May 6, 2024 (Actual)
- Last update posted
- Jul 22, 2025
2021 – 2024
United States locations
- U.S. sites
- 19
- U.S. states
- 7
- U.S. cities
- 18
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Carewell Arthritis Center | Apple Valley | California | 92307 | — |
| Medvin Clinical Research | Covina | California | 91722 | — |
| Inland Rheumatology Clinical Trials | Upland | California | 91786 | — |
| Medvin Clinical Research | Whittier | California | 90602 | — |
| International Medical Research | Daytona Beach | Florida | 32117 | — |
| Sweet Hope Research Specialty, Inc. | Hialeah | Florida | 33016 | — |
| San Marcus Research Clinic, Inc. | Miami Lakes | Florida | 33014 | — |
| Millennium Research | Ormond Beach | Florida | 32174 | — |
| West Broward Rheumatology Associates, Inc. | Tamarac | Florida | 33321 | — |
| Paramount Medical Research & Consulting, LLC | Middleburg Heights | Ohio | 44130 | — |
| Altoona Center for Clinical Research | Duncansville | Pennsylvania | 16635 | — |
| Saint Francis Hospital- Memphis | Memphis | Tennessee | 38119 | — |
| Arthritis and Rheumatology Research Institute | Allen | Texas | 75013 | — |
| Trinity Universal Research Assoc | Carrollton | Texas | 75007 | — |
| Arthritis & Osteoporosis Center of Coastal Bend | Corpus Christi | Texas | 78404 | — |
| Southwest Rheumatology Research LLC | Mesquite | Texas | 75150 | — |
| DM Clinical Research | Tomball | Texas | 77375 | — |
| Rheumatology Clinic of Houston | Tomball | Texas | 77377 | — |
| Rheumatology and Pulmonary Clinic | Beckley | West Virginia | 25801 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 23 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT05198310, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Jul 22, 2025 · Synced Oct 28, 2026
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Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT05198310 live on ClinicalTrials.gov.