A Study of a Mean Pulmonary Artery Pressure-Targeted Approach With Early and Rapid Treprostinil Therapy to Reverse Right Ventricular Remodeling in Participants With Pulmonary Arterial Hypertension
Public ClinicalTrials.gov record NCT05203510. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Phase 4, Prospective, Multicenter, Single-Arm Study of a Mean Pulmonary Artery Pressure-Targeted Approach With Early and Rapid Treprostinil Therapy to Reverse Right Ventricular Remodeling in Patients With Pulmonary Arterial Hypertension: ARTISAN (Afterload Reduction To Improve Right Ventricular Structure And FuNction)
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
The primary objective of this study is to assess the effect of early and rapid treprostinil therapy for mean pulmonary artery pressure (mPAP) reduction to improve right ventricular (RV) function and reverse RV remodeling in participants with pulmonary arterial hypertension (PAH).
Study identification
- NCT ID
- NCT05203510
- Recruitment status
- Active, not recruiting
- Study type
- Interventional
- Phase
- Phase 4
- Enrollment
- 52 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Oct 20, 2022 (Actual)
- Primary completion
- Apr 30, 2026 (Estimated)
- Completion
- Apr 30, 2028 (Estimated)
- Last update posted
- Dec 9, 2025
2022 – 2028
United States locations
- U.S. sites
- 28
- U.S. states
- 19
- U.S. cities
- 26
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Banner University Medical Center (University of Arizona) | Phoenix | Arizona | 85006 | — |
| HonorHealth John C. Lincoln Medical Center | Phoenix | Arizona | 85020 | — |
| University of California San Francisco - Fresno | Fresno | California | 93701 | — |
| Cedars-Sinai Medical Center | Los Angeles | California | 90048 | — |
| University of California Davis Medical Center | Sacramento | California | 95817 | — |
| University of California San Francisco Pulmonary, Critical Care, Allergy and Sleep Medicine | San Francisco | California | 94143 | — |
| Hartford Hospital | Hartford | Connecticut | 06106 | — |
| USF | Tampa | Florida | 33606 | — |
| Georgia Clinical Research | Austell | Georgia | 30106 | — |
| Northwestern Memorial Hospital | Chicago | Illinois | 60611 | — |
| Indiana University Health North Hospital | Indianapolis | Indiana | 46202 | — |
| Community Health Network | Indianapolis | Indiana | 46219 | — |
| Brigham and Women's Hospital | Boston | Massachusetts | 02115 | — |
| Henry Ford Health System | Detroit | Michigan | 48202 | — |
| University of Nebraska Medical Center | Omaha | Nebraska | 68198 | — |
| Morristown Medical Center | Morristown | New Jersey | 07960 | — |
| University of Rochester Medical Center | Rochester | New York | 14623 | — |
| University of North Carolina at Chapel Hill | Chapel Hill | North Carolina | 27599 | — |
| Duke University Medical Center | Durham | North Carolina | 27710 | — |
| University of Cincinnati | Cincinnati | Ohio | 45267 | — |
| The Ohio State University Wexner Medical Center | Columbus | Ohio | 43210 | — |
| Integris Baptist Medical Center | Oklahoma City | Oklahoma | 73112 | — |
| Oklahoma Heart Institute | Tulsa | Oklahoma | 74104 | — |
| Temple Hospital | Philadelphia | Pennsylvania | 19140 | — |
| Medical University of South Carolina | Charleston | South Carolina | 29425 | — |
| Prisma Health | Greenville | South Carolina | 29605 | — |
| UT Southwestern Medical Center | Dallas | Texas | 75390 | — |
| Carilion Clinic | Roanoke | Virginia | 24014 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT05203510, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Dec 9, 2025 · Synced Oct 19, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT05203510 live on ClinicalTrials.gov.