Efficacy and Safety of LYR-210 for the Treatment of Chronic Rhinosinusitis in Adults
Public ClinicalTrials.gov record NCT05219968. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
ENLIGHTEN 1: A Phase III, Randomized, Blinded, Controlled, Parallel-Group Trial to Evaluate the Efficacy and Safety of LYR-210 for the Treatment of Chronic Rhinosinusitis (CRS) in Adults
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
Multicenter, phase III, randomized, blinded, controlled, parallel group with safety extension phase with crossover or continued treatment.
Study identification
- NCT ID
- NCT05219968
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 3
- Enrollment
- 196 participants
Conditions and interventions
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Jan 27, 2022 (Actual)
- Primary completion
- Mar 4, 2024 (Actual)
- Completion
- Sep 16, 2024 (Actual)
- Last update posted
- May 2, 2025
2022 – 2024
United States locations
- U.S. sites
- 26
- U.S. states
- 13
- U.S. cities
- 24
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Lyra Investigational Site | Birmingham | Alabama | 35294-0012 | — |
| Lyra Investigational Site | Escondido | California | 92025 | — |
| Lyra Investigational Site | La Mesa | California | 91942 | — |
| Lyra Investigational Site | Sacramento | California | 95661 | — |
| Lyra Investigational Site | Torrance | California | 90503 | — |
| Lyra Investigational Site | Boca Raton | Florida | 33487-5713 | — |
| Lyra Investigational Site | Boynton Beach | Florida | 33426 | — |
| Lyra Investigational Site | Plantation | Florida | 33324 | — |
| Lyra Investigational Site | Port Saint Lucie | Florida | 34952 | — |
| Lyra Investigational Site | Chicago | Illinois | 60657 | — |
| Lyra Investigational Site | Louisville | Kentucky | 40220 | — |
| Lyra Investigational Site | Baltimore | Maryland | 21287 | — |
| Lyra Investigational Site | New Hyde Park | New York | 11042 | — |
| Lyra Investigational Site | New York | New York | 10003 | — |
| Lyra Investigational Site | New York | New York | 10016 | — |
| Lyra Investigational Site | New York | New York | 10029 | — |
| Lyra Investigational Site | Winston-Salem | North Carolina | 27103 | — |
| Lyra Investigational Site | Charleston | South Carolina | 29425 | — |
| Lyra Investigational Site | Spartanburg | South Carolina | 29303 | — |
| Lyra Investigational Site | Nashville | Tennessee | 37232-8605 | — |
| Lyra Investigational Site | Fort Worth | Texas | 76109 | — |
| Lyra Investigational Site | Houston | Texas | 77030 | — |
| Lyra Investigational Site | Mansfield | Texas | 76063 | — |
| Lyra Investigational Site | San Antonio | Texas | 78258 | — |
| Lyra Investigational Site | South Ogden | Utah | 84405 | — |
| Lyra Investigational Site | Norfolk | Virginia | 23507 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 29 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT05219968, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted May 2, 2025 · Synced Oct 20, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT05219968 live on ClinicalTrials.gov.