A Trial of 10 and 30 mg Doses of CVL-231 (Emraclidine) in Participants With Schizophrenia
Public ClinicalTrials.gov record NCT05227690. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Phase 2, Randomized, Double-blind, Placebo-controlled Trial to Evaluate the Efficacy, Safety, and Tolerability of Two Fixed Doses (10 mg and 30 mg QD) of CVL-231 (Emraclidine) in Participants With Schizophrenia Experiencing an Acute Exacerbation of Psychosis
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
This is a Phase 2, multicenter, randomized, double-blind, placebo-controlled, parallel-group, 6-week trial to evaluate the efficacy, safety, and tolerability of 2 fixed doses of CVL-231 (Emraclidine) (10 mg QD and 30 mg QD) in male and female participants who have schizophrenia and are experiencing an acute exacerbation of psychosis.
Study identification
- NCT ID
- NCT05227690
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 2
- Enrollment
- 385 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 18 Years to 65 Years
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Jun 30, 2022 (Actual)
- Primary completion
- Aug 23, 2024 (Actual)
- Completion
- Aug 26, 2024 (Actual)
- Last update posted
- Sep 17, 2025
2022 – 2024
United States locations
- U.S. sites
- 21
- U.S. states
- 9
- U.S. cities
- 21
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Little Rock, Arkansas | Little Rock | Arkansas | 72211-3702 | — |
| Anaheim, California | Anaheim | California | 92805-5854 | — |
| Garden Grove, California | Garden Grove | California | 92845-2506 | — |
| Lemon Grove, California | Lemon Grove | California | 91945-2956 | — |
| Montclair, California | Montclair | California | 91763-2231 | — |
| Riverside, California | Riverside | California | 92506-3257 | — |
| San Diego, California | San Diego | California | 92123 | — |
| Hialeah, Florida | Hialeah | Florida | 33012-4648 | — |
| Hollywood, Florida | Hollywood | Florida | 33021-5414 | — |
| Mangonia Park, Florida | Mangonia Park | Florida | 33407-2413 | — |
| Oakland Park, Florida | Oakland Park | Florida | 33334-4135 | — |
| Atlanta, Georgia | Atlanta | Georgia | 30328-4018 | — |
| Decatur, Georgia | Decatur | Georgia | 30030-3438 | — |
| Shreveport, Louisiana | Shreveport | Louisiana | 71101-4603 | — |
| Gaithersburg, Maryland | Gaithersburg | Maryland | 20877-1409 | — |
| Flowood, Mississippi | Flowood | Mississippi | 39232-8016 | — |
| North Canton, Ohio | North Canton | Ohio | 44720 | — |
| DeSoto, Texas | DeSoto | Texas | 75115-2092 | — |
| Houston, Texas | Houston | Texas | 77043-2735 | — |
| Irving, Texas | Irving | Texas | 75062-2323 | — |
| Richardson, Texas | Richardson | Texas | 75080 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 4 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT05227690, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Sep 17, 2025 · Synced Oct 20, 2026
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Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT05227690 live on ClinicalTrials.gov.