A Study of Combination Therapy With Guselkumab and Golimumab in Participants With Moderately to Severely Active Ulcerative Colitis
Public ClinicalTrials.gov record NCT05242484. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Phase 2b Randomized, Double-blind, Active-and Placebo-controlled, Parallel-group, Multicenter Study to Evaluate the Efficacy and Safety of Induction and Maintenance Combination Therapy With Guselkumab and Golimumab in Participants With Moderately to Severely Active Ulcerative Colitis
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
The purpose of this study is to evaluate the efficacy and safety of JNJ-78934804 as compared to guselkumab and golimumab in participants with moderately to severely active ulcerative colitis who have had an inadequate initial response, loss of response, or intolerance to one or more approved advanced therapy.
Study identification
- NCT ID
- NCT05242484
- Recruitment status
- Active, not recruiting
- Study type
- Interventional
- Phase
- Phase 2
- Enrollment
- 577 participants
Conditions and interventions
Conditions
Interventions
- Guselkumab Biological
- Golimumab Biological
- JNJ-78934804 Biological
- Placebo Drug
Biological · Drug
Eligibility (public fields only)
- Age range
- 18 Years to 65 Years
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Sep 19, 2022 (Actual)
- Primary completion
- May 15, 2025 (Actual)
- Completion
- Mar 27, 2029 (Estimated)
- Last update posted
- Sep 28, 2026
2022 – 2029
United States locations
- U.S. sites
- 63
- U.S. states
- 25
- U.S. cities
- 57
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Valley Gastroenterology Medical Group | Arcadia | California | 91006 | — |
| Southern California Research Center | Coronado | California | 92118 | — |
| Om Research LLC | Lancaster | California | 93534 | — |
| Cedars Sinai Medical Center | Los Angeles | California | 90048 | — |
| University of California San Francisco | San Francisco | California | 94115 | — |
| University of Colorado | Aurora | Colorado | 80045 | — |
| Peak Gastroenterology Associates | Colorado Springs | Colorado | 80907 | — |
| Medical Research Center of Connecticut | Hamden | Connecticut | 06518 | — |
| Yale University | New Haven | Connecticut | 06510 | — |
| MedStar Georgetown University Hospital | Washington D.C. | District of Columbia | 20007 | — |
| Pioneer Research Solutions Inc. | Coconut Creek | Florida | 33066 | — |
| Digestive and Liver Disease Institute | Kissimmee | Florida | 34741 | — |
| Osceola Regional Hospital | Kissimmee | Florida | 34741 | — |
| Florida Research Center Inc. | Lakewood Rch | Florida | 34211 | — |
| University of Miami | Miami | Florida | 33136 | — |
| Gastroenterology Group Of Naples | Naples | Florida | 34102 | — |
| Omega Research Consultants | Orlando | Florida | 32808 | — |
| Synergy Clinical Research | St. Petersburg | Florida | 33705 | — |
| GCP Clinical Research | Tampa | Florida | 33609 | — |
| Atlanta Gastroenterology Associates | Atlanta | Georgia | 30342 | — |
| Gastroenterolgy Associates of Central GA | Macon | Georgia | 31201 | — |
| Atlanta Gastroenterology Associates 1 | Marietta | Georgia | 30060 | — |
| Gastrointestinal Specialists of Georgia | Marietta | Georgia | 30060 | — |
| Gastroenterology Consultants | Roswell | Georgia | 30076 | — |
| Grand Teton Gastroenterology | Idaho Falls | Idaho | 83404 | — |
| IU Health University Hospital | Indianapolis | Indiana | 46202 | — |
| Gastroenterology of Southern Indiana | New Albany | Indiana | 47150 | — |
| Tri-State Gastroenterology Assoc | Crestview Hills | Kentucky | 41017 | — |
| University of Kentucky Chandler Medical Center | Lexington | Kentucky | 40536 | — |
| Jewish Hospital | Louisville | Kentucky | 40202 | — |
| Chevy Chase Clinical Research | Chevy Chase | Maryland | 20815-7313 | — |
| Beth Israel Deaconess Medical Center | Boston | Massachusetts | 02215-5400 | — |
| Brigham And Women's Hospital | Chestnut Hill | Massachusetts | 02467 | — |
| Huron Gastroenterology Associates Center for Digestive Care | Ypsilanti | Michigan | 48197 | — |
| Washington University | St Louis | Missouri | 63110 | — |
| Las Vegas Medical Research | Las Vegas | Nevada | 89113 | — |
| Care Access Las Vegas | Las Vegas | Nevada | 89148 | — |
| Dartmouth Hitchcock | Lebanon | New Hampshire | 03756 | — |
| Weill Cornell Medical College | New York | New York | 10021 | — |
| Lenox Hill Hospital | New York | New York | 10075 | — |
| Mohawk Valley Endoscopy Center | Utica | New York | 13502-6313 | — |
| University North Carolina at Chapel Hill | Chapel Hill | North Carolina | 27599 | — |
| Tryon Medical Group | Charlotte | North Carolina | 28210 | — |
| Onsite Clinical Solutions | Charlotte | North Carolina | 28277 | — |
| Care Access Research, Kinston | Kinston | North Carolina | 28501 | — |
| Great Lakes Gastroenterology Research, LLC | Mentor | Ohio | 44060 | — |
| Frontier Clinical Research | Uniontown | Pennsylvania | 15401 | — |
| Medical University of South Carolina | Charleston | South Carolina | 29425 | — |
| Digestive Disease Associates | Rock Hill | South Carolina | 29732 | — |
| Gastro One | Germantown | Tennessee | 38138 | — |
| Etsu Quillen College Of Medicine | Johnson City | Tennessee | 37604 | — |
| Vanderbilt University Medical Center | Nashville | Tennessee | 37067 | — |
| UT Southwestern Medical Center | Dallas | Texas | 75390-9063 | — |
| GI Specialists of Houston | Houston | Texas | 77346 | — |
| Gastroenterology Clinic Of San Antonio P A | San Antonio | Texas | 78229 | — |
| Texas Digestive Disease Consultants | Southlake | Texas | 76092 | — |
| Tyler Research Institute, LLC | Tyler | Texas | 75701 | — |
| Medical College Of Virginia Hospital | Richmond | Virginia | 23249 | — |
| Washington Gastroenterology, PLLC | Bellevue | Washington | 98004 | — |
| Swedish Medical Center | Seattle | Washington | 98104 | — |
| Virginia Mason Medical Center | Seattle | Washington | 98111 | — |
| Digestive Health Specialists | Tacoma | Washington | 98405 | — |
| Medical College Of Wisconsin | Milwaukee | Wisconsin | 53226-3522 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 340 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT05242484, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Sep 28, 2026 · Synced Oct 23, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT05242484 live on ClinicalTrials.gov.