A Study to Assess Adverse Events of Intramuscular AGN-151586 Injection in Adult Participants With Glabellar Lines
Public ClinicalTrials.gov record NCT05248893. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Phase 3, Multicenter, Open-label Study to Evaluate the Safety of AGN-151586 for the Treatment of Glabellar Lines
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
Facial lines that develop from repeated facial expression, such as glabellar lines (GL), are typically treated by selectively weakening specific muscles with botulinum toxin. The primary purpose of this study is to evaluate the safety of AGN-151586 over up to three treatments of the study drug to improve the appearance of glabellar lines. AGN-151586 is an investigational product being developed for the treatment of GL. Around 940 to 1100 adult participants with moderate to severe GL will be enrolled in the study in approximately 45 sites in the United States. This is an open-label study in which all participants will receive 5 intramuscular AGN-151586 injections to the glabellar complex on Day 1. Participants meeting retreatment criteria may receive up to 2 additional doses of treatment during the study. Participants will attend regular visits during the study at a study site. The effect of the treatment will be checked by medical assessments, blood tests, telephone calls, questionnaires and checking for side effects.
Study identification
- NCT ID
- NCT05248893
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 3
- Enrollment
- 992 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Feb 25, 2022 (Actual)
- Primary completion
- Jun 26, 2023 (Actual)
- Completion
- Jun 26, 2023 (Actual)
- Last update posted
- Sep 25, 2026
2022 – 2023
United States locations
- U.S. sites
- 41
- U.S. states
- 21
- U.S. cities
- 39
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Skin Wellness Dermatology - Homewood /ID# 241233 | Birmingham | Alabama | 35209-8314 | — |
| Advanced Research Associates - Glendale /ID# 232245 | Glendale | Arizona | 85308 | — |
| Skin Care and Laser Physicians of Beverly Hills /ID# 241237 | Los Angeles | California | 90069 | — |
| The Eye Research Foundation /ID# 232229 | Newport Beach | California | 92663-3637 | — |
| Cosmetic Laser Dermatology /ID# 243513 | San Diego | California | 92121-2119 | — |
| UC San Diego Health - University Center Lane - La Jolla /ID# 241243 | San Diego | California | 92122-1013 | — |
| Ava T. Shamban MD - Santa Monica. /ID# 241246 | Santa Monica | California | 90404-2208 | — |
| Art of Skin MD /ID# 241244 | Solana Beach | California | 92075-2228 | — |
| Moradi MD /ID# 241242 | Vista | California | 92083-6030 | — |
| AboutSkin Research, LLC /ID# 241702 | Greenwood Village | Colorado | 80111 | — |
| Susan H. Weinkle MD /ID# 233835 | Bradenton | Florida | 34209-5642 | — |
| Skin Research Institute LLC /ID# 232240 | Coral Gables | Florida | 33146-1837 | — |
| Skin and Cancer Associates, LLP /ID# 232228 | Miami | Florida | 33137-3254 | — |
| ForCare Clinical Research /ID# 241229 | Tampa | Florida | 33613-1244 | — |
| Hamilton Research, LLC /ID# 241232 | Alpharetta | Georgia | 30022 | — |
| Atlanta Biomedical Clinical Research /ID# 241258 | Atlanta | Georgia | 30331-2160 | — |
| Meridian Clinical Research Dermatology /ID# 241234 | Savannah | Georgia | 31406-2632 | — |
| DeNova Research /ID# 232231 | Chicago | Illinois | 60611 | — |
| Advanced Dermatology /ID# 241252 | Lincolnshire | Illinois | 60069 | — |
| Laser and Skin Surgery Center of Indiana /ID# 233834 | Indianapolis | Indiana | 46260-2386 | — |
| Coleman Center For Cosmetic Dermatologic Surgery /ID# 232230 | Metairie | Louisiana | 70006 | — |
| Etre Cosmetic Dermatology and Laser Center /ID# 232235 | New Orleans | Louisiana | 70130-4353 | — |
| Visage Dermatology and Aesthetic Center /ID# 241248 | Largo | Maryland | 20774-5341 | — |
| Rkmd, Llc /Id# 241239 | North Bethesda | Maryland | 20852-3093 | — |
| Michigan Center for Research Company /ID# 241255 | Clarkston | Michigan | 48346 | — |
| Rao Dermatology /ID# 243515 | Atlantic Highlands | New Jersey | 07716-1241 | — |
| image Dermatology, P.C. /ID# 241227 | Montclair | New Jersey | 07042 | — |
| The Rejuva Center /ID# 244285 | Latham | New York | 12110 | — |
| Mariwalla Dermatology /ID# 241240 | West Islip | New York | 11795-4916 | — |
| Northwest Dermatology Institute /ID# 233498 | Portland | Oregon | 97210-2859 | — |
| Perelman Center for Advanced Medicine - /ID# 243966 | Philadelphia | Pennsylvania | 19104-5127 | — |
| Sherman Aesthetic Center /ID# 241247 | Nashville | Tennessee | 37205-2205 | — |
| Tennessee Clinical Research Center /ID# 241254 | Nashville | Tennessee | 37215-2885 | — |
| DermResearch, Inc. Austin, TX /ID# 241228 | Austin | Texas | 78759 | — |
| Bellaire Dermatology Associates /ID# 232243 | Bellaire | Texas | 77401 | — |
| J&S Studies, Inc. /ID# 241236 | College Station | Texas | 77845-3898 | — |
| Dallas Center for Dermatology and Aesthetics /ID# 241245 | Dallas | Texas | 75225-6203 | — |
| Swinyer-Woseth Dermatology /ID# 241250 | Salt Lake City | Utah | 84117-4209 | — |
| The Education & Research Foundation, Inc. /ID# 241225 | Lynchburg | Virginia | 24501-1403 | — |
| Premier Clinical Research /ID# 233836 | Spokane | Washington | 99202 | — |
| EthiQ2 Research, LLC /ID# 241256 | Brookfield | Wisconsin | 53005 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 2 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT05248893, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Sep 25, 2026 · Synced Oct 25, 2026
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Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT05248893 live on ClinicalTrials.gov.