A Study to Evaluate the Efficacy and Safety of Gantenerumab in Participants at Risk for or at the Earliest Stages of Alzheimer's Disease (AD)
Public ClinicalTrials.gov record NCT05256134. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Phase III, Multicenter, Randomized, Parallel-Group, Double-Blind, Placebo-Controlled Study to Evaluate the Efficacy and Safety of Gantenerumab in Participants at Risk for or at the Earliest Stages of Alzheimer's Disease
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
A study to evaluate the efficacy and safety of gantenerumab in amyloid-positive, cognitively unimpaired participants at risk for or at the earliest stages of AD. The planned number of participants for this study is approximately 1200 participants randomized in a 1:1 ratio to receive either gantenerumab or placebo (600 participants randomized to gantenerumab and 600 participants randomized to placebo).
Study identification
- NCT ID
- NCT05256134
- Recruitment status
- Terminated
- Study type
- Interventional
- Phase
- Phase 3
- Enrollment
- 25 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 60 Years to 80 Years
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Apr 19, 2022 (Actual)
- Primary completion
- Mar 13, 2023 (Actual)
- Completion
- Mar 13, 2023 (Actual)
- Last update posted
- Jun 12, 2025
2022 – 2023
United States locations
- U.S. sites
- 32
- U.S. states
- 15
- U.S. cities
- 31
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Banner Alzheimer?s Institute | Phoenix | Arizona | 85006 | — |
| Banner Sun Health Research Insitute | Sun City | Arizona | 85351 | — |
| Banner Alzheimer's Institute | Tucson | Arizona | 85718 | — |
| California Neuroscience Research Medical Group, Inc | Sherman Oaks | California | 91403 | — |
| JEM Research LLC | Atlantis | Florida | 33462 | — |
| Visionary Investigators Network - Neurology Aventura | Aventura | Florida | 33180 | — |
| Bradenton Research Center | Bradenton | Florida | 34205 | — |
| Brain Matters Research, Inc. | Delray Beach | Florida | 33445 | — |
| Neuropsychiatric Research; Center of Southwest Florida | Fort Myers | Florida | 33912 | — |
| ClinCloud, LLC | Maitland | Florida | 32751 | — |
| K2 Medical Research, LLC | Maitland | Florida | 32751 | — |
| Optimus U Corp | Miami | Florida | 33125 | — |
| Renstar Medical Research | Ocala | Florida | 34470 | — |
| Charter Research - Winter Park/Orlando | Orlando | Florida | 32803 | — |
| Progressive Medical Research | Port Orange | Florida | 32127 | — |
| Alzheimer's Research and Treatment Center | Stuart | Florida | 34997 | — |
| Charter Research - Lady Lake/The Villages | The Villages | Florida | 32162 | — |
| Alzheimer?s Research and Treatment Center | Wellington | Florida | 33414 | — |
| Premiere Research Institute | West Palm Beach | Florida | 33407 | — |
| Center for Advanced Research & Education | Gainesville | Georgia | 30501 | — |
| Great Lakes Clinical Trials | Chicago | Illinois | 60640 | — |
| Via Christi Research | Wichita | Kansas | 67214 | — |
| Tandem Clinical Research, LLC | Marrero | Louisiana | 70072 | — |
| Quest Research Institute | Farmington Hills | Michigan | 48334 | — |
| University of Nebraska Medical Center; Dept of Neurological Sciences | Omaha | Nebraska | 68198-8440 | — |
| The Cognitive and Research Center of New Jersey | Springfield | New Jersey | 07081 | — |
| Velocity Clinical Research | East Syracuse | New York | 13057 | — |
| Alzheimer's Memory Center | Matthews | North Carolina | 28105 | — |
| Ohio State University; College of Medicine | Columbus | Ohio | 43210 | — |
| Senior Adults Specialty Research | Austin | Texas | 78757 | — |
| Kerwin Medical Center | Dallas | Texas | 75231 | — |
| Re:Cognition Health | Fairfax | Virginia | 22031 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 31 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT05256134, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Jun 12, 2025 · Synced Oct 21, 2026
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Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT05256134 live on ClinicalTrials.gov.