A Research Study to See How Well the New Weekly Medicine IcoSema, Which is a Combination of Insulin Icodec and Semaglutide, Controls Blood Sugar Level in People With Type 2 Diabetes Compared to Weekly Semaglutide (COMBINE 2)
Public ClinicalTrials.gov record NCT05259033. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A 52 Week Study Comparing the Efficacy and Safety of Once Weekly IcoSema and Once Weekly Semaglutide, Both Treatment Arms With or Without Oral Anti Diabetic Drugs, in Participants With Type 2 Diabetes Inadequately Controlled With a GLP 1 Receptor Agonist. COMBINE 2
Study identification
- NCT ID
- NCT05259033
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 3
- Lead sponsor
- Novo Nordisk A/S
- Industry
- Enrollment
- 683 participants
Conditions and interventions
Conditions
Interventions
- IcoSema Drug
- Semaglutide 1 mg Drug
Drug
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Apr 10, 2022
- Primary completion
- Dec 12, 2023
- Completion
- Jan 15, 2024
- Last update posted
- Jul 8, 2025
2022 – 2024
United States locations
- U.S. sites
- 50
- U.S. states
- 23
- U.S. cities
- 44
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Univ of AL at Birmingham_BRM | Birmingham | Alabama | 35294 | — |
| Pri Med Grp dba/Gil Ctr Fam | Gilbert | Arizona | 85296 | — |
| Clinical Research Institute of Arizona | Sun City West | Arizona | 85375 | — |
| John Muir Physicians Network | Concord | California | 94520 | — |
| Velocity Clin Res Los Angeles | Los Angeles | California | 90017 | — |
| Velocity Clin Res Wstlke | Los Angeles | California | 90057 | — |
| Valley Clinical Trials, Inc. | Northridge | California | 91325 | — |
| Premier Medical Center, Inc. | Toluca Lake | California | 91602 | — |
| Northeast Research Institute | Fleming Island | Florida | 32003 | — |
| Northeast Res Inst. Inc. | Jacksonville | Florida | 32204 | — |
| Est Cst Inst for Rsrch,Jksnvil | Jacksonville | Florida | 32216 | — |
| South Broward Research LLC | Miramar | Florida | 33027 | — |
| Adult Medicine of Lake County, Inc. | Mt. Dora | Florida | 32757 | — |
| Florida Inst For Clin Res | Orlando | Florida | 32825 | — |
| Florida Institute For Clinical Research | Orlando | Florida | 32825 | — |
| Oviedo Medical Research, LLC | Oviedo | Florida | 32765 | — |
| Metabolic Research Institute Inc | West Palm Beach | Florida | 33401 | — |
| Javara/Privia Med Grp GA,LLC | Albany | Georgia | 31707 | — |
| East West Med Res Inst | Honolulu | Hawaii | 96814 | — |
| Saltzer Medical Group Research | Nampa | Idaho | 83686-6011 | — |
| Endeavor Health | Skokie | Illinois | 60077 | — |
| Ileana J Tandron APMC | Slidell | Louisiana | 70461-4231 | — |
| MedStar Hlth Res Institute | Hyattsville | Maryland | 20782 | — |
| Northern Pines Hlth Ctr, PC | Buckley | Michigan | 49620 | — |
| Palm Research Center Inc-Vegas | Las Vegas | Nevada | 89148 | — |
| John J Shelmet, MD | Lawrenceville | New Jersey | 08648 | — |
| Albuquerque Clin Trials, Inc. | Albuquerque | New Mexico | 87102 | — |
| Southgate Medical Group, LLP | West Seneca | New York | 14224 | — |
| PharmQuest Life Sciences LLC | Greensboro | North Carolina | 27408 | — |
| Diab & Endo Assoc of Stark Co | Canton | Ohio | 44718 | — |
| New Venture Medical Research | Wadsworth | Ohio | 44281 | — |
| Thomas Jefferson Univ Di Rsrch Ctr | Philadelphia | Pennsylvania | 19107 | — |
| Palmetto Clinical Research | Summerville | South Carolina | 29485 | — |
| AM Diabetes And Endocrinology Center | Bartlett | Tennessee | 38133 | — |
| Chattanooga Medical Research, LLC | Chattanooga | Tennessee | 37404 | — |
| Amarillo Med Spec LLP | Amarillo | Texas | 79106 | — |
| Texas Diab & Endo, P.A. | Austin | Texas | 78731 | — |
| Texas Diabetes & Endocrinology | Austin | Texas | 78749 | — |
| Osvaldo A. Brusco MD PA | Corpus Christi | Texas | 78414 | — |
| North Texas Endocrine Center | Dallas | Texas | 75231 | — |
| UT Southwestern Med Cntr | Dallas | Texas | 75390-9302 | — |
| Diabetes and Thyroid Ctr of FW | Fort Worth | Texas | 76132 | — |
| DCOL Ctr for Clin Res | Longview | Texas | 75605 | — |
| Texas Diabetes & Endocrinology_Round Rock | Round Rock | Texas | 78681 | — |
| NE Clin Res of San Antonio | San Antonio | Texas | 78233 | — |
| Sugar Lakes Family Practice PA | Sugar Land | Texas | 77479 | — |
| Chrysalis Clinical Research | St. George | Utah | 84790 | — |
| Javara Inc. / Privia Medical Group LLC_Forest | Forest | Virginia | 24551 | — |
| Javara Inc/Privia Md GpLLC Fst | Forest | Virginia | 24551 | — |
| TPMG Clinical Research | Newport News | Virginia | 23606 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 86 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT05259033, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Jul 8, 2025 · Synced May 5, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete protocol, eligibility criteria, and contact information for NCT05259033 live on ClinicalTrials.gov.