Piromelatine 20 mg in Participants With Mild Dementia Due to Alzheimer's Disease
Public ClinicalTrials.gov record NCT05267535. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
Randomized, Delayed Start, Double Blind, Parallel Group, Placebo Controlled, Multicenter Study of Piromelatine 20 mg in Participants With Mild Dementia Due to Alzheimer's Disease
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
Randomized efficacy and safety study of piromelatine 20 mg versus placebo in participants with mild dementia due to Alzheimer's disease (AD) who are 2:107,510,000-107,540,000 polymorphism non-carriers with the primary objective to compare the effect of piromelatine to that of placebo on the AD Assessment Scale cognitive subscale (ADAS-cog14) at Week 26 of double-blind treatment.
Study identification
- NCT ID
- NCT05267535
- Recruitment status
- Terminated
- Study type
- Interventional
- Phase
- Phase 2, Phase 3
- Enrollment
- 216 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 60 Years to 85 Years
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Jun 15, 2022 (Actual)
- Primary completion
- Sep 12, 2024 (Actual)
- Completion
- Dec 12, 2024 (Actual)
- Last update posted
- Sep 9, 2026
2022 – 2024
United States locations
- U.S. sites
- 32
- U.S. states
- 11
- U.S. cities
- 24
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| ATP Clinical Research | Costa Mesa | California | 92626 | — |
| Collaborative Neuroscience Research, LLC | Long Beach | California | 90806 | — |
| Asclepes Research Centers, P.C. Dba Alliance Research | Long Beach | California | 90807 | — |
| Pacific Research Network, LLC | San Diego | California | 92103 | — |
| RAA Apex Acquisition LLC DBA Syrentis Clinical Research | Santa Ana | California | 92705 | — |
| The Mile High Research Center | Denver | Colorado | 80218 | — |
| Linfritz Research Institute Inc. | Coral Gables | Florida | 33134 | — |
| Finlay Medical Research Corp. | Greenacres City | Florida | 33467 | — |
| Velocity Clinical Research, Inc | Hallandale | Florida | 33009 | — |
| K2 Medical Research The Villages | Lady Lake | Florida | 32159 | — |
| Verus Clinical research Corp | Miami | Florida | 33125 | — |
| BioMed Research Institute, Inc. | Miami | Florida | 33126 | — |
| CCM Clinical Research Group, LLC | Miami | Florida | 33133 | — |
| Advance Medical Research Center | Miami | Florida | 33135 | — |
| Allied Biomedical Research Institute (Clinical Trials) | Miami | Florida | 33135 | — |
| Vitae Research Center LLC. | Miami | Florida | 33135 | — |
| Stein Gerontological Institute, Inc. | Miami | Florida | 33137 | — |
| Miami Dade Medical Research Institute | Miami | Florida | 33176 | — |
| K2 Medical Research Winter Garden | Ocoee | Florida | 34761 | — |
| Interspond, LLC, | Orlando | Florida | 32807 | — |
| The University of South Florida Board of Trustees, | Tampa | Florida | 33613 | — |
| Alzheimer's Research and Treatment Center | Wellington | Florida | 33414 | — |
| Velocity Clinical Research, Inc | Meridian | Idaho | 83642 | — |
| Ocean Medical Research | Jersey City | New Jersey | 08755, | — |
| Advanced Memory Research Institute of New Jersey | Toms River | New Jersey | 08755 | — |
| Integrative Clinical Trials LLC | Brooklyn | New York | 11229 | — |
| New York University School of Medicine | New York | New York | 10016 | — |
| AMC Research, LLC | Matthews | North Carolina | 28105 | — |
| Rhode Island mood and memory research institute | Island Park | Rhode Island | 02914 | — |
| Neurology Clinic, P.C. | Cordova | Tennessee | 38018 | — |
| Northwest Clinical Research Center | Bellevue | Washington | 98007 | — |
| Froedtert & Medical College of Wisconsin | Milwaukee | Wisconsin | 53226 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 5 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT05267535, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Sep 9, 2026 · Synced Oct 22, 2026
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Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT05267535 live on ClinicalTrials.gov.