ClinicalTrials.gov record
EVOLVE-MI: EVOLocumab Very Early After Myocardial Infarction
ClinicalTrials.gov ID: NCT05284747
Public ClinicalTrials.gov record NCT05284747. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
ClinicalTrials.gov public records Last synced May 19, 2026, 11:47 AM EDT
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
EVOLVE-MI: A Pragmatic Randomized Multicenter Trial of EVOLocumab Administered Very Early to Reduce the Risk of Cardiovascular Events in Patients Hospitalized With Acute Myocardial Infarction
Study identification
- NCT ID
- NCT05284747
- Recruitment status
- Active, not recruiting
- Study type
- Interventional
- Phase
- Phase 4
- Lead sponsor
- Amgen
- Industry
- Enrollment
- 6,019 participants
Conditions and interventions
Interventions
- Evolocumab Drug
- Routine Lipid Management Drug
Drug
Eligibility (public fields only)
- Age range
- 18 Years to 99 Years
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Oct 25, 2022
- Primary completion
- May 28, 2027
- Completion
- May 28, 2027
- Last update posted
- Oct 5, 2025
2022 – 2027
United States locations
- U.S. sites
- 81
- U.S. states
- 28
- U.S. cities
- 76
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| University of Alabama at Birmingham | Birmingham | Alabama | 35294 | — |
| Eastern Shore Research Institute | Fairhope | Alabama | 36532 | — |
| Heart Center Research LLC | Huntsville | Alabama | 35801-4317 | — |
| Northern Arizona Healthcare Corporation Cardiovascular Institute | Flagstaff | Arizona | 86001 | — |
| Scottsdale Healthcare at Shea - HonorHealth | Scottsdale | Arizona | 85258 | — |
| Pima Heart and Vascular Clinical Research | Tucson | Arizona | 85719 | — |
| John Muir Health and Cardiovascular Institute | Concord | California | 94520 | — |
| VA Greater Los Angeles Healthcare System | Los Angeles | California | 90073 | — |
| University of California Los Angeles | Los Angeles | California | 90095 | — |
| University of California-Irvine | Orange | California | 92868 | — |
| University of Colorado Hospital | Aurora | Colorado | 80045 | — |
| Bridgeport Hospital | Bridgeport | Connecticut | 06610 | — |
| Hartford Hospital | Hartford | Connecticut | 06106 | — |
| Cardiology Associates of Fairfield County PC | Stamford | Connecticut | 06905 | — |
| Excel Medical Clinical Trials | Boca Raton | Florida | 33434 | — |
| Clearwater Cardiovascular Consultants | Clearwater | Florida | 33756 | — |
| University of Florida at Gainesville | Gainesville | Florida | 32610 | — |
| University of Florida and Shands Hospital | Jacksonville | Florida | 32209 | — |
| AdventHealth Orlando | Orlando | Florida | 32803 | — |
| Cardiology Partners Clinical Research Institute | Palm Beach Gardens | Florida | 33410 | — |
| Baptist Health Care | Pensacola | Florida | 32501 | — |
| Ascension Sacred Heart | Pensacola | Florida | 32504 | — |
| Clearwater Cardiovascular Consultants | Safety Harbor | Florida | 34695 | — |
| Tampa Cardiovascular Interventions and Research | Tampa | Florida | 33614 | — |
| Clinical Site Partners Orlando dba Flourish Research | Winter Park | Florida | 32789 | — |
| Saint Lukes Boise Medical Center | Boise | Idaho | 83712 | — |
| Jesse Brown Veterans Affairs Medical Center | Chicago | Illinois | 60612 | — |
| Great Lakes Clinical Trials - Ravenswood | Chicago | Illinois | 60640 | — |
| Advocate Lutheran General Hospital | Park Ridge | Illinois | 60068 | — |
| Ascension Saint Vincent Heart Center | Indianapolis | Indiana | 46290 | — |
| Reid Physician Associates | Richmond | Indiana | 47374 | — |
| University of Kansas Hospital | Kansas City | Kansas | 66160 | — |
| Midwest Heart and Vascular Specialists | Overland Park | Kansas | 66211 | — |
| University of Louisville Health - Jewish Hospital | Louisville | Kentucky | 40202 | — |
| Massachusetts General Hospital | Boston | Massachusetts | 02114 | — |
| Henry Ford Hospital | Detroit | Michigan | 48202 | — |
| Healthy Heart Cardiology | Grand Rapids | Michigan | 49546 | — |
| Sparrow Clinical Research Institute | Lansing | Michigan | 48912 | — |
| McLaren Macomb Research Services | Mount Clemens | Michigan | 48043 | — |
| McLaren Northern Michigan Hospital | Petoskey | Michigan | 49770 | — |
| Advanced Cardiology Associates | Rochester Hills | Michigan | 48307 | — |
| Essentia Health Saint Marys Medical Center | Duluth | Minnesota | 55805 | — |
| Jackson Heart | Jackson | Mississippi | 39216 | — |
| Cardiology Associates of North Mississippi | Tupelo | Mississippi | 38801 | — |
| Saint Lukes Hospital of Kansas City | Kansas City | Missouri | 64111 | — |
| North Kansas City Hospital | North Kansas City | Missouri | 64116 | — |
| Advanced Heart Care LLC | Bridgewater | New Jersey | 08807 | — |
| Hackensack University Medical Center | Hackensack | New Jersey | 07601 | — |
| Saint Michaels Medical Center | Newark | New Jersey | 07102 | — |
| South Shore University Hospital Northwell Health | Bay Shore | New York | 11706 | — |
| New York Presbyterian-Weill Cornell Medical Center | New York | New York | 10065 | — |
| Hudson Valley Cardiovascular Practice PC | Poughkeepsie | New York | 12601 | — |
| University of Rochester Medical Center | Rochester | New York | 14642 | — |
| Richmond University Medical Center | Staten Island | New York | 10310 | — |
| Stony Brook Medicine | Stony Brook | New York | 11794 | — |
| Montefiore Medical Center | The Bronx | New York | 10580 | — |
| University of North Carolina Cardiology | Chapel Hill | North Carolina | 27599 | — |
| Novant Health Heart and Vascular Institute Presbyterian Medical Center | Charlotte | North Carolina | 28204 | — |
| Moses H Cone Memorial Hospital | Greensboro | North Carolina | 27401 | — |
| Aultman Hospital | Canton | Ohio | 44710 | — |
| The Ohio State University Wexner Medical Center | Columbus | Ohio | 43210 | — |
| Genesis Healthcare System | Zanesville | Ohio | 43701 | — |
| Ascension Saint John Bartlesville | Tulsa | Oklahoma | 74104 | — |
| Ascension Saint John Tulsa | Tulsa | Oklahoma | 74104 | — |
| Wellspan Chambersburg Hospital | Chambersburg | Pennsylvania | 17201 | — |
| Lancaster General Hospital/The Heart Group of Lancaster | Lancaster | Pennsylvania | 17603 | — |
| Reading Hospital Tower Health | West Reading | Pennsylvania | 19611 | — |
| Rhode Island Hospital | Providence | Rhode Island | 02903 | — |
| Kent Hospital | Warwick | Rhode Island | 02886 | — |
| Prisma Upstate and Midlands Greenville Hospital System | Columbia | South Carolina | 29203 | — |
| Upstate Cardiology | Greenville | South Carolina | 29607 | — |
| Tennova Healthcare-Turkey Creek Medical Center | Knoxville | Tennessee | 37934 | — |
| Ascension Saint Thomas Nashville | Nashville | Tennessee | 37205 | — |
| Vanderbilt University Medical Center | Nashville | Tennessee | 37232-8802 | — |
| Parkway Cardiology Associates | Oak Ridge | Tennessee | 37830 | — |
| Cardiovascular Research of Knoxville North Knoxville Medical Center | Powell | Tennessee | 37849 | — |
| Ascension Texas Cardiovascular | Austin | Texas | 78705 | — |
| Ascension Texas Cardiovascular Kyle | Kyle | Texas | 78640 | — |
| Bon Secours St Marys Hospital Richmond | Midlothian | Virginia | 23114 | — |
| Chippenham Hospital | Richmond | Virginia | 23225 | — |
| Aurora Saint Lukes Medical Center | Milwaukee | Wisconsin | 53215 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 39 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT05284747, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Oct 5, 2025 · Synced May 19, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete protocol, eligibility criteria, and contact information for NCT05284747 live on ClinicalTrials.gov.