Efficacy and Safety of LYR-210 for the Treatment of Chronic Rhinosinusitis in Adults (ENLIGHTEN 2)
Public ClinicalTrials.gov record NCT05295459. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
ENLIGHTEN 2: A Phase III, Randomized, Blinded, Controlled, Parallel-Group Trial to Evaluate the Efficacy and Safety of LYR-210 for the Treatment of Chronic Rhinosinusitis in Adults
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
Multicenter, phase III, randomized, blinded, controlled, parallel group.
Study identification
- NCT ID
- NCT05295459
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 3
- Enrollment
- 182 participants
Conditions and interventions
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- May 12, 2022
- Primary completion
- Apr 1, 2025
- Completion
- Apr 1, 2025
- Last update posted
- Feb 18, 2026
2022 – 2025
United States locations
- U.S. sites
- 31
- U.S. states
- 15
- U.S. cities
- 28
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Novak Clinical Trials | Tucson | Arizona | 85741 | — |
| Keck School of Medicine at USC Medical Center | Arcadia | California | 91007 | — |
| Sensa Health Clinical Research | Los Angeles | California | 90006 | — |
| Cedars-Sinai Medical Center | Los Angeles | California | 90048 | — |
| University of California - Irvine Medical Center | Orange | California | 92868 | — |
| Sacramento Ear Nose and Throat Surgical and Medical Group, Inc | Roseville | California | 95661 | — |
| University of California - Davis | Sacramento | California | 95817 | — |
| Regional Head & Neck Consulting - SENTA Clinic | San Diego | California | 92108 | — |
| Breathe Clear Institute | Torrance | California | 90503 | — |
| Colorado ENT and Allergy | Colorado Springs | Colorado | 80909 | — |
| Ear, Nose and Throat Associates of South Florida, P.A. | Boynton Beach | Florida | 33426 | — |
| ENT and Allergy Associates of Florida - Brandon | Brandon | Florida | 33511 | — |
| ENT and Allergy Associates of Florida - Plantation - Dr. Johnson | Plantation | Florida | 33324 | — |
| ENT and Allergy Associates of Florida - Plantation - Dr. Wright | Plantation | Florida | 33324 | — |
| ENT and Allergy Associates of Florida | Port Saint Lucie | Florida | 34952 | — |
| The University of Chicago Medical Center (UCMC) | Chicago | Illinois | 60637 | — |
| Indiana University | Indianapolis | Indiana | 46202 | — |
| University of Kansas Medical Center (KUMC) | Fairway | Kansas | 66205 | — |
| Tandem Clinical Research | Marrero | Louisiana | 70072 | — |
| Massachusetts Eye and Ear Infirmary | Boston | Massachusetts | 02114 | — |
| University of Missouri-Columbia | Columbia | Missouri | 65212 | — |
| St Louis University | St Louis | Missouri | 63104 | — |
| ENT and Allergy Associates, LLP - Fifth Avenue New York | New York | New York | 10016 | — |
| Columbia University | New York | New York | 10032 | — |
| University of Rochester | Rochester | New York | 14642 | — |
| ENT and Allergy Associates - White Plains | White Plains | New York | 10605 | — |
| Carolina Ear, Nose, & Throat Clinic/CENTRI, Inc. | Orangeburg | South Carolina | 29118 | — |
| Houston Methodist Hospital | Houston | Texas | 77030 | — |
| ENT Associates of Texas | McKinney | Texas | 75070 | — |
| Lyra Investigational Site | Ogden | Utah | 84405 | — |
| Lyra Investigational Site | Richmond | Virginia | 23235 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 26 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT05295459, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Feb 18, 2026 · Synced Sep 3, 2026
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Open the official record
The complete protocol, eligibility criteria, and contact information for NCT05295459 live on ClinicalTrials.gov.