Efficacy and Safety of LYR-210 for the Treatment of Chronic Rhinosinusitis in Adults (ENLIGHTEN 2)
Public ClinicalTrials.gov record NCT05295459. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
ENLIGHTEN 2: A Phase III, Randomized, Blinded, Controlled, Parallel-Group Trial to Evaluate the Efficacy and Safety of LYR-210 for the Treatment of Chronic Rhinosinusitis in Adults
Study identification
- NCT ID
- NCT05295459
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 3
- Lead sponsor
- Lyra Therapeutics
- Industry
- Enrollment
- 182 participants
Conditions and interventions
Conditions
Not listed
Interventions
Not listed
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- May 12, 2022
- Primary completion
- Apr 1, 2025
- Completion
- Apr 1, 2025
- Last update posted
- Feb 18, 2026
2022 – 2025
United States locations
- U.S. sites
- 8
- U.S. states
- 2
- U.S. cities
- 7
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Novak Clinical Trials | Tucson | Arizona | 85741 | — |
| Keck School of Medicine at USC Medical Center | Arcadia | California | 91007 | — |
| Sensa Health Clinical Research | Los Angeles | California | 90006 | — |
| Cedars-Sinai Medical Center | Los Angeles | California | 90048 | — |
| University of California - Irvine Medical Center | Orange | California | 92868 | — |
| Sacramento Ear Nose and Throat Surgical and Medical Group, Inc | Roseville | California | 95661 | — |
| University of California - Davis | Sacramento | California | 95817 | — |
| Regional Head & Neck Consulting - SENTA Clinic | San Diego | California | 92108 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT05295459, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Feb 18, 2026 · Synced May 17, 2026
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Open the official record
The complete protocol, eligibility criteria, and contact information for NCT05295459 live on ClinicalTrials.gov.