Study of Low-intensity Focused Ultrasound Effects on Cognitive fMRI Signals

ClinicalTrials.gov ID: NCT05303428

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Brief summary

Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.

Study aims to examine the effects of noninvasive brain stimulation on brain signals. This insight may have potential clinical implications for addiction, pain, and mental health populations. Participants will receive MRI and CT imaging. Participants receive low-intensity focused ultrasound (LIFU) to temporarily change brain activity. Participants then receive fMRI scans to measure changes in both resting and cognitive brain signaling using structured tasks. Heart rate, blood pressure, respiratory rate, and skin moisture is monitored. Participants complete a battery of questionnaires, both behavioral and symptom monitoring. The study takes place over 4 study visits.

Study identification

NCT ID: NCT05303428
Recruitment status: Enrolling by invitation
Study type: Interventional
Phase: Not applicable
Lead sponsor: Virginia Polytechnic Institute and State University; Other
Enrollment: 80 participants

Conditions and interventions

Conditions

Cognitive Change

Interventions

Neuromodulation with low-intensity focused ultrasound Other

Other

Eligibility (public fields only)

Age range: 18 Years to 65 Years
Sex: All
Healthy volunteers: Accepts healthy volunteers

This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.

Study timeline

Start date: Mar 10, 2026 (Actual)
Primary completion: Apr 2028 (Estimated)
Completion: Apr 2028 (Estimated)
Last update posted: Nov 9, 2026

2026 – 2028

United States locations

U.S. sites: 1
U.S. states: 1
U.S. cities: 1

Facility	City	State	ZIP	Site status
Fralin Biomedical Research Institute at VTC	Roanoke	Virginia	24016	—

Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.

About this trial record page

What this page shows: Public field values for ClinicalTrials.gov record NCT05303428, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
What this page does not do: No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
Where the data comes from: Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
Last refresh: Last update posted Nov 9, 2026 · Synced Nov 14, 2026