CASCADE-LUNG: Cancer Screening Assay Using DELFI; A Clinical Validation Study in Lung
Public ClinicalTrials.gov record NCT05306288. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
CASCADE-LUNG is a multisite, prospective, observational, blood specimen collection study in the elevated-risk lung cancer screening population. The primary objective is to demonstrate the performance characteristics, including sensitivity, specificity, positive predictive value (PPV) and negative predictive value (NPV) of the DELFI Lung Cancer Screening Test (DLCST) for the detection of pathologically-confirmed lung cancer in a screening population using LDCT, pathology, and follow-up as the reference method.
Study identification
- NCT ID
- NCT05306288
- Recruitment status
- Active, not recruiting
- Study type
- Observational
- Phase
- Not listed
- Enrollment
- 11,935 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 50 Years and older
- Sex
- All
- Healthy volunteers
- Not listed
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Apr 7, 2022 (Actual)
- Primary completion
- Jun 30, 2026 (Estimated)
- Completion
- Oct 30, 2026 (Estimated)
- Last update posted
- Mar 19, 2026
2022 – 2026
United States locations
- U.S. sites
- 66
- U.S. states
- 28
- U.S. cities
- 58
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Cullman Clinical Trials | Cullman | Alabama | 35055 | — |
| Science 37 (nationwide digital enrollment) | Culver City | California | 90230 | — |
| Providence Facey Medical Foundation | Mission Hills | California | 91345 | — |
| Hoag Hospital | Newport Beach | California | 92663 | — |
| Paradigm Clinical Research Center, Inc. | Redding | California | 96001 | — |
| San Francisco VA | San Francisco | California | 94121 | — |
| Clinical Research of California LLC | Walnut Creek | California | 94598 | — |
| SCL Health Research Institute, St. Mary's | Grand Junction | Colorado | 81501 | — |
| Paradigm Clinical Research Center | Wheat Ridge | Colorado | 80033 | — |
| Stamford Health | Stamford | Connecticut | 06904 | — |
| Advanced Research | Boynton Beach | Florida | 33347 | — |
| Morton Plant Hospital | Clearwater | Florida | 33756 | — |
| SIMEDHealth, LLC | Gainesville | Florida | 32607 | — |
| Galenus Group | Lehigh Acres | Florida | 33936 | — |
| Renstar Medical Research | Ocala | Florida | 34470 | — |
| United Medical Research | Port Orange | Florida | 32127 | — |
| American Clinical Trials, LLC. | Acworth | Georgia | 30101 | — |
| Centricity Research Columbus Piedmont | Columbus | Georgia | 31904 | — |
| ClinCept, LLC | Columbus | Georgia | 31904 | — |
| Coastal Heritage Clinical Research | Hinesville | Georgia | 31313 | — |
| Centricity Research Gwinnett Pulmonology | Lawrenceville | Georgia | 30046 | — |
| Centricity Research Rincon Pulmonology | Rincon | Georgia | 31326 | — |
| OSF Saint Francis Medical Center | Peoria | Illinois | 61637 | — |
| Springfield Clinic | Springfield | Illinois | 62703 | — |
| St. Elizabeth Healthcare | Edgewood | Kentucky | 41017 | — |
| Ochsner | New Orleans | Louisiana | 70121 | — |
| Johns Hopkins | Baltimore | Maryland | 21224 | — |
| Massachusetts General Hospital Cancer Center | Boston | Massachusetts | 02114 | — |
| Henry Ford Hospital | Detroit | Michigan | 48202 | — |
| Pulmonary Research Institute of Southeast Michigan | Farmington Hills | Michigan | 48336 | — |
| Minneapolis VA | Minneapolis | Minnesota | 55417 | — |
| Mayo Clinic | Rochester | Minnesota | 55905 | — |
| Hannibal Regional Healthcare System | Hannibal | Missouri | 63401 | — |
| Washington University | St Louis | Missouri | 63110 | — |
| Missouri Baptist Medical Center | St Louis | Missouri | 63131 | — |
| Somnos Clinical Research | Lincoln | Nebraska | 68510 | — |
| Internal Medicine Associate | Bridgeton | New Jersey | 08302 | — |
| CHRISTUS St. Vincent Regional Medical Center | Santa Fe | New Mexico | 87505 | — |
| University of Rochester Medical Center | Rochester | New York | 14642 | — |
| SUNY Upstate Medical University | Syracuse | New York | 13210 | — |
| University of North Carolina Chapel Hill | Chapel Hill | North Carolina | 27599 | — |
| Duke University | Durham | North Carolina | 27705 | — |
| Durham VA | Durham | North Carolina | 27705 | — |
| Coastal Carolina Health Care, P.A. | New Bern | North Carolina | 28562 | — |
| University of Cincinnati Medical Center | Cincinnati | Ohio | 45069 | — |
| Cleveland Clinic | Cleveland | Ohio | 44195 | — |
| Hightower Clinical | Oklahoma City | Oklahoma | 73134 | — |
| Northwest Research Center | Portland | Oregon | 97202 | — |
| Oregon Health Sciences University | Portland | Oregon | 97239 | — |
| Clinical Research Associates of Central Pa, LLC | DuBois | Pennsylvania | 15801 | — |
| University of Pennsylvania | Philadelphia | Pennsylvania | 19104 | — |
| Thomas Jefferson University | Philadelphia | Pennsylvania | 19107 | — |
| Pittsburgh VA Healthcare System | Pittsburgh | Pennsylvania | 15217 | — |
| Allegheny Health Network | Pittsburgh | Pennsylvania | 15224 | — |
| Ralph H Johnson VA | Charleston | South Carolina | 28401 | — |
| Medical University of South Carolina | Charleston | South Carolina | 29407 | — |
| LLM Research | Myrtle Beach | South Carolina | 29577 | — |
| Baptist Clinical Research Institute | Memphis | Tennessee | 38120 | — |
| Greater Heights Memorial Pulmonary and Sleep | Houston | Texas | 77008 | — |
| Houston Pulmonary Sleep and Allergy Associates | Houston | Texas | 77070 | — |
| North Houston Cancer Clinics | Huntsville | Texas | 77340 | — |
| CHRISTUS Trinity Clinic Pulmonary Medicine | Irving | Texas | 75038 | — |
| R&H Clinical Research, Inc. | Katy | Texas | 77494 | — |
| Lumi Research | Kingwood | Texas | 77339 | — |
| Central Virginia VA Health System: Hunter Holmes McGuire | Richmond | Virginia | 23249 | — |
| UW Medicine Valley Medical Center | Renton | Washington | 98055 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 1 non-U.S. site.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT05306288, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Mar 19, 2026 · Synced Oct 24, 2026
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Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT05306288 live on ClinicalTrials.gov.