Independent directory Public ClinicalTrials.gov records United States
ClinicalTrials.gov record
Active, not recruiting Phase 2 Interventional

Testing the Addition of Nivolumab to Standard Treatment for Patients With Metastatic or Unresectable Colorectal Cancer That Have a BRAF Mutation

ClinicalTrials.gov ID: NCT05308446

Public ClinicalTrials.gov record NCT05308446. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.

ClinicalTrials.gov public records Last synced Oct 18, 2026, 1:25 PM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

Official title

Randomized Phase II Trial of Encorafenib and Cetuximab With or Without Nivolumab (NSC #748726) for Patients With Previously Treated, Microsatellite Stable, BRAFV600E Metastatic and/or Unresectable Colorectal Cancer

Brief summary

Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.

This phase II trial tests whether adding nivolumab to the usual treatment (encorafenib and cetuximab) works better than the usual treatment alone to shrink tumors in patients with colorectal cancer that has spread to other places in the body (metastatic) or that cannot be removed by surgery (unresectable) and whose tumor has a mutation in a gene called BRAF. Encorafenib is in a class of medications called kinase inhibitors. It is used in patients whose cancer has a certain mutation (change) in the BRAF gene. It works by blocking the action of mutated BRAF that signals cancer cells to multiply. This helps to stop or slow the spread of cancer cells. Cetuximab is in a class of medications called monoclonal antibodies. It binds to a protein called EGFR, which is found on some types of cancer cells. This may help keep cancer cells from growing. Immunotherapy with monoclonal antibodies, such as nivolumab, may help the body's immune system attack the cancer, and may interfere with the ability of tumor cells to grow and spread. Giving nivolumab in combination with encorafenib and cetuximab may be more effective than encorafenib and cetuximab alone at stopping tumor growth and spreading in patients with metastatic or unresectable BRAF-mutant colorectal cancer.

Study identification

NCT ID
NCT05308446
Recruitment status
Active, not recruiting
Study type
Interventional
Phase
Phase 2
Enrollment
86 participants

Conditions and interventions

Eligibility (public fields only)

Age range
18 Years and older
Sex
All
Healthy volunteers
Healthy volunteers not accepted

This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.

Study timeline

Start date
Jul 19, 2022 (Actual)
Primary completion
Feb 28, 2026 (Actual)
Completion
Jun 1, 2027 (Estimated)
Last update posted
Jul 8, 2026

2022 – 2027

United States locations

U.S. sites
282
U.S. states
31
U.S. cities
226
Facility City State ZIP Site status
CTCA at Western Regional Medical Center Goodyear Arizona 85338 —
Mercy Cancer Center - Carmichael Carmichael California 95608 —
Mercy San Juan Medical Center Carmichael California 95608 —
Kaiser Permanente Dublin Dublin California 94568 —
Mercy Cancer Center - Elk Grove Elk Grove California 95758 —
Kaiser Permanente-Fremont Fremont California 94538 —
Kaiser Permanente-Fresno Fresno California 93720 —
UCI Health - Chao Family Comprehensive Cancer Center and Ambulatory Care Irvine California 92612 —
Kaiser Permanente-Modesto Modesto California 95356 —
Kaiser Permanente-Oakland Oakland California 94611 —
UC Irvine Health/Chao Family Comprehensive Cancer Center Orange California 92868 —
Mercy Cancer Center - Rocklin Rocklin California 95765 —
Kaiser Permanente-Roseville Roseville California 95661 —
Kaiser Permanente Downtown Commons Sacramento California 95814 —
Mercy Cancer Center - Sacramento Sacramento California 95816 —
Kaiser Permanente-South Sacramento Sacramento California 95823 —
Kaiser Permanente-San Francisco San Francisco California 94115 —
Kaiser Permanente-Santa Teresa-San Jose San Jose California 95119 —
Kaiser Permanente San Leandro San Leandro California 94577 —
Kaiser Permanente Medical Center - Santa Clara Santa Clara California 95051 —
Kaiser Permanente-Santa Rosa Santa Rosa California 95403 —
Kaiser Permanente-South San Francisco South San Francisco California 94080 —
Kaiser Permanente-Vallejo Vallejo California 94589 —
Kaiser Permanente-Walnut Creek Walnut Creek California 94596 —
Woodland Memorial Hospital Woodland California 95695 —
UCHealth University of Colorado Hospital Aurora Colorado 80045 —
Rocky Mountain Cancer Centers-Penrose Colorado Springs Colorado 80907 —
UCHealth Memorial Hospital Central Colorado Springs Colorado 80909 —
Memorial Hospital North Colorado Springs Colorado 80920 —
Poudre Valley Hospital Fort Collins Colorado 80524 —
Cancer Care and Hematology-Fort Collins Fort Collins Colorado 80528 —
UCHealth Greeley Hospital Greeley Colorado 80631 —
UCHealth Highlands Ranch Hospital Highlands Ranch Colorado 80129 —
Medical Center of the Rockies Loveland Colorado 80538 —
CTCA at Southeastern Regional Medical Center Newnan Georgia 30265 —
Kaiser Permanente Moanalua Medical Center Honolulu Hawaii 96819 —
Saint Alphonsus Cancer Care Center-Boise Boise Idaho 83706 —
Saint Luke's Cancer Institute - Boise Boise Idaho 83712 —
Saint Alphonsus Cancer Care Center-Caldwell Caldwell Idaho 83605 —
Kootenai Health - Coeur d'Alene Coeur d'Alene Idaho 83814 —
Saint Luke's Cancer Institute - Fruitland Fruitland Idaho 83619 —
Saint Luke's Cancer Institute - Meridian Meridian Idaho 83642 —
Saint Alphonsus Cancer Care Center-Nampa Nampa Idaho 83687 —
Saint Luke's Cancer Institute - Nampa Nampa Idaho 83687 —
Kootenai Clinic Cancer Services - Post Falls Post Falls Idaho 83854 —
Kootenai Clinic Cancer Services - Sandpoint Sandpoint Idaho 83864 —
Saint Luke's Cancer Institute - Twin Falls Twin Falls Idaho 83301 —
Rush-Copley Medical Center Aurora Illinois 60504 —
Advocate Good Shepherd Hospital Barrington Illinois 60010 —
Illinois CancerCare-Bloomington Bloomington Illinois 61704 —
Illinois CancerCare-Canton Canton Illinois 61520 —
Illinois CancerCare-Carthage Carthage Illinois 62321 —
Centralia Oncology Clinic Centralia Illinois 62801 —
University of Illinois Chicago Illinois 60612 —
Advocate Illinois Masonic Medical Center Chicago Illinois 60657 —
AMG Crystal Lake - Oncology Crystal Lake Illinois 60014 —
Carle at The Riverfront Danville Illinois 61832 —
Cancer Care Specialists of Illinois - Decatur Decatur Illinois 62526 —
Decatur Memorial Hospital Decatur Illinois 62526 —
Illinois CancerCare-Dixon Dixon Illinois 61021 —
Advocate Good Samaritan Hospital Downers Grove Illinois 60515 —
Carle Physician Group-Effingham Effingham Illinois 62401 —
Crossroads Cancer Center Effingham Illinois 62401 —
Advocate Sherman Hospital Elgin Illinois 60123 —
Illinois CancerCare-Eureka Eureka Illinois 61530 —
Illinois CancerCare-Galesburg Galesburg Illinois 61401 —
Advocate South Suburban Hospital Hazel Crest Illinois 60429 —
Illinois CancerCare-Kewanee Clinic Kewanee Illinois 61443 —
AMG Libertyville - Oncology Libertyville Illinois 60048 —
Condell Memorial Hospital Libertyville Illinois 60048 —
Illinois CancerCare-Macomb Macomb Illinois 61455 —
Carle Physician Group-Mattoon/Charleston Mattoon Illinois 61938 —
Cancer Care Center of O'Fallon O'Fallon Illinois 62269 —
Advocate Christ Medical Center Oak Lawn Illinois 60453-2699 —
Illinois CancerCare-Ottawa Clinic Ottawa Illinois 61350 —
Advocate Lutheran General Hospital Park Ridge Illinois 60068 —
Illinois CancerCare-Pekin Pekin Illinois 61554 —
Illinois CancerCare-Peoria Peoria Illinois 61615 —
Illinois CancerCare-Peru Peru Illinois 61354 —
Illinois CancerCare-Princeton Princeton Illinois 61356 —
Southern Illinois University School of Medicine Springfield Illinois 62702 —
Springfield Clinic Springfield Illinois 62702 —
Springfield Memorial Hospital Springfield Illinois 62781 —
Carle Cancer Center Urbana Illinois 61801 —
Illinois CancerCare - Washington Washington Illinois 61571 —
Rush-Copley Healthcare Center Yorkville Illinois 60560 —
Northwest Cancer Center - Crown Point Crown Point Indiana 46307 —
Northwest Oncology LLC Dyer Indiana 46311 —
Northwest Cancer Center - Hobart Hobart Indiana 46342 —
Saint Mary Medical Center Hobart Indiana 46342 —
Franciscan Health Indianapolis Indianapolis Indiana 46237 —
Saint Catherine Hospital Indianapolis Indiana 46312 —
Franciscan Saint Elizabeth Health - Lafayette East Lafayette Indiana 47905 —
Woodland Cancer Care Center Michigan City Indiana 46360 —
Franciscan Health Mooresville Mooresville Indiana 46158 —
The Community Hospital Munster Indiana 46321 —
Women's Diagnostic Center - Munster Munster Indiana 46321 —
Northwest Cancer Center - Valparaiso Valparaiso Indiana 46383 —
Mary Greeley Medical Center Ames Iowa 50010 —
McFarland Clinic - Ames Ames Iowa 50010 —
McFarland Clinic - Boone Boone Iowa 50036 —
Mercy Medical Center - Des Moines Des Moines Iowa 50314 —
McFarland Clinic - Trinity Cancer Center Fort Dodge Iowa 50501 —
McFarland Clinic - Jefferson Jefferson Iowa 50129 —
McFarland Clinic - Marshalltown Marshalltown Iowa 50158 —
LSU Health Baton Rouge-North Clinic Baton Rouge Louisiana 70805 —
Our Lady of the Lake Physician Group Baton Rouge Louisiana 70808 —
Ochsner Hematology Oncology North Shore - Covington (West Region) Covington Louisiana 70433 —
Ochsner Medical Center Jefferson New Orleans Louisiana 70121 —
Trinity Health Saint Joseph Mercy Hospital Ann Arbor Ann Arbor Michigan 48106 —
Bronson Battle Creek Battle Creek Michigan 49017 —
Trinity Health IHA Medical Group Hematology Oncology - Brighton Brighton Michigan 48114 —
Trinity Health Medical Center - Brighton Brighton Michigan 48114 —
Trinity Health IHA Medical Group Hematology Oncology - Canton Canton Michigan 48188 —
Trinity Health Medical Center - Canton Canton Michigan 48188 —
Chelsea Hospital Chelsea Michigan 48118 —
Trinity Health IHA Medical Group Hematology Oncology - Chelsea Hospital Chelsea Michigan 48118 —
Henry Ford Hospital Detroit Michigan 48202 —
Henry Ford Health Saint John Hospital Detroit Michigan 48236 —
Henry Ford River District Hospital East China Township Michigan 48054 —
Cancer Hematology Centers - Flint Flint Michigan 48503 —
Genesee Hematology Oncology PC Flint Michigan 48503 —
Genesys Hurley Cancer Institute Flint Michigan 48503 —
Hurley Medical Center Flint Michigan 48503 —
Corewell Health Grand Rapids Hospitals - Butterworth Hospital Grand Rapids Michigan 49503 —
Trinity Health Grand Rapids Hospital Grand Rapids Michigan 49503 —
Henry Ford Saint John Hospital - Academic Grosse Pointe Woods Michigan 48236 —
Henry Ford Saint John Hospital - Van Elslander Grosse Pointe Woods Michigan 48236 —
Bronson Methodist Hospital Kalamazoo Michigan 49007 —
West Michigan Cancer Center Kalamazoo Michigan 49007 —
Beacon Kalamazoo Cancer Center Kalamazoo Michigan 49009 —
University of Michigan Health - Sparrow Lansing Lansing Michigan 48912 —
Trinity Health Saint Mary Mercy Livonia Hospital Livonia Michigan 48154 —
Henry Ford Saint John Hospital - Macomb Medical Macomb Michigan 48044 —
Trinity Health Muskegon Hospital Muskegon Michigan 49444 —
Corewell Health Lakeland Hospitals - Niles Hospital Niles Michigan 49120 —
Cancer and Hematology Centers of Western Michigan - Norton Shores Norton Shores Michigan 49444 —
Henry Ford Health Providence Novi Hospital Novi Michigan 48374 —
Henry Ford Medical Center-Columbus Novi Michigan 48377 —
Corewell Health Reed City Hospital Reed City Michigan 49677 —
MyMichigan Medical Center Saginaw Saginaw Michigan 48601 —
Oncology Hematology Associates of Saginaw Valley PC Saginaw Michigan 48604 —
Corewell Health Lakeland Hospitals - Marie Yeager Cancer Center Saint Joseph Michigan 49085 —
Henry Ford Health Providence Southfield Hospital Southfield Michigan 48075 —
Bhadresh Nayak MD PC-Sterling Heights Sterling Heights Michigan 48312 —
MyMichigan Medical Center Tawas Tawas City Michigan 48764 —
Munson Medical Center Traverse City Michigan 49684 —
Henry Ford Health Warren Hospital Warren Michigan 48093 —
Henry Ford Warren Hospital - GLCMS Warren Michigan 48093 —
Macomb Hematology Oncology PC Warren Michigan 48093 —
Henry Ford West Bloomfield Hospital West Bloomfield Michigan 48322 —
Saint Mary's Oncology/Hematology Associates of West Branch West Branch Michigan 48661 —
University of Michigan Health - West Wyoming Michigan 49519 —
Huron Gastroenterology PC Ypsilanti Michigan 48106 —
Trinity Health IHA Medical Group Hematology Oncology Ann Arbor Campus Ypsilanti Michigan 48197 —
Mercy Hospital Coon Rapids Minnesota 55433 —
Essentia Health - Deer River Clinic Deer River Minnesota 56636 —
Essentia Health Cancer Center Duluth Minnesota 55805 —
Fairview Southdale Hospital Edina Minnesota 55435 —
Essentia Health Hibbing Clinic Hibbing Minnesota 55746 —
Abbott-Northwestern Hospital Minneapolis Minnesota 55407 —
North Memorial Medical Health Center Robbinsdale Minnesota 55422 —
Park Nicollet Clinic - Saint Louis Park Saint Louis Park Minnesota 55416 —
Regions Hospital Saint Paul Minnesota 55101 —
United Hospital Saint Paul Minnesota 55102 —
Essentia Health Sandstone Sandstone Minnesota 55072 —
Essentia Health Virginia Clinic Virginia Minnesota 55792 —
Saint Francis Medical Center Cape Girardeau Missouri 63703 —
Community Hospital of Anaconda Anaconda Montana 59711 —
Billings Clinic Cancer Center Billings Montana 59101 —
Bozeman Health Deaconess Hospital Bozeman Montana 59715 —
Benefis Sletten Cancer Institute Great Falls Montana 59405 —
Logan Health Medical Center Kalispell Montana 59901 —
Community Medical Center Missoula Montana 59804 —
Dartmouth Hitchcock Medical Center/Dartmouth Cancer Center Lebanon New Hampshire 03756 —
Hunterdon Medical Center Flemington New Jersey 08822 —
Roswell Park Cancer Institute Buffalo New York 14263 —
Southeastern Medical Oncology Center-Clinton Clinton North Carolina 28328 —
Southeastern Medical Oncology Center-Goldsboro Goldsboro North Carolina 27534 —
Southeastern Medical Oncology Center-Jacksonville Jacksonville North Carolina 28546 —
FirstHealth of the Carolinas-Moore Regional Hospital Pinehurst North Carolina 28374 —
Strecker Cancer Center-Belpre Belpre Ohio 45714 —
Miami Valley Hospital South Centerville Ohio 45459 —
Adena Regional Medical Center Chillicothe Ohio 45601 —
Mount Carmel East Hospital Columbus Ohio 43213 —
Columbus Oncology and Hematology Associates Inc Columbus Ohio 43214 —
Riverside Methodist Hospital Columbus Ohio 43214 —
Grant Medical Center Columbus Ohio 43215 —
The Mark H Zangmeister Center Columbus Ohio 43219 —
Doctors Hospital Columbus Ohio 43228 —
Miami Valley Hospital Dayton Ohio 45409 —
Premier Blood and Cancer Center Dayton Ohio 45409 —
Dayton Physician LLC - Englewood Dayton Ohio 45415 —
Miami Valley Hospital North Dayton Ohio 45415 —
Delaware Health Center-Grady Cancer Center Delaware Ohio 43015 —
Grady Memorial Hospital Delaware Ohio 43015 —
Columbus Oncology and Hematology Associates Dublin Ohio 43016 —
Atrium Medical Center-Middletown Regional Hospital Franklin Ohio 45005-1066 —
Dayton Physicians LLC-Atrium Franklin Ohio 45005 —
Miami Valley Cancer Care and Infusion Greenville Ohio 45331 —
Mount Carmel Grove City Hospital Grove City Ohio 43123 —
Kettering Medical Center Kettering Ohio 45429 —
Fairfield Medical Center Lancaster Ohio 43130 —
OhioHealth Mansfield Hospital Mansfield Ohio 44903 —
OhioHealth Marion General Hospital Marion Ohio 43302 —
Memorial Hospital Marysville Ohio 43040 —
Knox Community Hospital Mount Vernon Ohio 43050 —
Licking Memorial Hospital Newark Ohio 43055 —
Southern Ohio Medical Center Portsmouth Ohio 45662 —
Springfield Regional Cancer Center Springfield Ohio 45504 —
Springfield Regional Medical Center Springfield Ohio 45504 —
Toledo Clinic Cancer Centers-Toledo Toledo Ohio 43623 —
Upper Valley Medical Center Troy Ohio 45373 —
Saint Ann's Hospital Westerville Ohio 43081 —
Genesis Healthcare System Cancer Care Center Zanesville Ohio 43701 —
Cancer Centers of Southwest Oklahoma Research Lawton Oklahoma 73505 —
University of Oklahoma Health Sciences Center Oklahoma City Oklahoma 73104 —
Mercy Hospital Oklahoma City Oklahoma City Oklahoma 73120 —
Clackamas Radiation Oncology Center Clackamas Oregon 97015 —
Providence Cancer Institute Clackamas Clinic Clackamas Oregon 97015 —
Providence Newberg Medical Center Newberg Oregon 97132 —
Saint Alphonsus Cancer Care Center-Ontario Ontario Oregon 97914 —
Providence Willamette Falls Medical Center Oregon City Oregon 97045 —
Providence Portland Medical Center Portland Oregon 97213 —
Providence Saint Vincent Medical Center Portland Oregon 97225 —
Lehigh Valley Hospital-Cedar Crest Allentown Pennsylvania 18103 —
Lehigh Valley Hospital - Muhlenberg Bethlehem Pennsylvania 18017 —
University of Pennsylvania/Abramson Cancer Center Philadelphia Pennsylvania 19104 —
Reading Hospital West Reading Pennsylvania 19611 —
Rhode Island Hospital Providence Rhode Island 02903 —
Prisma Health Cancer Institute - Spartanburg Boiling Springs South Carolina 29316 —
Medical University of South Carolina Charleston South Carolina 29425 —
Prisma Health Cancer Institute - Easley Easley South Carolina 29640 —
Prisma Health Cancer Institute - Butternut Greenville South Carolina 29605 —
Prisma Health Cancer Institute - Faris Greenville South Carolina 29605 —
Prisma Health Greenville Memorial Hospital Greenville South Carolina 29605 —
Prisma Health Cancer Institute - Eastside Greenville South Carolina 29615 —
Prisma Health Cancer Institute - Greer Greer South Carolina 29650 —
Prisma Health Cancer Institute - Seneca Seneca South Carolina 29672 —
Vanderbilt University/Ingram Cancer Center Nashville Tennessee 37232 —
The Don and Sybil Harrington Cancer Center Amarillo Texas 79106 —
UT Southwestern Simmons Cancer Center - RedBird Dallas Texas 75237 —
UT Southwestern/Simmons Cancer Center-Dallas Dallas Texas 75390 —
UT Southwestern/Simmons Cancer Center-Fort Worth Fort Worth Texas 76104 —
UT MD Anderson Cancer Center Houston Texas 77030 —
UT Southwestern Clinical Center at Richardson/Plano Richardson Texas 75080 —
Huntsman Cancer Institute/University of Utah Salt Lake City Utah 84112 —
Dartmouth Cancer Center - North Saint Johnsbury Vermont 05819 —
Swedish Cancer Institute-Edmonds Edmonds Washington 98026 —
Swedish Cancer Institute-Issaquah Issaquah Washington 98029 —
Swedish Medical Center-First Hill Seattle Washington 98122 —
United Hospital Center Bridgeport West Virginia 26330 —
West Virginia University Healthcare Morgantown West Virginia 26506 —
ThedaCare Regional Cancer Center Appleton Wisconsin 54911 —
Duluth Clinic Ashland Ashland Wisconsin 54806 —
Aurora Cancer Care-Southern Lakes VLCC Burlington Wisconsin 53105 —
Aurora Saint Luke's South Shore Cudahy Wisconsin 53110 —
Marshfield Medical Center-EC Cancer Center Eau Claire Wisconsin 54701 —
Aurora Health Care Germantown Health Center Germantown Wisconsin 53022 —
Aurora Cancer Care-Grafton Grafton Wisconsin 53024 —
Aurora BayCare Medical Center Green Bay Wisconsin 54311 —
Aurora Cancer Care-Kenosha South Kenosha Wisconsin 53142 —
Aurora Bay Area Medical Group-Marinette Marinette Wisconsin 54143 —
Marshfield Medical Center-Marshfield Marshfield Wisconsin 54449 —
Aurora Cancer Care-Milwaukee Milwaukee Wisconsin 53209 —
Aurora Saint Luke's Medical Center Milwaukee Wisconsin 53215 —
Aurora Sinai Medical Center Milwaukee Wisconsin 53233 —
Marshfield Medical Center - Minocqua Minocqua Wisconsin 54548 —
ProHealth D N Greenwald Center Mukwonago Wisconsin 53149 —
Cancer Center of Western Wisconsin New Richmond Wisconsin 54017 —
ProHealth Oconomowoc Memorial Hospital Oconomowoc Wisconsin 53066 —
Vince Lombardi Cancer Clinic - Oshkosh Oshkosh Wisconsin 54904 —
Aurora Cancer Care-Racine Racine Wisconsin 53406 —
Marshfield Medical Center-Rice Lake Rice Lake Wisconsin 54868 —
Vince Lombardi Cancer Clinic-Sheboygan Sheboygan Wisconsin 53081 —
Marshfield Medical Center-River Region at Stevens Point Stevens Point Wisconsin 54482 —
Aurora Medical Center in Summit Summit Wisconsin 53066 —
Vince Lombardi Cancer Clinic-Two Rivers Two Rivers Wisconsin 54241 —
UW Cancer Center at ProHealth Care Waukesha Wisconsin 53188 —
Aurora Cancer Care-Milwaukee West Wauwatosa Wisconsin 53226 —
Aurora West Allis Medical Center West Allis Wisconsin 53227 —
Marshfield Medical Center - Weston Weston Wisconsin 54476 —

Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.

Non-U.S. locations

This page focuses on the U.S. directory. The official record also lists 4 non-U.S. sites.

About this trial record page

What this page shows
Public field values for ClinicalTrials.gov record NCT05308446, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
What this page does not do
No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
Where the data comes from
Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
Last refresh
Last update posted Jul 8, 2026 · Synced Oct 18, 2026

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Open the official record

The complete public registry record, listed eligibility criteria, and available contact information for NCT05308446 live on ClinicalTrials.gov.

View official ClinicalTrials.gov record →