ClinicalTrials.gov record
Active, not recruiting Phase 2 Interventional

Testing the Addition of Nivolumab to Standard Treatment for Patients With Metastatic or Unresectable Colorectal Cancer That Have a BRAF Mutation

ClinicalTrials.gov ID: NCT05308446

Public ClinicalTrials.gov record NCT05308446. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.

ClinicalTrials.gov public records Last synced May 8, 2026, 3:55 AM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

Official title

Randomized Phase II Trial of Encorafenib and Cetuximab With or Without Nivolumab (NSC #748726) for Patients With Previously Treated, Microsatellite Stable, BRAFV600E Metastatic and/or Unresectable Colorectal Cancer

Study identification

NCT ID
NCT05308446
Recruitment status
Active, not recruiting
Study type
Interventional
Phase
Phase 2
Lead sponsor
National Cancer Institute (NCI)
NIH
Enrollment
84 participants

Conditions and interventions

Eligibility (public fields only)

Age range
18 Years and older
Sex
All
Healthy volunteers
Healthy volunteers not accepted

This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.

Study timeline

Start date
Jul 18, 2022
Primary completion
Sep 29, 2026
Completion
Sep 29, 2026
Last update posted
Apr 20, 2026

2022 – 2026

United States locations

U.S. sites
282
U.S. states
31
U.S. cities
226
Facility City State ZIP Site status
CTCA at Western Regional Medical Center Goodyear Arizona 85338
Mercy Cancer Center - Carmichael Carmichael California 95608
Mercy San Juan Medical Center Carmichael California 95608
Kaiser Permanente Dublin Dublin California 94568
Mercy Cancer Center - Elk Grove Elk Grove California 95758
Kaiser Permanente-Fremont Fremont California 94538
Kaiser Permanente-Fresno Fresno California 93720
UCI Health - Chao Family Comprehensive Cancer Center and Ambulatory Care Irvine California 92612
Kaiser Permanente-Modesto Modesto California 95356
Kaiser Permanente-Oakland Oakland California 94611
UC Irvine Health/Chao Family Comprehensive Cancer Center Orange California 92868
Mercy Cancer Center - Rocklin Rocklin California 95765
Kaiser Permanente-Roseville Roseville California 95661
Kaiser Permanente Downtown Commons Sacramento California 95814
Mercy Cancer Center - Sacramento Sacramento California 95816
Kaiser Permanente-South Sacramento Sacramento California 95823
Kaiser Permanente-San Francisco San Francisco California 94115
Kaiser Permanente-Santa Teresa-San Jose San Jose California 95119
Kaiser Permanente San Leandro San Leandro California 94577
Kaiser Permanente Medical Center - Santa Clara Santa Clara California 95051
Kaiser Permanente-Santa Rosa Santa Rosa California 95403
Kaiser Permanente-South San Francisco South San Francisco California 94080
Kaiser Permanente-Vallejo Vallejo California 94589
Kaiser Permanente-Walnut Creek Walnut Creek California 94596
Woodland Memorial Hospital Woodland California 95695
UCHealth University of Colorado Hospital Aurora Colorado 80045
Rocky Mountain Cancer Centers-Penrose Colorado Springs Colorado 80907
UCHealth Memorial Hospital Central Colorado Springs Colorado 80909
Memorial Hospital North Colorado Springs Colorado 80920
Poudre Valley Hospital Fort Collins Colorado 80524
Cancer Care and Hematology-Fort Collins Fort Collins Colorado 80528
UCHealth Greeley Hospital Greeley Colorado 80631
UCHealth Highlands Ranch Hospital Highlands Ranch Colorado 80129
Medical Center of the Rockies Loveland Colorado 80538
CTCA at Southeastern Regional Medical Center Newnan Georgia 30265
Kaiser Permanente Moanalua Medical Center Honolulu Hawaii 96819
Saint Alphonsus Cancer Care Center-Boise Boise Idaho 83706
Saint Luke's Cancer Institute - Boise Boise Idaho 83712
Saint Alphonsus Cancer Care Center-Caldwell Caldwell Idaho 83605
Kootenai Health - Coeur d'Alene Coeur d'Alene Idaho 83814
Saint Luke's Cancer Institute - Fruitland Fruitland Idaho 83619
Saint Luke's Cancer Institute - Meridian Meridian Idaho 83642
Saint Alphonsus Cancer Care Center-Nampa Nampa Idaho 83687
Saint Luke's Cancer Institute - Nampa Nampa Idaho 83687
Kootenai Clinic Cancer Services - Post Falls Post Falls Idaho 83854
Kootenai Clinic Cancer Services - Sandpoint Sandpoint Idaho 83864
Saint Luke's Cancer Institute - Twin Falls Twin Falls Idaho 83301
Rush-Copley Medical Center Aurora Illinois 60504
Advocate Good Shepherd Hospital Barrington Illinois 60010
Illinois CancerCare-Bloomington Bloomington Illinois 61704
Illinois CancerCare-Canton Canton Illinois 61520
Illinois CancerCare-Carthage Carthage Illinois 62321
Centralia Oncology Clinic Centralia Illinois 62801
University of Illinois Chicago Illinois 60612
Advocate Illinois Masonic Medical Center Chicago Illinois 60657
AMG Crystal Lake - Oncology Crystal Lake Illinois 60014
Carle at The Riverfront Danville Illinois 61832
Cancer Care Specialists of Illinois - Decatur Decatur Illinois 62526
Decatur Memorial Hospital Decatur Illinois 62526
Illinois CancerCare-Dixon Dixon Illinois 61021
Advocate Good Samaritan Hospital Downers Grove Illinois 60515
Carle Physician Group-Effingham Effingham Illinois 62401
Crossroads Cancer Center Effingham Illinois 62401
Advocate Sherman Hospital Elgin Illinois 60123
Illinois CancerCare-Eureka Eureka Illinois 61530
Illinois CancerCare-Galesburg Galesburg Illinois 61401
Advocate South Suburban Hospital Hazel Crest Illinois 60429
Illinois CancerCare-Kewanee Clinic Kewanee Illinois 61443
AMG Libertyville - Oncology Libertyville Illinois 60048
Condell Memorial Hospital Libertyville Illinois 60048
Illinois CancerCare-Macomb Macomb Illinois 61455
Carle Physician Group-Mattoon/Charleston Mattoon Illinois 61938
Cancer Care Center of O'Fallon O'Fallon Illinois 62269
Advocate Christ Medical Center Oak Lawn Illinois 60453-2699
Illinois CancerCare-Ottawa Clinic Ottawa Illinois 61350
Advocate Lutheran General Hospital Park Ridge Illinois 60068
Illinois CancerCare-Pekin Pekin Illinois 61554
Illinois CancerCare-Peoria Peoria Illinois 61615
Illinois CancerCare-Peru Peru Illinois 61354
Illinois CancerCare-Princeton Princeton Illinois 61356
Southern Illinois University School of Medicine Springfield Illinois 62702
Springfield Clinic Springfield Illinois 62702
Springfield Memorial Hospital Springfield Illinois 62781
Carle Cancer Center Urbana Illinois 61801
Illinois CancerCare - Washington Washington Illinois 61571
Rush-Copley Healthcare Center Yorkville Illinois 60560
Northwest Cancer Center - Crown Point Crown Point Indiana 46307
Northwest Oncology LLC Dyer Indiana 46311
Northwest Cancer Center - Hobart Hobart Indiana 46342
Saint Mary Medical Center Hobart Indiana 46342
Franciscan Health Indianapolis Indianapolis Indiana 46237
Saint Catherine Hospital Indianapolis Indiana 46312
Franciscan Saint Elizabeth Health - Lafayette East Lafayette Indiana 47905
Woodland Cancer Care Center Michigan City Indiana 46360
Franciscan Health Mooresville Mooresville Indiana 46158
The Community Hospital Munster Indiana 46321
Women's Diagnostic Center - Munster Munster Indiana 46321
Northwest Cancer Center - Valparaiso Valparaiso Indiana 46383
Mary Greeley Medical Center Ames Iowa 50010
McFarland Clinic - Ames Ames Iowa 50010
McFarland Clinic - Boone Boone Iowa 50036
Mercy Medical Center - Des Moines Des Moines Iowa 50314
McFarland Clinic - Trinity Cancer Center Fort Dodge Iowa 50501
McFarland Clinic - Jefferson Jefferson Iowa 50129
McFarland Clinic - Marshalltown Marshalltown Iowa 50158
LSU Health Baton Rouge-North Clinic Baton Rouge Louisiana 70805
Our Lady of the Lake Physician Group Baton Rouge Louisiana 70808
Ochsner Hematology Oncology North Shore - Covington (West Region) Covington Louisiana 70433
Ochsner Medical Center Jefferson New Orleans Louisiana 70121
Trinity Health Saint Joseph Mercy Hospital Ann Arbor Ann Arbor Michigan 48106
Bronson Battle Creek Battle Creek Michigan 49017
Trinity Health IHA Medical Group Hematology Oncology - Brighton Brighton Michigan 48114
Trinity Health Medical Center - Brighton Brighton Michigan 48114
Trinity Health IHA Medical Group Hematology Oncology - Canton Canton Michigan 48188
Trinity Health Medical Center - Canton Canton Michigan 48188
Chelsea Hospital Chelsea Michigan 48118
Trinity Health IHA Medical Group Hematology Oncology - Chelsea Hospital Chelsea Michigan 48118
Henry Ford Hospital Detroit Michigan 48202
Henry Ford Health Saint John Hospital Detroit Michigan 48236
Henry Ford River District Hospital East China Township Michigan 48054
Cancer Hematology Centers - Flint Flint Michigan 48503
Genesee Hematology Oncology PC Flint Michigan 48503
Genesys Hurley Cancer Institute Flint Michigan 48503
Hurley Medical Center Flint Michigan 48503
Corewell Health Grand Rapids Hospitals - Butterworth Hospital Grand Rapids Michigan 49503
Trinity Health Grand Rapids Hospital Grand Rapids Michigan 49503
Henry Ford Saint John Hospital - Academic Grosse Pointe Woods Michigan 48236
Henry Ford Saint John Hospital - Van Elslander Grosse Pointe Woods Michigan 48236
Bronson Methodist Hospital Kalamazoo Michigan 49007
West Michigan Cancer Center Kalamazoo Michigan 49007
Beacon Kalamazoo Cancer Center Kalamazoo Michigan 49009
University of Michigan Health - Sparrow Lansing Lansing Michigan 48912
Trinity Health Saint Mary Mercy Livonia Hospital Livonia Michigan 48154
Henry Ford Saint John Hospital - Macomb Medical Macomb Michigan 48044
Trinity Health Muskegon Hospital Muskegon Michigan 49444
Corewell Health Lakeland Hospitals - Niles Hospital Niles Michigan 49120
Cancer and Hematology Centers of Western Michigan - Norton Shores Norton Shores Michigan 49444
Henry Ford Health Providence Novi Hospital Novi Michigan 48374
Henry Ford Medical Center-Columbus Novi Michigan 48377
Corewell Health Reed City Hospital Reed City Michigan 49677
MyMichigan Medical Center Saginaw Saginaw Michigan 48601
Oncology Hematology Associates of Saginaw Valley PC Saginaw Michigan 48604
Corewell Health Lakeland Hospitals - Marie Yeager Cancer Center Saint Joseph Michigan 49085
Henry Ford Health Providence Southfield Hospital Southfield Michigan 48075
Bhadresh Nayak MD PC-Sterling Heights Sterling Heights Michigan 48312
MyMichigan Medical Center Tawas Tawas City Michigan 48764
Munson Medical Center Traverse City Michigan 49684
Henry Ford Health Warren Hospital Warren Michigan 48093
Henry Ford Warren Hospital - GLCMS Warren Michigan 48093
Macomb Hematology Oncology PC Warren Michigan 48093
Henry Ford West Bloomfield Hospital West Bloomfield Michigan 48322
Saint Mary's Oncology/Hematology Associates of West Branch West Branch Michigan 48661
University of Michigan Health - West Wyoming Michigan 49519
Huron Gastroenterology PC Ypsilanti Michigan 48106
Trinity Health IHA Medical Group Hematology Oncology Ann Arbor Campus Ypsilanti Michigan 48197
Mercy Hospital Coon Rapids Minnesota 55433
Essentia Health - Deer River Clinic Deer River Minnesota 56636
Essentia Health Cancer Center Duluth Minnesota 55805
Fairview Southdale Hospital Edina Minnesota 55435
Essentia Health Hibbing Clinic Hibbing Minnesota 55746
Abbott-Northwestern Hospital Minneapolis Minnesota 55407
North Memorial Medical Health Center Robbinsdale Minnesota 55422
Park Nicollet Clinic - Saint Louis Park Saint Louis Park Minnesota 55416
Regions Hospital Saint Paul Minnesota 55101
United Hospital Saint Paul Minnesota 55102
Essentia Health Sandstone Sandstone Minnesota 55072
Essentia Health Virginia Clinic Virginia Minnesota 55792
Saint Francis Medical Center Cape Girardeau Missouri 63703
Community Hospital of Anaconda Anaconda Montana 59711
Billings Clinic Cancer Center Billings Montana 59101
Bozeman Health Deaconess Hospital Bozeman Montana 59715
Benefis Sletten Cancer Institute Great Falls Montana 59405
Logan Health Medical Center Kalispell Montana 59901
Community Medical Center Missoula Montana 59804
Dartmouth Hitchcock Medical Center/Dartmouth Cancer Center Lebanon New Hampshire 03756
Hunterdon Medical Center Flemington New Jersey 08822
Roswell Park Cancer Institute Buffalo New York 14263
Southeastern Medical Oncology Center-Clinton Clinton North Carolina 28328
Southeastern Medical Oncology Center-Goldsboro Goldsboro North Carolina 27534
Southeastern Medical Oncology Center-Jacksonville Jacksonville North Carolina 28546
FirstHealth of the Carolinas-Moore Regional Hospital Pinehurst North Carolina 28374
Strecker Cancer Center-Belpre Belpre Ohio 45714
Miami Valley Hospital South Centerville Ohio 45459
Adena Regional Medical Center Chillicothe Ohio 45601
Mount Carmel East Hospital Columbus Ohio 43213
Columbus Oncology and Hematology Associates Inc Columbus Ohio 43214
Riverside Methodist Hospital Columbus Ohio 43214
Grant Medical Center Columbus Ohio 43215
The Mark H Zangmeister Center Columbus Ohio 43219
Doctors Hospital Columbus Ohio 43228
Miami Valley Hospital Dayton Ohio 45409
Premier Blood and Cancer Center Dayton Ohio 45409
Dayton Physician LLC - Englewood Dayton Ohio 45415
Miami Valley Hospital North Dayton Ohio 45415
Delaware Health Center-Grady Cancer Center Delaware Ohio 43015
Grady Memorial Hospital Delaware Ohio 43015
Columbus Oncology and Hematology Associates Dublin Ohio 43016
Atrium Medical Center-Middletown Regional Hospital Franklin Ohio 45005-1066
Dayton Physicians LLC-Atrium Franklin Ohio 45005
Miami Valley Cancer Care and Infusion Greenville Ohio 45331
Mount Carmel Grove City Hospital Grove City Ohio 43123
Kettering Medical Center Kettering Ohio 45429
Fairfield Medical Center Lancaster Ohio 43130
OhioHealth Mansfield Hospital Mansfield Ohio 44903
OhioHealth Marion General Hospital Marion Ohio 43302
Memorial Hospital Marysville Ohio 43040
Knox Community Hospital Mount Vernon Ohio 43050
Licking Memorial Hospital Newark Ohio 43055
Southern Ohio Medical Center Portsmouth Ohio 45662
Springfield Regional Cancer Center Springfield Ohio 45504
Springfield Regional Medical Center Springfield Ohio 45504
Toledo Clinic Cancer Centers-Toledo Toledo Ohio 43623
Upper Valley Medical Center Troy Ohio 45373
Saint Ann's Hospital Westerville Ohio 43081
Genesis Healthcare System Cancer Care Center Zanesville Ohio 43701
Cancer Centers of Southwest Oklahoma Research Lawton Oklahoma 73505
University of Oklahoma Health Sciences Center Oklahoma City Oklahoma 73104
Mercy Hospital Oklahoma City Oklahoma City Oklahoma 73120
Clackamas Radiation Oncology Center Clackamas Oregon 97015
Providence Cancer Institute Clackamas Clinic Clackamas Oregon 97015
Providence Newberg Medical Center Newberg Oregon 97132
Saint Alphonsus Cancer Care Center-Ontario Ontario Oregon 97914
Providence Willamette Falls Medical Center Oregon City Oregon 97045
Providence Portland Medical Center Portland Oregon 97213
Providence Saint Vincent Medical Center Portland Oregon 97225
Lehigh Valley Hospital-Cedar Crest Allentown Pennsylvania 18103
Lehigh Valley Hospital - Muhlenberg Bethlehem Pennsylvania 18017
University of Pennsylvania/Abramson Cancer Center Philadelphia Pennsylvania 19104
Reading Hospital West Reading Pennsylvania 19611
Rhode Island Hospital Providence Rhode Island 02903
Prisma Health Cancer Institute - Spartanburg Boiling Springs South Carolina 29316
Medical University of South Carolina Charleston South Carolina 29425
Prisma Health Cancer Institute - Easley Easley South Carolina 29640
Prisma Health Cancer Institute - Butternut Greenville South Carolina 29605
Prisma Health Cancer Institute - Faris Greenville South Carolina 29605
Prisma Health Greenville Memorial Hospital Greenville South Carolina 29605
Prisma Health Cancer Institute - Eastside Greenville South Carolina 29615
Prisma Health Cancer Institute - Greer Greer South Carolina 29650
Prisma Health Cancer Institute - Seneca Seneca South Carolina 29672
Vanderbilt University/Ingram Cancer Center Nashville Tennessee 37232
The Don and Sybil Harrington Cancer Center Amarillo Texas 79106
UT Southwestern Simmons Cancer Center - RedBird Dallas Texas 75237
UT Southwestern/Simmons Cancer Center-Dallas Dallas Texas 75390
UT Southwestern/Simmons Cancer Center-Fort Worth Fort Worth Texas 76104
M D Anderson Cancer Center Houston Texas 77030
UT Southwestern Clinical Center at Richardson/Plano Richardson Texas 75080
Huntsman Cancer Institute/University of Utah Salt Lake City Utah 84112
Dartmouth Cancer Center - North Saint Johnsbury Vermont 05819
Swedish Cancer Institute-Edmonds Edmonds Washington 98026
Swedish Cancer Institute-Issaquah Issaquah Washington 98029
Swedish Medical Center-First Hill Seattle Washington 98122
United Hospital Center Bridgeport West Virginia 26330
West Virginia University Healthcare Morgantown West Virginia 26506
ThedaCare Regional Cancer Center Appleton Wisconsin 54911
Duluth Clinic Ashland Ashland Wisconsin 54806
Aurora Cancer Care-Southern Lakes VLCC Burlington Wisconsin 53105
Aurora Saint Luke's South Shore Cudahy Wisconsin 53110
Marshfield Medical Center-EC Cancer Center Eau Claire Wisconsin 54701
Aurora Health Care Germantown Health Center Germantown Wisconsin 53022
Aurora Cancer Care-Grafton Grafton Wisconsin 53024
Aurora BayCare Medical Center Green Bay Wisconsin 54311
Aurora Cancer Care-Kenosha South Kenosha Wisconsin 53142
Aurora Bay Area Medical Group-Marinette Marinette Wisconsin 54143
Marshfield Medical Center-Marshfield Marshfield Wisconsin 54449
Aurora Cancer Care-Milwaukee Milwaukee Wisconsin 53209
Aurora Saint Luke's Medical Center Milwaukee Wisconsin 53215
Aurora Sinai Medical Center Milwaukee Wisconsin 53233
Marshfield Medical Center - Minocqua Minocqua Wisconsin 54548
ProHealth D N Greenwald Center Mukwonago Wisconsin 53149
Cancer Center of Western Wisconsin New Richmond Wisconsin 54017
ProHealth Oconomowoc Memorial Hospital Oconomowoc Wisconsin 53066
Vince Lombardi Cancer Clinic - Oshkosh Oshkosh Wisconsin 54904
Aurora Cancer Care-Racine Racine Wisconsin 53406
Marshfield Medical Center-Rice Lake Rice Lake Wisconsin 54868
Vince Lombardi Cancer Clinic-Sheboygan Sheboygan Wisconsin 53081
Marshfield Medical Center-River Region at Stevens Point Stevens Point Wisconsin 54482
Aurora Medical Center in Summit Summit Wisconsin 53066
Vince Lombardi Cancer Clinic-Two Rivers Two Rivers Wisconsin 54241
UW Cancer Center at ProHealth Care Waukesha Wisconsin 53188
Aurora Cancer Care-Milwaukee West Wauwatosa Wisconsin 53226
Aurora West Allis Medical Center West Allis Wisconsin 53227
Marshfield Medical Center - Weston Weston Wisconsin 54476

Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.

Non-U.S. locations

This page focuses on the U.S. directory. The official record also lists 4 non-U.S. sites.

About this trial record page

What this page shows
Public field values for ClinicalTrials.gov record NCT05308446, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
What this page does not do
No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
Where the data comes from
Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
Last refresh
Last update posted Apr 20, 2026 · Synced May 8, 2026

Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.

Open the official record

The complete protocol, eligibility criteria, and contact information for NCT05308446 live on ClinicalTrials.gov.

View official ClinicalTrials.gov record →