ClinicalTrials.gov record
A Study to Verify the Clinical Benefit of Aducanumab in Participants With Early Alzheimer's Disease
ClinicalTrials.gov ID: NCT05310071
Public ClinicalTrials.gov record NCT05310071. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Phase 3b/4 Multicenter, Randomized, Double-Blind, Placebo-Controlled, Parallel-Group Study to Verify the Clinical Benefit of Aducanumab (BIIB037) in Participants With Alzheimer's Disease
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
The primary objective of this study is to verify the clinical benefit of monthly doses of aducanumab in slowing cognitive and functional impairment as measured by changes in the Clinical Dementia Rating Scale Sum of Boxes (CDR-SB) score as compared with placebo in participants with early Alzheimer's disease.
Study identification
- NCT ID
- NCT05310071
- Recruitment status
- Terminated
- Study type
- Interventional
- Phase
- Phase 3
- Enrollment
- 1,027 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 60 Years to 85 Years
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Jun 1, 2022
- Primary completion
- Aug 11, 2024
- Completion
- Aug 11, 2024
- Last update posted
- Apr 22, 2025
2022 – 2024
United States locations
- U.S. sites
- 130
- U.S. states
- 36
- U.S. cities
- 110
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Gilbert Neurology Partners, PLLC | Gilbert | Arizona | 85297 | — |
| Xenoscience Inc. | Phoenix | Arizona | 85004 | — |
| Banner Alzheimer's Institute | Phoenix | Arizona | 85006 | — |
| Barrow Neurological Institute | Phoenix | Arizona | 85013 | — |
| HonorHealth Neurology | Scottsdale | Arizona | 85251 | — |
| Mayo Clinic Arizona | Scottsdale | Arizona | 85259 | — |
| Banner Sun Health Research Institute | Sun City | Arizona | 85351 | — |
| Banner Alzheimer's Institute | Tucson | Arizona | 85012 | — |
| Health Initiatives Research | Fayetteville | Arkansas | 72703 | — |
| Sun Valley Behaivoral Med Center | El Centro | California | 92243 | — |
| Neuropain Medical Center | Fresno | California | 93710 | — |
| Neurology Center of North Orange County | Fullerton | California | 92835 | — |
| Irvine Center for Clinical Research, Inc. | Irvine | California | 92614 | — |
| Mary S. Easton Center for Alzheimer's Disease Research, UCLA | Los Angeles | California | 90095 | — |
| Hoag Memorial Hospital Presbyterian | Newport Beach | California | 92663 | — |
| Stanford Hospital and Clinics | Palo Alto | California | 94304 | — |
| VA Palo Alto Health Care System | Palo Alto | California | 94304 | — |
| Anderson Clinical Research | Redlands | California | 92374 | — |
| Sutter Health-San Francisco | San Francisco | California | 94115 | — |
| University of California San Francisco (PARENT) | San Francisco | California | 94143 | — |
| The Neuron Clinic | San Marcos | California | 92069 | — |
| Syrentis Clinical Research | Santa Ana | California | 92705 | — |
| California Neuroscience Research, LLC | Sherman Oaks | California | 91403 | — |
| Viking Clinical Research Center | Temecula | California | 92591 | — |
| University of Colorado Anschutz Medical Campus | Aurora | Colorado | 80045 | — |
| Mountain Neurological Research Center | Basalt | Colorado | 81621 | — |
| Yale University | Fairfield | Connecticut | 06824 | — |
| Institute for Neurodegenerative Disorders (IND) | New Haven | Connecticut | 06510 | — |
| Yale University School Of Medicine | New Haven | Connecticut | 06511 | — |
| Research Center for Clinical Studies, Inc. | Norwalk | Connecticut | 06851 | — |
| Howard University Health Sciences | Washington D.C. | District of Columbia | 20060-0002 | — |
| Neurology of Central Florida Research Center, LLC | Altamonte Springs | Florida | 32714 | — |
| JEM Research Institute | Atlantis | Florida | 33462 | — |
| Neurology Offices of South Florida, PLLC | Boca Raton | Florida | 33428 | — |
| ECommunity Research, LLC | Boca Raton | Florida | 33486 | — |
| Nova Clinical Research, LLC | Bradenton | Florida | 34209 | — |
| JY Research Institute | Cutler Bay | Florida | 45417 | — |
| Brain Matters Research | Delray Beach | Florida | 33445 | — |
| Neuropsychiatric Research Center of Southwest Florida | Fort Myers | Florida | 33912 | — |
| Infinity Clinical Research, LLC | Hollywood | Florida | 33024 | — |
| Charter Research, LLC | Lady Lake | Florida | 32159 | — |
| ARS - Lake Oconee | Lakeland | Florida | 33803 | — |
| Medical Research Center | Miami | Florida | 33165 | — |
| Renstar Medical Research | Ocala | Florida | 34470 | — |
| K2 Medical Research, LLC | Ocoee | Florida | 34761 | — |
| K2 Medical Research, LLC | Orlando | Florida | 32751 | — |
| K2 Medical Research | Orlando | Florida | 32751 | — |
| Headlands Research LLC | Orlando | Florida | 32819 | — |
| Conquest Research | Orlando | Florida | 32832 | — |
| Quantum Laboratories Inc. | Pompano Beach | Florida | 33064 | — |
| United Medical Research | Port Orange | Florida | 32127 | — |
| Brain Matters Research | Stuart | Florida | 34997 | — |
| K2 Medical Research Tampa | Tampa | Florida | 33607 | — |
| USF Health Byrd Institute | Tampa | Florida | 33613 | — |
| Hawaii Pacific Neuroscience | Honolulu | Hawaii | 96817 | — |
| Great Lakes Clinical Trials, LLC Ravenswood dba Flourish Research | Chicago | Illinois | 60637 | — |
| University of Chicago Medical Center | Chicago | Illinois | 60637 | — |
| Alexian Brothers Medical Center - Neuroscience Research Institute | Elk Grove Village | Illinois | 60007 | — |
| Indiana University School of Medicine | Indianapolis | Indiana | 46202 | — |
| University of Kansas Medical Center Research Institute, Inc. | Fairway | Kansas | 66205 | — |
| Ascension Via Christi Research, a division of Ascension Via Christi Hospitals Wichita, Inc. | Wichita | Kansas | 67214 | — |
| University of Kentucky Medical Center | Lexington | Kentucky | 40506 | — |
| Ochsner Health System PARENT | New Orleans | Louisiana | 70121 | — |
| LSU Health Sciences Center Shreveport | Shreveport | Louisiana | 71103 | — |
| University of Maryland Medical Center | Baltimore | Maryland | 21201 | — |
| McLean Hospital | Belmont | Massachusetts | 02478 | — |
| Brigham and Women's Hospital Department of Neurology | Boston | Massachusetts | 02115-5804 | — |
| Beth Israel Deaconess Medical Center | Boston | Massachusetts | 02215 | — |
| ActivMed Practices and Research | Methuen | Massachusetts | 01844 | — |
| Boston Center for Memory | Newton | Massachusetts | 02459 | — |
| Donald S. Marks, M.D., P.C. | Plymouth | Massachusetts | 02360 | — |
| Wayne State University - Detroit Medical Center | Detroit | Michigan | 48201 | — |
| Michigan Institute for Neurological Disorders | Farmington Hills | Michigan | 48334 | — |
| Center for Memory and Aging | Saint Paul | Minnesota | 55130 | — |
| Hattiesburg Clinic, PA | Hattiesburg | Mississippi | 39401 | — |
| Sharlin Health and Neurology | Ozark | Missouri | 65721 | — |
| University of Nebraska Medical Center | Omaha | Nebraska | 68198-3285 | — |
| Cleveland Clinic Lou Ruvo Center for Brain Health | Las Vegas | Nevada | 89106 | — |
| Las Vegas Medical Research | Las Vegas | Nevada | 89113 | — |
| The Cognitive Research Center of New Jersey | Springfield | New Jersey | 07081 | — |
| CenExel Advanced Memory Research Institute of NJ | Toms River | New Jersey | 08755 | — |
| Neurological Associates of Albany, PC | Albany | New York | 12208 | — |
| Dent Neurologic Institute | Amherst | New York | 14226 | — |
| Social Psychiatry Research Institute (SPRI) | Brooklyn | New York | 11235 | — |
| New York University Medical Center PRIME | New York | New York | 10016 | — |
| Mount Sinai | New York | New York | 10029 | — |
| South Shore Neurologic Associates, P.C. | Patchogue | New York | 11772 | — |
| Finger Lakes Clinical Research | Rochester | New York | 14618 | — |
| University of Rochester - PARENT | Rochester | New York | 14642 | — |
| Richmond Behavioral Associates ERG Clinical Research - New York PLLC | Staten Island | New York | 10314 | — |
| Stony Brook University Hospital | Stony Brook | New York | 11794 | — |
| SUNY Upstate Medical University | Syracuse | New York | 13210 | — |
| IMA Evaluations LLC | Tarrytown | New York | 10591 | — |
| Duke University | Durham | North Carolina | 27710 | — |
| AMC Research, LLC | Matthews | North Carolina | 28105 | — |
| Wake Forest Baptist Health Sciences | Winston-Salem | North Carolina | 27157 | — |
| Cleveland Clinic Foundation | Cleveland | Ohio | 44195 | — |
| Ohio State University Medical Center | Columbus | Ohio | 43210 | — |
| Neuro-Behavioral Clinical Research, Inc. | North Canton | Ohio | 44720 | — |
| Lynn Health Science Institute | Oklahoma City | Oklahoma | 73112 | — |
| Central States Research, LLC | Tulsa | Oklahoma | 74136 | — |
| Oregon Health & Science University (OHSU) | Portland | Oregon | 97239 | — |
| Abington Neurological Associates, LTD | Abington | Pennsylvania | 19001 | — |
| The Clinical Trial Center, LLC | Jenkintown | Pennsylvania | 19046 | — |
| Penn Memory Center | Philadelphia | Pennsylvania | 19104 | — |
| Rhode Island Hospital | East Providence | Rhode Island | 02915-2237 | — |
| Rhode Island Mood & Memory Research Institute | East Providence | Rhode Island | 02915 | — |
| Butler Hospital | Providence | Rhode Island | 02906 | — |
| Coastal Neurology PA | Port Royal | South Carolina | 29935 | — |
| Neurology Clinic, PC | Cordova | Tennessee | 38018 | — |
| Genesis Neuroscience Clinic | Knoxville | Tennessee | 37909 | — |
| Senior Adult Specialty Research | Austin | Texas | 78757 | — |
| Headlands Research - Brownsville | Brownsville | Texas | 78526 | — |
| Kerwin Medical Center | Dallas | Texas | 75231 | — |
| UT Southwestern Medical Center | Dallas | Texas | 75390-8896 | — |
| University of North Texas Health Science Center | Fort Worth | Texas | 76107 | — |
| Baylor College Of Medicine | Houston | Texas | 77030 | — |
| The Methodist Hospital Research Institute | Houston | Texas | 77030 | — |
| Clinical Trial Network LLC | Houston | Texas | 77074 | — |
| Central Texas Neurology Consultants | Round Rock | Texas | 78681 | — |
| University of Texas Health Science Center at San Antonio | San Antonio | Texas | 78229 | — |
| The Memory Clinic | Bennington | Vermont | 05201 | — |
| University of Virginia Health System | Charlottesville | Virginia | 22903 | — |
| Glennan Center for Geriatrics and Gerontology | Norfolk | Virginia | 23510 | — |
| National Clinical Research Inc. - Richmond | Richmond | Virginia | 23294 | — |
| University of Washington Medical Center | Seattle | Washington | 98109 | — |
| Kingfisher Cooperative, LLC | Spokane | Washington | 99202 | — |
| University of Wisconsin-Madison | Madison | Wisconsin | 53705 | — |
| Marshfield Clinic | Marshfield | Wisconsin | 54449 | — |
| Medical College of Wisconsin, Inc. | Milwaukee | Wisconsin | 53226 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 135 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT05310071, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Apr 22, 2025 · Synced Sep 3, 2026
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Open the official record
The complete protocol, eligibility criteria, and contact information for NCT05310071 live on ClinicalTrials.gov.