Phase 2/3 Adaptive Study of VX-147 in Adult and Pediatric Participants With APOL1-Mediated Proteinuric Kidney Disease

ClinicalTrials.gov ID: NCT05312879

Public ClinicalTrials.gov record NCT05312879. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.

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ClinicalTrials.gov public records Last synced Apr 22, 2026, 10:18 AM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

Official title

A Phase 2/3 Adaptive, Double-blind, Placebo-Controlled Study to Evaluate the Efficacy and Safety of VX-147 in Adult and Pediatric Subjects With APOL1-mediated Proteinuric Kidney Disease

Study identification

NCT ID: NCT05312879
Recruitment status: Recruiting
Study type: Interventional
Phase: Phase 2, Phase 3
Lead sponsor: Vertex Pharmaceuticals Incorporated; Industry
Enrollment: 466 participants

Conditions and interventions

Conditions

Proteinuric Kidney Disease

Interventions

Placebo Drug
VX-147 Drug

Drug

Eligibility (public fields only)

Age range: 10 Years to 65 Years
Sex: All
Healthy volunteers: Not listed

This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.

Study timeline

Start date: Mar 29, 2022
Primary completion: Jun 1, 2028
Completion: May 6, 2030
Last update posted: Apr 16, 2026

2022 – 2030

United States locations

U.S. sites: 227
U.S. states: 33
U.S. cities: 148

Facility	City	State	ZIP	Site status
Alabama Kidney Research	Alabaster	Alabama	35007	Recruiting
EmVenio Research - Mobile Unit - Birmingham	Birmingham	Alabama	35210	Recruiting
Cardiology, P.C.	Birmingham	Alabama	35211	Completed
Children's Hospital of Alabama	Birmingham	Alabama	35233	Recruiting
The Kirklin Clinic - Nephrology	Birmingham	Alabama	35294	Recruiting
Nephrology Associates	Fairhope	Alabama	36532	Recruiting
Heart Center Research LLC	Huntsville	Alabama	35801	Recruiting
Nephrology Consultants, LLC	Huntsville	Alabama	35805	Recruiting
Renal Associates of Alabama, LLC	Montgomery	Alabama	36117	Recruiting
Arizona Kidney Disease and Hypertension Center - Banner Desert Office	Mesa	Arizona	85202	Withdrawn
Arizona Kidney Disease and Hypertension Center - Thomas Office	Phoenix	Arizona	85016	Recruiting
Phoenix Children's Hospital, Inc. - Nephrology	Phoenix	Arizona	85016	Recruiting
CHI St. Vincent Heart Clinic Arkansas- Cardiology and Medicine Clinic - Little Rock	Little Rock	Arkansas	72204	Completed
UAMS Medical Center - Pulmonology	Little Rock	Arkansas	72205	Completed
The Medical Research Group - Saint Agnes Medical Center	Fresno	California	93720	Recruiting
Amicis Research Center - Balboa	Granada Hills	California	91344	Recruiting
Kidney Care Center of North Valley	Granada Hills	California	91344	Recruiting
Eastside Clinical Research Associates	Los Angeles	California	90022	Recruiting
Kaiser Permanente Los Angeles Medical Center	Los Angeles	California	90027	Recruiting
Cedars-Sinai Medical Center	Los Angeles	California	90048	Recruiting
UCLA Division of Nephrology	Los Angeles	California	90095	Completed
UCI Center for Clinical Research	Orange	California	92868	Recruiting
Kaiser Permanente Sacramento Medical Center	Sacramento	California	95825	Recruiting
Helen Diller Medical Center at Parnassus Heights	San Francisco	California	94143	Recruiting
UCLA Lundquist Institute at Harbor-UCLA Medical Center	Torrance	California	90502	Recruiting
Kidney and Hypertension Center	Victorville	California	92395	Completed
Greater Hartford Nephrology	Bloomfield	Connecticut	06002	Recruiting
Nephrology & Hypertension Associates, PC	Middlebury	Connecticut	06762	Recruiting
Yale University - Yale Nephrology Clinical Research Clinic	New Haven	Connecticut	06510	Recruiting
Children's National Hospital - Nephrology	Washington D.C.	District of Columbia	20010	Recruiting
The George Washington University - GW Medical Faculty Associates	Washington D.C.	District of Columbia	20037	Recruiting
Veterans Affairs Medical Center - Washington D.C	Washington D.C.	District of Columbia	20422	Recruiting
Bay Pines Foundation	Bay Pines	Florida	33744	Recruiting
Nova Clinical Research, LLC - Bradenton - 59th St	Bradenton	Florida	34209	Recruiting
Clinical Research of Brandon, LLC	Brandon	Florida	33511	Recruiting
AMR-Miami	Coral Gables	Florida	33134	Completed
Horizon Research Group - Coral Gables	Coral Gables	Florida	33134	Completed
South Florida Nephrology Research	Coral Springs	Florida	33071	Recruiting
Delray Physician Care Center	Delray Beach	Florida	33445	Recruiting
North Florida/South Georgia Veterans Health System	Gainesville	Florida	32608	Recruiting
Shands Hospital - Nephrology	Gainesville	Florida	32610	Recruiting
Velocity Clinical Research - Hallandale Beach	Hallandale	Florida	33009	Completed
Qway Research	Hialeah	Florida	33010	Completed
Elixia Pines	Hollywood	Florida	33024	Completed
UF Health Cardiovascular Center - Jacksonville	Jacksonville	Florida	32209	Recruiting
South Florida Research Institute	Lauderdale Lakes	Florida	33313	Recruiting
Total Research Group, LLC	Miami	Florida	33126	Recruiting
MedBio Trials	Miami	Florida	33180	Withdrawn
Cordova Research Institute	Miami	Florida	33182	Recruiting
South Florida Research	Miami Springs	Florida	33166	Recruiting
CTR Oakwater, LLC	Orlando	Florida	32806	Active, not recruiting
Synexus Clinical Research - Orlando	Orlando	Florida	32806	Completed
Omega Research Orlando, LLC - Mercy Dr	Orlando	Florida	32808	Recruiting
Infigo Clinical Research	Sanford	Florida	32771	Recruiting
Genesis Clinical Research	Tampa	Florida	33603	Completed
Elixia Tampa	Tampa	Florida	33618	Completed
American Clinical Trials LLC - Acworth	Acworth	Georgia	30101	Recruiting
Kaiser Permanente Georgia	Atlanta	Georgia	30305	Recruiting
Emory School of Medicine - Renal Division	Atlanta	Georgia	30308	Recruiting
Advanced Clinical Research of Atlanta	Atlanta	Georgia	30309	Completed
Morehouse School of Medicine, Grady Memorial Hospital	Atlanta	Georgia	30310	Recruiting
Emory Childrens Center - Nephrology	Atlanta	Georgia	30322	Recruiting
Synexus Clinical Research - Atlanta (DRS)	Atlanta	Georgia	30328	Recruiting
Fides Clinical Research	Atlanta	Georgia	30342	Recruiting
Augusta University Medical College of Georgia - Adult Sickle Cell Clinic	Augusta	Georgia	30912	Recruiting
Coastal Medical Research	Brunswick	Georgia	31520	Completed
Randomize Now - College Park	College Park	Georgia	30337	Recruiting
Clincept - Veterans Pkwy.	Columbus	Georgia	31904	Recruiting
Renal Associates	Columbus	Georgia	31904	Recruiting
Georgia Nephrology - Decatur	Decatur	Georgia	30030	Recruiting
Atlanta VA Healthcare System	Decatur	Georgia	30033	Completed
American Clinical Trials LLC - Douglasville	Douglasville	Georgia	30134	Recruiting
Southeast Kidney Associates	East Point	Georgia	30344	Recruiting
Javara Inc./Privia Medical Group - Fayetteville, GA	Fayetteville	Georgia	30214	Recruiting
Georgia Nephrology - Lawrenceville - Billing Office	Lawrenceville	Georgia	30046	Recruiting
Javara Inc./Privia Medical Group - Savannah, GA	Savannah	Georgia	31406	Recruiting
Inova Clinical Trials and Research Center	Tyrone	Georgia	30290	Recruiting
Rophe Adult and Pediatric Medicine	Union City	Georgia	30291	Recruiting
Synexus Clinical Research - Chicago (DRS)	Chicago	Illinois	60602	Recruiting
EmVenio Research - Chicago	Chicago	Illinois	60608	Recruiting
Ann & Robert H. Lurie Children's Hospital of Chicago - Nephrology	Chicago	Illinois	60611-2605	Recruiting
Northwestern Medical Group	Chicago	Illinois	60611	Recruiting
UChicago Medicine - Comer Children's Hospital	Chicago	Illinois	60637	Recruiting
NANI Research LLC - Evergreen Park IL	Evergreen Park	Illinois	60805	Recruiting
Edward Hines Jr VA Hospital	Hines	Illinois	60141	Recruiting
Essential Concepts Research Solutions	Palos Hills	Illinois	60465	Completed
NANI Research LLC - Fort Wayne IN	Fort Wayne	Indiana	46804	Recruiting
IU School of Medicine - Nephrology	Indianapolis	Indiana	46202	Recruiting
Nephrology Physicians, LLC	Mishawaka	Indiana	46545	Completed
University of Iowa Health Care Medical Center- Nephrology	Iowa City	Iowa	52242	Recruiting
Clinical & Translational Science Unit (CTSU) - Nephrology	Kansas City	Kansas	66160	Completed
Premier Clinical Research	Overland Park	Kansas	66210	Completed
Renal Associates of Baton Rouge	Baton Rouge	Louisiana	70808	Recruiting
LCMC Health	Metairie	Louisiana	70006	Recruiting
Barnum Medical Research - Bienville St	Natchitoches	Louisiana	71457	Completed
Louisiana Clinical and Translational Science (LA CaTS) Center	New Orleans	Louisiana	70112	Completed
University Medical Center - New Orleans - Nephrology	New Orleans	Louisiana	70112	Recruiting
Ochsner Medical Center - New Orleans	New Orleans	Louisiana	70121	Recruiting
Northwest Louisiana Nephrology, LLC	Shreveport	Louisiana	71101	Recruiting
Louisiana State University Health Shreveport	Shreveport	Louisiana	71103	Recruiting
Monroe Research, LLC	West Monroe	Louisiana	71291	Recruiting
Javara Inc./Privia Medical Group - Annapolis, MD	Annapolis	Maryland	21401	Recruiting
University of Maryland Medical Center - General Clinical Research Center	Baltimore	Maryland	21201	Completed
The Johns Hopkins University - Johns Hopkins Hospital - Nephrology	Baltimore	Maryland	21287	Recruiting
Mid-Atlantic Permanente Research Institute	Gaithersburg	Maryland	20879	Recruiting
Patient First Clinical Trials	Lutherville	Maryland	21093	Recruiting
MD Medical Research	Oxon Hill	Maryland	20745	Recruiting
Javara Inc./Privia Medical Group - Silver Spring, MD - Columbia Pike	Silver Spring	Maryland	20901	Recruiting
Tufts Medical Center	Boston	Massachusetts	02111	Recruiting
Boston Medical Center	Boston	Massachusetts	02118	Recruiting
Beth Israel Deaconess Medical Center - Nephrology	Boston	Massachusetts	02215	Recruiting
Whittier Street Health Center	Roxbury	Massachusetts	02120	Recruiting
Renal and Transplant Associates of New England, PC	Springfield	Massachusetts	01107	Completed
Kidney Care and Transplant Services of New England - West Springfield	West Springfield	Massachusetts	01089	Recruiting
A. Alfred Taubman Health Care Center - Nephrology Clinic at Taubman Center	Ann Arbor	Michigan	48109	Recruiting
Henry Ford Health System - Nephrology	Detroit	Michigan	48202	Recruiting
Quest Research Institute	Farmington Hills	Michigan	48334	Completed
AA Medical Research Center	Flint	Michigan	48504	Recruiting
Sparrow Clinical Research Institute	Lansing	Michigan	48912	Recruiting
St. Clair Nephrology Research	Roseville	Michigan	48066	Completed
Center for Advanced Kidney Research	Saint Clair Shores	Michigan	48081	Recruiting
InterMed Consultants - Edina Clinic	Edina	Minnesota	55435	Completed
Minneapolis VA Healthcare System	Minneapolis	Minnesota	55417	Completed
Nephrology Associates, P.C. - Columbus	Columbus	Mississippi	39705	Recruiting
Prime Health and Wellness	Fayette	Mississippi	39069	Recruiting
UMMC Grenada Hospital	Grenada	Mississippi	38901	Completed
G.V. (Sonny) Montgomery VAMC	Jackson	Mississippi	39216	Completed
Olive Branch Family Medical Center	Olive Branch	Mississippi	38654	Recruiting
SKY Integrative Medical Center	Ridgeland	Mississippi	39157	Recruiting
Nephrology and Hypertension Associates - Tupelo	Tupelo	Mississippi	38801	Recruiting
Center for Specialized Medicine - Nephrology	St Louis	Missouri	63104	Completed
Barnes-Jewish Center for Outpatient Health	St Louis	Missouri	63108	Recruiting
St. Louis Children's Hospital - Nephrology	St Louis	Missouri	63110	Recruiting
St. Louis Heart and Vascular, P.C.	St Louis	Missouri	63136	Recruiting
Nevada Kidney Disease and Hypertension Centers	Las Vegas	Nevada	89106	Withdrawn
DaVita Kidney Care - Las Vegas	Las Vegas	Nevada	89107	Recruiting
CUH - Sheridan Pavilion - Three Cooper Plaza	Camden	New Jersey	08103	Recruiting
Hackensack University Medical Center	Hackensack	New Jersey	07601	Recruiting
Bioluminux Clinical Research New Jersey	Hamilton	New Jersey	08690	Recruiting
Jersey Shore University Medical Center	Neptune City	New Jersey	07753	Recruiting
Rutgers Doctors Office Center	Newark	New Jersey	07103	Recruiting
New Mexico VA Healthcare System	Albuquerque	New Mexico	87108	Completed
Renal Medicine Associates	Albuquerque	New Mexico	87109	Completed
Kings County Hospital	Brooklyn	New York	11203	Recruiting
SUNY Downstate Health Sciences University	Brooklyn	New York	11203	Recruiting
Clindove Research LLC	Brooklyn	New York	11221	Completed
New York Presbyterian Queens	Flushing	New York	11365	Recruiting
Zucker School of Medicine	Great Neck	New York	11021	Recruiting
Scott Research, Inc.	Laurelton	New York	11413	Recruiting
VA New York Harbor Healthcare System	New York	New York	10010	Completed
Grossman School of Medicine	New York	New York	10016	Recruiting
Synexus Clinical Research - New York (DRS)	New York	New York	10017	Completed
The Rogosin Kidney Center	New York	New York	10021	Recruiting
Icahn School of Medicine at Mount Sinai - Nephrology	New York	New York	10029	Recruiting
General Nephrology Clinic - New York City	New York	New York	10032	Recruiting
NYC Health + Hospital/Harlem	New York	New York	10037	Recruiting
Kidney Medical Associates, PLLC	The Bronx	New York	10461	Completed
Montefiore Einstein - Albert Einstein College of Medicine	The Bronx	New York	10461	Recruiting
Montefiore Einstein Hospital - Moses Campus	The Bronx	New York	10467	Recruiting
James J. Peters VA Medical Center	The Bronx	New York	10468	Recruiting
North Carolina Nephrology P.A. - Cary	Cary	North Carolina	27511	Recruiting
UNC Clinical and Translational Research Center	Chapel Hill	North Carolina	27599-7155	Recruiting
Metrolina Nephrology Associates - Freedom Dr	Charlotte	North Carolina	28208	Recruiting
Duke University Hospital - Children's Health Center	Durham	North Carolina	27710	Recruiting
Eastern Nephrology Associates - Greenville Office	Greenville	North Carolina	27834	Recruiting
Eastern Nephrology Associates - Jacksonville Office	Jacksonville	North Carolina	28546	Recruiting
Eastern Nephrology Associates - Kinston Office	Kinston	North Carolina	28504	Recruiting
Eastern Nephrology Associates - New Bern Office	New Bern	North Carolina	28562	Recruiting
Eastern Nephrology Associates - Wilmington Office	Wilmington	North Carolina	28401	Recruiting
Brookview Hills Research Associates	Winston-Salem	North Carolina	27103	Completed
UC - DCI McMillan Research Unit	Cincinnati	Ohio	45206	Recruiting
Cincinnati VA Medical Center	Cincinnati	Ohio	45220	Completed
Louis Stokes Cleveland VA medical Center	Cleveland	Ohio	44106	Recruiting
UH Cleveland Medical Center - Nephrology	Cleveland	Ohio	44106	Recruiting
Cleveland Clinic - Main Campus	Cleveland	Ohio	44195	Recruiting
Ohio State University - Wexner Medical Center - Nephrology Clinical Trials Unit	Columbus	Ohio	43201	Recruiting
Jefferson Health - 33 South 9th Street	Philadelphia	Pennsylvania	19107	Completed
Lewis Katz School of Medicine at Temple University - Section of Nephrology	Philadelphia	Pennsylvania	19140	Recruiting
Jefferson Einstein Philadelphia Hospital - Nephrology	Philadelphia	Pennsylvania	19141	Recruiting
Children's Hospital of Pittsburgh - Nephrology	Pittsburgh	Pennsylvania	15224	Active, not recruiting
Lifespan Clinical Research Center	East Providence	Rhode Island	02915	Recruiting
Pharmacorp Clinical Trials, Inc	Charleston	South Carolina	29412	Recruiting
Medical University of South Carolina - Pulmonology	Charleston	South Carolina	29425	Recruiting
Columbia Nephrology Associates, PA	Columbia	South Carolina	29203	Recruiting
Carolina Nephrology, PA	Spartanburg	South Carolina	29306	Recruiting
Southeast Renal Research Institute	Chattanooga	Tennessee	37404	Recruiting
Le Bonheur Children's Hospital - Outpatient Clinic	Memphis	Tennessee	38105	Recruiting
CNS Healthcare - Memphis	Memphis	Tennessee	38119	Recruiting
Nashville General Hospital - Meharry Medical College - Nephrology	Nashville	Tennessee	37208	Recruiting
Nashville VA Medical Center	Nashville	Tennessee	37212	Recruiting
Nephrology Clinical Trials Center	Nashville	Tennessee	37232	Recruiting
Dallas Renal Group - Mansfield	Arlington	Texas	76002	Completed
Arlington Nephrology	Arlington	Texas	76015	Completed
Baylor Scott and White Research Institute - Nephrology	Dallas	Texas	75204	Recruiting
Dallas Renal Group- Dallas	Dallas	Texas	75230	Recruiting
Zenos Clinical Research	Dallas	Texas	75230	Recruiting
Nephrotex Research Group	Dallas	Texas	75231	Completed
Dallas Renal Group - Liberty Dallas Dialysis Center	Dallas	Texas	75237	Recruiting
Dallas Nephrology Associates - Dallas Landry Office	Dallas	Texas	75246	Recruiting
Southwest Family Medicine Associates (SFMA) - Dallas	Dallas	Texas	75325	Recruiting
UTSW Medical Center - Nephrology	Dallas	Texas	75390	Recruiting
Davita Clinical Research - El Paso	El Paso	Texas	79925	Recruiting
Cook Children's Medical Center	Fort Worth	Texas	76104	Recruiting
Prolato Clinical Research Center - Kirby Dr	Houston	Texas	77054	Recruiting
Ronald Ralph MD PA	Houston	Texas	77054	Recruiting
Houston Medical Research Institute, LLC	Houston	Texas	77074	Completed
Clinical Research Strategies - Romano North Main Office	Houston	Texas	77090	Completed
Frenova-Southwest Houston	Houston	Texas	77099	Completed
NTKDA Lewisville	Lewisville	Texas	75057	Completed
Prime Clinical Research Inc - Lewisville	Lewisville	Texas	75067	Recruiting
Texas Tech University Health Sciences Center	Lubbock	Texas	79430	Recruiting
Prime Clinical Research - Mansfield - Regency Parkway	Mansfield	Texas	76063	Recruiting
San Antonio Kidney Disease Center Physicians Group - Medical Center	San Antonio	Texas	78229	Withdrawn
University of Texas Health Science Center - Nephrology	San Antonio	Texas	78229	Completed
San Antonio Kidney Disease Center Physicians Group - Westover Hills	San Antonio	Texas	78251	Completed
Kidney Specialists of N Houston, PLLC	Shenandoah	Texas	77384	Recruiting
Renal Research of Montgomery County, PLLC	The Woodlands	Texas	77384	Recruiting
Tranquil Clinical Research	Webster	Texas	77598	Recruiting
UVA Health - Nephrology Clinical Research Center	Charlottesville	Virginia	22908	Recruiting
Tidewater Kidney Specialists - Church St.	Norfolk	Virginia	23504	Recruiting
York Clinical Research, LLC	Norfolk	Virginia	23504	Completed
McGuire Research Institute, Inc. (151)	Richmond	Virginia	23249	Recruiting
Virginia Commonwealth University - Division of Nephrology	Richmond	Virginia	23298	Recruiting
Nephrology Associates of Tidewater, LTD	Virginia Beach	Virginia	23454	Completed
UW Medical Center - Montlake - Nephrology	Seattle	Washington	98195	Recruiting
Medical College of Wisconsin - Pulmonology	Milwaukee	Wisconsin	53226	Recruiting
Milwaukee Nephrologists - Wauwatosa	Wauwatosa	Wisconsin	53226	Recruiting

Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.

Non-U.S. locations

This page focuses on the U.S. directory. The official record also lists 91 non-U.S. sites.

About this trial record page

What this page shows: Public field values for ClinicalTrials.gov record NCT05312879, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
What this page does not do: No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
Where the data comes from: Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
Last refresh: Last update posted Apr 16, 2026 · Synced Apr 22, 2026

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