ClinicalTrials.gov record
Phase 2/3 Adaptive Study of VX-147 in Adult and Pediatric Participants With APOL1-Mediated Proteinuric Kidney Disease
ClinicalTrials.gov ID: NCT05312879
Public ClinicalTrials.gov record NCT05312879. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Phase 2/3 Adaptive, Double-blind, Placebo-Controlled Study to Evaluate the Efficacy and Safety of VX-147 in Adult and Pediatric Subjects With APOL1-mediated Proteinuric Kidney Disease
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
The purpose of this study is to evaluate the efficacy, safety, tolerability, and pharmacokinetics (PK) of VX-147 in adult and pediatric participants with apolipoprotein L1 (APOL1)-mediated proteinuric kidney disease.
Study identification
- NCT ID
- NCT05312879
- Recruitment status
- Active, not recruiting
- Study type
- Interventional
- Phase
- Phase 2, Phase 3
- Enrollment
- 522 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 10 Years to 65 Years
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Mar 30, 2022 (Actual)
- Primary completion
- Jun 2, 2028 (Estimated)
- Completion
- May 7, 2030 (Estimated)
- Last update posted
- Oct 26, 2026
2022 – 2030
United States locations
- U.S. sites
- 223
- U.S. states
- 33
- U.S. cities
- 147
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Alabama Kidney Research | Alabaster | Alabama | 35007 | — |
| EmVenio Research - Mobile Unit - Birmingham | Birmingham | Alabama | 35210 | — |
| Cardiology, P.C. | Birmingham | Alabama | 35211 | — |
| Children's Hospital of Alabama | Birmingham | Alabama | 35233 | — |
| The Kirklin Clinic - Nephrology | Birmingham | Alabama | 35294 | — |
| Nephrology Associates | Fairhope | Alabama | 36532 | — |
| Heart Center Research LLC | Huntsville | Alabama | 35801 | — |
| Nephrology Consultants, LLC | Huntsville | Alabama | 35805 | — |
| Renal Associates of Alabama, LLC | Montgomery | Alabama | 36117 | — |
| Arizona Kidney Disease and Hypertension Center - Thomas Office | Phoenix | Arizona | 85016 | — |
| Phoenix Children's Hospital, Inc. - Nephrology | Phoenix | Arizona | 85016 | — |
| CHI St. Vincent Heart Clinic Arkansas- Cardiology and Medicine Clinic - Little Rock | Little Rock | Arkansas | 72204 | — |
| UAMS Medical Center - Pulmonology | Little Rock | Arkansas | 72205 | — |
| The Medical Research Group - Saint Agnes Medical Center | Fresno | California | 93720 | — |
| Amicis Research Center - Balboa | Granada Hills | California | 91344 | — |
| Kidney Care Center of North Valley | Granada Hills | California | 91344 | — |
| Eastside Clinical Research Associates | Los Angeles | California | 90022 | — |
| Kaiser Permanente Los Angeles Medical Center | Los Angeles | California | 90027 | — |
| Cedars-Sinai Medical Center | Los Angeles | California | 90048 | — |
| UCLA Division of Nephrology | Los Angeles | California | 90095 | — |
| UCI Center for Clinical Research | Orange | California | 92868 | — |
| Kaiser Permanente Sacramento Medical Center | Sacramento | California | 95825 | — |
| Helen Diller Medical Center at Parnassus Heights | San Francisco | California | 94143 | — |
| UCLA Lundquist Institute at Harbor-UCLA Medical Center | Torrance | California | 90502 | — |
| Kidney and Hypertension Center | Victorville | California | 92395 | — |
| Greater Hartford Nephrology | Bloomfield | Connecticut | 06002 | — |
| Nephrology & Hypertension Associates, PC | Middlebury | Connecticut | 06762 | — |
| Yale University - Yale Nephrology Clinical Research Clinic | New Haven | Connecticut | 06510 | — |
| Children's National Hospital - Nephrology | Washington D.C. | District of Columbia | 20010 | — |
| The George Washington University - GW Medical Faculty Associates | Washington D.C. | District of Columbia | 20037 | — |
| Veterans Affairs Medical Center - Washington D.C | Washington D.C. | District of Columbia | 20422 | — |
| Bay Pines Foundation | Bay Pines | Florida | 33744 | — |
| Nova Clinical Research, LLC - Bradenton - 59th St | Bradenton | Florida | 34209 | — |
| Clinical Research of Brandon, LLC | Brandon | Florida | 33511 | — |
| AMR-Miami | Coral Gables | Florida | 33134 | — |
| Horizon Research Group - Coral Gables | Coral Gables | Florida | 33134 | — |
| South Florida Nephrology Research | Coral Springs | Florida | 33071 | — |
| Delray Physician Care Center | Delray Beach | Florida | 33445 | — |
| North Florida/South Georgia Veterans Health System | Gainesville | Florida | 32608 | — |
| Shands Hospital - Nephrology | Gainesville | Florida | 32610 | — |
| Velocity Clinical Research - Hallandale Beach | Hallandale | Florida | 33009 | — |
| Qway Research | Hialeah | Florida | 33010 | — |
| Elixia Pines | Hollywood | Florida | 33024 | — |
| UF Health Cardiovascular Center - Jacksonville | Jacksonville | Florida | 32209 | — |
| South Florida Research Institute | Lauderdale Lakes | Florida | 33313 | — |
| Total Research Group, LLC | Miami | Florida | 33126 | — |
| Cordova Research Institute | Miami | Florida | 33182 | — |
| South Florida Research | Miami Springs | Florida | 33166 | — |
| CTR Oakwater, LLC | Orlando | Florida | 32806 | — |
| Synexus Clinical Research - Orlando | Orlando | Florida | 32806 | — |
| Omega Research Orlando, LLC - Mercy Dr | Orlando | Florida | 32808 | — |
| Infigo Clinical Research | Sanford | Florida | 32771 | — |
| Genesis Clinical Research | Tampa | Florida | 33603 | — |
| Elixia Tampa | Tampa | Florida | 33618 | — |
| American Clinical Trials LLC - Acworth | Acworth | Georgia | 30101 | — |
| Kaiser Permanente Georgia | Atlanta | Georgia | 30305 | — |
| Emory School of Medicine - Renal Division | Atlanta | Georgia | 30308 | — |
| Advanced Clinical Research of Atlanta | Atlanta | Georgia | 30309 | — |
| Morehouse School of Medicine, Grady Memorial Hospital | Atlanta | Georgia | 30310 | — |
| Emory Childrens Center - Nephrology | Atlanta | Georgia | 30322 | — |
| Synexus Clinical Research - Atlanta (DRS) | Atlanta | Georgia | 30328 | — |
| Fides Clinical Research | Atlanta | Georgia | 30342 | — |
| Augusta University Medical College of Georgia - Adult Sickle Cell Clinic | Augusta | Georgia | 30912 | — |
| Coastal Medical Research | Brunswick | Georgia | 31520 | — |
| Randomize Now - College Park | College Park | Georgia | 30337 | — |
| Clincept - Veterans Pkwy. | Columbus | Georgia | 31904 | — |
| Renal Associates | Columbus | Georgia | 31904 | — |
| Georgia Nephrology - Decatur | Decatur | Georgia | 30030 | — |
| Atlanta VA Healthcare System | Decatur | Georgia | 30033 | — |
| American Clinical Trials LLC - Douglasville | Douglasville | Georgia | 30134 | — |
| Southeast Kidney Associates | East Point | Georgia | 30344 | — |
| Javara Inc./Privia Medical Group - Fayetteville, GA | Fayetteville | Georgia | 30214 | — |
| Georgia Nephrology - Lawrenceville - Billing Office | Lawrenceville | Georgia | 30046 | — |
| Javara Inc./Privia Medical Group - Savannah, GA | Savannah | Georgia | 31406 | — |
| Inova Clinical Trials and Research Center | Tyrone | Georgia | 30290 | — |
| Rophe Adult and Pediatric Medicine | Union City | Georgia | 30291 | — |
| Synexus Clinical Research - Chicago (DRS) | Chicago | Illinois | 60602 | — |
| EmVenio Research - Chicago | Chicago | Illinois | 60608 | — |
| Ann & Robert H. Lurie Children's Hospital of Chicago - Nephrology | Chicago | Illinois | 60611-2605 | — |
| Northwestern Medical Group | Chicago | Illinois | 60611 | — |
| UChicago Medicine - Comer Children's Hospital | Chicago | Illinois | 60637 | — |
| NANI Research LLC - Evergreen Park IL | Evergreen Park | Illinois | 60805 | — |
| Edward Hines Jr VA Hospital | Hines | Illinois | 60141 | — |
| Essential Concepts Research Solutions | Palos Hills | Illinois | 60465 | — |
| NANI Research LLC - Fort Wayne IN | Fort Wayne | Indiana | 46804 | — |
| IU School of Medicine - Nephrology | Indianapolis | Indiana | 46202 | — |
| Nephrology Physicians, LLC | Mishawaka | Indiana | 46545 | — |
| University of Iowa Health Care Medical Center- Nephrology | Iowa City | Iowa | 52242 | — |
| Clinical & Translational Science Unit (CTSU) - Nephrology | Kansas City | Kansas | 66160 | — |
| Premier Clinical Research | Overland Park | Kansas | 66210 | — |
| Renal Associates of Baton Rouge | Baton Rouge | Louisiana | 70808 | — |
| LCMC Health | Metairie | Louisiana | 70006 | — |
| Barnum Medical Research - Bienville St | Natchitoches | Louisiana | 71457 | — |
| Louisiana Clinical and Translational Science (LA CaTS) Center | New Orleans | Louisiana | 70112 | — |
| University Medical Center - New Orleans - Nephrology | New Orleans | Louisiana | 70112 | — |
| Ochsner Medical Center - New Orleans | New Orleans | Louisiana | 70121 | — |
| Northwest Louisiana Nephrology, LLC | Shreveport | Louisiana | 71101 | — |
| Louisiana State University Health Shreveport | Shreveport | Louisiana | 71103 | — |
| Monroe Research, LLC | West Monroe | Louisiana | 71291 | — |
| Javara Inc./Privia Medical Group - Annapolis, MD | Annapolis | Maryland | 21401 | — |
| University of Maryland Medical Center - General Clinical Research Center | Baltimore | Maryland | 21201 | — |
| The Johns Hopkins University - Johns Hopkins Hospital - Nephrology | Baltimore | Maryland | 21287 | — |
| Mid-Atlantic Permanente Research Institute | Gaithersburg | Maryland | 20879 | — |
| Patient First Clinical Trials | Lutherville | Maryland | 21093 | — |
| MD Medical Research | Oxon Hill | Maryland | 20745 | — |
| Javara Inc./Privia Medical Group - Silver Spring, MD - Columbia Pike | Silver Spring | Maryland | 20901 | — |
| Tufts Medical Center | Boston | Massachusetts | 02111 | — |
| Boston Medical Center | Boston | Massachusetts | 02118 | — |
| Beth Israel Deaconess Medical Center - Nephrology | Boston | Massachusetts | 02215 | — |
| Whittier Street Health Center | Roxbury | Massachusetts | 02120 | — |
| Renal and Transplant Associates of New England, PC | Springfield | Massachusetts | 01107 | — |
| Kidney Care and Transplant Services of New England - West Springfield | West Springfield | Massachusetts | 01089 | — |
| A. Alfred Taubman Health Care Center - Nephrology Clinic at Taubman Center | Ann Arbor | Michigan | 48109 | — |
| Henry Ford Health System - Nephrology | Detroit | Michigan | 48202 | — |
| Quest Research Institute | Farmington Hills | Michigan | 48334 | — |
| AA Medical Research Center | Flint | Michigan | 48504 | — |
| Sparrow Clinical Research Institute | Lansing | Michigan | 48912 | — |
| St. Clair Nephrology Research | Roseville | Michigan | 48066 | — |
| Center for Advanced Kidney Research | Saint Clair Shores | Michigan | 48081 | — |
| InterMed Consultants - Edina Clinic | Edina | Minnesota | 55435 | — |
| Minneapolis VA Healthcare System | Minneapolis | Minnesota | 55417 | — |
| Nephrology Associates, P.C. - Columbus | Columbus | Mississippi | 39705 | — |
| Prime Health and Wellness | Fayette | Mississippi | 39069 | — |
| UMMC Grenada Hospital | Grenada | Mississippi | 38901 | — |
| G.V. (Sonny) Montgomery VAMC | Jackson | Mississippi | 39216 | — |
| Olive Branch Family Medical Center | Olive Branch | Mississippi | 38654 | — |
| SKY Integrative Medical Center | Ridgeland | Mississippi | 39157 | — |
| Nephrology and Hypertension Associates - Tupelo | Tupelo | Mississippi | 38801 | — |
| Center for Specialized Medicine - Nephrology | St Louis | Missouri | 63104 | — |
| Barnes-Jewish Center for Outpatient Health | St Louis | Missouri | 63108 | — |
| St. Louis Children's Hospital - Nephrology | St Louis | Missouri | 63110 | — |
| St. Louis Heart and Vascular, P.C. | St Louis | Missouri | 63136 | — |
| DaVita Kidney Care - Las Vegas | Las Vegas | Nevada | 89107 | — |
| CUH - Sheridan Pavilion - Three Cooper Plaza | Camden | New Jersey | 08103 | — |
| Hackensack University Medical Center | Hackensack | New Jersey | 07601 | — |
| Bioluminux Clinical Research New Jersey | Hamilton | New Jersey | 08690 | — |
| Jersey Shore University Medical Center | Neptune City | New Jersey | 07753 | — |
| Rutgers Doctors Office Center | Newark | New Jersey | 07103 | — |
| New Mexico VA Healthcare System | Albuquerque | New Mexico | 87108 | — |
| Renal Medicine Associates | Albuquerque | New Mexico | 87109 | — |
| Kings County Hospital | Brooklyn | New York | 11203 | — |
| SUNY Downstate Health Sciences University | Brooklyn | New York | 11203 | — |
| Clindove Research LLC | Brooklyn | New York | 11221 | — |
| New York Presbyterian Queens | Flushing | New York | 11365 | — |
| Zucker School of Medicine | Great Neck | New York | 11021 | — |
| Scott Research, Inc. | Laurelton | New York | 11413 | — |
| VA New York Harbor Healthcare System | New York | New York | 10010 | — |
| Grossman School of Medicine | New York | New York | 10016 | — |
| Synexus Clinical Research - New York (DRS) | New York | New York | 10017 | — |
| The Rogosin Kidney Center | New York | New York | 10021 | — |
| Icahn School of Medicine at Mount Sinai - Nephrology | New York | New York | 10029 | — |
| General Nephrology Clinic - New York City | New York | New York | 10032 | — |
| NYC Health + Hospital/Harlem | New York | New York | 10037 | — |
| Kidney Medical Associates, PLLC | The Bronx | New York | 10461 | — |
| Montefiore Einstein - Albert Einstein College of Medicine | The Bronx | New York | 10461 | — |
| Montefiore Einstein Hospital - Moses Campus | The Bronx | New York | 10467 | — |
| James J. Peters VA Medical Center | The Bronx | New York | 10468 | — |
| North Carolina Nephrology P.A. - Cary | Cary | North Carolina | 27511 | — |
| UNC Clinical and Translational Research Center | Chapel Hill | North Carolina | 27599-7155 | — |
| Metrolina Nephrology Associates - Freedom Dr | Charlotte | North Carolina | 28208 | — |
| Duke University Hospital - Children's Health Center | Durham | North Carolina | 27710 | — |
| Eastern Nephrology Associates - Greenville Office | Greenville | North Carolina | 27834 | — |
| Eastern Nephrology Associates - Jacksonville Office | Jacksonville | North Carolina | 28546 | — |
| Eastern Nephrology Associates - Kinston Office | Kinston | North Carolina | 28504 | — |
| Eastern Nephrology Associates - New Bern Office | New Bern | North Carolina | 28562 | — |
| Eastern Nephrology Associates - Wilmington Office | Wilmington | North Carolina | 28401 | — |
| Brookview Hills Research Associates | Winston-Salem | North Carolina | 27103 | — |
| UC - DCI McMillan Research Unit | Cincinnati | Ohio | 45206 | — |
| Cincinnati VA Medical Center | Cincinnati | Ohio | 45220 | — |
| Louis Stokes Cleveland VA medical Center | Cleveland | Ohio | 44106 | — |
| UH Cleveland Medical Center - Nephrology | Cleveland | Ohio | 44106 | — |
| Cleveland Clinic - Main Campus | Cleveland | Ohio | 44195 | — |
| Ohio State University - Wexner Medical Center - Nephrology Clinical Trials Unit | Columbus | Ohio | 43201 | — |
| Jefferson Health - 33 South 9th Street | Philadelphia | Pennsylvania | 19107 | — |
| Lewis Katz School of Medicine at Temple University - Section of Nephrology | Philadelphia | Pennsylvania | 19140 | — |
| Jefferson Einstein Philadelphia Hospital - Nephrology | Philadelphia | Pennsylvania | 19141 | — |
| Children's Hospital of Pittsburgh - Nephrology | Pittsburgh | Pennsylvania | 15224 | — |
| Lifespan Clinical Research Center | East Providence | Rhode Island | 02915 | — |
| Pharmacorp Clinical Trials, Inc | Charleston | South Carolina | 29412 | — |
| Medical University of South Carolina - Pulmonology | Charleston | South Carolina | 29425 | — |
| Columbia Nephrology Associates, PA | Columbia | South Carolina | 29203 | — |
| Carolina Nephrology, PA | Spartanburg | South Carolina | 29306 | — |
| Southeast Renal Research Institute | Chattanooga | Tennessee | 37404 | — |
| Le Bonheur Children's Hospital - Outpatient Clinic | Memphis | Tennessee | 38105 | — |
| CNS Healthcare - Memphis | Memphis | Tennessee | 38119 | — |
| Nashville General Hospital - Meharry Medical College - Nephrology | Nashville | Tennessee | 37208 | — |
| Nashville VA Medical Center | Nashville | Tennessee | 37212 | — |
| Nephrology Clinical Trials Center | Nashville | Tennessee | 37232 | — |
| Dallas Renal Group - Mansfield | Arlington | Texas | 76002 | — |
| Arlington Nephrology | Arlington | Texas | 76015 | — |
| Baylor Scott and White Research Institute - Nephrology | Dallas | Texas | 75204 | — |
| Dallas Renal Group- Dallas | Dallas | Texas | 75230 | — |
| Zenos Clinical Research | Dallas | Texas | 75230 | — |
| Nephrotex Research Group | Dallas | Texas | 75231 | — |
| Dallas Renal Group - Liberty Dallas Dialysis Center | Dallas | Texas | 75237 | — |
| Dallas Nephrology Associates - Dallas Landry Office | Dallas | Texas | 75246 | — |
| Southwest Family Medicine Associates (SFMA) - Dallas | Dallas | Texas | 75325 | — |
| UTSW Medical Center - Nephrology | Dallas | Texas | 75390 | — |
| Davita Clinical Research - El Paso | El Paso | Texas | 79925 | — |
| Cook Children's Medical Center | Fort Worth | Texas | 76104 | — |
| Prolato Clinical Research Center - Kirby Dr | Houston | Texas | 77054 | — |
| Ronald Ralph MD PA | Houston | Texas | 77054 | — |
| Houston Medical Research Institute, LLC | Houston | Texas | 77074 | — |
| Clinical Research Strategies - Romano North Main Office | Houston | Texas | 77090 | — |
| Frenova-Southwest Houston | Houston | Texas | 77099 | — |
| NTKDA Lewisville | Lewisville | Texas | 75057 | — |
| Prime Clinical Research Inc - Lewisville | Lewisville | Texas | 75067 | — |
| Texas Tech University Health Sciences Center | Lubbock | Texas | 79430 | — |
| Prime Clinical Research - Mansfield - Regency Parkway | Mansfield | Texas | 76063 | — |
| University of Texas Health Science Center - Nephrology | San Antonio | Texas | 78229 | — |
| San Antonio Kidney Disease Center Physicians Group - Westover Hills | San Antonio | Texas | 78251 | — |
| Kidney Specialists of N Houston, PLLC | Shenandoah | Texas | 77384 | — |
| Renal Research of Montgomery County, PLLC | The Woodlands | Texas | 77384 | — |
| Tranquil Clinical Research | Webster | Texas | 77598 | — |
| UVA Health - Nephrology Clinical Research Center | Charlottesville | Virginia | 22908 | — |
| Tidewater Kidney Specialists - Church St. | Norfolk | Virginia | 23504 | — |
| York Clinical Research, LLC | Norfolk | Virginia | 23504 | — |
| McGuire Research Institute, Inc. (151) | Richmond | Virginia | 23249 | — |
| Virginia Commonwealth University - Division of Nephrology | Richmond | Virginia | 23298 | — |
| Nephrology Associates of Tidewater, LTD | Virginia Beach | Virginia | 23454 | — |
| UW Medical Center - Montlake - Nephrology | Seattle | Washington | 98195 | — |
| Medical College of Wisconsin - Pulmonology | Milwaukee | Wisconsin | 53226 | — |
| Milwaukee Nephrologists - Wauwatosa | Wauwatosa | Wisconsin | 53226 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 91 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT05312879, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Oct 26, 2026 · Synced Oct 27, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT05312879 live on ClinicalTrials.gov.