Study to Evaluate the Efficacy and Safety of K-877-ER and CSG452 in Participants With NASH With Liver Fibrosis
Public ClinicalTrials.gov record NCT05327127. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
Study to Evaluate the Efficacy and Safety of Combination Therapy of K-877-ER and CSG452 in Participants With Noncirrhotic Nonalcoholic Steatohepatitis (NASH) With Liver Fibrosis
Study identification
- NCT ID
- NCT05327127
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 2
- Lead sponsor
- Kowa Research Institute, Inc.
- Industry
- Enrollment
- 228 participants
Conditions and interventions
Conditions
Interventions
- K-877-ER Drug
- CSG452 Drug
- Placebo Drug
Drug
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Nov 13, 2022
- Primary completion
- May 19, 2026
- Completion
- Jun 2, 2026
- Last update posted
- Jun 25, 2026
2022 – 2026
United States locations
- U.S. sites
- 37
- U.S. states
- 18
- U.S. cities
- 33
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Adobe Clinical Research, LLC | Tucson | Arizona | 85712 | — |
| Arizona Liver Health | Tucson | Arizona | 85712 | — |
| Arcare Center for Clinical Research | Little Rock | Arkansas | 72205 | — |
| Clinical Trials Research | Lincoln | California | 95648 | — |
| United Clinical Research Institute | Los Alamitos | California | 90720 | — |
| Velocity Clinical Research | Los Angeles | California | 90057 | — |
| Alliance Clinical Research | Poway | California | 92064 | — |
| Nature Coast Clinical Research, LLC | Inverness | Florida | 34452 | — |
| ENCORE Borland Groover Clinical Research | Jacksonville | Florida | 32256 | — |
| Miami Clinical Research | Miami | Florida | 33155 | — |
| Ocala GI Research | Ocala | Florida | 34471 | — |
| Sensible Healthcare Clinical Research, LLC | Ocoee | Florida | 34761 | — |
| Centricity Research | Columbus | Georgia | 31904 | — |
| Gastrointestinal Specialists of Georgia, PC | Marietta | Georgia | 30060 | — |
| Iowa Digestive Disease Center | Clive | Iowa | 50325 | — |
| Tandem Clinical Research, LLC | Marrero | Louisiana | 70072 | — |
| Mid-Atlantic GI Research, LLC | Greenbelt | Maryland | 20770 | — |
| Boston Medical Center Boston University Chobanian & Avedisian School of Medicine | Boston | Massachusetts | 02118 | — |
| University of Michigan | Ann Arbor | Michigan | 48109 | — |
| GI Alliance Research | Flowood | Mississippi | 39232 | — |
| GI Associates Research, LLC | Columbia | Missouri | 65201 | — |
| Jefferson City Medical Group | Jefferson City | Missouri | 65109 | — |
| Lucas Research, Inc. | Morehead City | North Carolina | 28557 | — |
| DSI Research Northridge, LLC | Dayton | Ohio | 45414 | — |
| Penn State Health/Penn State College of Medicine | Hershey | Pennsylvania | 17033 | — |
| GI Alliance Research | Cedar Park | Texas | 78613 | — |
| GI Alliance Research | Dallas | Texas | 75246 | — |
| GI Alliance Research | Garland | Texas | 75044 | — |
| GLRI McAllen Research | Pharr | Texas | 78577 | — |
| Northeast Clinical Rsearch of San Antonio | San Antonio | Texas | 78233 | — |
| Endeavor Clinical Trials | San Antonio | Texas | 78240 | — |
| Impact Research Institute | Waco | Texas | 76710 | — |
| Digestive Health Research of Central Texas, LLC | Waco | Texas | 76712 | — |
| North Richmond Health Research | Richmond | Virginia | 23229 | — |
| GI Select Health Research | Richmond | Virginia | 23236 | — |
| Centricity | Suffolk | Virginia | 23435 | — |
| Liver Institute Northwest | Seattle | Washington | 98105 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 40 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT05327127, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Jun 25, 2026 · Synced Jul 22, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete protocol, eligibility criteria, and contact information for NCT05327127 live on ClinicalTrials.gov.