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Recruiting Phase 3 Interventional

Abatacept in Immune Checkpoint Inhibitor Myocarditis

ClinicalTrials.gov ID: NCT05335928

Public ClinicalTrials.gov record NCT05335928. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.

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ClinicalTrials.gov public records Last synced Jul 29, 2026, 12:21 AM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

Official title

AbatacepT foR ImmUne Checkpoint Inhibitor Associated Myocarditis (ATRIUM): A Phase 3, Investigator-Initiated, Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Efficacy and Safety of Abatacept in ICI Myocarditis

Brief summary

Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.

The primary aim is to test whether abatacept, as compared to placebo, is associated with a reduction in major adverse cardiac events (MACE) among participants hospitalized with myocarditis secondary to an immune checkpoint inhibitor (ICI). The primary outcome, MACE, is a composite of first occurrence of cardiovascular death, non-fatal sudden cardiac arrest, cardiogenic shock, significant ventricular arrythmias, significant bradyarrythmias, or incident heart failure.

Study identification

NCT ID
NCT05335928
Recruitment status
Recruiting
Study type
Interventional
Phase
Phase 3
Enrollment
390 participants

Conditions and interventions

Interventions

Drug

Eligibility (public fields only)

Age range
18 Years and older
Sex
All
Healthy volunteers
Healthy volunteers not accepted

This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.

Study timeline

Start date
Jul 1, 2022
Primary completion
Nov 19, 2026
Completion
Apr 19, 2027
Last update posted
Sep 9, 2025

2022 – 2027

United States locations

U.S. sites
29
U.S. states
21
U.S. cities
24
Facility City State ZIP Site status
Cedars-Sinai Medical Center Los Angeles California 02127 Recruiting
University of California Los Angeles Los Angeles California 90095 Recruiting
MedStar Health Research Institute, Georgetown University Washington D.C. District of Columbia 20010 Recruiting
Moffitt Cancer Center Tampa Florida 33612 Recruiting
University of Chicago Chicago Illinois 60637 Recruiting
Franciscan Health Indianapolis Indiana 46237 Recruiting
University of Kansas Medical Center Kansas City Kansas 66160 Recruiting
University of Kentucky Lexington Kentucky 40536-0200 Recruiting
Maine Health Portland Maine 04102 Recruiting
Johns Hopkins Baltimore Maryland 21287 Recruiting
Massachusetts General Hospital Boston Massachusetts 02114 Recruiting
Beth Israel Deaconess Medical Center Boston Massachusetts 02115 Recruiting
Boston Medical Center Boston Massachusetts 02118 Recruiting
Brigham and Women's Hospital Boston Massachusetts 02215 Recruiting
University of Michigan Ann Arbor Michigan 48109 Recruiting
Mayo Clinic Rochester Minnesota 55905 Recruiting
Robert Wood Johnson University Hospital New Brunswick New Jersey 08901 Recruiting
Columbia University Irving Medical Center New York New York 10032 Recruiting
Memorial Sloan Kettering Cancer Center New York New York 10065 Recruiting
University of North Carolina Chapel Hill Chapel Hill North Carolina 27599-7075 Recruiting
Cleveland Clinic Cleveland Ohio 44195 Recruiting
Lehigh Valley Health Network Bethlehem Pennsylvania 18017 Recruiting
University of Pennsylvania Philadelphia Pennsylvania 19104 Recruiting
Allegheny-Singer Research Institution Pittsburgh Pennsylvania 15212 Recruiting
University of Texas Southwestern Dallas Texas 72535 Recruiting
MD Anderson Cancer Center Houston Texas 77030 Not yet recruiting
University of Utah Salt Lake City Utah 84132 Recruiting
University of West Virginia Morgantown West Virginia 26506 Recruiting
Aurora St Luke's Medical Center Milwaukee Wisconsin 53215 Recruiting

Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.

Non-U.S. locations

This page focuses on the U.S. directory. The official record also lists 2 non-U.S. sites.

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About this trial record page

What this page shows
Public field values for ClinicalTrials.gov record NCT05335928, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
What this page does not do
No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
Where the data comes from
Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
Last refresh
Last update posted Sep 9, 2025 · Synced Jul 29, 2026

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Open the official record

The complete protocol, eligibility criteria, and contact information for NCT05335928 live on ClinicalTrials.gov.

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